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Failure characteristics of three-body model composed of rock and coal with different strength and stiffness

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Transactions of Nonferrous Metals Society of China 2014年第5期24卷 1538-1546页

作者：赵增辉王渭明代春泉严纪兴山东科技大学矿山灾害预防控制省部共建国家重点实验室培育基地青岛266590 山东科技大学矿业与安全工程学院青岛266590 山东科技大学土木工程与建筑学院青岛266590

Four different types of three-body model composed of rock and coal with different strength and stiffness were established in order to study the failure characteristics of compound model such as roof-coal-floor. Through stress analysis of the element with variable strength and stiffness extracted from the strong-weak interface, the tri-axial compressive strength of the weak body and strong body near the interface as well as the areas away from the contact surface was found. Then, on the basis of three-dimensional fast Lagrangian method of continua and strain softening constitutive model composed of Coulomb-Mohr shear failure with tensile cut-off, stress and strain relationship of the four three-body combined models were analyzed under different confining pressures by numerical simulation. Finally, the different features of local shear zones and plastic failure areas of the four different models and their development trend with increasing confining pressure were discussed. The results show that additional stresses are derived due to the lateral deformation constraints near the strong-weak interface area, which results in the strength increasing in weak body and strength decreasing in strong body. The weakly consolidated soft rock and coal cementation exhibit significant strain softening behavior and bear compound tension-shear failure under uni-axial compression. With the increase of confining pressure, the tensile failure disappears from the model, and the failure type of composed model changes to local shear failure with different number of shearing bands and plastic failure zones. This work shows important guiding significance for the mechanism study of seismic, rock burst, and coal bump.

关键词： three-body model composed of rock and coal strength near strong-weak interface local shear band plastic failure zone

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding chun Chen Heng Zhao Bin dai Lei Ye Tao Song Shuai Huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang Jian Wu Hui Hong Wei quan Xinyu Qiao chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

Modeling and simulation of bow wave effect in probe and drogue aerial refueling

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Chinese Journal of Aeronautics 2016年第2期29卷 448-461页

作者： dai Xunhua Wei Zibo quan quan School of Automation Science and Electrical Engineering Beihang University

In a probe and drogue aerial refueling system, the bow wave of the receiver aircraft will produce a strong aerodynamic effect on the drogue once the receiver follows the drogue at a close distance. It is a major difficulty of docking control in the probe and drogue refueling. This paper analyses the bow wave effect and presents a simple method to model it. Firstly, the inviscid flow around the receiver is modeled based on the stream function defined by basic stream singularities. Secondly, a correction function is developed to eliminate the error caused by the absence of air vis- cosity. Then, the aerodynamic coefficients are used to calculate the induced aerodynamic force on the drogue. The obtained model is in an analytical form that can be easily applied to the controller design and the real-time simulations. In the verification part, computational fluid dynamics （CFD） simulation tests are conducted to validate the obtained flow fields and aerodynamic forces. Finally, the modeling method is applied to an F-16 receiver aircraft in a previously developed autonomous aerial refueling simulation system. The simulations results are analyzed and compared with the NASA flight-test data, which demonstrates the effectiveness of the proposed method.

关键词： Aerial refueling Aerodynamic Bow wave Modeling Probe and drogueUAV

CeCl_3·7H_2O as an efficient catalyst for one-pot synthesis of β-amino ketones by three-component Mannich reaction

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Chinese Chemical Letters 2010年第1期21卷 31-34页

作者： Yan dai[a], Bin Dong Li[a], Heng Dao quan[b] chun Xu Lü[a] [a]School of Chemical Engineering Nanjing University of Science Technology Nanjing 210094 China [b]National Institute of Advanced Industrial Science Technology Ibaraki 3058565 Japan

Cerium trichloride heptahydrate(CeCl_3·7H_2O) was found to be an efficient and recyclable catalyst for the three-component direct Mannich reaction of anilines and benzaldehydes with *** protocol has advantages of hig... 详细信息

关键词： Cerium trichloride heptahydrate Mannich reaction β-Amino ketones Lewis acid

Reversible Plasticity Shape Memory Effect in SEBS/Crystallizable Paraffin: Influence of Paraffin Content

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Chinese Journal of Polymer Science 2022年第12期40卷 1697-1705,I0011页

作者： Shao-quan Zhao Jia-chun Feng State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200433China Yiwu Research Institute of Fudan University Yiwu 322000China

Polymers with reversible plasticity shape memory effect(RPSME)have attracted considerable attention due to their simple programming and large ***,the exact mechanisms of RPSME are still not thoroughly *** this work,the RPSME of SEBS/crystallizable paraffin was investigated by comparatively analyzing the performances and microstructures of samples with different paraffin *** was found the shape fixing ratios(Rfs)of samples increased with the paraffin content,and interestingly,a significant improvement in Rf was observed when the paraffin content exceeded 60 wt%.Tensile test results showed that the deformation characteristics of samples changed from elastic to plastic as the paraffin content increased above 60 wt%.By exploring the crystallization behaviors of paraffin in various SEBS/paraffin samples,it was revealed that the microstructures of SEBS/paraffin were different when the paraffin content was below 50 wt%and above 60 wt%.In samples with low paraffin content(below 50 wt%),nearly all paraffin was co-crystallized with ethylene-co-butylene(EB)chains and its crystallization was severely restricted;while in samples with high paraffin content(above 60 wt%),“excess”paraffin appeared and this part of paraffin crystallized on the template of the EB/paraffin co-crystals,which might be responsible for the elastic-to-plastic transition and the sharp increase in *** on the above results,a possible structural model was proposed to explain the exact mechanism of RPSME in SEBS/paraffin.

关键词： Reversible plasticity shape memory effect Poly(styrene-b-(ethylene-co-butylene)-b-styrene) Crystallizable paraffin Paraffin content

Effect of Alloying Element on Electromagnetic Interference Shielding Effectiveness of Binary Magnesium Alloys

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Acta Metallurgica Sinica(English Letters) 2019年第7期32卷 817-824页

作者： Zhu Luo Xian-Hua Chen Kai Song chun-quan Liu Yan dai Di Zhao Fu-Sheng Pan College of Materials Science and Engineering Chongqing University Chongqing 400045 China Chongqing Academy of Science and Technology Chongqing 401123 China

The microstructure,electrical conductivity and electromagnetic interference shielding effectiveness of Mg-X(X=Al,Sn,Y and Gd)alloys in as-cast and solution states were systematically investigated in this *** electrical conductivity and electromagnetic shielding capacity of binary magnesium alloys decrease linearly with alloying element *** electromagnetic shielding effectiveness of the binary magnesium alloys with the same alloying element content is as follows:Mg-Gd

关键词： Binary magnesium alloys Electrical conductivity Electromagnetic shielding effectiveness Alloying element

Inverse Problems for the Dirac Operator on a Star Graph

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Acta Mathematica Sinica,English Series 2023年第1期39卷 161-175页

作者： dai quan LIU Chuan Fu YANG School of Mathematics and Statistics Nanjing University of Science and TechnologyNanjing 210094P.R.China

Following the previous work,we shall study some inverse problems for the Dirac operator on an equilateral star *** is proven that the so-called Weyl function uniquely determines the ***,we pay attention to the inverse problem of recovering the potentials from the spectral data,which consists of the eigenvalues and weight matrices,and present a constructive *** basic tool in this paper is the method of spectral mappings developed by Yurko.

关键词： Inverse problem Dirac operator on graph Weyl function weight matrix

Visual interpretability for deep learning：a survey

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Frontiers of Information Technology & Electronic Engineering 2018年第1期19卷 27-39页

作者： quan-shi ZHANG Song-chun ZHU University of California Los Angeles California 90095 USA

This paper reviews recent studies in understanding neural-network representations and learning neural networks with interpretable/disentangled middle-layer *** deep neural networks have exhibited superior performance in various tasks,interpretability is always Achilles' heel of deep neural *** present,deep neural networks obtain high discrimination power at the cost of a low interpretability of their black-box *** believe that high model interpretability may help people break several bottlenecks of deep learning,e.g.,learning from a few annotations,learning via human–computer communications at the semantic level,and semantically debugging network *** focus on convolutional neural networks(CNNs),and revisit the visualization of CNN representations,methods of diagnosing representations of pre-trained CNNs,approaches for disentangling pre-trained CNN representations,learning of CNNs with disentangled representations,and middle-to-end learning based on model ***,we discuss prospective trends in explainable artificial intelligence.

关键词： Artificial intelligence Deep learning Interpretable model