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MicroRNA-181c provides neuroprotection in an intracerebral hemorrhage model

Neural Regeneration Research 2020年第7期15卷 1274-1282页

作者： xi lu Hui-Yuan Zhang Zhi-Yi He First Affiliated Hospital of China Medical University

Apoptosis is an important factor during the early stage of intracerebral ***-181 c plays a key regulatory role in ***,whether miR-181 c is involved in apoptosis of prophase cells after intracerebral hemorrhage remains ***,in vitro and in vivo experiments were conducted to test this *** vivo experiments:collagenase type VII was injected into the basal ganglia of adult Sprague-Dawley rats to establish an intracerebral hemorrhage ***-181 c mimic or inhibitor was injected in situ 4 hours after intracerebral *** functional defects(neurological severity scores)were assessed 1,7,and 14 days after model *** deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling and western blot assay were conducted 14 days after model *** vitro experiments:PC12 cells were cultured under oxygen-glucose deprivation,and hemins were added to simulate intracerebral hemorrhage in ***-181 c mimic or inhibitor was added to regulate miR-181 c expression.3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay,luciferase reporter system,and western blot assay were *** results revealed differences in miR-181 c expression in brain tissues of both patients and rats with cerebral *** addition,in vitro experiments found that miR-181 c overexpression could upregulate the Bcl-2/Bax ratio to inhibit apoptosis,while inhibition of miR-181 c expression could reduce the Bcl-2/Bax ratio and aggravate apoptosis of *** of apoptosis occurred through the phosphoinositide 3 kinase(PI3 K)/Akt pathway by targeting of phosphatase and tensin homolog deleted on chromosome ten(PTEN).Higher miR-181 c overexpression correlated with lower neurological severity scores,indicating better recovery of neurological *** conclusion,miR-181 c affects the prognosis of intracerebral hemorrhage by regulating apoptosis,and these effects might

关键词： apoptosis Bcl-2/Bax intracerebral hemorrhage miR-181c nerve cells neurological function neuroprotection PTEN regulation

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Multi-Task Learning for Food Identification and Analysis with Deep Convolutional Neural Networks

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Journal of Computer Science & Technology 2016年第3期31卷 489-500页

作者： xi-Jin Zhang Yi-Fan lu Song-Hai Zhang Department of Computer Science and Technology Tsinghua University Beijing 100084 China

In this paper, we proposed a multi-task system that can identify dish types, food ingredients, and cooking methods from food images with deep convolutional neural networks. We built up a dataset of 360 classes of different foods with at least 500 images for each class. To reduce the noises of the data, which was collected from the Internet, outlier images were detected and eliminated through a one-class SVM trained with deep convolutional features. We simultaneously trained a dish identifier, a cooking method recognizer, and a multi-label ingredient detector. They share a few low-level layers in the deep network architecture. The proposed framework shows higher accuracy than traditional method with handcrafted features, and the cooking method recognizer and ingredient detector can be applied to dishes which are not included in the training dataset to provide reference information for users.

关键词： multi-task learning convolutional neural network food recognition machine learning

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Cobalt-catalyzed reductive alkynylation to construct C(sp)-C(sp^(3))and C(sp)-C(sp^(2))bonds

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Chinese Chemical Letters 2024年第7期35卷 253-258页

作者： Lei Wan Yizhou Tong xi lu Yao Fu Hefei National Research Center for Physical Sciences at the Microscale iChEMCAS Key Laboratory of Urban Pollutant ConversionAnhui Province Key Laboratory of Biomass Clean EnergyUniversity of Science and Technology of ChinaHefei 230026China Key Laboratory of Precision and Intelligent Chemistry School of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefei 230026China

Transition-metal-catalyzed cross-electrophile coupling has emerged as a reliable method for constructing carbon–carbon ***,we report a general method,cobalt-catalyzed reductive alkynylation,to construct C(sp)-C(sp^(3))and C(sp)-C(sp^(2))*** presented reaction has a broad substrate scope,enabling the efficient cross-electrophile coupling between alkynyl bromides with alkyl halides and aryl or alkenyl(pseudo)*** presented reaction is conducted under mild conditions,tolerating many functional groups,thus suitable for the modification and synthesis of biologically active molecules.

关键词： Cobalt-catalysis Cross-electrophile coupling Carbon-carbon bond formation Reductive alkynylation Alkyne synthesis

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DIRECT NUMERICAL SIMULATION OF TURBULENT HEAT TRANSFER IN A WALL-NORMAL ROTATING CHANNEL FLOW

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Journal of Hydrodynamics 2006年第1期18卷 26-31页

作者： LI Bu-yang LIU Nan-sheng lu xi-yun Department of Mechanics and Mechanical Engineering University of Science and Technology of ChinaHefei 230026 China

Direct Nmerical Simulation （DNS） of turbulent heat transfer in a wall-normal rotating channel flow has been carried out for the rotation number Nr from 0 to 0.1, the Reynolds number 194 based on the friction velocity of non ro taring case and the half-height of the channel, and the Prandtl number 1. The objective of this study is to reveal the effects of rotation on the characteristics of turbulent flow and heat transfer. Based on the present calculated results, two typical rotation regimes are identified. When 0 〈 Nr 〈 0.06, turbu lence and thermal statistics correlated with the spanwise veloc ity fluctuation are enhanced since the shear rate of spanwise mean flow induced by Coriolis force increases; however, the other statistics are suppressed. When Nr 〉 0.06, turbulence and thermal statistics are suppressed significantly because the Coriolis force effect plays as a dominated role in the rotating flow. Remarkable change of the direction of near wall streak structures based on the velocity and temperature fluctuations is identified.

关键词： Direct Numerical Simulation (DNS) wallnormal rotating channel flow turbulent heat transfer thermal statistics

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Stabilization of Cu/ZnO Based Catalysts by Nickel Additive in Methanol Decomposition

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Chemical Research in Chinese Universities 2001年第4期17卷 420-425页

作者： xi Jing-yu WANG Zhi-fei lu Gong-xuan State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsThe Chinese Academy of SciencesLanzhou 730000P.R.China

A series of Cu/Zn based catalysts with and without Ni, prepared by the co-precipitation method, has been studied for methanol decomposition. CO and H2 are the major products. The Cu/Zn catalysts show a low initial activity and a poor stability. The formation of the CuZn alloys was observed in the deactivated Cu/Zn catalysts which were used for methanol decomposition at 250 . When small amounts of Ni were added in the catalyst, the Cu/Zn/Ni(molar ratio 5/4/ x) catalysts showed a high activity at a low temperature. The activity and the stability of the catalyst depend on the nickel content. The activity of the Cu/Zn/Ni catalysts was maintained at a. relatively stable value of 78% conversion of methanol with 95% selectivity of H2, 93% selectivity of CO, and a more than 70% yield of hydrogen was obtained at 250 C when x >1. The stability of the Cu/Zn/Ni (molar ratio 5/4/x) catalysts showed the maximum (ca 88%) when x=1. The stabilization effect of nickel on the Cu/Zn based catalysts may lead to the increasing of the dispersion of active Cu species and the prevention of CuZn alloys formation.

关键词： Nickel Cu/Zn catalysts Stabilization Methanol Decomposition

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Electrochemical performance of Li-rich cathode material,0.3Li_2MnO_3-0.7LiMn_(1/3)Ni_(1/3)Co_(1/3)O_2 microspheres with F-doping

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Rare Metals 2019年第3期38卷 189-198页

作者： Ting Liu Shi-xi Zhao lu-lu Gou xia Wu Ce-Wen Nan Graduate School at Shenzhen Tsinghua University School of Materials Science and Engineering Tsinghua University

Layered F-doped cathode materials 0.3 Li_2 MnO_3-0.7 LiMn_(1/3)Ni_(1/3)CO_(1/3))O_(2-x)F_x(x = 0, 0.01, 0.02, 0.03, 0.04,0.05) microspheres made up of nanosized primary grains were prepared through co-precipitation method. The sample of x = 0.02 demonstrates a large discharge capacity of226 mAh g^(-1) over 100 cycles at 0.1 C and excellent rate performance with discharge capacity of 96 mAh g-1 at 5.0 C and room temperature. Particularly, this material shows much enhanced electrochemical performances even at high temperature of 55 ℃. It delivers a quite high discharge capacity of 233.7 mAh·g^(-1) at 1.0 C with capacity retention as high as 97.9% after 100 cycles. The results demonstrate that the fluorine incorporation stabilizes the cathode structure and maintains stable interfacial resistances.

关键词： Lithium-ion battery Cathode materials 0.3Li2MnO3-0.7LiMn1/3Ni1/3Co1/3O2-xFx F-doped

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Pancreatic cancer incidence and mortality patterns in 2006-2015 and prediction of the epidemiological trend to 2025 in China

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World Journal of Clinical Cases 2022年第14期10卷 4404-4413页

作者： Min-Yue Yin Li-Ting xi lu Liu Jin-Zhou Zhu Li-Juan Qian chun-Fang Xu Department of Gastroenterology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

BACKGROUND Due to dietary patterns,the aging population,and other high-risk factors,the occurrence of pancreatic cancer(PC)has been rapidly increasing in *** To present the epidemiological trends of PC in China over the past decade and the estimated trend in 2025 and to compare the international differences in PC morbidity and *** This study used a series of nationally representative data from the National Central Cancer Registry of China(NCCR),the International Agency for Research on Cancer and the Institute for Health Metrics and Evaluation *** data of the PC incidence and mortality from 2006 to 2015 in China were extracted from the NCCR *** regression models were used to estimate the incidence and mortality rates of PC in *** The age-standardized rates of PC in China increased from 3.65 per 100000 in 2006 to 4.31 per 100000 in 2015 and were estimated to reach up to 5.52 per 100000 in *** mortality went from 3.35 per 100000 in 2006 to 3.78 per 100000 in 2015,estimated to reach up to 4.6 per 100000 in *** number of new cases and deaths was low before 45 years and the peak age of onset was 85-89 *** incidence and mortality rates in men were higher than those in women regardless of the region in *** addition,the incidence and mortality rates in China were higher than the average level around the ***,disabilityadjusted life years attributed to PC in China were 197.22 years per 100000,above the average level around the *** This study presented an increasing trend of PC in China and differences in morbidity,mortality and disability-adjusted life years between Chinese and global *** need to be made to decrease the PC incidence and improve patient outcomes.

关键词： Pancreatic cancer China Epidemiology Incidence Mortality

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Small cell lung cancer with peripheral neuropathy as the first symptom:Two case reports

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World Journal of Clinical Cases 2025年第9期13卷 30-40页

作者： Man luo xiao-xi lu Dan-Yang Meng Jin Hu Department of Neurology Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Information Technology Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Small cell lung cancer(SCLC)is the most malignant type of lung *** in the latent period and early stage of the tumor,SCLC is prone to produce distant metastases with complex and diverse clinical *** is most closely related to paraneoplastic syndrome,and some cases present as paraneoplastic peripheral neuropathy(PPN).PPN in SCLC appears early,lacks specificity,and often occurs before diagnosis of the primary *** is easy to be misdiagnosed as a primary disease of the nervous system,leading to missed diagnosis and delayed diagnosis and *** SUMMARY This paper reports two cases of SCLC with limb weakness as the first *** first symptoms of one patient were rash,limb weakness,and abnormal *** patient was repeatedly referred to the hospital for limb weakness and rash for>1 year,during which time,treatment with hormones and immunosuppressants did not lead to significant improvement,and the condition gradually *** patient was later diagnosed with SCLC,and the dyskinesia did not worsen as the dermatomyositis improved after antineoplastic and hormone *** second case presented with limb numbness and weakness as the first symptom,but the patient did not pay attention to ***,the patient was diagnosed with SCLC after facial edema caused by tumor thrombus invading the ***,he was diagnosed with extensive SCLC and died 1 year after *** The two cases had PPN and abnormal electromyography,highlighting its correlation with early clinical indicators of SCLC.

关键词： Paraneoplastic peripheral neuropathy Small cell lung cancer Peripheral neuropathy Electromyography Dermatomyositis Case report

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A Fragment of Cadherin-Like Protein Enhances Bacillus thuringiensis Cry1B and Cry1C Toxicity to Spodoptera exigua(Lepidoptera:Noctuidae)

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Journal of Integrative Agriculture 2012年第4期11卷 628-638页

作者： lu Qiong ZHANG Yongojun CAO Guang-chun ZHANG Li-li LIANG Ge-mei lu Yan-hui WU Kong-ming GAO xi-wu GUO Yu-yuan College of Agriculture and Biotechnology China Agricultural University Beijing 100193 P.R.China State Key Laboratory for Biology of Plant Diseases and Insect Pests/Institute of Plant Protection Chinese Academy of Agricultural Sciences Beijing 100193 P.R. China

Cry toxins produced by Bacillus thuringiensis（Bt） are effective biological insecticides against certain insect *** this study,bioassay results indicated that Cry1B and Cry1C were toxic to Spodoptera *** also identified a cadherin-like gene in *** that could enhance the toxicity of Cry1B and *** cadherin-like gene identified from the larvae midgut tissue was cloned by reverse transcription polymerase chain reaction（RT-PCR） and rapid amplification of cDNA ends（RACE）.The full-length cDNA of the gene consisted of 5 220 bp encoding 1 740 amino acid with a predicted molecular mass of 196 *** search analysis showed that the predicted amino acid sequence had a high sequence identity to the published sequences of cadherin-like proteins from other Lepidoptera *** expression of the cadherin-like gene detected by qRT-PCR analysis revealed that the cadherin-like gene was mainly present in the gut of 4th instar larvae and during different life *** results suggested that the commercial development of this synergist has the potential to enhance Cry1B and Cry1C toxicity against Lepidoptera insects.

关键词： Bacillus thuringiensis cadherin-like Spodoptera exigua enhancement toxicity

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高等农业院校教师参与农村科技服务的意愿及影响因素研究

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兵团教育学院学报 2025年第1期35卷 47-55页

作者：刘芬熊春林周曦蓉湖南农业大学东方科技学院湖南长沙410128 湖南农业大学公共管理与法学学院湖南长沙410128

从教师的个体特征、家庭特征、学科特征、参与动机、参与机会、参与能力6个维度提出研究假设,依据6所高等农业院校578名教师的调查数据,采用二元Logistic模型实证研究高等农业院校教师参与农村科技服务的意愿及影响因素。结果表明:表示... 详细信息

从教师的个体特征、家庭特征、学科特征、参与动机、参与机会、参与能力6个维度提出研究假设,依据6所高等农业院校578名教师的调查数据,采用二元Logistic模型实证研究高等农业院校教师参与农村科技服务的意愿及影响因素。结果表明:表示愿意参与农村科技服务的教师占72.7%;教师参与意愿受到教师的专业、家人支持力度、所在学科享有社会声誉与团队协作紧密等自身特征,获得职称晋升、社会赞誉、实现人生价值等参与动机,激励制度完善、组织体系健全、基地平台良好等参与机会,以及市场驾驭、沟通交往、自我调节等参与能力的影响。对此,应聚焦高等农业院校教师的实际需求,充分激发其内在动机,积极创造良好的机会,有效培养其综合能力,以提高教师参与农村科技服务的意愿,促使高等农业院校有效肩负起新时代科教兴农与农业农村现代化的使命担当。

关键词：高等农业院校教师参与意愿影响因素二元Logistic 科教兴农

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