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Synthesis and characterization of star-comb styrene/butadiene copolymer

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Chinese Chemical Letters 2010年第11期21卷 1370-1373页

作者： qing Min zhang Chuang Chen Hong Xia zhang chun qing zhang Yang Li Xi Gao Jian State Key Laboratory of Fine Chemicals Department of Polymer Science and Engineering School of Chemical Engineering Dalian University of Technology Dalian 116012 China Liaoning Province Key Laboratory of Polymer Science and Engineering Dalian 116012 China

A novel star-comb styrene/butadiene copolymer（SC-SBC） was synthesized by anionic polymerization and grafting reaction with epoxidized star liquid polybutadiene（ESPB） as coupling *** overall shape of the star-comb macromolecules can be altered by changing the molecular weight and number of the side *** molecular parameters and mechanical properties of the SC-SBC resins were *** notched izod impact strength of the SC-SBC resins are excellent and reach as high as to 239 J/m.

关键词： Anionic polymerization Epoxidation Grafting reaction Star-comb copolymer Side chain

Assessing acceptance in mindfulness with direct-worded items:The development and initial validation of the Athlete Mindfulness Questionnaire

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Journal of Sport and Health Science 2017年第3期6卷 311-320页

作者： chun-qing zhang Pak-Kwong chung Gangyan Si Department of Physical Education Hong Kong Baptist University Department of Health and Physical Education Hong Kong Institute of Education

Purpose:The purpose of the current study was to develop and validate a sport-specific mindfulness measure,the Athlete Mindfulness Questionnaire(AMQ),through 5 related studies using 4 separate samples of Chinese *** AMQ is a 3-factor measure designed to assess mindfulness that reflects present-moment attention,awareness,and acceptance in a sport ***:In Study 1,an initial pool of items was generated based on previous literature,existing mindfulness scales,as well as interviews with and feedback from the athletes,coaches,and mindfulness *** support for the 3-factor structure of the AMQ was established via exploratory factor analysis in Study 2,and cross-validated through confirmatory factor analysis in Studies 3 and *** Study 5,a modified 3-factor AMQ with direct-worded acceptance items was examined in a fourth independent ***:Convergent and concurrent validities of the acceptance subscale failed to be established in Studies 3 and 4 which may be due to the inattention and confusion of the athletes whilst interpreting the reverse-worded items.A modified 16-item AMQ in Study 5 displayed satisfactory model fit and acceptable internal *** importantly,convergent and concurrent validities of the 16-item AMQ were ***3 subscales showed significant positive associations with mindfulness,flow,well-being,and positive affect and significant negative associations with experiential avoidance,burnout,and negative ***:The AMQ is a psychometrically sound measure of mindfulness in a sport *** importance of using direct-worded acceptance items is discussed.

关键词： Athlete Mindfulness Reliability Scale Sport Validity

Synthesis and Characterization of Ion-exchange Sulfonated Poly (ether sulfone)

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Chinese Chemical Letters 2006年第4期17卷 447-448页

作者： Fan Xiu MENG chun qing zhang Lian LIU Yuan Yuan zhang Department of Polymer Materials Science School of Chemical Engineer Dalian University of Technology Dalian 116012

N,N＇-Bis（3-hydroxyphenyl）-1,8,4,5-naphthalenetetracarboxylic bisimide was prepared from the reaction of 1,8,4,5-naphthalenetetrcarboxylic acid dianhydride and 2-aminophenol in N, N-dimethylformamide. Polymerization of this bisimide with 4,4＇-difluorodiphenylsulfone and disodium 3,3＇-disulfonate4,4＇-difluorodiphenylsulfone gave ion-exchange sulfonated poly（ether sulfone）. The structure of the title compound was characterized with H-NMR and its polymer was characterized with FT-IR.

关键词： Bisimide ion-exchange polymer sulfonated poly(ether sulfone).

Percutaneous transhepatic intraportal biopsy using gastroscope biopsy forceps for diagnosis of a pancreatic neuroendocrine neoplasm:A case report

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World Journal of Gastroenterology 2023年第7期29卷 1235-1242页

作者： Guang-Chuan Wang Guang-Jun Huang chun-qing zhang Qian Ding Department of Gastroenterology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina

BACKGROUND Pancreatic neuroendocrine neoplasms(PNENs)are a rare group of neoplasms originating from the islets of the *** vein tumor thrombosis has been reported in 33%of patients with *** the histopathological diagnosis of PNENs is usually based on percutaneous biopsy or endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA),these approaches may be impeded by gastric varices,poor access windows,or anatomically contiguous critical *** a pathological diagnosis using a gastroscope biopsy forceps via percutaneous transhepatic intravascular pathway is an innovative method that has rarely been *** SUMMARY A 72-year-old man was referred to our hospital for abdominal pain and *** contrast-enhanced magnetic resonance imaging revealed a wellenhanced tumor(size:2.4 cm×1.2 cm×1.2 cm)in the pancreatic tail with portal vein *** pathological diagnosis via EUS-FNA was not possible because of diffuse gastric *** performed a percutaneous transportal biopsy of the portal vein tumor thrombus using a gastroscope biopsy *** examination revealed a pancreatic neuroendocrine neoplasm(G2)with somatostatin receptors 2(+),allowing systemic *** Intravascular biopsy using gastroscope biopsy forceps appears to be a safe and effective method for obtaining a histopathological *** welldesigned clinic trials are required to obtain more definitive evidence,this procedure may help improve the diagnosis of portal vein thrombosis and related diseases.

关键词： Percutaneous transhepatic intravascular biopsy Portal vein tumor thrombosis Gastroscope biopsy forceps Pancreatic neuroendocrine neoplasms Case report

Transjugular intrahepatic portosystemic shunt is effective in patients with chronic portal vein thrombosis and variceal bleeding

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Hepatobiliary & Pancreatic Diseases International 2021年第2期20卷 128-136页

作者： Xiao-Yan Sun Guang-Chuan Wang Jing Wang Guang-Jun Huang chun-qing zhang Department of Gastroenterology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China Department of Infectious Diseases Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China

Background:Studies about treatment of patients with chronic portal vein thrombosis(CPVT)are still limited,especially in different types of *** study aimed to evaluate the effect of transjugular intrahepatic portosystemic shunt(TIPS)in all types of CPVT with variceal ***:Patients with CPVT who received TIPS treatment between January 2011 and June 2019 were divided into four types according to the extent of *** patients had a history of variceal *** characteristics and clinical parameters were collected and *** on procedure success rate,variation in portal vein pressure,rebleeding,hepatic encephalopathy(HE),stent stenosis,and overall mortality were ***:A total of 189 patients were included in this study(39 in type 1,84 in type 2,48 in type 3,18 in type 4).The TIPS procedure success rate was 86.2%.The success rate was significantly different among the four types(89.7%vs.88.1%vs.83.3%vs.77.8%,P=0.001).In the TIPS success group,portal vein pressure was significantly reduced from 27.15±6.59 to 19.74±6.73 mm Hg after the procedure(P<0.001)and the rebleeding rate was significantly lower than that of the fail group(14.7%vs.30.8%,P=0.017).In addition,there were no significant differences in HE rate(30.7%vs.26.9%,P=0.912)or overall mortality(12.9%vs.19.2%,P=0.403)between the TIPS success group and the fail *** the TIPS success group,we found that the occurrence of HE was significantly different(P=0.020)among the four types,while there were no significant differences in rebleeding rate(P=0.669),stent stenosis rate(P=0.056),or overall mortality(P=0.690).Conclusions:TIPS was safe and effective in decreasing portal vein pressure and rebleeding rate in patients with CPVT.

关键词： Chronic portal vein thrombosis Transjugular intrahepatic portosystemic shunt Variceal bleeding Hepatic encephalopathy

Identification of in vitro and in vivo metabolites of 12β-hydroxylveratroylzygadenine associated with neurotoxicity by using HPLC–MS/MS

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Chinese Chemical Letters 2014年第8期25卷 1107-1111页

作者： Yue Cong Jing-Gong Guo Zhi Tang qing-chun zhang Zong-Wei Cai Institute of Pharmacy Pharmaceutical College Henan University State Key Laboratory of Environmental and Biological Analysis Department of Chemistry Hong Kong Baptist University The Key Laboratory of Plant Stress Biology Henan University

Metabolism study was carried out on 12b-hydroxylveratroylzygadenine（VOG） that is a cevine-type alkaloid existing in Veratrum nigrum L. and a neurotoxic component. In order to better understand the potential mechanism of neurotoxicity of VOG, this study measured VOG-induced DNA damage in the cerebellum and cerebral cortex of mice after 7 days repetitive oral dose by using single-cell gel electrophoresis（Comet assay）. High performance liquid chromatography-tandem mass spectrometry（LC–MS/MS） was developed and applied to separate and identify in vitro and in vivo metabolites of VOG for investing the possible relationship of metabolism and neurotoxicity. In vitro experiment was carried out using rat liver microsomes, while the in vivo study was conducted on rats. The obtained results indicated that VOG might cause DNA damage in cerebellum and cerebral cortex of mice in a dosedependent manner. Hydrolysis of ester bond and O-demethylation were proposed to be the main in vivo metabolic pathways of VOG, while the major in vitro metabolic pathways were proposed as methyl oxidation to aldehyde, dehydrogenation, hydrolysis of ester bond, hydrolysis of ester bond together with acetylation, and methoxylation. O-Demethylation reaction was likely to be associated with reactive oxygen species production, leading to the DNA damage.

关键词： 12β-Hydroxylveratroylzygadenine Metabolites O-Demethylation LC-MS

Risk factors for early rebleeding and mortality in acute variceal hemorrhage

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World Journal of Gastroenterology 2014年第47期20卷 17941-17948页

作者： Jing-Run Zhao Guang-Chuan Wang Jin-Hua Hu chun-qing zhang Department of Gastroenterology Shandong Provincial Hospital Affiliated to Shandong University Department of Gastroenterology Liaocheng People’s Hospital

AIM: To investigate the risk factors for 6-wk rebleeding and mortality in acute variceal hemorrhage (AVH) patients treated by percutaneous transhepatic variceal embolization (PTVE).

关键词： Acute variceal hemorrhage Percutaneous transhepatic variceal embolization Hepatic vein pressure gradient

Carvedilol may attenuate liver cirrhosis by inhibiting angiogenesis through the VEGF-Src-ERK signaling pathway

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World Journal of Gastroenterology 2015年第32期21卷 9566-9576页

作者： Qian Ding Xiang-Guo Tian Yan Li Qi-Zhi Wang chun-qing zhang Department of Gastroenterology Provincial Hospital Affiliated to Shandong University

AIM: To investigate the effect of carvedilol on angiogenesis and the underlying signaling ***: The effect of carvedilol on angiogenesis was examined using a human umbilical vascular endothelial cell(HUVEC) model. The effect of carvedilol on cell viability was measured by CCK8 assay. Flow cytometry was used to assess the effect of carvedilol on cell cycle progression. Cell migration, transwell migration and tube formation assays were performed to analyze the effect of carvedilol on HUVEC function. Vascular endothelial growth factor(VEGF) induced activation of HUVECs, which were pretreated with different carvedilol concentrations or none. Western blot analysis detected the phosphorylation levels of three cell signaling pathway proteins, VEGFR-2, Src, and extracellular signal-regulated kinase(ERK). The specific Src inhibitor PP2 was used to assess the role of Src in the VEGF-induced angiogenic ***: Carvedilol inhibited HUVEC proliferation in a dose-dependent manner(IC50 = 38.5 mmol/L). The distribution of cells in the S phase decreased from 43.6% to 37.2%, 35.6% and 17.8% by 1, 5 and 10 μmol/L carvedilol for 24 h, respectively. Carvedilol(10 μmol/L) reduced VEGF-induced HUVEC migration from 67.54 ± 7.83 to 37.11 ± 3.533(P < 0.001). Carvedilol concentrations of 5 μmol/L and 10 μmol/L reduced cell invasion from 196.3% ± 18.76% to 114.0% ± 12.20% and 51.68% ± 8.28%, respectively. VEGFinduced tube formation was also reduced significantly by 5 μmol/L and 10 μmol/L carvedilol from 286.0 ± 36.72 to 135.7 ± 18.13(P < 0.05) and 80.27 ± 11.16(P < 0.01) respectively. We investigated several intracellular protein levels to determine the reason for these reductions. Treatment with 10 μmol/L carvedilol reduced VEGF-induced tyrosine phosphorylation of VEGFR-2 from 175.5% ± 8.54% to 52.67% ± 5.33%(P < 0.01). Additionally, 10 μmol/L carvedilol reduced VEGF-induced ERK 1/2 phosphorylation from 181.9% ± 18.61% to 56.45% ± 7.64%(P < 0.01). The VEGFinduced increase

关键词： Carvedilol Adrenergic β-antagonists Angiogenesis L

Angiotensin-converting enzyme 2 improves liver fibrosis in mice by regulating autophagy of hepatic stellate cells

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世界胃肠病学杂志:英文版 2023年第33期29卷 4975-4990页

作者： Ying Wu Ai-Hong Yin Jun-Tao Sun Wei-Hua Xu chun-qing zhang Department of Gastroenterology The Second HospitalCheeloo College of MedicineShandong UniversityJinan 250033Shandong ProvinceChina Department of Gastroenterology Shandong Second Provincial General HospitalJinan 250000Shandong ProvinceChina Department of Gastroenterology Shandong Provincial HospitalCheeloo College of MedicineShandong UniversityJinan 250021Shandong ProvinceChina

BACKGROUND Liver fibrosis is the common pathological process associated with the occurrence and development of various chronic liver *** present,there is still a lack of effective prevention and treatment methods in clinical *** stellate cell(HSC)plays a key role in liver *** recent years,the study of liver fibrosis targeting HSC autophagy has become a hot spot in this research ***-converting enzyme 2(ACE2)is a key negative regulator of reninangiotensin system,and its specific molecular mechanism on autophagy and liver fibrosis needs to be further *** To investigate the effect of ACE2 on hepatic fibrosis in mice by regulating HSC autophagy through the Adenosine monophosphate activates protein kinases(AMPK)/mammalian target of rapamycin(mTOR)*** Overexpression of ACE2 in a mouse liver fibrosis model was induced by injection of liver-specific recombinant adeno-associated virus ACE2 vector(rAAV2/8-ACE2).The degree of liver fibrosis was assessed by histopathological staining and the biomarkers in mouse serum were measured by Luminex multifactor *** number of apoptotic HSCs was assessed by terminal deoxynucleoitidyl transferase-mediated dUTP nick-end labeling(TUNEL)and immunofluorescence *** electron microscopy was used to identify the changes in the number of HSC *** effect of ACE2 overexpression on Wu Y et ***2 improves liver fibrosis through autophagy WJG https://*** 4976 September 7,2023 Volume 29 Issue 33 autophagy-related proteins was evaluated by multicolor immunofluorescence *** expression of autophagy-related indicators and AMPK pathway-related proteins was measured by western *** A mouse model of liver fibrosis was successfully established after 8 wk of intraperitoneal injection of carbon tetrachloride(CCl4).rAAV2/8-ACE2 administration reduced collagen deposition and alleviated the degree of liver fibrosis in ***

关键词： Angiotensin-converting enzyme 2 Hepatic stellate cells Autophagy Liver fibrosis Portal hypertension Mice