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A continuing 30-year decline in water quality of Jiaojiang Estuary, China

Water Science and Engineering 2015年第1期8卷 20-29页

作者： chun-ye wang Bin Zhou Bei Huang College of Marine Science Shanghai Ocean University College of Science Hangzhou Normal University Zhejiang Provincial Zhoushan Ocean Ecological Environment Monitoring Station

A quantitative description of a long-term series of aquatic environmental factors and their spatial distributions was generated using measured data from the Jiaojiang Estuary from 1982 to 2011. The aquatic environmental factors included suspended matter, salinity, and nutrients. Based on these factors, the aquatic ecosystem health in the Jiaojiang Estuary over the last 30 years was analyzed. The results indicated that the suspended matter concentration in the estuary was mainly affected by the amounts of suspended sediment and solid waste, with the value fluctuating over a long period, and the range of high concentration expanded continually; the salinity was mainly affected by precipitation and surface water resources, showing an overall decreasing trend, and the region with low salinity moved seaward and toward the reclamation areas; and the nutritional status, mainly affected by discharge of industrial wastewater and domestic sewage, was satisfactory in the 1980s and 1990s, but the status became severe in recent years. Reclamation had a great influence on these three factors： high reclamation strength led to a significant increase in the suspended matter concentration and a deterioration of the nutritional status, and the reclamation rate was negatively related with the salinity in the estuary. There was a significant positive correlation between the health status of the aquatic ecosystem and salinity, with a correlation coefficient of 0.93. The correlation coefficient between the health status and nutritional status was -0.71, while the correlation between the suspended matter concentration and health status was not as significant as that of the other two factors. The dynamics of the aquatic environment could be divided into four stages： sustainable health from the 1980s to the 1990s, continued deterioration from 2000 to 2003, improvement from 2004 to 2005, and secondary deterioration from 2006 to 2011. The Jiaojiang Estuary is faced with imminent environmental

关键词： Water quality decline Aquatic ecosystem health Aquatic environmental factor Suspended matter concentration Salinity Nutritional status Jiaojiang Estuary

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Effect of mild moxibustion on intestinal microbiota and NLRP6 inflammasome signaling in rats with post-inflammatory irritable bowel syndrome

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World Journal of Gastroenterology 2019年第32期25卷 4696-4714页

作者： chun-Hui Bao chun-ye wang Guo-Na Li Yi-Lu Yan Di wang Xiao-Ming Jin Lu-Yi Wu Hui-Rong Liu Xiao-Mei wang Zheng Shi Huan-Gan Wu Key Laboratory of Acupuncture and Immunological Effects Shanghai University of Traditional Chinese MedicineShanghai 200030China Stark Neurosciences Research Institute Indiana University School of MedicineIndianapolisIN 46202United States

BACKGROUND About one-third of refractory irritable bowel syndrome(IBS)cases are caused by gastrointestinal(GI)infection/inflammation,known as post-infectious/postinflammatory IBS(PI-IBS).Although it is known that intestinal microbiota and host NOD-like receptor family pyrin domain containing 6(NLRP6)inflammsome signaling are closely related to PI-IBS and moxibustion has a therapeutic effect on PI-IBS,whether moxibustion regulates the intestinal flora and host NLRP6 events in PI-IBS remains *** To examine the regulatory effect of moxibustion on intestinal microbiota and host NLRP6 inflammatory signaling in *** Sprague-Dawley rats were divided into a normal control group,a model control group,a mild moxibustion group,and a sham mild moxibustion ***-IBS rats in the mild moxibustion group were treated with moxibusiton at bilateral Tianshu(ST 25)and Zusanli(ST36)for 7 consecutive days for 10 min each *** sham group rats were given the same treatment as the mild moxibustion group except the moxa stick was not *** withdrawal reflex(AWR)score was measured to assess the visceral sensitivity,and colon histopathology and ultrastructure,colonic myeloperoxidase(MPO)activity,and serum C-reactive protein(CRP)level were measured to evaluate low-grade colonic inflammation in *** relative abundance of selected intestinal bacteria in rat feces was detected by 16S rDNA PCR and the NLRP6 inflammsome signaling in the colon was detected by immunofluorescence,qRTPCR,and Western *** The AWR score was significantly decreased and the low-grade intestinal inflammation reflected by serum CRP and colonic MPO levels was inhibited in the mild moxibustion group compared with the sham *** moxibustion remarkably increased the relative DNA abundances of Lactobacillus,Bifidobacterium,and Faecalibacterium prausnitzii but decreased that of Escherichia coli in the gut of PI-IBS ***,mild moxibustion induced mRNA and protein expre

关键词： Moxibustion Post-inflammation irritable bowel syndrome Intestinal microbes NLRP6 inflammasome Intestinal inflammation Visceral hypersensitivity Traditional Chinese medicine

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Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding chun Chen Heng Zhao Bin Dai Lei ye Tao Song Shuai Huang Jia wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

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区域经济一体化与地方行政立法模式的变革

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科技与法律 2007年第3期 81-87页

作者：王春业淮北煤炭师范学院

随着我国区域经济一体化的发展,原有的分片分块、各自为政的地方行政立法模式已经不能适应并阻碍了区域经济的进一步发展,需构建一种新的地方行政立法模式。在行政立法方面,我国上有行政法规和部门规章,下有地方规章,而中间的空隙似乎... 详细信息

随着我国区域经济一体化的发展,原有的分片分块、各自为政的地方行政立法模式已经不能适应并阻碍了区域经济的进一步发展,需构建一种新的地方行政立法模式。在行政立法方面,我国上有行政法规和部门规章,下有地方规章,而中间的空隙似乎太大。对于经济区域内的共同事项,中央行政立法缺乏针对性,而地方规章的范围又过于局限。有必要在此中间层次上增加一个跨区划的区域行政立法形式。在法制统一的前提下,经授权由相关区划政府的有关人员在协商自愿的基础上组成一个行政立法机构共同制定适用于该区域内各区划的区域性行政立法,这也是新时期条件下发挥地方行政立法积极性、主动性的另一种表现形式。

关键词：区域一体化地方立法行政立法立法变革跨区划立法

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现代园林中景观挡土墙的表现方法探析

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黑龙江农业科学 2011年第3期 90-93页

作者：李文叶春旺东北林业大学黑龙江哈尔滨150040

论述了如何在保证其功能性的前提下,把挡土墙作为园林中的一种景观元素来对待,引入景观设计的艺术手法,进行景观艺术性设计和艺术性装饰,使之成为与周边环境及其它造景要素相协调的景观挡土墙。

关键词：现代园林景观挡土墙表现方法

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基于生态修复理念的西汉帝陵大遗址生态景观规划设计研究

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北方园艺 2011年第13期 98-101页

作者：谢得娟王小林叶春旺弓弼西北农林科技大学林学院陕西杨凌712100 渭南市华县林业局陕西华县714100 东北林业大学园林学院黑龙江哈尔滨150040

通过分析挖掘西汉五陵塬地区的历史、民俗文化,以恢复生态学理论为指导,总结出西汉帝陵大遗址区生态景观设计原则,探讨了如何在城郊大遗址保护中运用生态设计手法创造出具有生态效应和持久魅力的遗址区景观规划设计案例。

关键词：生态修复西汉帝陵大遗址景观设计

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基于多向PLS方法的间歇过程质量预测

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系统仿真学报 2004年第6期16卷 1168-1170,1174页

作者：李春富叶昊王桂增清华大学自动化系北京100084

间歇生产过程中,很多质量指标不能在线测量,通常是在反应结束后通过离线分析得到。本文应用多向部分最小二乘(MPLS)方法建立软测量模型,通过在线测量的过程变量对产品质量进行预测。针对异丁烯酸甲酯(MMA)聚合反应过程中的数据进行仿真... 详细信息

间歇生产过程中,很多质量指标不能在线测量,通常是在反应结束后通过离线分析得到。本文应用多向部分最小二乘(MPLS)方法建立软测量模型,通过在线测量的过程变量对产品质量进行预测。针对异丁烯酸甲酯(MMA)聚合反应过程中的数据进行仿真,结果表明,MPLS方法能够在反应初期就有效的预测出最后的产品质量指标。

关键词：多向部分最小二乘间歇过程软测量建模

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CPP及VEGF与急性脑梗死的相关性

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热带医学杂志 2017年第10期17卷 1358-1361页

作者：张春野王昆祥佳木斯大学附属第一医院急诊科黑龙江佳木斯154000 佳木斯大学附属第一医院神经二科黑龙江佳木斯154000

目的研究和肽素(CPP)及血管内皮生长因子(VEGF)水平在急性脑梗死患者诊断、病情预测及相关性。方法选取2013年9月至2016年9月间于佳木斯大学附属第一医院确诊并接受治疗的急性脑梗死患者共98例为研究组,另选取同一时期在本院接受头颅磁... 详细信息

目的研究和肽素(CPP)及血管内皮生长因子(VEGF)水平在急性脑梗死患者诊断、病情预测及相关性。方法选取2013年9月至2016年9月间于佳木斯大学附属第一医院确诊并接受治疗的急性脑梗死患者共98例为研究组,另选取同一时期在本院接受头颅磁共振检查,结果显示一切正常者98例为对照组。用ELISA法检测两组患者的CPP和VEGF水平;用NIHSS法来评价两组患者的神经系统功能;通过对患者进行MRI检查来划分病灶;用CDU检测患者的颈动脉硬化程度,根据IMT判断标准分为正常组、增厚组和斑块形成组,分别对各指标进行分析。结果研究组与对照组比较,在平均血小板体积(MPV)、纤维蛋白原(Fg)、血尿酸(UA)指标上差异无统计学意义(P>0.05),在TG、HDL-C、FPG、HCY、PCT、RDW、HTC等指标上差异均有统计学意义(P0.05)。结论 CPP和VEGF水平可以用来预测脑梗死的发生,且灵敏度较高;可以用来检测脑梗死患者神经功能的缺损程度;可以用来检测颈动脉病变的发生率;为急性脑梗死的诊断和预后提供重要依据。

关键词： CPP VEGF 急性脑梗死

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Real-time fluorescent quantitative immuno-PCR method for determination of fluoranthene in water samples with a molecular beacon

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Journal of Environmental Sciences 2010年第5期22卷 796-800页

作者： Qiyan ye Huisheng Zhuang chun Zhou Qiong'e wang College of Environmental Science and Engineering Donghua University Shanghai 201620 China School of Environmental Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanhai 201620 China

A reliable and sensitive competitive real-time fluorescent quantitative immuno-PCR （RTFQ-IPCR） assay using a molecular beacon was developed for the determination of trace fluoranthene （FL） in the *** optimized assay conditions,FL can be determined in the concentration range from 1 fg/mL to 100 ng/mL,with y=0.194x ＋ 7.859,and a correlation coefficient of 0.967 was identified,with a detection limit of 0.6 fg/*** water samples were successfully analyzed,recovery was between 90% and 116%,with intra-day relative standard deviation （RSD） of 6.7%-12.8% and inter-day RSD of 8.4%-15.2%.The results obtained from RTFQ-IPCR were confirmed by ELISA,showing good accuracy and suitability to analyze FL in field *** a highly sensitive method,the molecular beacon-based RTFQ-IPCR is acceptable and promising for providing reliable test results to make environmental decisions.

关键词： fluoranthene real-time fluorescent quantitative irnmuno-PCR molecular beacon

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Verticality Detection Algorithm Based on Local Image Sharpness Criterion

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Chinese Journal of Mechanical Engineering 2012年第1期25卷 173-178页

作者： ZHANG Jin wang Zhong ye Shenghua YANG chun LI Lin State Key Laboratory of Precision Measuring Technology and Instruments Tianjin UniversityTianjin 300072China

In the high precision image measurement system, the verticality error between the axis of the shooting system and the measured object can bring error of the measurement result. The high demand of the system’s vertical degree is raised by measure system due to the demands of high precision and disposable full field imaging in the micro-parts imaging measurement. The existing method of optical axis verticality detection cannot meet the demand all. In order to achieve the high-precision adjustment of the system optical axis, the algorithm of detecting verticality based on regional image definition is proposed. First, the objected standard image is divided into fixed area. Then, the object plane is moved from the downside to the upside of the focus plane, meanwhile, recording the definition function values of each standard image region at each step, and fitting out the clearest positions of the regions. Finally, according to the inter-regional relations between the locations and the height difference of the each regional clearest position, the small angle between the optical axis and the measured surface can be calculated. The experiment is based on the given image of lithography template with the scale of 10 μm as move unit, and the results show that this method effective reduced the small angle between the system optical axis and the measured body in high-precision image measuring system, the evaluation accuracy is less than 0.1°, meeting the requirements in high-precision measurement. The proposed method of detecting verticality based on regional image definition can evaluate the verticality error between the axis of the shooting system and the measured object accurately, effectively and conveniently.

关键词： verticality detection image definition optical axis adjustment

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