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Diabetes and cancer: Associations, mechanisms, and implications for medical practice

World Journal of Diabetes 2014年第3期5卷 372-380页

作者： chun-xiao xu Hong-Hong Zhu Yi-Min Zhu Department of Chronic Non-Communicable Diseases Control and Prevention Zhejiang Provincial Center for Disease Control and Prevention Department of Public Health College of Health and Human Services Western Kentucky University Department of Epidemiology and Biostatistics School of Public Health Zhejiang University

Both diabetes mellitus and cancer are prevalent diseases worldwide. It is evident that there is a substantial increase in cancer incidence in diabetic patients. Epidemiologic studies have indicated that diabetic patients are at significantly higher risk of common cancers including pancreatic, liver, breast, colorectal, urinary tract, gastric and female reproductive cancers. Mortality due to cancer is moderately increased among patients with diabetes compared with those without. There is increasing evidence that some cancers are associated with diabetes, but the underlying mechanisms of this potential association have not been fully elucidated. Insulin is a potent growth factor that promotes cell proliferation and carcinogenesis directly and/or through insulin-like growth factor 1(IGF-1). Hyperinsulinemia leads to an increase in the bioactivity of IGF-1 by inhibiting IGF binding protein-1. Hyperglycemia serves as a subordinate plausible explanation of carcinogenesis. High glucose may exert direct and indirect effects upon cancer cells to promote proliferation. Also chronic inflammation is considered as a hallmark of carcinogenesis. The multiple drugs involved in the treatment of diabetes seem to modify the risk of cancer. Screening to detect cancer at an early stage and appropriate treatment of diabetic patients with cancer are important to improve their prognosis. This paper summarizes the associations between diabetes and common cancers, interprets possible mechanisms involved, and addresses implications for medical practice.

关键词： Diabetes mellitus Cancer Association Mechanism Medical practice

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Lack of association between lysyl oxidase-like 1 polymorphisms and primary open angle glaucoma: a meta-analysis

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International Journal of Ophthalmology(English edition) 2014年第3期7卷 550-556页

作者： Wen Sun Yan Sheng Yu Weng chun-xiao xu Susan E.I.Williams Yu-Tao Liu Michael A.Hauser R.Rand Allingham Ming-Juan Jin Guang-Di Chen Department of Ophthalmology the First Affiliated HospitalZhejiang University School of Medicine Department of Clinical Laboratory Sir Run Run Shaw Hospital Zhejiang University School of Medicine Department of Public Health Zhejiang University School of Medicine Division of Ophthalmology Department of NeurosciencesUniversity of the Witwatersrand Center for Human Genetics Duke University Medical Center Durham North Carolina 27710 USA Department of Ophthalmology Duke University Eye CenterDurham North Carolina 27710 USA

AIM:To study the associations between lysyl oxidaselike 1(LOXL1)polymorphisms and primary open angle glaucoma(POAG)remain *** this study,we have performed a meta-analysis to investigate the association of LOXL1 polymorphisms with POAG ***:Published literature from PubMed and other databases were *** studies evaluating the association between LOXL1 polymorphisms(rs2165241,rs1048661,rs3825942)and POAG risk were *** odds ratio(OR)and 95%confidence interval(CI)were calculated using random-or fixed-effects ***:Twelve studies were identified as eligible articles,with thirteen(2098 cases and 16 473 controls),thirteen(1795 cases and 2916 controls)and sixteen population cohorts(2456 cases and 2846 controls)for the association of rs2165241,rs1048661 and rs3825942with POAG risk *** analyses showed noassociation between each LOXL1 polymorphism and POAG risk,and the negative associations were remained when the subjects were stratified as Caucasian and *** heterozygote of rs2165241 was associated with reduced POAG risk in hospital-based populations(TC vs CC:OR,0.79,95%CI:0.63-0.99),and rs1048661was associated with increased POAG risk in hospitalbased populations in a dominant model(TT vs CC+CT:OR,1.23,95%CI:1.01-1.50);however,these associations were not found in population-based ***:This meta-analysis suggests that LOXL1 polymorphisms are not associated with POAG *** the limited sample size,the associations of LOXL1 polymorphisms with POAG risk in hospital-based populations await further investigation.

关键词： glaucoma gene polymorphism metaanalysis lysyl oxidase-like 1

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风障外流场风速分布的预测

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同济大学学报（自然科学版） 2004年第1期32卷 31-34页

作者：丛晓春张旭同济大学暖通空调与燃气研究所上海200092

作为减少风力、创造相对低速的局部微环境的主要措施,防护林风障对于保护道路、农田免受风沙流和风雪流侵袭,减少露天粉状物料堆对环境的污染有着重要意义.对于空气穿过风障这一复杂问题,采用高阶封闭模型——雷诺应力模型(RSM)计算,并... 详细信息

作为减少风力、创造相对低速的局部微环境的主要措施,防护林风障对于保护道路、农田免受风沙流和风雪流侵袭,减少露天粉状物料堆对环境的污染有着重要意义.对于空气穿过风障这一复杂问题,采用高阶封闭模型——雷诺应力模型(RSM)计算,并对气-叶阻力系数Cd,进行了理论推导,得出它是与叶片面积密度、风障结构以及下垫面粗糙度有关的变量,从而证实了相关现场观测结果.最后取不同的Cd值进行了数值计算,预测了外流场风速的分布情况.

关键词：高阶封闭模型气-叶阻力系数风障

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“工作岛”式机械创新实验室的建设与成效

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实验室研究与探索 2016年第9期35卷 259-262页

作者：肖春水徐洪李新辉陈秀浙江师范大学行知学院浙江金华321004

为了充分发挥实验室在提高学生创新能力上的作用,提出工作岛模式的机械创新实验室的建设思路。通过以完成创新项目为主要工作目标、严格的工作时间和进度计划、组长负责制下的分工协作和"师徒制"促梯队建设四个方面强化生产企业的工作模... 详细信息

为了充分发挥实验室在提高学生创新能力上的作用,提出工作岛模式的机械创新实验室的建设思路。通过以完成创新项目为主要工作目标、严格的工作时间和进度计划、组长负责制下的分工协作和"师徒制"促梯队建设四个方面强化生产企业的工作模式,营造创新工作氛围,构建学习与生产的"工作岛"。以有效服务于创新活动为原则,做到小而精;场地的配制,以最短工作路径为原则,围绕创新作品制作,形成环形岛式格局。针对创新的特殊要求从管理体制和安全管理两个方面阐述"工作岛"的运行。2年实践表明,工作岛式的机械创新实验室在培养和提高学生的创新能力上富有一定的成效。

关键词：创新工作岛机械创新实验室师徒制管理体制

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广义含时谐振子的精确解和Berry相因数

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物理学报 1991年第1期40卷 25-32页

作者：高孝纯许晶波钱铁铮浙江大学物理系杭州310027

本文利用Lewis-Riesenfeld的量子理论,求出广义含时谐振子的精确解。研究了此精确解的绝热渐近极限,并求出广义谐振子在量子绝热情形的Berry相因数。进而利用此精确解构造了广义含时谐振子的相干态,并得到相应的经典Hannay角。

关键词：谐振子精确解 Berry相因数

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei xu Ying Zeng Yun-Dong Wu xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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新型智能变电站通信网络时间同步脆弱性分析

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光通信研究 2017年第3期3期(20)卷 16-19页

作者：张纯笑徐嘉龙张亮余萍金乃正华北电力大学电气与电子工程学院河北保定071003 国网浙江省电力公司杭州310007 国网浙江省电力公司绍兴供电公司浙江绍兴312000

为了确保对新型智能变电站时间同步的动态监控,分析了新型智能变电站中心交换设备时间同步的脆弱性,利用有色Petri网对新型智能变电站中心交换设备对时的运行进行建模,给出了新型智能变电站中心交换设备对时攻击有色Petri网模型。利用... 详细信息

为了确保对新型智能变电站时间同步的动态监控,分析了新型智能变电站中心交换设备时间同步的脆弱性,利用有色Petri网对新型智能变电站中心交换设备对时的运行进行建模,给出了新型智能变电站中心交换设备对时攻击有色Petri网模型。利用线性代数数学分析工具,根据状态方程来验证所建模型攻击的可达性,从而找到时间同步脆弱性点并给出解决建议。

关键词：新型智能变电站中心交换机有色Petri网时间同步的脆弱性状态方程攻击的可达性

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Ni-catalyzed cross-electrophile alkyl-alkyl coupling reactions

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Science China Chemistry 2025年

作者： Li-xu You Lan Tian chun-Ling Guo Shun-Xi Li Yu-Cheng Liu Yu-Long Li Wei Shu College of Chemistry and Environmental Engineering Key Laboratory of Green Catalysis of Higher Education Institutes of Sichuan Sichuan University of Science and Engineering Guangming Advanced Research Institute Shenzhen Grubbs Institute Department of Chemistry and Guangdong Provincial Key Laboratory of Catalysis Southern University of Science and Technology

Introducing saturated carbon-carbon bonds into organic molecules significantly increases the three-dimensional configuration,thus altering the physical and chemical properties as well as the functions of molecules. Transition-metal-catalyzed carboncarbon cross-couplings represent one of the most straightforward, efficient and modular alternatives to build saturation in a single step. However, the efficient construction of alkyl-alkyl bonds remains a formidable challenge due to the precise manipulation of multiple alkyl metallic intermediates as well as associated competitive side reactions and selectivity control. Over the past years, Ni-catalyzed cross-coupling under reductive conditions has gained more and more attention for alkyl-alkyl crosscoupling partially attributing to the low-valent state of metal centers under reducing conditions, which suppresses the competitive β-hydride elimination process, thus facilitating the formation of alkyl-alkyl bonds. In this review, the initiative and progress of Ni-catalyzed cross-electrophile alkyl-alkyl cross-coupling, including the efforts in racemic and enantioselective formation of alkyl-alkyl bonds, have been summarized and discussed. Moreover, the challenges and further opportunities in this area have also been discussed.

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Validation of four different risk stratification models in 1559 patients undergoing isolated coronary artery bypass grafting surgery in a single center in China

Validation of four different risk stratification models in 1...

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第十三次全国心血管病学术会议

作者： ZHANG chun-xiao,xu Jian-ping,WEI Yui,SHI Yi Department of Cardiovascular Surgery,Cardiovascular Institute and Fuwai Hospital,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 1000730,China

Objective This study aimed to evaluate the accuracy of four existing risk stratification models(the society of thoracic surgeons 2008 cardiac surgery risk models for coronary artery bypass grafting surgery(CABG),the European system for cardiac operative risk evaluation(EuroSCORE),the American College of Cardiology/American Heart Association model (the ACC/AHA model) and the initial parsonnet’s score) in predicting operate mortality in Chinese patients undergoing

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宝钢地区大气边界层的湍流结构特征分析

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同济大学学报（自然科学版） 2004年第9期32卷 1136-1140页

作者：丛晓春张旭何大四同济大学暖通空调与燃气研究所上海200092

针对宝钢厂区开放性尘源对周边地区造成的严重大气环境污染问题 ,对该地区的风速和风向进行了 6个月的连续现场观测 ,并将观测数据加以整理 ,得出该地区的湍流结构特征值 :湍流强度在不稳定层结、中性层结和稳定层结下分别为 5 8% ,4 6 ... 详细信息

针对宝钢厂区开放性尘源对周边地区造成的严重大气环境污染问题 ,对该地区的风速和风向进行了 6个月的连续现场观测 ,并将观测数据加以整理 ,得出该地区的湍流结构特征值 :湍流强度在不稳定层结、中性层结和稳定层结下分别为 5 8% ,4 6 %和 38% ;湍流时间、空间积分尺度的平均值分别为 84 .1s和 2 2 2 .7m ;湍谱在惯性副区内虽受下垫面影响 ,波峰较窄 ,但仍能较好地满足“ - 2 / 3律” .同时将大气污染扩散系数的实测值与文献值加以对照发现 :实测的扩散参数要大于文献值 ,最大偏差约为 5 1.5 % ,平均偏差为 2 2 .4 % .

关键词：现场观测湍流特征结构大气扩散系数

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