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Risks of incident heart failure with preserved ejection fraction in Chinese patients hospitalized for cardiovascular diseases

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Journal of Geriatric Cardiology 2019年第12期16卷 885-893页

作者： Jun-xia ZHANG Yi-xian LIU chun-lei xia Peng CHU Xin-Liang QU Lin-Lin ZHU Shao-Liang CHEN Department of Cardiology Nanjing First Hospital Nanjing Medical University

Background Endogenous aldehyde damages DNA and potentiates an ageing phenotype. The aldehyde dehydrogenase 2(ALDH2) rs671 polymorphism has a prevalence of 30%–50% in Asian populations. In this study, we aimed to analyze risk factors contributing to the development of heart failure with preserved ejection fraction(HFpEF) along with the genetic exposure in Chinese patients hospitalized with cardiovascular diseases(CVD). Methods From July 2017 to October 2018, a total of 770 consecutive Chinese patients with normal left ventricular ejection fractions(LVEF) and established CVD(hypertension, coronary heart diseases, or diabetes) were enrolled in this prospective cross-sectional study. HFpEF was defined by the presence of at least one of symptom(dyspnoea and fatigue) or sign(rales and ankle swelling) related to heart failure;N-terminal pro-B-Type natriuretic peptide(NT pro-BNP ≥ 280 pg/mL);LVEF ≥ 50%;and at least one criterion related to elevated ventricular filling pressure or diastolic dysfunction(left atrial diameter > 40 mm, E/E’ ≥ 13, E’/A’ < 1 or concurrent atrial fibrillation). Logistic regression was performed to yield adjusted odds ratios(ORs) for HFp EF incidence associated with traditional and/or genetic exposures. Results Finally, among 770 patients with CVD, 92(11.9%) patients were classified into the HFpEF group according to the diagnostic criteria. The mean age of the participants was 67 ± 12 years, and 278(36.1%) patients were females. A total of 303(39.4%) patients were ALDH2*2 variant carriers. In the univariate analysis, eight exposures were found to be associated with HFpEF: atrial fibrillation, ALDH2*2 variants, hypertension, age, anaemia, smoking, alcohol consumption and sex. Multivariable logistic regression showed that 4 ‘A’ variables(atrial fibrillation, ALDH2*2 variants, age and anaemia) were significantly associated with an increased risk of HFpEF. Atrial fibrillation was associated with a 3.8-fold increased HFpEF risk(95% CI: 2.21–6.61, P < 0.0

关键词： Aldehyde dehydrogenase 2 Cardiovascular diseases Diastolic dysfunction Heart failure with preserved ejection fraction Riskfactor

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Left atrial diameter and atrial fibrillation,but not elevated NT-proBNP,predict the development of pulmonary hypertension in patients with HFpEF

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Journal of Geriatric Cardiology 2020年第7期17卷 400-409页

作者： Yi-xian LIU Hui LI Yi-Yuan xia chun-lei xia Xin-Liang QU Peng CHU Wen-Yin ZHOU Lin-Lin ZHU Li LI Shao-Liang CHEN Jun-xia ZHANG Department of Cardiology Nanjing First HospitalNanjing Medical UniversityNanjingChina Laboratory of Cardiovascular Diseases Nanjing Heart CentreNanjingChina Department of Cardiology Guangzhou Red Cross HospitalJinan UniversityGuangzhouChina Department of Cardiology Nanjing First HospitalNanjing Medical UniversityNo.68 Changle RoadNanjing 210006China

Background The determinants of pulmonary hypertension(PH)due to heart failure with preserved ejection fraction(HFpEF)have been poorly investigated in patients with cardiovascular diseases(CVD).Methods From July 12017 to March 312019,a total of 149 consecutive HFp EF patients hospitalized with CVD were enrolled in this prospective cross-sectional study.A systolic pulmonary artery pressure(PASP)>35 mm Hg estimated by echocardiography was defined as PH-HFp *** regression was performed to establish predictors of PH in HFpEF *** Overall,the mean age of participants was 72±11 years,and 74(49.7%)patients were females.A total of 59(39.6%)patients were diagnosed with PH-HFpEF by *** left atrial diameter(LAD)was related to the ratio of the transmitral flow velocities/mitral annulus tissue velocities in early diastole(E/E’)and the left ventricular diameter in systole(LVDs).N-Terminal pro B-type natriuretic peptide(NT-proBNP)was not found to be associated with LAD and impaired diastolic or systolic function of the left *** logistic regression showed that atrial fibrillation(AF)increased the risk of PH-HFpEF incidence 3.46-fold with a 95%confidence interval(CI)of 1.44–8.32,P=***,LAD≥45 mm resulted in a 3.43-fold increased risk,95%CI:1.51–7.75,P=***,the significance levels of NT-proBNP,age and LVEF were underpowered in the regression *** variables,AF and LAD≥45 mm,predicted the PH-HFpEF incidence(C-statistic=0.773,95%CI:0.695–0.852,P<0.001).Conclusions Two parameters associated with electrical and anatomical remodelling of the left atrium were related to the incidence of PH in HFpEF patients with CVD.

关键词： Atrial fibrillation Ejection fraction Heart failure Left atrial diameter Pulmonary hypertension

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白血病患儿骨髓间充质干细胞与白血病细胞株K562/AO2生长增殖及凋亡的相关性

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中国组织工程研究 2016年第41期20卷 6112-6117页

作者：雷春霞武汉市儿童医院新生儿内科湖北省武汉市430016

背景:骨髓微环境是白血病的发病根源,微环境的改变对白血病细胞的生物学行为和性能有一定的影响。目的:探讨白血病患儿骨髓间充质干细胞对K562/AO2细胞生长增殖及凋亡的影响。方法:体外环境下进行K562/AO2细胞单独悬浮培养,K562/AO2细... 详细信息

背景:骨髓微环境是白血病的发病根源,微环境的改变对白血病细胞的生物学行为和性能有一定的影响。目的:探讨白血病患儿骨髓间充质干细胞对K562/AO2细胞生长增殖及凋亡的影响。方法:体外环境下进行K562/AO2细胞单独悬浮培养,K562/AO2细胞与白血病患儿骨髓间充质干细胞共培养。锥虫蓝染色计数活细胞数,描绘两组细胞生长曲线,PI单染法检测细胞周期,Annexin V/PI法检测细胞凋亡情况。结果与结论:(1)单独培养组前3 d细胞生长未出现明显改变,第4天开始细胞增殖速度明显加快,并于培养第6天达到最高峰。共培养组整体增殖曲线较为平缓,无明显的增殖高峰;(2)单独培养组的G0-G1期细胞比例显著低于共培养组,S期细胞比例显著高于共培养组(P<0.05)。两组G2-M期细胞比例差异无显著性意义;(3)单独培养组的细胞凋亡数显著高于共培养组(P<0.05);(4)结果表明,与白血病患儿骨髓间充质干细胞共培养后K562/AO2细胞生长受到抑制,细胞周期阻滞在G0-G1期,且会对K562/AO2细胞凋亡产生抵抗作用。

关键词：干细胞骨髓干细胞白血病骨髓间充质干细胞白血病细胞株细胞增殖细胞凋亡细胞周期

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CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-Cui Mao Hui-Lin Jiang Bao-xia Dong Yun-lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： CO 2 methanation Metal hydride Ni catalysts Carbonate Metal-carbonate interface

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PM2.5对支气管上皮细胞中VEGF、ROS的影响

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中国现代医学杂志 2017年第10期27卷 20-24页

作者：雷春霞杨敏刘彩霞湖北省武汉市儿童医院湖北武汉430016 湖北医药学院附属太和医院湖北十堰442000

目的探讨细颗粒物(PM2.5)对支气管上皮细胞中血管内皮生长因子(VEGF)、活性氧类(ROS)的影响。方法培养支气管上皮细胞16HBE,分为4组:生理盐水对照组、25μg/ml PM2.5组、50μg/ml PM2.5组和100μg/ml PM2.5组,测定各组细胞增殖活性、ROS... 详细信息

目的探讨细颗粒物(PM2.5)对支气管上皮细胞中血管内皮生长因子(VEGF)、活性氧类(ROS)的影响。方法培养支气管上皮细胞16HBE,分为4组:生理盐水对照组、25μg/ml PM2.5组、50μg/ml PM2.5组和100μg/ml PM2.5组,测定各组细胞增殖活性、ROS及VEGF表达水平。结果 50μg/ml PM2.5组和100μg/ml PM2.5组细胞增殖活性分别为(89.80±5.85)%和(77.20±7.70)%,低于生理盐水对照组(P<0.05);50μg/ml PM2.5组和100μg/ml PM2.5组染毒12和24 h ROS均高于生理盐水对照组(P<0.05),其中100μg/ml PM2.5组染毒12和24 h ROS水平均最高,分别为(16.60±0.40)和(24.01±0.55);50μg/ml PM2.5组和100μg/ml PM2.5组VEGF蛋白表达高于生理盐水对照组(P<0.05),其中100μg/ml PM2.5组VEGF蛋白表达水平最高(0.892±0.028)。结论 PM2.5能对支气管上皮细胞造成氧化损伤,上调VEGF蛋白表达。

关键词： PM2.5 支气管上皮细胞 VEGF ROS

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Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian Yang Jiang Wu Xueshun Xie Pengfei xia Jinxin Lu Jiale Liu lei Bai xiang Li Zhengquan Yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

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Mechanism of the inhibitory effect of carnosine on amygdaloid kindled seizures in Sprague-Dawley rats

Mechanism of the inhibitory effect of carnosine on amygdaloi...

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中国神经科学学会第六届学术会议暨学会成立十周年庆祝大会

作者： Jin chun-lei, Yang Li-xia, Zhuge Zhen-bing, Fan Yan-ying, Chen Zhong Dept of Phanna, Sch of Med, ZJU, Hangzhou 310031

＜正＞The mechanism of the inhibitory effect of carnosine （beta-alanyl-L-histidine） on amygdaloid kindled seizures was investigated in rats. Intraperitoneal injection of carnosine （500, 1000, 1500 mg/kg, i.p.） significantly decreased seizure stage, afterdischarge duration and generalized seizure duration, and significantly prolonged generalized seizure latency of amygdaloid kindled seizures,in a dose-dependent,

关键词： carnsoine epilepsy glutamate histamine H1-receptor

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两种可靠性加速测试方法及失效率评估与预测

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电子质量 2020年第11期 44-47页

作者：雷春霞昕诺飞灯具(上海)有限公司上海200233

可靠性测试项目种类有很多,如何选择,用较少的样品数及较少的测试时间来最大化的发现产品的失效率和失效模式,从而进一步提高产品的可靠性,这个是电子行业内普遍比较感兴趣的课题。该文结合笔者多年在电子产品领域的研发设计和可靠性工... 详细信息

可靠性测试项目种类有很多,如何选择,用较少的样品数及较少的测试时间来最大化的发现产品的失效率和失效模式,从而进一步提高产品的可靠性,这个是电子行业内普遍比较感兴趣的课题。该文结合笔者多年在电子产品领域的研发设计和可靠性工作经验,推荐两种可靠性加速测试方法:双85测试和高低温冲击测试,并重点介绍了两种测试方法的加速因子计算;同时介绍了一种用卡方分布来推测产品失效率的计算方法,最后该文根据一个实际电子产品的案例,给出如何根据产品的预期失效率设计双85测试的测试时间和测试样品数,以及如何根据产品的预期使用寿命内总开关次数设计高低温冲击测试的测试条件和测试循环数。

关键词：可靠性加速测试双85测试高低温冲击测试加速因子卡方分布失效率平均失效时间(MTTF) 使用寿命

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马铃薯块茎形成的生理生化基础和分子机制

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生物技术通报 2022年第4期38卷 44-57页

作者：雷春霞李灿辉陈永坤龚明云南师范大学生命科学学院生物能源持续开发利用教育部工程研究中心云南省生物质能与环境生物技术重点实验室昆明650500 云南师范大学马铃薯科学研究院云南省马铃薯生物学重点实验室昆明650500 新疆师范大学生命科学学院乌鲁木齐830054

马铃薯(Solanum tuberosum L.)块茎诱导和形成是其生长发育和产量决定最重要的事件,涉及多重环境因素与植物激素及信号分子的互作以及这种互作对大量关键基因及多条信号转导与代谢途径的调控。概述了马铃薯块茎形成的生理生化基础,包括... 详细信息

马铃薯(Solanum tuberosum L.)块茎诱导和形成是其生长发育和产量决定最重要的事件,涉及多重环境因素与植物激素及信号分子的互作以及这种互作对大量关键基因及多条信号转导与代谢途径的调控。概述了马铃薯块茎形成的生理生化基础,包括块茎形成的过程及影响块茎形成的内源因素和环境条件;讨论了块茎诱导形成过程中信号转导途径及相关基因、蛋白、miRNAs、激素和第二信使分子等对块茎形成的调节;构建了块茎诱导形成过程中可能的分子互作网络;展望了未来研究的方向和可能的突破点,旨在为将来通过精准分子育种手段来培育高产优质的马铃薯品种提供借鉴和新思路。

关键词：马铃薯块茎形成诱导信号转导分子机制

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早产、足月胎兔动脉导管平滑肌细胞中胱硫醚-γ-裂解酶mRNA表达及意义

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湖北医药学院学报 2011年第6期30卷 573-576,620页

作者：雷春霞李涛陈明湖北医药学院附属太和医院儿童医疗中心湖北十堰442000 湖北医药学院教务处湖北十堰442000

目的:研究早产和足月胎兔动脉导管平滑肌细胞胱硫醚-γ-裂解酶(cystathionine-γ-lyase,CSE)mRNA的表达情况。方法:选取日本大耳白胎兔早产组(孕25 d)、足月组(孕30 d)各10只,分离动脉导管平滑肌组织,采用组织块改良贴壁法进行胎兔动脉... 详细信息

目的:研究早产和足月胎兔动脉导管平滑肌细胞胱硫醚-γ-裂解酶(cystathionine-γ-lyase,CSE)mRNA的表达情况。方法:选取日本大耳白胎兔早产组(孕25 d)、足月组(孕30 d)各10只,分离动脉导管平滑肌组织,采用组织块改良贴壁法进行胎兔动脉导管平滑肌细胞的体外培养,半定量逆转录集合酶链(RT-PCR)检测胱硫醚-γ-裂解酶mRNA的表达。结果:经10～15 d培养后,倒置显微镜下观察,动脉导管平滑肌细胞呈梭形或放射状生长,高低起伏形成典型的"峰-谷"样,早产组和足月组CSE mRNA的表达值分别为(29.67±6.7)和(10.35±4.5),两组比较差异有统计学意义(P<0.05)。结论:早产及足月胎兔动脉导管平滑肌细胞均表达CSE mRNA,表达量可能与胎龄有关,提示动脉导管组织可能内源性生成H2S气体,且在宫内低氧环境中H2S可能是维持动脉导管开放状态的一个重要因素。

关键词：硫化氢胱硫醚-γ-裂解酶胎兔动脉导管

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