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Magnetic Properties of Nanocrystalline Powder Cores Fabricated by Mechanically Crushed Powders

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Journal of Iron and Steel Research International 2015年第1期22卷 67-71页

作者： chun-bo huang Tian-cheng LIU Xiang-yue WANG Cao-wei LU De-ren LI Zhi-chao LU China Iron and Steel Research Institute Group Advanced Technology and Materials Co. Ltd.

Fe73. 5 Cu1 Nb3 Si15.5B7 nanocrystalline powder cores with different particle sizes ranging from 10 to 125 9m were fabricated by cold-pressing techniques. The cores exhibited increased core loss P cv and decreased initial permea- bility μi with addition of fine powders below 50 μm in size, and the content should be less than 40 mass%. It was thought to be closely related to the high coercive force H c due to the stresses generated during the crushing process and high demagnetization fields of small powders. Furthermore, modifying the alloy compositions by adding defined amount of Ni could improve the soft magnetic properties, including superior characteristics of permeability under high direct current （DC） bias field and comparable low core loss at high frequency.

关键词： nanocrystalline powder core mechanical crush particle size DC bias

Magnetic Properties of Nanocrystalline Powder Cores Using Mechanically Crushed Powders

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Journal of Iron and Steel Research International 2014年第3期21卷 348-351页

作者： chun-bo huang Tian-cheng LIU Xiang-yue WANG Cao-wei LU De-ren LI Zhi-chao LU China Iron and Steel Research Institute Group R&D Center of Advanced Technology and Materials Co. Ltd.

Toroidal shape FeCuNbSiB nanocrystalline alloy powder cores were prepared by cold pressing using me- chanically crushed and ball-milled powders, respectively. The morphologies and their effects on the magnetic proper- ties of the compacted cores were investigated. Compared with ball-milled powders, mechanically crushed ones have more regular shapes and rounder edges, which lead to better inter-particle insulation. FeCuNbSiB nanocrystalline al- loy powder cores fabricated from mechanically crushed powders exhibit remarkably lower core loss of about 248.2 kW/m3 at 100 kHz for maximum flux density Bm 0.1 T, and more stable permeability up to 10 MHz. Moreover, the dc-bias property could be improved significantly using mechanically crushed powders.

关键词： nanocrystaUine powder core morphology core loss high frequency property

炭/复合航空刹车材料的结构完整性对摩擦系数的影响

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新型炭材料 2003年第2期18卷 111-116页

作者：蒋建纯黄伯云熊翔中南大学国家粉末冶金重点实验室湖南长沙410083

　炭炭复合材料(C C)为类石墨结构,其石墨化程度部分表征了材料的结构完整程度。通过验证C C材料的石墨化程度对刹车副的刹车力矩特性及刹车过程中摩擦系数的影响,探讨了C C摩擦材料的摩擦磨损机理。C C材料晶体的棱、缘、角部的活化... 详细信息

　炭炭复合材料(C C)为类石墨结构,其石墨化程度部分表征了材料的结构完整程度。通过验证C C材料的石墨化程度对刹车副的刹车力矩特性及刹车过程中摩擦系数的影响,探讨了C C摩擦材料的摩擦磨损机理。C C材料晶体的棱、缘、角部的活化点影响材料的物理吸附和化学吸附性能,降低了飞机刹车前几秒钟内的摩擦系数;材料内部的碳氧络合物的多少则影响到刹车副体积温度为400℃～500℃时摩擦系数的大小。这二者的共同作用劣化了刹车副的制动性能。

关键词：炭/炭复合材料航空刹车材料结构完整性摩擦系数化学吸附物理吸附摩擦制动性能

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding chun Chen Heng Zhao Bin Dai Lei Ye Tao Song Shuai huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo Li Xingwei Lei Liuyang Tang Daochen Wen bo Zeng Xiaofeng Zhang Zichao huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

Application of Dorzagliatin in peritoneal dialysis patients with type 2 diabetes mellitus:A case report

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World Journal of Diabetes 2025年第1期16卷 204-210页

作者： Fang Chen bo An Wen-Cheng An Gang Fu Wei huang Hui-Xian Yan Department of Endocrinology Beijing Haidian HospitalBeijing 100080China Department of Nephrology Beijing Haidian HospitalBeijing Haidian Section of Peking University Third HospitalBeijing 100080China

BACKGROUND Treating diabetes in dialysis patients remains a challenge,with many hypoglycemic drugs requiring dose adjustments or avoidance in these *** SUMMARY This report describes an 83-year-old female patient with a 30-year history of type 2 diabetes(T2DM)who had struggled to control her blood sugar for more than a *** had a history of high blood pressure for 30 years,had undergone continuous ambulatory peritoneal dialysis for more than two years,was 163 cm tall,weighed 77 kg,and had a body mass index of 28.98 kg/*** intensive insulin therapy at a daily dose of 150 units,adding Dorzagliatin at a dosage of 75 mg orally twice daily led to immediate blood sugar improvement and a gradual reduction in insulin *** one month of follow-up,the fasting plasma glucose was 6-8 mmol/L,and the 2-hour postprandial glucose was 8-12 mmol/*** To our knowledge,this report is the first to use Dorzagliatin to treat type 2 diabetes peritoneal dialysis patients with challenging glucose ***,a novel glucokinase activator primarily metabolized by the liver,exhibits no pharmacokinetic differences among patients with varying degrees of chronic kidney *** has a high plasma protein binding rate and may not be cleared by peritoneal dialysis,potentially offering a new glycemic control option for Type 2 diabetic patients on peritoneal dialysis.

关键词： Dorzagliatin Type 2 diabetes mellitus Peritoneal dialysis Glucokinase activator Glucose control Case report

Prediction and stratification for the surgical adverse events after minimally invasive esophagectomy:A two-center retrospective study

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World Journal of Gastroenterology 2025年第3期31卷 50-61页

作者： Qi-Hong Zhong Jiang-Shan huang Fei-Long Guo Jing-Yu Wu Mao-Xiu Yuan Jia-Fu Zhu Wen-Wei Lin Sui Chen Zhen-Yang Zhang Jiang-bo Lin Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina The Graduate School Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina

BACKGROUND Minimally invasive esophagectomy(MIE)is a widely accepted treatment for esophageal cancer,yet it is associated with a significant risk of surgical adverse events(SAEs),which can compromise patient recovery and long-term *** preoperative identification of high-risk patients is critical for improving *** To establish and validate a risk prediction and stratification model for the risk of SAEs in patients with *** This retrospective study included 747 patients who underwent MIE at two centers from January 2019 to February *** were separated into a train set(n=549)and a validation set(n=198).After screening by least absolute shrinkage and selection operator regression,multivariate logistic regression analyzed clinical and intraoperative variables to identify independent risk factors for SAEs.A risk stratification model was constructed and validated to predict the probability of *** SAEs occurred in 10.2%of patients in train set and 13.6%in the validation *** with SAE had significantly higher complication rate and a longer hospital stay after *** key independent risk factors identified included chronic obstructive pulmonary disease,a history of alcohol consumption,low forced expiratory volume in the first second,and low albumin *** stratification model has excellent prediction accuracy,with an area under the curve of 0.889 for the training set and an area under the curve of 0.793 for the validation *** The developed risk stratification model effectively predicts the risk of SAEs in patients undergoing MIE,facilitating targeted preoperative interventions and improving perioperative management.

关键词： Surgical adverse events Minimally invasive esophagectomy Esophageal cancer Stratification model Perioperative management

Enhanced flow injection analysis for measurements of S-nitrosothiols species in biological samples using highly selective amperometric nitric oxide sensor

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Chinese Chemical Letters 2012年第2期23卷 229-232页

作者： chun Cui huang Hui bo Shao Key Laboratory of Cluster Science Ministry of Education of ChinaSchool of ChemistryBeijing Institute of TechnologyBeijing 100081China

A highly selective nitric oxide（NO） sensor is fabricated and applied to devise an enhanced flow injection analysis（FIA） system for S-nitrosothiols（RSNOs） measurement in biological *** NO sensor is prepared using a polytetrafluoroethylene（PTFE） gas-permeable membrane loaded with Teflon AF？ solution,a copolymer of tetrafluoroethylene and 2,2-bis（trifluoroethylene）-4,5-difluoro -l,3-dioxole,to improve *** method is much simpler and possesses good performance over a wide range of RSNOs *** deviation for three parallel measurements of blood plasma is 4.0%.The use of the gas sensing configuration as the detector enhances selectivity of the FIA measurement *** less selective electrochemical detectors that do not use PTFE/Teflon type outer membranes.

关键词： Enhanced FIA method Plasma RSNOs Highly selective NO sensor

Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： Zhao-Jun Zhang Wen-Wei Wang Jing-Shui Zhen bo-Cheng Li De-Cheng Cai Yang-Yang Du Hui huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model