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A Hf-doped dual-phase high-entropy alloy: phase evolution and wear features

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Rare Metals 2024年第1期43卷 324-333页

作者： Hao Ren Rui-Run Chen Xue-Feng Gao Tong Liu Gang Qin Yu-lung chiu Shi-Ping Wu Jing-Jie Guo National Key Laboratory for Precision Hot Processing of Metals School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001China School of Metallurgy and Materials University of BirminghamEdgbastonBirmingham B152TTUK

Initially defined high entropy alloys(HEAs)usually exhibit a single-phase solid-solution ***,two and/or more types of phases in HE As possibly induce the desired microstructure features,which contribute to improving the wear properties of HE ***,we prepare a series of(AlCoCrFeNi)_(100-x)Hf_(x)(x=0,2,4and 6;at%) HEAs and concern their phase compositions,micro structures and wear *** leads to the formation of(Ni,Co)_(2)Hf-type Laves phase and tailors the microstructure from a body-centered cubic(BCC) singlephase structure to a hypoeutectic *** increased hardness from~HV 512.3 to~HV 734.1 is due to solid-solution strengthening,grain refinement strengthening and precipitated phase *** a few oxides(Al_(2)O_(3)+Cr_(2)O_(3)) caused by the wear heating contribute to an 85.5% decrease in wear rate of the HEA system from6.71×10^(-5) to 0.97×10^(-5) m^(3)·N^(-1)·m^(-1).In addition,Hf addition changes the wear mechanism from abrasive wear,mild oxidative wear and adhesive wear to oxidative wear and adhesive wear.

关键词： High entropy alloy Laves phase Hardness Wear mechanism

Introduction of rare-earth element Sc in alloy design to modify wear features of dual-phase high-entropy alloy

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Rare Metals 2024年第2期43卷 817-828页

作者： Hao Ren Rui-Run Chen Xue-Feng Gao Tong Liu Gang Qin Yu-lung chiu Shi-Ping Wu Jing-Jie Guo Guo National Key Laboratory for Precision Hot Processing of Metals School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin150001China School of Metallurgy and Materials University of BirminghamBirminghamB152TTUK

Tailoring the alloy composition,which induces the hard secondary phase to increase hardness and strength to improve the wear features,is a feasible approach for developing wear-resistant metal ***,a group of(AlCoCrFeNi)_(100–x)Sc_(x)(x=0–2.0,at%)high-entropy alloys(HEAs)are designed and the phase compositions and wear behaviors are ***-doped HEA series contain the primary body-centered cubic(BCC)and eutectic phases,in which the eutectic phase is composed of the alternately grown BCC and Laves *** addition promotes the diffusion of Ni atoms from BCC phase to form the Sc-rich Laves phase at the grain *** hardness increases due to solid solution strengthening and second phase *** the second phase strengthening plays a more significant role relative to solid solution *** phase and the oxides caused by wear heating prevent the direct contact between friction pair and HEAs,thus inducing a decreased wear rate from 6.82×10^(−5) to 3.47×10^(−5)m^(3)·N^(−1)·m^(−1).Moreover,the wear mechanism changes from adhesive wear,abrasive wear and oxidative wear to abrasive wear and oxidative wear.

关键词： High entropy alloy(HEA) Laves phase Hardness Wear mechanism

Review of Computational Approaches to Optimization Problems in Inhomogeneous Rods and Plates

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Communications on Applied Mathematics and Computation 2024年第1期6卷 236-256页

作者： Weitao Chen chiu-Yen Kao Department of Mathematics University of California at Riverside900 University AveRiversideCA92521USA Department of Mathematical Sciences Claremont McKenna College850 Columbia AveClaremontCA91711USA

In this paper,we review computational approaches to optimization problems of inhomogeneous rods and *** consider both the optimization of eigenvalues and the localization of *** problems are motivated by physical problems including the determination of the extremum of the fundamental vibration frequency and the localization of the vibration *** demonstrate how an iterative rearrangement approach and a gradient descent approach with projection can successfully solve these optimization problems under different boundary conditions with different densities given.

关键词： Inhomogeneous rods and plates Bi-Laplacian Optimization of eigenvalues Localization of eigenfunctions Rearrangement

Vonoprazan 10 mg or 20 mg *** 15 mg as maintenance therapy in Asian patients with healed erosive esophagitis:A randomized controlled trial

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Chinese Medical Journal 2024年第8期137卷 962-971页

作者： Yinglian Xiao Jiaming Qian Shutian Zhang Ning Dai Hoon Jai chun Chengtang chiu Chui Fung Chong Nobuo Funao Yuuichi Sakurai Jessica D.Eisner Li Xie Minhu Chen Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510062China Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100006China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Gastroenterology Sir Run Run Shaw HospitalSchool of Medicine Zhejiang UniversityHangzhouZhejiang 310020China Department of Internal Medicine Korea University Anam HospitalKorea University College of Medicine73 Goryeodae-roSeongbuk-guSeoul 02841Republic of Korea Department of Gastroenterology&Hepatology Linkou Medical CenterChang Gung Memorial HospitalTaoyuanTaiwan 33353China College of Medicine Chang Gung UniversityTaoyuanTaiwan 33353China Takeda Development Center Asia Singapore 018981Singapore Takeda Pharmaceutical Company Chuo-kuOsaka 540-8645Japan Takeda Pharmaceuticals International Company CambridgeMA02142 USA China Medical Team Takeda ChinaBeijing 100027China Hoffmann-La Roche Basel4070 Switzerland Abbott Laboratories Lake ForestIL 60045USA

Background:Erosive esophagitis(EE)is a gastroesophageal reflux disease characterized by mucosal breaks in the *** pump inhibitors are widely used as maintenance therapy for EE,but many patients still *** this trial,we evaluated the noninferiority of vonoprazan *** as maintenance therapy in patients with healed ***:We performed a double-blind,double-dummy,multicenter,phase 3 clinical trial among non-Japanese Asian adults with endoscopically confirmed healed EE from April 2015 to February *** from China,South Korea,and Malaysia were randomized to vonoprazan 10 mg or 20 mg once daily or lansoprazole 15 mg once daily for 24 *** primary endpoint was endoscopically confirmed EE recurrence rate over 24 weeks with a noninferiority margin of 10%using a two-sided 95%confidence interval(CI).Treatment-emergent adverse events(TEAEs)were ***:Among 703 patients,EE recurrence was observed in 24/181(13.3%)and 21/171(12.3%)patients receiving vonoprazan 10 mg or 20 mg,respectively,and 47/184(25.5%)patients receiving lansoprazole(differences:-12.3%[95%CI,-20.3%to-4.3%]and-13.3%[95%CI,-21.3%to-5.3%],respectively),meeting the primary endpoint of noninferiority to lansoprazole in preventing EE recurrence at 24 *** of superiority(upper bound of 95%CI<0%)was also *** 12 weeks,endoscopically confirmed EE recurrence was observed in 5/18,2/20,and 7/20 of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** were experienced by 66.8%(157/235),69.0%(156/226),and 65.3%(158/242)of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** most common TEAE was upper respiratory tract infection in 12.8%(30/235)and 12.8%(29/226)patients in vonoprazan 10 mg and 20 mg groups,respectively and 8.7%(21/242)patients in lansoprazole ***:Vonoprazan maintenance therapy was well-tolerated and noninferior to lansoprazole for preventing EE recurrence i

关键词： Erosive esophagitis Lansoprazole Maintenance therapy Potassium-competitive acid blockers Vonoprazan

Classification of high-ordered topological nodes towards Moiré flat bands in twisted bilayers

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 133-147页

作者： Fan Cui Congcong Le Qiang Zhang Xianxin Wu Jiangping Hu Ching-Kai chiu Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China RIKEN Interdisciplinary Theoretical and Mathematical Sciences(iTHEMS) Wako 351-0198Japan CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Kavli Institute of Theoretical Sciences University of Chinese Academy of SciencesBeijing 100190China New Cornerstone Science Laboratory Beijing 100190China

At magic twisted angles,Dirac cones in twisted bilayer graphene(TBG)can evolve into flat bands,serving as a critical playground for the study of strongly correlated *** chiral symmetry is introduced,rigorous mathematical proof confirms that the flat bands are locked at zero energy in the entire Moiré Brillouin zone(BZ).Yet,TBG is not the sole platform that exhibits this absolute band *** to this flatness phenomenon are topological nodes and their specific locations in the *** this study,considering twisted bilayer systems that preserve chiral symmetry,we classify various ordered topological nodes in base layers and all possible node locations across different ***,we constrain the node locations to rotational centers,such as Γ and M points,to ensure the interlayer coupling retains equal strength in all *** this classification as a foundation,we systematically identify the conditions under which Moiré flat bands ***,through the extension of holomorphic functions,we provide proof that flat bands are locked at zero energy,shedding light on the origin of the band ***,beyond Dirac cones,numerous twisted bilayer nodal platforms can host flat bands with a degeneracy number of more than two,such as four-fold,six-fold,and *** multiplicity of degeneracy in flat bands might unveil more complex and enriched correlation physics.

关键词： twisted bilayer systems high-ordered topological nodes Moriéflat bands high degeneracy

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“If Somebody Needed Help, I Went Over”: Social Capital and Therapeutic Communities of Older Adult Farmers in British Columbia Floods

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International Journal of Disaster Risk Science 2024年第2期15卷 290-301页

作者： Kyle Breen Siyu Ru Luna Vandeweghe Jenna chiu Lindsay Heyland Haorui Wu School of Social Work Dalhousie UniversityHalifaxNS B3H 1S2Canada

Older adults in disaster contexts are often thought of as a passive, vulnerable population that lacks agency and capacities to cope in the aftermath. However, it can be argued that older adults may have underrecognized strengths that can be utilized pre-, peri-, and post-disaster. One of these strengths is older adults' unique social capital that stems from long-standing connections with other members of their respective communities. Using data from in-depth, semistructured interviews with farmers in British Columbia 3–11 months after the 2021 floods, this research explored the experiences of older adult farmers' recovery. The farmers discussed how they leveraged their social capital to aid in their recovery efforts from the flood event. By using their bonding social capital, older adult farmers transformed their existing, deep-rooted connections into post-disaster assistance. This, in turn, generated the idea of the therapeutic community, helping community members cope in the aftermath. This research indicated the need to further examine how older adults in disaster settings can be viewed as assets with community knowledge and skills as opposed to solely as a vulnerable population.

关键词： British Columbia Flood disaster Older adults Qualitative research Social capital Therapeutic community

A prospective cohort of men with localized prostate cancer on active surveillance protocol in Hong Kong,China:what did we learn?

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Asian Journal of Andrology 2024年第3期26卷 245-249页

作者： Xiaobo Wu Ivan Ching-Ho Ko Cindy Yeuk-Lam Hong Samuel Chi-Hang Yee Jeremy Yuen-chun Teoh Samson Yun-Sang Chan Ho-Man Tam Chi-Kwok Chan Chi-Fai Ng Peter Ka-Fung chiu SH Ho Urology Centre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong KongChina

This study aimed to report the outcomes of active surveillance(AS)in the management of low-risk prostate cancer(PCa).It recruited87 men who were prospectively followed up according to the Prostate Cancer Research International Active Surveillance(PRIAS)protocol with local adaptation at SH Ho Urology Centre,Prince of Wales Hospital,Hong Kong,*** investigated the predictorsof disease progression and found that baseline prostate-specific antigen density(PSAD)and the presence of the highest ProstateImaging-Reporting and Data System(PI-RADS)score 5 lesion on magnetic resonance imaging(MRI)are significantly correlatedwith disease ***,men with PSAD>0.2 ng ml^(−2)or PI-RADS 4 or 5 lesions had significantly worse upgradingfree survival compared to those with PSAD≤0.2 ng ml−2 and PI-RADS 2 or 3 *** study concludes that AS is a safe andeffective management strategy for selected patients to defer radical treatment and that most disease progression can be detectedafter the first repeated *** combination of PSAD>0.2 ng ml^(−2)and PI-RADS 4 or 5 lesions may serve as a useful predictorof early disease progression and provide a guide to optimize follow-up protocols for men in different risk groups.

关键词： active surveillance cohort localized prostate cancer

Detecting fake reviewers in heterogeneous networks of buyers and sellers:a collaborative training-based spammer group algorithm

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Cybersecurity 2024年第2期7卷 44-67页

作者： Qi Zhang Zhixiang Liang Shujuan Ji Benyong Xing Dickson K.W.chiu Shandong Provincial Key Laboratory of Wisdom Mine Information Technology Shandong University of Science and TechnologyQingdao 266590ShandongChina Zhejang University-University of linois at Urbana-Champaign Institute Haining 314499ZhejiangChina School of Civil Engineering Beijing Jiaotong UniversityBeijing 100044China Faculty of Education The University of Hong KongPok Fu LamHong KongChina

It is not uncommon for malicious sellers to collude with fake reviewers(also called spammers)to write fake reviews for multiple products to either demote competitors or promote their products'reputations,forming a gray industry *** detect spammer groups in a heterogeneous network with rich semantic information from both buyers and sellers,researchers have conducted extensive research using Frequent Item Mining-based and graph-based ***,these methods cannot detect spammer groups with cross-product attacks and do not jointly consider structural and attribute features,and structure-attribute correlation,resulting in poorer detection ***-fore,we propose a collaborative training-based spammer group detection algorithm by constructing a heterogene-ous induced sub-network based on the target product set to detect cross-product attack spammer *** jointly consider all available features,we use the collaborative training method to learn the feature representations of *** addition,we use the DBSCAN clustering method to generate candidate groups,exclude innocent ones,and rank them to obtain spammer *** experimental results on real-world datasets indicate that the overall detection performance of the proposed method is better than that of the baseline methods.

关键词： Spammer group Heterogeneous network Collaborative training DBSCAN

Glucagon-like peptide 1 receptor agonist:A potential game changer for cholangiocarcinoma

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World Journal of Gastroenterology 2024年第34期30卷 3862-3867页

作者： Ronnakrit Trakoonsenathong Ching-Feng chiu Charupong Saengboonmee Cho-Kalaphruek Excellent Research Project for Medical Students Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Department of Biochemistry Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Center for Translational Medicine Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Graduate Institute of Metabolism and Obesity Sciences Taipei Medical UniversityTaipei 11031Taiwan

Glucagon-like peptide-1 receptor(GLP-1R)agonist,a subgroup of incretin-based anti-diabetic therapies,is an emerging medication with benefits in reducing blood glucose and weight and increasing cardiovascular ***,concerns have been raised about GLP-1R agonists increasing the risk of particular ***,several epidemiological studies reported contradictory findings of incretin-based therapy on the risk modification for cholangiocarcinoma(CCA).The first cohort study demonstrated that incretin-based therapy was associated with an increased risk of *** studies,however,showed a null effect of incretinbased therapy on CCA risk for dipeptidyl peptidase-4 inhibitor nor GLP-1R ***,glucagon-like peptide 1 receptor is multifunctional,including promoting cell *** GLP-1R expressions were associated with progressive phenotypes of CCA cells in ***,the GLP-1R agonist showed anti-tumor effects on CCA cells in vitro and in vivo with unclear *** recent report also showed that GLP-1R agonists suppressed the expression of GLP-1R in CCA cells in vitro and in vivo,leading to the inhibition of CCA tumor *** editorial reviews recent evidence,discusses the potential effects of GLP-1R agonists in CCA patients,and proposes underlying mechanisms that would benefit from further basic and clinical investigation.

关键词： Carcinogenesis Cholangiocarcinoma Diabetes mellitus Incretin Glucagon-like peptide 1 receptor