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Preparation of submicrocrystal Al-Ti-B master alloy and its influence on microstructure and properties of AZ91D

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China Foundry 2017年第6期14卷 513-518页

作者： Tian-shun Dong Xiao-dong Zheng Xiao-bing Li Guo-lu Li Tuo Wang chun-xiang cui School of Material Science and Engineering Hebei University of Technology Tianjin 300130 China Key Lab. for New Type of Functional Materials of Hebei Province Hebei University of Technology Tianjin 300130 China

To improve the mechanical properties of AZ91D magnesium alloy,the submicrocrystal Al-Ti-B master alloy was prepared with copper mold inject casting method,and the influence of submicrocrystal Al-Ti-B master alloy on the microstructure and mechanical properties of AZ91D was *** show that,the distribution of Ti B_2 phase in submicrocrystal Al-Ti-B alloy is even and disperse,and the average size of Ti Al_3 phase is reduced from 10-30μm to～1μ*** properties of AZ91D refined with submicrocrystal Al-Ti-B master alloy are better than that with coarse-grained Al-Ti-B master alloy without copper mold inject *** tensile strength,elongation and Brinell hardness of AZ91D are increased by 10.6%,25%and 18.1%,***,refinement of AZ91D with submicrocrystal Al-Ti-B that is obtained by copper mold inject casting is an effective method to improve its mechanical properties.

关键词： copper mold inject casting submicrocrystal Al-Ti-B refinement AZ91D

氧化石墨烯水泥浆体流变性能的定量化研究（英文）

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新型炭材料 2016年第6期31卷 574-584页

作者：王琴王健吕春祥崔鑫有李时雨王皙北京建筑大学土木与交通工程学院工程结构与新材料北京市高校工程研究中心绿色建筑与节能技术北京市重点实验室北京100044 中国科学院山西煤炭化学研究所碳纤维制备技术国家工程实验室山西太原030001

采用流变仪和激光共聚焦显微镜对不同氧化石墨烯(GO)掺量的新拌水泥浆体的流变参数以及浆体微观形态进行了定量化研究,并采用Modified-Bingham(M-B)模型和Herschel-Bulkley(H-B)模型对所测数据进行了拟合处理,提出了GO影响新拌水泥浆体... 详细信息

采用流变仪和激光共聚焦显微镜对不同氧化石墨烯(GO)掺量的新拌水泥浆体的流变参数以及浆体微观形态进行了定量化研究,并采用Modified-Bingham(M-B)模型和Herschel-Bulkley(H-B)模型对所测数据进行了拟合处理,提出了GO影响新拌水泥浆体的作用机理。结果表明,GO的掺入可以使新拌浆体中在减水剂作用下分散的水泥颗粒发生再次凝聚,形成重组絮凝结构,且随着GO掺量的增加,重组絮凝结构的数量越多,从而使得浆体流变性发生显著变化。一方面,新拌浆体的塑性粘度、屈服应力以及触变性随GO掺量的提高而显著增加。另一方面,GO的掺入提高了新拌浆体的临界剪切速率,使其在较大剪切速率下的流变行为仍然表现为剪切变稀;降低了浆体的剪切增稠程度,提高了浆体的稳定性。

关键词：氧化石墨烯水泥浆体流变性能絮凝结构

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang Jian Wu Hui Hong Wei Quan Xinyu Qiao chun cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

Hypoglycemic polysaccharides from Auricularia auricula and Auricularia polytricha inhibit oxidative stress,NF-κB signaling and proinflammatory cytokine production in streptozotocin-induced diabetic mice

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Food Science and Human Wellness 2021年第1期10卷 87-93页

作者： Huan xiang Dongxiao Sun-Waterhouse chun cui School of Food Science and Engineering South China University of TechnologyGuangzhou510640GuangdongChina Guangdong Weiwei Biotechnology Co. LTDGuangzhou510640GuangdongChina School of Chemical Sciences The University of AucklandPrivate Bag 92019AucklandNew Zealand

Auricularia auricula(AA)and Auricularia polytricha(AP)are popular edible *** study successfully produced hypoglycemic polysaccharides from un-smashed or smashing and sieving(through a 10-mesh sieve)AA and AP(termed as AAP/AAP-10 and APP/APP-10)via scalable processes(water extraction,ethanolic precipitation and deproteinization).This is the first report to compare the effectiveness of AAP and APP in combating streptozotocin-induced oxidative stress and diabetes-related changes in mice(body weight,fasting blood glucose,serum insulin,proinflammatory mediator and cytokines,oxidative stress-related products,antioxidant enzymes).APP and AAP with different molecular weights and monosaccharide molar ratios could be therapeutic options for diabetes with a low dose(100 mg/kg/day)likely working *** the same dose,APP generally performed more effective than AAP,and AAP-10/APP-10 seemed slightly more beneficial than AAP/*** mechanism underlying these antidiabetic functions might involve the NF-κB and associated signalling *** is cheaper than AA,thereby representing a favorable source of functional polysaccharides.

关键词： Polysaccharides Auricularia auricula Auricularia polytricha Hypoglycemic effect Oxidative stress

Effects of substrate temperature and deposition time on the morphology and corrosion resistance of FeCoCrNiMo0.3 high-entropy alloy coating fabricated by magnetron sputtering

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International Journal of Minerals,Metallurgy and Materials 2020年第10期27卷 1388-1397页

作者： chun-duo Dai Yu Fu Jia-xiang Guo cui-wei Du Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China Key Laboratory for Corrosion and Protection Ministry of EducationBeijing 100083China Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China

The effects of substrate temperature and deposition time on the morphology and corrosion resistance of FeCoCrNiMo0.3 coating fabricated by magnetron sputtering were investigated by scanning electron microscopy and electrochemical *** FeCoCrNiMo0.3 coating was mainly composed of the face-centered cubic *** substrate temperature promoted the densification of the coating,and the pitting resistance and protective ability of the coating in 3.5wt%NaCl solution was thus *** the deposition time was prolonged at 500℃,the thickness of the coating remarkably ***,the pitting resistance improved as the deposition time increased from 1 to 3 h;however,further improvement could not be obtained for the coating sputtered for 5 ***,the pitting resistance of the FeCoCrNiMo0.3 coating sputtered at 500℃for 3 h exceeds those of most of the reported high-entropy alloy coatings.

关键词： high-entropy alloy coating magnetron sputtering microstructure corrosion

绿原酸对中性粒细胞功能及胞外诱捕网形成的影响及机制

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中国药理学通报 2025年第1期41卷 101-107页

作者：杨运刘娅王翠彭春红贵州中医药大学第二临床医学院贵州贵阳550025 七星关区中医妇幼集团医院贵州毕节551700 毕节市中医医院贵州毕节551700 贵州医科大学临床医学院贵州贵阳550025 贵州省人民医院呼吸与危重医学科贵州贵阳550002 国家卫健委肺脏免疫性疾病重点实验室贵州贵阳550002

目的探究绿原酸(chlorogenic acid,CGA)对中性粒细胞(neutrophil,NEU)功能及中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)形成的影响及机制。方法从小鼠骨髓中分离并纯化NEU;将NEU与CGA共培养,通过CCK-8法筛选共培养适合的干预浓度;检测NEU迁移能力、髓过氧化物酶(MPO)以及脱颗粒弹性蛋白酶(NE)、基质金属蛋白酶9(MMP-9)的水平观察CGA对NEU功能的影响;免疫荧光法观察NETs的主要结构组蛋白H3及DNA骨架,以及检测NEU释放的游离DNA(cf-DNA)含量,观察NETs的形成情况;检测NEU产生的活性氧(ROS)水平,以确定CGA是否影响NEU释放NETs过程中的ROS的生成。结果CGA在浓度为100、200、400μmol·L^(-1)时对NEU活性有明显抑制作用(P<0.01)。与空白组(Blank)相比,CGA(100、200、400μmol·L^(-1))干预后,细胞迁移能力及MPO、NE、MMP-9分泌量增加(P<0.05),组蛋白H3及DNA骨架、cf-DNA的释放量明显增加(P<0.01),细胞产生的ROS也明显增加(P<0.01),上述作用在一定范围内具有浓度依赖性。结论CGA能够增强NEU功能及促进NETs的形成,可能与促进细胞内ROS水平增加有关。

关键词：绿原酸中性粒细胞胞外诱捕网免疫抗菌活性氧

Loads and Dynamic Response Characteristic on FPSO Under Internal Solitary Waves

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China Ocean Engineering 2024年第5期38卷 785-796页

作者： ZHANG Rui-rui LI cui PU chun-rong LIU Qian YOU Yun-xiang School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China China Resources(Nanjing)Municipal Design Co. Ltd.Nanjing 315100China State Key Laboratory of Ocean Engineering Shanghai Jiaotong UniversityShanghai 200240China

According to the established prediction model of internal solitary wave loads on FPSO in the previous work,the lumped mass model and the movement equations of finite displacement in time domain,the dynamic response model of interaction between internal solitary waves and FPSO with mooring lines were *** calculations and analysis,time histories of dynamic loads of FPSO exerted by internal solitary waves,FPSO’s motion and dynamic tension of mooring line were *** effects of the horizontal pretension of mooring line,the amplitude of internal solitary wave and layer fluid depth on dynamic response behavior of FPSO were *** was shown that the internal solitary waves had significant influence on FPSO,such as the large magnitude horizontal drift and a sudden tension *** internal solitary wave of −170 m amplitude in the ocean with upper and lower layer fluid depth ratio being 60:550,the dynamic loads reached 991.132 kN(horizontal force),18067.3 kN(vertical force)and−5042.92 kN·m(pitching moment).Maximum of FPSO’s horizontal drift was 117.56 *** increment of upstream mooring line approached 401.48 kN and that of backflow mooring line was−140 ***,the loads remained nearly constant with different pretension but increased obviously with the changing amplitude and layer fluid depth *** increments of mooring lines also changed little with the pretension but increased rapidly when amplitude and layer fluid depth ratio ***,FPSO’s motion increased quickly with not only the horizontal pretension but also the amplitude of internal solitary wave and layer fluid depth ratio.

关键词： internal solitary wave(ISW) dynamic response FPSO dynamic loads tension increment

iTRAQ-based quantitative proteome characterization of wheat grains during filling stages

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Journal of Integrative Agriculture 2017年第10期16卷 2156-2167页

作者： cui Yong YANG Ming-ming DONG Jian ZHAO Wan-chun GAO xiang College of Agronomy Northwest A&F University Yangling 712100 P.R.China Wheat Engineering Research Center of Shaanxi Province Yangling 712100 P.R. China

Using isobaric tags for relative and absolute quantification （iTRAQ） and associated analytic technologies, we have cataloged and compared 7 069 unique wheat proteins expressed during four substages of the filling stage. Among them, 859 are differentially expressed, showing at least a 2-fold difference in concentration across substages. Differentially expressed proteins （DEPs） includind high-molecular weight giutenin subunit （W5AIU1）, low-molecular weight glutenin subunit （QSW3V4）, gliadin/avenin-like seed protein （D2KFG9）, and avenin-like protein （W5DVL2）, all of which have previously been identified as important for nutritional quality and bread-making properties, and all of which were found to increase at the latter stages of development. We have applied statistical techniques to group the proteins into hierarchical clusters, and have consulted databases to infer functional and other relationships among the identified proteins.

关键词： wheat proteome isobaric tags for relative and absolute quantification (iTRAQ) grain filling

Effects of cosolvent on formation and morphology of microspheres in precipitation polymerization of divinylbenzene in supercritical carbon dioxide

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Chinese Chemical Letters 2011年第4期22卷 489-492页

作者： chun Sheng LiJing cui Liang Xiao Li Zhu xiang Zheng Kong Key Laboratory of Fluorine Chemistry and Chemical Materials of Shandong Province College of Chemistry and Chemical Engineering University of Jinan Jinan 250022 China

Precipitation polymerizations of divinylbenzene（DVB） in pure supercritical carbon dioxide,and parallel runs with presence of a cosolvent were carried *** results showed that use of acetone as the cosolvent contributed greatly to the formation of the monodisperse *** microspheres,with obviously higher uniformity than reported up to date,were achieved using 6-7 mL of acetone in a reactor of 50 mL with DVB concentration of 0.4 mol/L under 16 MPa,a much lower pressure than previously reported without use of cosolvent.

关键词： Polydivinylbenzene microspheres Precipitation polymerization Supercritical carbon dioxide Cosolvent