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Analysis of the impact of immunotherapy efficacy and safety in patients with gastric cancer and liver metastasis

World Journal of Gastrointestinal Surgery 2024年第3期16卷 700-709页

作者： Kai liu chun-Xiao Wu Hui Liang Tao Wang Ji-Yuan Zhang Xiao-Tao Wang Department of Radiation and Oncology Traditional Chinese Hospital of Lu’an affiliated to Anhui University of Traditional Chinese MedicineLu’an 237000Anhui ProvinceChina Department of Gastroenterology Ehu branch of Xishan People’s Hospital of Wuxi CityWuxi 214116Jiangsu ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Guangzhou University of Traditional Chinese MedicineGuangzhou 510400Guangdong ProvinceChina Department of Gastrointestinal Surgery Hunan Provincial People’s HospitalChangsha 410002Hunan ProvinceChina Department of Traditional Chinese medicine Ehu branch of Xishan People’s Hospital of Wuxi CityWuxi 214116Jiangsu ProvinceChina

BACKGROUND Gastric cancer(GC)is the fifth most common type of cancer and has the fourth highest death rate among all *** is a lack of studies examining the impact of liver metastases on the effectiveness of immunotherapy in individuals diagnosed with *** To investigate the influence of liver metastases on the effectiveness and safety of immunotherapy in patients with advanced *** This retrospective investigation collected clinical data of patients with advanced stomach cancer who had immunotherapy at our hospital from February 2021 to January *** baseline attributes were compared using either the Chi-square test or the Fisher exact probability *** chi-square test and Kaplan-Meier survival analysis were employed to assess the therapeutic efficacy and survival duration in GC patients with and without liver *** The analysis comprised 48 patients diagnosed with advanced GC,who were categorized into two groups:A liver metastasis cohort(n=20)and a non-liver metastatic cohort(n=28).Patients with liver metastasis exhibited a more deteriorated physical condition compared to those without liver *** objective response rates in the cohort with metastasis and the cohort without metastasis were 15.0%and 35.7%(P>0.05),***,the disease control rates in these two cohorts were 65.0%and 82.1%(P>0.05),*** median progression-free survival was 5.0 months in one group and 11.2 months in the other group,with a hazard ratio of 0.40 and a significance level(P)less than *** median overall survival was 12.0 months in one group and 19.0 months in the other group,with a significance level(P)greater than *** Immunotherapy is less effective in GC patients with liver metastases compared to those without liver metastasis.

关键词： Gastric cancer Spread of cancer to the liver Treatment with immunotherapy Effectiveness of treatment

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Gallbladder carcinosarcoma with a poor prognosis: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1817-1823页

作者： Yi Dai Min Meng Qi-Zhi Luo Yuan-Jun liu Fan Xiao chun-Hua Wang Department of Hepatobiliary Surgery Suining Central HospitalSuining 629000Sichuan ProvinceChina The Cancer Center Suining Central HospitalSuining 629000Sichuan ProvinceChina Department of Pathology Suining Central HospitalSuining 629000Sichuan ProvinceChina Department of Liver Surgery&Liver Transplantation West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Carcinosarcoma of the gallbladder is a rare malignant tumor with a very poor *** date,only approximately 100 patients have been reported in the English *** prognosis of this tumor type is poor,the preoperative diagnosis is difficult,and there is a possibility of a *** present an unsuccessful case of carcinosarcoma of the gallbladder with a preoperative misdiagnosis and rapid early postoperative ***,we have a deeper understanding of the poor prognosis of gallbladder carcinosarcoma(GBC)*** SUMMARY The patient is a 65-year-old *** was admitted to the hospital because of right upper abdomen distending pain and discomfort for half a *** magnetic resonance imaging revealed a polycystic mass in the right lobe of the liver and the fossa of the *** admission,the patient was diagnosed with a liver abscess,which was treated by abscess puncture ***,this treatment was *** and cholecystectomy were performed one month after the *** pathologic examination revealed carcinosarcoma of the gallbladder,and the resected specimen contained two tumor *** month after surgery,the patient's tumor recurred in situ and started to compress the duodenum,resulting in duodenal obstruction and *** treatment was not *** patient died of gastrointestinal hemorrhage and hypovolemic *** Carcinosarcoma of the gallbladder is a rare malignant tumor that is easily misdiagnosed preoperatively and has a poor prognosis.

关键词： Gallbladder disease Carcinosarcoma Misdiagnosis Poor prognosis Pathological diagnosis Recurrence Case report

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A novel route to enhance high-temperature mechanical property and thermal shock resistance of low-carbon Mgo-C bricks by introducing ZrSiO_(4)

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Journal of Iron and Steel Research International 2024年第6期31卷 1436-1448页

作者： chun-hui Sun Ling-ling Zhu Hao Yan Wei Zhao Jing-xuan liu Lin Ren Xian-tang Zhao Xiao-song Tong Shu-wen Yu Beijing Lirr High-Temperature Materials Co. Ltd.Beijing 102211China School of Materials Science and Engineering Henan Province Industrial Technology Research Institute of Resources and MaterialsZhengzhou UniversityZhengzhou 450001HenanChina School of Chemistry and Chemical Engineering Suzhou UniversitySuzhou 234000AnhuiChina

Conventional MgO-C bricks(graphite content>14 wt.%)produce a great deal of greenhouse gas emission,while low-carbon MgO-C bricks have serious thermal shock resistance during high-temperature *** enhance the high-temperature mechanical property and thermal shock resistance of low-carbon MgO-C bricks,a novel route of introducing ZrSiO_(4) powder into low-carbon MgO-C bricks was reported in such refractories with 2 wt.% flaky *** results indicate that the low-carbon MgO-C brick with 0.5 wt.%ZrSiO_(4) addition has the maximum hot modulus of rupture at 1400℃ and the corresponding specimen fired in the carbon embedded atmosphere has the maximum residual strength ratio(98.6%)after three thermal shock *** is found that some needle-like AlON and plate-like Al_(2)O_(3)-ZrO_(2) composites were in situ formed in the matrices after the low-carbon MgO-C bricks were coked at 1400℃,which can enhance the high-temperature mechanical property and thermal shock resistance due to the effect of fiber toughening and particle ***,CO_(2) emission of the newly developed low-carbon MgO-C bricks is reduced by 58.3% per ton steel after using them as the working lining of a 90 t vacuum oxygen decarburization ladle.

关键词： Low-carbon MgO-C brick ZrsiO_(4) Synergistic toughening effect High-temperature mechanical property Thermal shock resistance Vacuum oxygen decarburization ladle

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Molecular analyses display the increasing diversity of Podostemaceae in China

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Plant Diversity 2024年第3期46卷 421-424页

作者： Zhi-Zhong Li Zhun Xu Shuang Wu Lang-Xing Yuan chun-Yu Zou Yan liu Jian-Yong Lin Shi-Chu Liang Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection(Guangxi Normal University) Ministry of EducationGuilin 541006China Wuhan Botanical Garden Chinese Academy of SciencesWuhan 430074China Sino-Africa Joint Research Center Chinese Academy of SciencesWuhan 430074China Guangxi Association for Science and Technology Nanning 530023China Tropical Crops Genetic Resources Institute Chinese Academy of Tropical Agricultural SciencesHaikou 571101China Guangxi Institute of Botany Chinese Academy of SciencesGuilin 541006China Guangxi Forestry Research Institute Nanning 530028China

Podostemaceae(riverweed family),one of the largest aquatic plant families in the world,comprises about 350 species in 51 genera placed in three subfamilies,Podostemoideae,Weddellinoideae,and Tristichoideae(Koi et al.,2022).Most Podostemaceae genera(~38)are monotypic or oligotypic,with a high level of endemism(Koi et al.,2018,2022).Members of Podostemaceae adhere to rocks in fast-flowing rivers,streams,or waterfalls in the subtropics and tropics(Koi et al.,2018).As an adaptation to fastrunning currents,the morphological structure of river-weeds tends to be extremely reduced,including a loss or reduction of primary shoots or roots(Koi and Kato,2007).The vegetative mass of these plants resembles lichens or bryophytes,and are thus known commonly as“dream bryophytes”(Philbrick and Retana,1998).Podostemaceae plants flower when the water level drops during the dry *** recent years,anthropogenic factors and climate change have severely affected river weed habitats,decreasing populations of these plants.

关键词： roots season habitat

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Effects of Lactobacillus paracasei N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis

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World Journal of Gastroenterology 2024年第11期30卷 1556-1571页

作者： Yan-Chao Hu Xiang-chun Ding Hui-Juan liu Wan-Long Ma Xue-Yan Feng Li-Na Ma Department of Infectious Disease General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Infectious Disease Clinical Research Center of Ningxia Yinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Hepatitis B cirrhosis(HBC)is a chronic disease characterized by irreversible diffuse liver damage and aggravated by intestinal microbial imbalance and metabolic *** the relationship between certain single probiotics and HBC has been explored,the impact of the complex ready-to-eat Lactobacillus paracasei N1115(LP N1115)supplement on patients with HBC has not been *** To compare the changes in the microbiota,inflammatory factor levels,and liver function before and after probiotic treatment in HBC *** This study included 160 HBC patients diagnosed at the General hospital of Ningxia Medical University between October 2018 and December *** were randomly divided into an intervention group that received LP N1115 supplementation and routine treatment and a control group that received routine treatment *** samples were collected at the onset and conclusion of the 12-wk intervention *** structure of the intestinal microbiota and the levels of serological indicators,such as liver function and inflammatory factors,were *** Following LP N1115 intervention,the intestinal microbial diversity significantly increased in the intervention group(P<0.05),and the structure of the intestinal microbiota was characterized by an increase in the proportions of probiotic microbes and a reduction in harmful ***,the intervention group demonstrated notable improvements in liver function indices and significantly lower levels of inflammatory factors(P<0.05).CONCLUSION LP N1115 is a promising treatment for ameliorating intestinal microbial imbalance in HBC patients by modulating the structure of the intestinal microbiota,improving liver function,and reducing inflammatory factor levels.

关键词： Hepatitis B cirrhosis N1115 ready-to-eat lactobacillus Inflammation Liver function Lachnospiraceae incertae sedis Probiotic

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Isolation of exogenous fungi from Notoginseng Radix et Rhizoma and preliminary analysis of toxigenic fungi

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Journal of Future Foods 2024年第2期4卷 179-182页

作者： Lei Zhou Xiangsheng Zhao Xiaomin liu Hefang Wan chun Sui Xuyu Chen Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of EducationNational Engineering Laboratory for Breeding of Endangered Medicinal MaterialsInstitute of Medicinal Plant Development(IMPLAD)Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine Hainan Branch of the Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeHaikou 570311China

Notoginseng Radix et Rhizoma(Sanqi in Chinese)is a precious traditional Chinese herbal *** has the effect of dispersing blood stasis and stopping bleeding,reducing swelling and fixing ***,it tends to contaminate with harmful fungi during storage,which may make it much less *** order to understand the fungal contamination of Notoginseng Radix et Rhizoma and master its composition of the exogenous *** surface fungi of Notoginseng Radix et Rhizoma samples collected from six Chinese provinces and districts were investigated by using dilution plate *** of aflatoxins by UPLC-MS/*** results showed that Penicillium citrinum was dominantly isolated from Notoginseng Radix et Rhizoma samples from No.1 to *** flavus,which produces aflatoxin,was dominantly isolated from Notoginseng Radix et Rhizoma samples from No.5 and *** addition,kinds of mycotoxin were assayed which were produced by three of those identified *** three fungi strains produced aflatoxin B1(AFB1)and one strain HBSQ1-5 additionally produced other three kinds of mycotoxin,AFB2,AFG1 and *** is the results implied that it will be very important to take serious cautions when using Notoginseng Radix et *** well as,understanding the composition of the exogenous fungi of Notoginseng Radix et Rhizoma and the strains of toxin-producing fungi,which can play an important role in guiding the storage of Notoginseng Radix et Rhizoma.

关键词： Notoginseng Radix et Rhizoma Exogenous fungal Amplicon sequencing Mycotoxin

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Tongue image feature correlation analysis in benign lung nodules and lung cancer

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Digital Chinese Medicine 2024年第2期7卷 120-128页

作者： SHI Yulin liu Jiayi chun Yi liu Lingshuang XU Jiatuo The Academic Affairs Office Shanghai University of Traditional Chinese MedicineShanghai 201203China School of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China Longhua hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 200032China

Objective To analyze the differences in the correlation of tongue image indicators among patients with benign lung nodules and lung *** From July 1;2020 to March 31;2022;clinical information of lung cancer patients and benign lung nodules patients was collected at the Oncology Department of Longhua hos-pital Affiliated to Shanghai University of Traditional Chinese Medicine and the Physical Ex-amination Center of Shuguang hospital Affiliated to Shanghai University of Traditional Chi-nese Medicine;*** obtained tongue images from patients with benign lung nod-ules and lung cancer using the TFDA-1 digital tongue diagnosis instrument;and analyzed these images with the TDAS V2.0 *** extracted indicators included color space pa-rameters in the Lab system for both the tongue body(TB)and tongue coating(TC)(TB/TC-L;TB/TC-a;and TB/TC-b);textural parameters[TB/TC-contrast(CON);TB/TC-angular second moment(ASM);TB/TC-entropy(ENT);and TB/TC-MEAN];as well as TC parameters(perAll and perPart).The bivariate correlation of TB and TC features was analyzed using Pearson’s or Spearman’s correlation analysis;and the overall correlation was analyzed using canonical correlation analysis(CCA).Results Samples from 307 patients with benign lung nodules and 276 lung cancer patients were included after excluding outliers and extreme *** correlation analysis indi-cated that the correlation of TB-L with TC-L;TB-b with TC-b;and TB-b with perAll in lung cancer group was higher than that in benign nodules ***;the correlation of TB-a with TC-a;TB-a with perAll;and the texture parameters of the TB(TB-CON;TB-ASM;TB-ENT;and TB-MEAN)with the texture parameters of the TC(TC-CON;TC-ASM;TC-ENT;and TC-MEAN)in benign nodules group was higher than lung cancer *** further demon-strated a strong correlation between the TB and TC parameters in lung cancer group;with the first and second pairs of typical variables in benign nodules and lung cancer groups in

关键词： Benign lung nodules Lung cancer Tongue image Correlation analysis Differential diagnosis

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Dramatic Difference Between Cu_(20)H_(8)and Cu_(20)H_(9)Clusters in Catalysis

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CCS Chemistry 2024年第6期6卷 1581-1590页

作者： chun-Yu liu Tong-Yu liu Zong-Jie Guan Song Wang Yuan-Yuan Dong Feng Hu De-en Jiang Quan-Ming Wang Department of Chemistry Engineering Research Center of Advanced Rare Earth Materials(Ministry of Education)Tsinghua UniversityBeijing 100084 Jiangsu Engineering Research Centre for Digital Textile Inkjet Printing Key Laboratory of Eco-Textile Jiangnan UniversityMinistry of EducationWuxiJiangsu 214122 Department of Chemical and Biomolecular Engineering Vanderbilt UniversityNashvilleTennessee 37235 Department of Chemistry Vanderbilt UniversityNashvilleTennessee 37235 College of Chemistry and Chemical Engineering Hunan UniversityChangsha 410082 Hefei National Research Center for Physical Sciences at the Microscale School of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefeiAnhui 230026

Sensitivity to structure and composition is very challenging to establish in nanocatalysis due to inadequate definition of structures that are very close in *** synthesized a pair of atomically precise copper clusters that are very close in composition,[Cu_(20)H_(9)(Tf-dpf)_(10)]·BF4(Cu_(20)H_(9))and[Cu_(20)H_(8)(Tf-dpf)_(10)]·(BF_(4))_(2)(Cu_(20)H_(8)),by using a pyridyl-functionalized flexible amidinate ligand,N,N′-di(5-trifluoromethyl-2-pyridyl)*** one-hydride difference in their composition leads to significant variation in geometric and electronic structures and,consequently,distinctly different optical and catalytic ***_(20)H_(8)exhibits 25 times higher catalytic activity than Cu_(20)H_(9)(96.7%vs 3.7%in yield)in the selective hydrogenation of anα,β-unsaturated aldehyde(cinnamaldehyde)to saturated aldehyde(3-phenylpropanal).Electrospray ionization mass spectrometry combined with density functional theory calculations reveal that the greater ease of dissociation of one Tf-dpf ligand compared to Cu_(20)H_(8)is the key to its higher *** work demonstrates a clear case of structure and composition sensitivity in nanocatalysis and that one hydride,out of∼330 atoms in the nanoclusters,can make a huge difference in the catalytic *** insights will be useful in the design and synthesis of atomically precise nanocatalysts.

关键词： copper cluster hydride amidinate ligand structural transformation hydrogenation catalysis

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Bioinspired coacervate-based bioinks for construction of multiscale tissue engineering scaffolds

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Nano Research 2024年第9期17卷 8209-8219页

作者： Zhongwei Guo Shiqiang Zhang Yilin Guo Jingjing Xia Xiao Wu Hao Hu Rongcheng Hu Fangli Huang Qiulei Gao chun liu Jingjiang Qiu Wei Sun School of Mechanics and Safety Engineering Zhengzhou UniversityZhengzhou 450001China Department of Mechanical Engineering and Mechanics Tsinghua UniversityBeijing 100084China Precision Medicine Institute Guangdong Provincial Key Laboratory of Orthopedics and TraumatologyThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Mechanical Engineering Drexel UniversityPhiladelphiaPA 19104USA

Engineering hydrogels that resemble biological tissues of various lengths via conventional fabrication techniques remains ***-dimensional(3D)bioprinting has emerged as an advanced approach for constructing complex biomimetic 3D architectures,which are currently restricted by the limited number of available bioinks with high printability,biomimicry,biocompatibility,and proper mechanical *** by ubiquitous coacervation phenomena in biology,we present a unique mineral-biopolymer coacervation strategy that enables the hierarchical assembly of nanoclay and recombinant human collagen(RHC).This system was observed to undergo a coacervation transition(liquid‒liquid phase separation)*** formed dense phase separated from its supernatant is the coacervate of clay-RHC-rich complexes,where polymer chains are sandwiched between silicate *** dynamics simulation was first used to verify and explore the coacervation ***,the coacervates were demonstrated to be potential bioinks that exhibited excellent self-supporting and shear-thinning viscoelastic *** extrusion-based printing,the versatility of the bioink was demonstrated by reconstructing the key features of several biological tissues,including multilayered lattice,vascular,nose,and ear-like structures,without the need for precrosslinking operations or support ***,the printed scaffolds were cytocompatible,elicited minimal inflammatory responses,and promoted bone regeneration in calvarial defects.

关键词： bioinks coacervation mineral-biopolymer nanoclay tissue engineering scaffold

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Emerging probing perspective of two-dimensional materials physics:terahertz emission spectroscopy

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Light(Science & Applications) 2024年第7期13卷 1278-1298页

作者： Yifei Wu Yuqi Wang Di Bao Xiaonan Deng Simian Zhang Lin Yu-chun Shengxian Ke Jianing liu Yingjie liu Zeli Wang Pingren Ham Andrew Hanna Jiaming Pan Xinyue Hu Zhengcao Li Ji Zhou Chen Wang State Key Laboratory of New Ceramics and Fine Processing Key Laboratory of Advanced Materials of Ministry of EducationSchool of Materials Science and EngineeringTsinghua University100084 BeijingChina Beijing Advanced Innovation Center for Integrated Circuits 100084 BeijingChina

Terahertz(THz)emission spectroscopy(TES)has emerged as a highly effective and versatile technique for investigating the photoelectric properties of diverse materials and nonlinear physical processes in the past few ***,research on two-dimensional(2D)materials has experienced substantial growth due to their atomically thin structures,exceptional mechanical and optoelectronic properties,and the potential for applications in flexible electronics,sensing,and ***,these materials offer advantages such as tunable bandgap,high carrier mobility,wideband optical absorption,and relatively short carrier *** applying TES to investigate the 2D materials,their interfaces and heterostructures,rich information about the interplay among photons,charges,phonons and spins can be unfolded,which provides fundamental understanding for future *** it is timely to review the nonlinear processes underlying THz emission in 2D materials including optical rectification,photon-drag,high-order harmonic generation and spin-to-charge conversion,showcasing the rich diversity of the TES employed to unravel the complex nature of these *** applications based on THz emissions,such as THz lasers,ultrafast imaging and biosensors,are also *** further,we analyzed the unique advantages of spintronic terahertz emitters and the future technological advancements in the development of new THz generation mechanisms leading to advanced THz sources characterized by wide bandwidth,high power and integration,suitable for industrial and commercial *** continuous advancement and integration of TES with the study of 2D materials and heterostructures promise to revolutionize research in different areas,including basic materials physics,novel optoelectronic devices,and chips for post-Moore’s era.

关键词： optoelectronic versatile exceptional

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