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Chinese Chemical Letters 2011年第11期22卷 1371-1374页

作者： Hong Wei Ma Bai Wang chun qing zhang Yang Li Yan Ming Hu Yu Rong Wang Liaoning Key Laboratory of Polymer Science and Engineering School of Chemical Engineering Dalian University of Technology Dalian Liaoning 116024 China

The novel functionalized triblock copolymers,poly[（4-vinylphenyl）dimethylsilane]-b-polybutadiene-b-poly[（4-vinylphenyl）-dimethylsilane] （PVPDMS-b-PBd-b-PVPDMS）,were synthesized by anionic polymerization method using high vacuum technique. The hydrocarbon-soluble dilithium initiator synthesized from l,3-di[l-（methylphenyl）ethenyl]benzene（MPEB） was used to synthesize polybutadiene（PBd） precursors and the triblock copolymers in the presence of *** precursors and copolymers were characterized by size exclusion chromatography（SEC）,~1HNMR and DSC techniques.

关键词： Anionic polymerization Functionalized triblock copolymers High vacuum technique

Transjugular intrahepatic portosystemic shunt for the prevention of recurrent esophageal variceal bleeding in patients with cavernous transformation of portal vein

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Hepatobiliary & Pancreatic Diseases International 2018年第6期17卷 517-523页

作者： Zhao-Peng Li Sui-Sui Wang Guang-Chuan Wang Guang-Jun Huang Jing-Qin Cao chun-qing zhang Department of Gastroenterology Shandong Provincial Hospital Affiliated to Shandong UniversityJinan 250021China Department of Interventional Radiology Jining No.1 People’s HospitalJining 272011China Department of Pediatrics The Affiliated Hospital of Jining Medical CollegeJining 272000China

Background: Treatment options for patients with cavernous transformation of portal vein(CTPV) are limited. This study aimed to evaluate the feasibility, efficacy and safety of transjugular intrahepatic portosystemic shunt(TIPS) to prevent recurrent esophageal variceal bleeding in patients with CTPV. Methods: We retrospectively analyzed 67 consecutive patients undergone TIPS from January 2011 to December 2016. All patients were diagnosed with CTPV. The indication for TIPS was a previous episode of variceal bleeding. The data on recurrent bleeding, stent patency, hepatic encephalopathy and survival were retrieved and analyzed. Results: TIPS procedure was successfully performed in 56 out of 67(83.6%) patients with CTPV. TIPS was performed via a transjugular approach alone( n = 15), a combined transjugular/transhepatic approach( n = 33) and a combined transjugular/transsplenic approach( n = 8). Mean portosystemic pressure gradient(PSG) decreased from 28.09 ± 7.28 mmHg to 17.53 ± 6.12 mmHg after TIPS( P < 0.01). The probability of the remaining free recurrent variceal bleeding was 87.0%. The probability of TIPS patency reached 81.5%. Hepatic encephalopathy occurrence was 27.8%, and survival rate was 88.9% until the end of follow-up. Four out of 11 patients who failed TIPS died, and 4 had recurrent bleeding. Conclusions: TIPS should be considered a safe and feasible alternative therapy to prevent recurrent esophageal variceal bleeding in patients with CTPV, and to achieve clinical improvement.

关键词： Cavernous transformation Portal vein Transjugular intrahepatic portosystemic shunt Variceal rebleeding Portal hypertension

Modeling of LF refining process:a review

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Journal of Iron and Steel Research International 2024年第2期31卷 289-317页

作者： Zi-cheng Xin Jiang-shan zhang Kai-xiang Peng Jun-guo zhang chun-hui zhang qing Liu State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing100083China School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing100083China Tangshan Branch Hebei Iron and Steel Co.Ltd.Tangshan063000HebeiChina Xinjiang Bayi Iron and Steel Co. Ltd.Baosteel GroupWulumuqi830022XinjiangChina

With the increasing demand for energy conservation and emission reduction,more attentions have been paid to the intelligentization,greenization and low carbonization during the transformation and upgrading of steelmaking *** furnace(LF)refining is one of the key procedures in steelmaking process and has been widely used in steelmaking plants for its high equipment matching degree,low equipment investment and outstanding refining *** to the main tasks of LF refining process,the modeling methods of temperature prediction model,slag-making model,alloying model,argon blowing model and model of inclusions behavior were systematically reviewed,and the advantages and disadvantages of each modeling method were *** addition,the technical framework for the future has also been proposed based on existing works,including classification of raw materials,graphic representation of knowledge,introduction,upgradation and management of device/equipment,customization of steelmaking,modeling of refining process,synergy of models,intelligentization of decision-making,automation of control,and digitization of processes and operations,aiming to provide a reference for the modeling and intelligent development of LF refining process.

关键词： LF refining Temperature prediction Slag-making Alloying Argon blowing Inclusion behavior Modeling method

Synthesis and Properties of SEPS-g-PEO Copolymers with Varying Branch Lengths

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Chinese Journal of Polymer Science 2018年第8期36卷 934-942页

作者： Zhong-Fu Zhao Pei-Ying Liu chun-qing zhang Wei Liu Yan-Hui Wang Tao Tang Yi-Fu Ding Yan-Dong zhang Fan-Zhi Meng State Key Laboratory of Fine Chemicals School of Chemical EngineeringDalian University of Technology State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of Sciences Department of Mechanical Engineering University of Colorado Boulder

Poly（ethylene oxide）（PEO） was controllably grafted from styrene-b-（ethylene-co-propylene）-b-styrene （SEPS） backbones by combining lithiation of styrenic units and living monomer-activated anionic ring-opening polymerization of ethylene oxide （EO） monomers with the aid of co-initiators triisobutyl aluminum. The as-synthesized SEPS-g-PEO copolymers were characterized by SEC, 1H-NMR, FTIR, SAXS, AFM and DSC. When the branch length is relatively small, increase of PEO fraction leads to the increase of the correlation length between neighboring hard domains, but the degree of correlation reduces. When the branch length is relatively large, the phase-separated structures become random both in terms of size and spatial correlation, and macro-phase separated structures appear. The crystallization behavior of the PEO branches can be effectively inhibited in SEPS-g-PEO, so no significant crystallization takes place until the fraction of PEO branches is 20.1 wt%, which greatly promotes the rapid delivery of hydrophilic drugs in the hot-melting pressure- sensitive adhesives （HMPSAs） based on SEPS-g-PEO. Their cumulative release amount of a model drug could achieve 80%, more than twice the value in the HMPSAs based on linear PEO-containing styrenic block copolymers.

关键词： Living anionic polymerization SEPS-g-PEO copolymers Phase structures Drug delivery

Metformin attenuates motility,contraction,and fibrogenic response of hepatic stellate cells in vivo and in vitro by activating AMP-activated protein kinase

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World Journal of Gastroenterology 2018年第7期24卷 819-832页

作者： Zhen Li Qian Ding Li-Ping Ling Ying Wu Dong-Xiao Meng Xiao Li chun-qing zhang Department of Gastroenterology Shandong Provincial Hospital Affiliated to Shandong UniversityJinan 250021Shandong ProvinceChina Shandong Provincial engineering and technological research center for liver disease prevention and control Jinan 250021Shandong ProvinceChina

AIM To investigate the effect of metformin on activated hepatic stellate cells(HSCs) and the possible signaling pathways involved. METHODS A fibrotic mouse model was generated by intraperitoneal injection of carbon tetrachloride(CCl_4) and subsequent treatment with or without metformin. The level of fibrosis was detected by hematoxylin-eosin staining, Sirius Red staining, and immunohistochemistry. The HSC cell line LX-2 was used for in vitro studies. The effect of metformin on cell proliferation(CCK8 assay),motility(scratch test and Transwell assay), contraction(collagen gel contraction assay), extracellular matrix(ECM) secretion(Western blot), and angiogenesis(ELISA and tube formation assay) was investigated. We also analyzed the possible signaling pathways involved by Western blot *** Mice developed marked liver fibrosis after intraperitoneal injection with CCl_4 for 6 wk. Metformin decreased the activation of HSCs, reduced the deposition of ECM, and inhibited angiogenesis in CCl_4-treated mice. Platelet-derived growth factor(PDGF) promoted the fibrogenic response of HSCs in vitro, while metformin inhibited the activation, proliferation, migration, and contraction of HSCs, and reduced the secretion of ECM. Metformin decreased the expression of vascular endothelial growth factor(VEGF) in HSCs through inhibition of hypoxia inducible factor(HIF)-1α in both PDGF-BB treatment and hypoxic conditions, and it down-regulated VEGF secretion by HSCs and inhibited HSC-based angiogenesis in hypoxic conditions in vitro. The inhibitory effects of metformin on activated HSCs were mediated by inhibiting the Akt/mammalian target of rapamycin(m TOR) and extracellular signal-regulated kinase(ERK) pathways via the activation of adenosine monophosphate-activated protein kinase(AMPK).CONCLUSION Metformin attenuates the fibrogenic response of HSCs in vivo and in vitro, and may therefore be useful for the treatment of chronic liver diseases.

关键词： hepatic stellate cell intrahepatic vascular resistance angiogenesis contraction liver fibrosis adenosine monophosphate-activated protein kinase

Comparison of modified percutaneous transhepatic variceal embolization and endoscopic cyanoacrylate injection for gastric variceal rebleeding

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World Journal of Gastroenterology 2013年第5期19卷 706-714页

作者： Jing Wang Xiang-Guo Tian Yan Li chun-qing zhang Fu-Li Liu Yi Cui Ji-Yong Liu Department of Gastroenterology Provincial Hospital Affiliated to Shandong University

AIM:To compare the efficacy of modified percutaneous transhepatic variceal embolization(PTVE)with 2-octyl-cyanoacrylate(2-OCA)and endoscopic variceal obturation(EVO)with an injection of 2-OCA for prophylaxis of gastric variceal rebleeding. METHODS:In this retrospective study,the medical records of liver cirrhosis patients with gastric variceal bleeding who underwent either endoscopic 2-OCA(EVO) or modified PTVE using 2-OCA at Shandong Provincial Hospital from January 2006 to December 2008 were *** demographics,rebleeding rate,survival rate,and complications were compared between the two groups(PTVE and EVO).All results were expressed as mean±SD,or as a *** variables were compared by two sample Student t tests, and qualitative variables were compared by the Fisher exact test or theχ 2 test(with Yates correction)where appropriate.A P value less than 0.05 was considered *** computation was performed using SPSS 13.0 software. RESULTS:A total of 77 patients were included;45 patients who underwent EVO and 32 patients who received *** the follow-up(19.78±7.70 mo in the EVO group,vs 21.53±8.56 mo in the PTVE group) rebleeding occurred in 17 patients in the EVO group and in 4 patients in the PTVE group(37.78%vs 12.5%, P=0.028).The cumulative rebleeding-free rate was 75%,59%,and 49%in 1,2,and 3 years respectively for EVO,and 93%,84%,and 84%for PTVE(P=0.011). Cox analysis was used to identify independent factors that predicted rebleeding after *** including age,gender,cause,Child-Pugh classification, size of gastric varices(GV),location of GV,and treatment methods were *** was revealed that Child-Pugh classification[risk ratio(RR)2.10,95%CI:1.03-4.28,P=0.040],choice of treatment(RR 0.25, 95%CI:0.08-0.80,P=0.019),and size of GV(RR 2.14, 95%CI:1.07-4.28,P=0.032)were the independent factors for predicting ***-up computed tomography revealed that cyanoacrylate was retained in the var

关键词： Gastric varices Endoscopic variceal obturation Percutaneous transhepatic variceal embolization 2-octyl-cyanoacrylate Bleeding

Quasi-two dimensional Ruddlesden−Popper halide perovskites for laser applications

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Frontiers of physics 2024年第2期19卷 53-71页

作者： Kun Chen Qianpeng zhang Yin Liang Jiepeng Song chun Li Shi Chen Fang Li qing zhang School of Mechanical and Electrical Engineering Wuhan Institute of TechnologyWuhan 430205China School of Materials Science and Engineering Peking UniversityBeijing 100871China Institute of Applied Physics and Materials Engineering Macao UniversityMacao 999078China

Quasi-two-dimensional(2D)Ruddlesden‒Popper(RP)halide perovskites,as a kind of emerged two-dimensional layered materials,have recently achieved great attentions in lasing materials field owing to their large exciton binding energy,high emission yield,large optical gain,and wide-range tuning of optical *** review will introduce research progresses of RP halide perovskites for lasing applications in aspects of materials,photophysics,and devices with emphasis on emission and lasing properties tailored by the molecular composition and *** materials,structures and fabrications are introduced in the first ***,the optical transitions and amplified spontaneous emission properties are discussed from the aspects of electronic structure,exciton,gain dynamics,and interface ***,the research progresses on lasing devices are summarized and several types of lasers including VCSEL,DFB lasers,microlasers,random lasers,plasmonic lasers,and polariton lasers are *** last,the challenges and perspectives would be provided.

关键词： two-dimensional materials metal halide perovskite Ruddlesden−Popper halide perovskites lasing emission

MDCT angiography to evaluate the therapeutic effect of PTVE for esophageal varices

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World Journal of Gastroenterology 2013年第10期19卷 1563-1571页

作者： Aitao Sun Yong-Jun Shi Zhuo-Dong Xu Xiang-Guo Tian Jin-Hua Hu Guang-Chuan Wang chun-qing zhang Department of Gastroenterology Provincial Hospital Affiliated with Shandong University Department of Radiology Provincial Hospital Affiliated with Shandong UniversityJinan 250021Shandong ProvinceChina

Abstract AIM:To evaluate the role of multi-detector row computed tomography(MDCT) angiography for assessing the therapeutic effects of percutaneous transhepatic variceal embolization(PTVE) for esophageal varices(EVs).METHODS:The subjects of this prospective study were 156 patients who underwent PTVE with cyanoacrylate for *** were divided into three groups according to the filling range of cyanoacrylate in EVs and their feeding vessels:(1) group A,complete obliteration,with at least 3 cm of the lower EVs and peri-/EVs,as well as the adventitial plexus of the gastric cardia and fundus filled with cyanoacrylate;(2) group B,partial obliteration of varices surrounding the gastric cardia and fundus,with their feeding vessels being obliterated with cyanoacrylate,but without reaching lower EVs;and(3) group C,trunk obliteration,with the main branch of the left gastric vein being filled with cyanoacrylate,but without reaching varices surrounding the gastric cardia or *** performed chart reviews and a prospective follow-up using MDCT images,angiography,and gastrointestinal ***:The median follow-up period was 34 *** rate of eradication of varices for all patients was 56.4%(88/156) and the rate of relapse was 31.3%(41/131).The rates of variceal eradication at 1,3,and 5 years after PTVE were 90.2%,84.1% and 81.7%,respectively,for the complete group;61.2%,49% and 42.9%,respectively,for the partial group;with no varices disappearing in the trunk *** relapsefree rates at 1,3 and 5 years after PTVE were 91.5%,86.6% and 81.7%,respectively,for the complete group;71.1%,55.6% and 51.1%,respectively,for the partial group;and all EVs recurred in the trunk ***-Meier analysis showed P values of 0.000 and 0.000,and odds ratios of 3.824 and 3.603 for the rates of variceal eradication and relapse free rates,*** in EVs disappeared with time,but those in the EVs and other feeding vessels remained permanently in the vessels wit

关键词： Multi-detector row computed tomography Percutaneous transhepatic variceal embolization Cyanoacrylate Esophageal varices Therapeutic effect

Design parameter optimization method for a prestressed steel structure driven by multi-factor coupling

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Frontiers of Structural and Civil Engineering 2024年第7期18卷 1066-1083页

作者： Guo-Liang SHI Zhan-Sheng LIU De-chun LU qing-Wen zhang Majid DEZHKAM Ze-Qiang WANG Faculty of Architecture Civil and Transportation EngineeringBeijing University of TechnologyBeijing 100124China The Key Laboratory of Urban Security and Disaster Engineering of the Ministry of Education Beijing University of TechnologyBeijing 100124China Beijing Building Construction Research Institute Co. Ltd.Beijing 100039China

To achieve efficient structural design,it is crucial to reduce the cost of materials while ensuring structural *** study proposes an optimization method for design parameters(DPs)in a prestressed steel structure driven by multi-factor *** accomplish this,a numerical proxy model of prestressed steel structures is established with integration of DPs and mechanical parameters(MPs).A data association-parameter analysis-optimization selection system is established.A correlation between DPs and MPs is established using a back propagation(BP)neural *** correlation provides samples for parameter analysis and optimization *** are used to characterize the safety of the *** on the safety grade analysis,the key DPs that affect the mechanical properties of the structure are obtained.A mapping function is created to match the MPs and the key *** optimal structural DPs are obtained by setting structural materials as the optimization objective and safety energy as the constraint *** theoretical model is applied to an 80-m-span gymnasium and verified with a scale test physical *** MPs obtained using the proposed method are in good agreement with the experimental *** with the traditional design method,the design cycle can be shortened by more than 90%.Driven by the optimal selection method,a saving of more than 20% can be achieved through reduction of structural material ***,the cross-sectional dimensions of radial cables have a substantial influence on vertical *** initial tension and cross-sectional size of the upper radial cable exhibit the most pronounced impact on the stress distribution in that *** initial tension and cross-sectional size of the lower radial cable hold the greatest sway over the stress distribution in that cable.

关键词： structure design association relationship performance analysis optimum selection experimental verification

Impaired State-Dependent Potentiation of GABAergic Synaptic Currents Triggers Seizures in a Genetic Generalized Epilepsy Model

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Impaired State-Dependent Potentiation of GABAergic Synaptic ...