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Homocysteine aggravates cerebral hemorrhage in rats: Correlation with oxygen-free radical production and cell apoptosis in tissue surrounding hematoma

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Neural Regeneration Research 2010年第13期5卷 1004-1009页

作者： Yingying Liu Xinjun Li chun Wang chun Chen Ping Liu Qin Feng Duanxiu liao Xiaogang Li Department of Neurology People's Hospital of Deyang City Deyang 618000 Sichuan Province China Department of Neurosurgery People's Hospital of Deyang City Deyang 618000 Sichuan Province China Department of Neurology Hospital Affiliated to Luzhou Medical College Luzhou 646000 Sichuan Province China

BACKGROUND： Previous studies have demonstrated that homocysteine is an independent risk factor for ischemic stroke, as determined by detection of apoptosis and oxygen-free radical scavengers following cerebral ischemia. However, the mechanisms of homocysteine remain unclear Several reports have addressed the effects of homocysteine on ischemic stroke. OBJECTIVE： To analyze the effects of homocysteine on apoptosis, intracellular superoxide dismutase （SOD） activity, and malondialdehyde content in tissue surrounding hematoma in rats with cerebral hemorrhage, and to determine the action pathway of malondialdehyde following cerebral hemorrhage. DESIGN, TIME AND SETTING： The randomized, controlled, animal experiment was performed at the Laboratory of Molecular Biology, Hospital Affiliated to Luzhou Medical College, China from April 2007 to April 2008. MATERIALS： In situ apoptosis detection kit （Roche, Mannheim, Germany）, SOD detection kit and malondialdehyde detection kit （Nanjing Jiancheng Bioengineering Institute, China）, and homocysteine （Sigma, St Louis, MO, USA） were used in the present study. METHODS： A total of 75 Sprague Dawley rats were equally and randomly assigned to sham surgery model, and homocysteine groups. Autologous blood was infused into the caudate putamen of rats to establish models of cerebral hemorrhage in model and homocysteine groups. Homocysteine was injected directly into the brain through the skull at the hematoma hemisphere at 30 minutes after model induction in the homocysteine group. MAIN OUTCOME MEASURES： At 6, 12, 24, and 72 hours, as well as 1 week, post-surgery, neurological deficits were observed in each group. Brain water content was measured using the dry-wet weight method. Cell apoptosis in tissue surrounding the hematoma was detected utilizing terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling （TUNEL）. SOD activity and malondialdehyde content in tissue surrounding the hematoma were respectively measured usin

关键词： homocysteine cerebral hemorrhage apoptosis superoxide dismutase malondialdehyde neural regeneration

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Enhanced Kerr Nonlinearities Caused by Cross talk Between Optical and Microwave Transitions

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Communications in Theoretical Physics 2008年第10期50卷 961-964页

作者： HU Zheng-Feng DENG Jian-liao DU chun-Guang WANG Yu-Zhu The Key Laboratory of Quantum Optics Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Science Shanghai 201800 China Department of Physics Tsinghua University Beijing 100084 China

We investigate the enhanced Kerr nonlinearities in four-level atomic vapors driven by a coupling,probe andmicrowave *** the optical one-photon and two-photon resonant conditions,the linear and nonlinear responsesof the weak probe field can be modified by the cross talk among optical and microwave *** enhanced Kerrnonlinearity can form bright optical solitons of the probe field.

关键词：非线性原子域光学微波

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The utilization of traditional Chinese medicine and associated factors in taiwan in 2002

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Chinese Medical Journal 2009年第13期122卷 1544-1548页

作者： chun-chuan Shih Jaung-geng Lin Chien-chang liao Yi-chang Su Graduate Institute of Chinese Medical Science College of Chinese Medicine China Medical University Taichung Taiwan China Graduate Institute of Acupuncture Science College of Chinese Medicine China Medical University Taichung Taiwan China Dry Lab China Medical University Hospital Taichung Taiwan China

Background Previous studies have noted that there is a high utilization rate of traditional Chinese medicine （TCM） services in taiwan, China and in western countries, but few studies investigated factors associated with the utilization of TCM in taiwan. This study analyzes the utilization rate and the factors associated with the utilization of TCM in taiwan. Methods Data for this study were from the 2002 HPKAP Survey that conducted the face-to-face questionnaire interviews of people aged 15 years and over from October 2002 to March 2003 in taiwan. This study analyzed the utilization of TCM outpatient services, including admission to the hospital and clinic visits. Results A total of 26 755 participants completed the survey in the six-month period. The data revealed that 10.4% of participants had utilized TCM services in the past one month while 4.2% of participants utilized TCM only （without using Western medicine outpatient services （WM） or Folk therapy （FT））. The average visits of TCM services per patient was higher among people who had utilized TCM and FT services （2.68 visits） than among those who had utilized WM and FT services （2.15 visits） or TCM services alone （2.15 visits） during the previous one month. Younger people （odds ratio OR = 1.78, 95%CI= 1.47-2.16）, women （compared with men）, and people with higher education levels （OR = 1.58, 95%CI= 1.25-1.98） were more likely to visit TCM than compared groups. People with self-reported poor health status （OR = 2.07, 95%CI= 1.76-2.44） and people who exercise regularly （OR = 1.17, 95%CI= 1.07-1.27） had higher ORs to visit TCM service than comparison group. Conclusions There is a high utilization of TCM in taiwan. Further studies are needed to investigate the related factors and determinants between the utilization of TCM and the utilization of FT in taiwan.

关键词： traditional Chinese medicine utilization survey complementary and alternative medicine

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金秋沙糖橘在广西西林县的引种表现及高接丰产栽培技术

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南方园艺 2024年第2期35卷 18-22页

作者：黄茂景黄其椿廖惠红黄燕晓费永红朱玉萍邹岑汪妮娜李玉梅西林县水果站广西西林533500 广西壮族自治区农业科学院园艺研究所广西南宁530007 百色市农业科学研究所广西百色533612 西林县科技服务中心广西西林533500

金秋沙糖橘是早熟的优良沙糖橘品种,为调整西林县沙糖橘成熟期,缓解沙糖橘集中上市的销售压力,笔者通过调查高接换种或引种金秋沙糖橘嫁接苗的物候期、果实品质和病虫害发生情况来评价其在西林县的种植表现。结果表明:西林县金秋沙糖橘... 详细信息

金秋沙糖橘是早熟的优良沙糖橘品种,为调整西林县沙糖橘成熟期,缓解沙糖橘集中上市的销售压力,笔者通过调查高接换种或引种金秋沙糖橘嫁接苗的物候期、果实品质和病虫害发生情况来评价其在西林县的种植表现。结果表明:西林县金秋沙糖橘最佳采收上市时间为9月底至11月上旬,比沙糖橘提早45~60 d。10月中旬金秋沙糖橘可溶性固形物含量15.10%,可滴定酸含量0.37%,售价7~13元/kg,可在适宜金秋沙糖橘的地区适度规模发展。此外,总结金秋沙糖橘高接丰产技术。

关键词：金秋沙糖橘引种高接栽培技术

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赤水金钗石斛种源调查及HPLC指纹图谱比较

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中国现代中药 2024年第7期26卷 1134-1140页

作者：何丽倩刘志霞李锦妍廖娴刘志华黄月纯桂蜀华刘舒萍魏刚广州中医药大学中药学院广东广州510006 赤水芝绿金钗石斛生态园开发有限公司贵州遵义564700 广州中医药大学第一附属医院广东广州510405 道地药材品质保障与资源持续利用全国重点实验室北京100700

目的:调查赤水野生金钗石斛种源状况,建立高效液相色谱法(HPLC)指纹图谱,初步探讨野生种源与石上仿野生样品的差异。方法:采用文献查阅和实地走访相结合的方法对贵州省赤水市野生金钗石斛种源及生境状况进行调查;采用HPLC指纹图谱对金... 详细信息

目的:调查赤水野生金钗石斛种源状况,建立高效液相色谱法(HPLC)指纹图谱,初步探讨野生种源与石上仿野生样品的差异。方法:采用文献查阅和实地走访相结合的方法对贵州省赤水市野生金钗石斛种源及生境状况进行调查;采用HPLC指纹图谱对金钗石斛野生种源、石上仿野生种植及产于6个基地的成熟干品与鲜品进行分析。结果:在赤水市石堡乡寻找到附生在古树上的野生金钗石斛种源,生长年限分别在50、30、20年左右;4棵古树上分别有金钗石斛80~100丛,每丛约10~15株,总质量为40~50 kg;金钗石斛野生种源与石上仿野生样品HPLC指纹图谱有7个共有特征峰,指认了3个特征峰成分,其相似度均在0.940以上。结论:赤水野生金钗石斛资源稀少,仅附生在极少量古树上;石上仿野生种植及不同基地的金钗石斛与古树上的野生种源指纹图谱相似度较高,石上仿野生种植模式所产金钗石斛能与野生种质保持一致。

关键词：金钗石斛种源调查仿野生种植指纹图谱

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阿尔茨海默病不同治疗方式研究新进展

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广州医药 2024年第3期55卷 236-244页

作者：袁行勇姚春陈炜王晋平黄钰铧曲一荻曾汉林崔恩山廖雨芯广西中医药大学广西南宁530000 广西中医药大学第一附属医院广西南宁530023

阿尔茨海默病(Alzheimer’s disease,AD)是一种复杂的、起病隐秘的、病因不明的、缺乏特异性诊断方式的神经退行性病变。面对与日俱增的患病率,却缺乏有效的治疗方式。中医药治疗方式具有多层次、多靶点、多通路的独特优势,中西医结合... 详细信息

阿尔茨海默病(Alzheimer’s disease,AD)是一种复杂的、起病隐秘的、病因不明的、缺乏特异性诊断方式的神经退行性病变。面对与日俱增的患病率,却缺乏有效的治疗方式。中医药治疗方式具有多层次、多靶点、多通路的独特优势,中西医结合方式的互补,非药物疗法的辅助,干细胞疗法、新的分子药物、抗体及蛋白疫苗、γ感官刺激等新颖的实验阶段新疗法等方式治疗AD。本文综述近年来的不同治疗方式治疗AD研究新进展,旨在为临床上治疗AD提供新思路、新方法及参考价值。

关键词：阿尔茨海默病治疗方式中西医疗法干细胞疗法新疗法

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Epidemiological characteristics of central nervous system tumors in children: a 5-year review of 3180 cases from Beijing Tiantan Hospital

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Chinese Neurosurgical Journal 2022年第3期8卷 188-194页

作者： Zhi-ming Liu Chih-yi liao Heng Zhang Zhe Han Jun-mei Wang Zhen-yu Ma chun-de Li Jian Gong Wei Liu tao Sun Yong-ji Tian Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Center of Brain TumorBeijing Institute for Brain DisordersBeijing Key Laboratory of Brain TumorBeijingChina Department of Neuropathology Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina

Background:To describe the epidemiological characteristics of central nervous system(CNS)tumors in children,based on the neurosurgery department of Beijing Tiantan ***:From January 2015 to December 2019,3180 children were histopathologically diagnosed with CNS tumors based on the 2016 World Health Organization(WHO)classification of *** were 0 to 15 years *** analyzed age-related gender preferences,tumor locations,and the histological grades of the *** addition,the epidemiological characteristics of the five most common intracranial tumors were compared to the previous ***:In this study,intracranial and spinal tumors account for 96.4%(3066)and 3.6%(114)of all tumors,with a preponderance of supratentorial tumors(57.9%).Among all pediatric patients,low-grade tumors comprise 67.1%(2135).The integral gender ratio of males to females is 1.47:1 and the average age of patients is 7.59 years *** five most common intracranial tumors are craniopharyngioma(15.4%),medulloblastoma(14.3%),pilocytic astrocytoma(11.8%),diffuse astrocytoma(9.8%),and anaplastic ependymoma(4.8%).Conclusions:Due to the lack of national data on childhood brain tumors,we used a large nationally representative population sample based on the largest pediatric neurosurgery center in *** analyzed the data of the past 5 years,reflecting the incidence of CNS tumors in Chinese children to a certain extent,and laying a data foundation for subsequent clinical studies.

关键词： Epidemiology Central nervous system tumors Pediatric World Health Organization classification

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Achieving ultrahigh electrochemical performance by surface design and nanoconfined water manipulation

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National Science Review 2022年第6期9卷 143-152页

作者： Haisheng Li Kui Xu Pohua Chen Youyou Yuan Yi Qiu Ligang Wang Liu Zhu Xiaoge Wang Guohong Cai Liming Zheng chun Dai Deng Zhou Nian Zhang Jixin Zhu Jinglin Xie Fuhui liao Hailin Peng Yong Peng Jing Ju Zifeng Lin Junliang Sun College of Chemistry and Molecular Engineering Beijing National Laboratory for Molecular Sciences Peking University Key Laboratory of Flexible Electronics and Institute of Advanced Materials Jiangsu National Synergetic Innovation Center for Advanced MaterialsNanjing Tech University Core Labs King Abdullah University of Science and Technology Electron Microscopy Centre of Lanzhou University Lanzhou University School of Chemical and Environmental Engineering China University of Mining and Technology State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences Analytical Instrumentation Center Peking University School of Physical Science and Technology Electron Microscopy Centre of Lanzhou University and Key Laboratory of Magnetism and Magnetic Materials of the Ministry of Education Lanzhou University College of Materials Science and Engineering Sichuan University

The effects of nanoconfined water and the charge storage mechanism are crucial to achieving the ultrahigh electrochemical performance of two-dimensional transition metal carbides(MXenes). We propose a facile method to manipulate nanoconfined water through surface chemistry modification. By introducing oxygen and nitrogen surface groups, more active sites were created for Ti3C2MXene, and the interlayer spacing was significantly increased by accommodating three-layer nanoconfined water. Exceptionally high capacitance of 550 F g-1(2000 F cm-3) was obtained with outstanding high-rate performance. The atomic scale elucidation of the layer-dependent properties of nanoconfined water and pseudocapacitive charge storage was deeply probed through a combination of ‘computational and experimental microscopy’. We believe that an understanding of, and a manipulation strategy for, nanoconfined water will shed light on ways to improve the electrochemical performance of MXene and other two-dimensional materials.

关键词： two-dimensional material MXene nanoconfined water energy storage mechanism supercapacitors

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Effects of Differential First-Line Antiretroviral Therapy(ART)Regimens on Mortality among HIV/AIDS Children in Southwest China:A 15-year Retrospective Cohort Study

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Biomedical and Environmental Sciences 2023年第11期36卷 1079-1083页

作者： CHEN Qiu Li liao Yan Yan QIN Shan Fang LU chun Yan PAN Pei Jiang WANG Hai Long JIANG Jun Jun ZHENG Zhi Gang QIN Feng Xiang HONG Wen NING Chuan Yi YE Li LIANG Hao Guangxi Key Laboratory of AIDS Prevention and Treatment School of Public HealthGuangxi Medical UniversityNanning 530021GuangxiChina Biosafety IlI Laboratory Life Science InstituteGuangxi Medical UniversityNanning 530021GuangxiChina Guangxi AIDS Diagnosis and Treatment Quality Control Center Chest Hospital of Guangxi Zhuang Autonomous RegionLiuzhou 545005GuangxiChina Guangxi Center for Disease Prevention and Control Nanning 530021GuangxiChina Nursing College Guangxi Medical UniversityNanning 530021GuangxiChina

Human immunodeficiency virus(HIV)is a serious public health ***,1.7 million(1.3–2.1 million)children aged 0–14 were living with HIV at the end of 2021,90%of whom lived in low-and middle-income *** Immune Deficiency ... 详细信息

关键词： mortality Therapy HIV/AIDS

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基于多孔介质的某大口径装药床点传火特性

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含能材料 2022年第5期30卷 502-510页

作者：廖万予薛晓春南京理工大学能源与动力工程学院江苏南京210094

为了深入研究主装药的装填密度对点火药燃气在药床内传播特性的影响,搭建了某大口径密实装药床点传火系统试验平台,试验拍摄记录了火焰序列图及部分测压点压力变化情况;采用多孔介质模型模拟药室内的颗粒药床,建立了与试验装置对应的点... 详细信息

为了深入研究主装药的装填密度对点火药燃气在药床内传播特性的影响,搭建了某大口径密实装药床点传火系统试验平台,试验拍摄记录了火焰序列图及部分测压点压力变化情况;采用多孔介质模型模拟药室内的颗粒药床,建立了与试验装置对应的点传火系统模型,对点火药燃气在颗粒药床中的流动过程进行数值模拟,将模拟计算结果与试验结果进行对比,验证模型的可靠性,再计算不同装填密度下燃气在药床内温度场和压力场的传播特性。结果表明,计算所得与试验拍摄的火焰传播序列过程及试验测得的压力曲线均吻合较好,验证了模型的可靠性;在任意孔隙率条件下,0~10 ms时,火焰阵面轴向位移的发展较快,轴向速度由25~30 m·s^(-1)减小到10 m·s^(-1),而10~40 ms轴向速度逐渐减小到2~3 m·s^(-1);同样,在任意孔隙率条件下,火焰阵面径向位移的发展集中在2.2~3.0 ms时段内,且3.0 ms时径向速度都将减小到20~22 m·s^(-1),但较大的孔隙率初始时刻的径向速度较大;当孔隙率由0.3增大至0.5时,药室内不同位置处的压力差由0.24 MPa减小到0.20 MPa,压力差减小了16.7%,点火的均匀性和瞬时性提高。随着孔隙率增大,点火传播过程中药室内火焰阵面的轴向和径向阻力减小,火焰阵面沿轴向的扩展位移越大,轴向和径向上的火焰传播初速度也越大,但末速度趋于一致;药室内的压力越小,药室内的压力差也减小。

关键词：装填密度多孔介质模型点传火孔隙率

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