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Design of Waveguide Integrated Ge-Quantum-Well Electro-Absorption Modulators

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Chinese Physics Letters 2011年第1期28卷 102-105页

作者： ZHAO Hong-Wei HU Wei-Xuan XUE chun-lai CHENG Bu-Wen WANG Qi-Ming State Key Laboratory of Integrated Optoelectronics Institute of Semiconductors Chinese Academy of Sciences Beijing 100083

We present two designs for a waveguide Oe-quantum-well electro-absorption modulator. In our designs, the strip SOI waveguides are butt-coupled and evanescent-coupled to the modulator, respectively. The proposed Gequantum-weB electro-absorption modulator is based on quantum-confined Stark effect （QCSE）, having a 3-dB bandwidth above 50GHz, as well as a low switching power （around 60fJ/bit at 1435nm）. In the butt-coupled design, the optimized extinction ratio is up to 11.4 dB, while the insertion loss is only 6. 74 dB. For the second one, which utilizes evanescent coupling, the extinction ratio and insertion loss are 9.18 dB and 6. 72 dB, respectively.

关键词： Optics quantum optics and lasers

A Repressor in 5′-UTR of hKv4.3 Gene

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Chemical Research in Chinese Universities 2006年第2期22卷 197-200页

作者： LI Hao JIANG chun-lai YU Xiang-hui WU Yong-ge LI Wei KONG Wei College of Life Science Jilin University Changchun 130012 P. R. China Jilin Teacher＇s Institute of Engineering Technology Changchun 130052 P. R. China

The effect of repressors on ion channel gene expression was studied. The hKv4. 3 promoter and the sequence （＋ 2-- ＋ 160, S160） of 5＇-UTR of the hKv4. 3 gene was cloned into the pβ-gal-Basic vector. The transient expression of the pβ-gal vector and the analysis of the relative activity of β-galactosidase were carried out. The analysis of the mRNA level was carried out with the RT-PCR method. S160 could intensively repress the expression of the hKv4. 3 gene with position-specificity. The level of mRNA did not alter obviously. A repressor（ S160）, in 5＇-UTR of the hKv4. 3 gene was found and its repression to gene expression may play a role in the post-transcription process.

关键词： hKv4. 3 gene Repressor

Terrain reconstruction from Chang'e-3 PCAM images

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Research in Astronomy and Astrophysics 2015年第7期15卷 1057-1067页

作者： Wen-Rui Wang Xin Ren Fen-Fei Wang Jian-Jun Liu chun-lai Li National Astronomical Observatories Chinese Academy of Sciences

The existing terrain models that describe the local lunar surface have limited resolution and accuracy, which can hardly meet the needs of rover navigation,positioning and geological analysis. China launched the lunar probe Chang＇e-3 in December, 2013. Chang＇e-3 encompassed a lander and a lunar rover called ＂Yutu＂（Jade Rabbit）. A set of panoramic cameras were installed on the rover mast. After acquiring panoramic images of four sites that were explored, the terrain models of the local lunar surface with resolution of 0.02 m were reconstructed. Compared with other data sources, the models derived from Chang＇e-3 data were clear and accurate enough that they could be used to plan the route of Yutu.

关键词： space vehicles: rover -- space vehicles: instruments: panoramic camera-- methods: terrain reconstruction -- techniques: image processing: orthoimage

Roles of conventional and complementary therapies in recurrent hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2023年第1期15卷 19-35页

作者： Hsiang-chun lai Hung-Jen Lin Long-Bin Jeng Sheng-Teng Huang Graduate Institute of Chinese Medicine School of Chinese MedicineCollege of Chinese MedicineChina Medical UniversityTaichung 40447Taiwan Department of Chinese Medicine China Medical University HospitalTaichung 40447Taiwan Organ Transplantation Center China Medical University HospitalTaichung 40447Taiwan School of Chinese Medicine China Medical UniversityTaichung 40447Taiwan Cancer Research Center for Traditional Chinese Medicine Department of Medical ResearchChina Medical University HospitalTaichung 40447Taiwan An-Nan Hospital China Medical UniversityTainan 709204Taiwan

Hepatocellular carcinoma(HCC)is the fifth most common type of cancer and the fourth leading cause of cancer-related deaths in the *** has a reported recurrence rate of 70%-80%after 5 years of *** tumor recurrence is the most critical factor associated with HCC *** salvage therapies for recurrent HCC include re-hepatectomy or liver transplantation,transcatheter arterial chemoembolization,Y-90,target therapy,and immunotherapy;however,these conventional treatment modalities have yet to achieve consistently favorable ***,previous studies have demonstrated that conventional therapies in combination with traditional Chinese medicine(TCM),acupuncture,moxibustion or dietary supplements could notably benefit patients with HCC recurrence by strengthening and augmenting the overall management ***,systemic reviews related to the interactions between complementary therapies and conventional therapy in recurrent HCC are *** this review,we discuss the molecular mechanisms underlying the functions of complementary therapies for recurrent HCC,which include augmenting the local control to improve the congestion status of primary tumors and reducing multicentric tumor occurrence via inducing autophagy,apoptosis or cell cycle *** and its derivatives may play important roles in helping to control HCC recurrence by inhibiting epithelial-mesenchymal transition,migration,invasion,and metastasis,inhibiting cancer stem cells,and ameliorating drug resistance.

关键词： Recurrence Hepatocellular carcinoma Complementary therapy Traditional Chinese medicine Cancer stemness Drug resistance

Application value of multi-slice spiral computed tomography for imaging determination of metastatic lymph nodes of gastric cancer

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World Journal of Gastroenterology 2013年第34期19卷 5732-5737页

作者： chun-lai Dai Zhi-Gang Yang Li-Ping Xue Yu-Mei Li Department of Radiology the First Hospital of Jilin University Press of Maternal and Child Health Care of China Medicine Periodical House of Jilin Province Department of Pediatrics the First Hospital of Jilin University

AIM:To evaluate the application value of multi-slice spiral computed tomography(MSCT)for imaging determination of metastatic lymph nodes of gastric cancer and to explore reasonable diagnostic ***:Sixty patients with gastric cancer underwent 64 MSCT scans before *** cancer samples and perigastric lymph nodes were obtained after operation,formalin fixation and haematoxylineosin *** metastatic conditions of gastric cancer and perigastric lymph nodes were determined under a light microscope.A total of 605 lymph nodes were grouped and assessed according to distribution,size,shape and degree of lymph node ***,the findings were compared with the postoperative pathological ***:Among 605 lymph nodes,358 were confirmed as metastatic,accounting for 59.2%.A total of535 lymph nodes were detected in original axis images combined with multiplanar reconstruction images of *** metastatic lymph nodes had specific signs in computed *** study showed that the long diameter of lymph nodes≥8 mm indicated metastasis;the sensitivity and specificity were 79.6%and78.8%,*** difference of the mean value of lymph node enhancement density≥80 Hu indicated metastasis;the sensitivity and specificity were81.6%and 75.6%,*** ratio of short diameter to long diameter of lymph nodes≥0.7 indicated metastasis;the sensitivity and specificity were85.6%and 71.8%,***:MSCT is a non-invasive and reliable method for preoperative examination of gastric *** and specificity for prediction of lymph node metastasis are high.

关键词： X-ray computer Gastric cancer Metastatic lymph nodes

Synthesis of a new series of anti-rhinovirus compounds

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Chinese Chemical Letters 2007年第4期18卷 400-402页

作者： Shi Yong Fan chun lai Mi Jun Yang Song Li Zhi Bing Zheng Institute of Pharmacology and Toxicology Academy of Military Medical Sciences Beijing 100850 China School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 China

The synthesis of a series of 3,6-dichloropyridazine derivatives was described. In vitro experiment, all compounds exhibited an anti-rhinovirus activity, and one of the compounds 6g showed the comparable activity as ou... 详细信息

关键词： 3,6-Dichoropyridazine derivatives Synthesis Anti-rhinovirus

Preface: The Chang'e-3 lander and rover mission to the Moon

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Research in Astronomy and Astrophysics 2014年第12期14卷 1511-1513页

作者： Wing-Huen Ip Jun Yan chun-lai Li Zi-Yuan Ouyang Institute of Astronomy National Central University National Astronomical Observatories Chinese Academy of Sciences

The Chang＇e-3 （CE-3） lander and rover mission to the Moon was an in- termediate step in China＇s lunar exploration program, which will be followed by a sample return mission. The lander was equipped with a number of remote-sensing instruments including a pair of cameras （Landing Camera and Terrain Camera） for recording the landing process and surveying terrain, an extreme ultraviolet camera for monitoring activities in the Earth＇s plasmasphere, and a first-ever Moon-based ultravi- olet telescope for astronomical observations. The Yutu rover successfully carried out close-up observations with the Panoramic Camera, mineralogical investigations with the VIS-NIR Imaging Spectrometer, study of elemental abundances with the Active Particle-induced X-ray Spectrometer, and pioneering measurements of the lunar sub- surface with Lunar Penetrating Radar. This special issue provides a collection of key information on the instrumental designs, calibration methods and data processing pro- cedures used by these experiments with a perspective of facilitating further analyses of scientific data from CE-3 in preparation for future missions.

关键词： Chang'e-3 - Moon lander - rover - radar - lunar telescope

An Investigation of Effect of Stand-Off Distance on the Material Removal Characteristics and Surface Generation in Fluid Jet Polishing

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Nanomanufacturing and Metrology 2020年第2期3卷 112-122页

作者： chun Jin Wang Chi Fai Cheung lai Ting Ho Yee Man Loh State Key Laboratory of Ultra-precision Machining Technology Department of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

Fluid jet polishing(FJP)is a versatile polishing process that has many advantages compared to other polishing ***-off distance(SOD)is one of the key parameters in flu id jet polishi ***,relatively little research work has been carried out to investigate its effect of SOD on material removal characteristics and surface generation in *** this paper,a systematic investigation of the effect of SOD on the tool influence function and surface topography in FJP was *** were designed for FJP two kinds of materials corresponding to ductile and brittle *** are nickel copper(NiCu)alloy and BK7 optical glass,*** this study,the SOD was varied from 2 to 35 *** and discussions were made on its effect on the shape of TIF,material removal rate,and surface *** is interesting to note that the TIF shape becomes a Gaussian-like shape with large SOD both on NiCu and BK7,which provides a novel way to optimize the TIF in *** variation of the material removal rate and surface roughness versus SOD on NiCu and BK7 were also determined from the experimental ***,the surface topography of NiCu and BK7 were characterized from the results measured from the white light interferometer and scan electron *** outcome of the study provides a better understanding of the material removal characteristics and surface generation mechanism in FJP.

关键词： Fluid jet polishing Material removal characteristics Stand-off distance Tool influence function Surface generation Ultra-precision machining

Impact of COVID-19 on liver

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World Journal of Clinical Cases 2021年第27期9卷 7998-8007页

作者： Yu-Jang Su Chen-Wang Chang Ming-Jen Chen Yen-chun lai Department of Emergency Medicine MacKay Memorial HospitalTaipei City 10449Taiwan Poison Center Department of Emergency MedicineMacKay Memorial HospitalTaipei City 10449Taiwan Yuanpei University of Medical Technology HsinChu 30015Taiwan MacKay Junior College of Medicine Nursing and ManagementTaipei City 25245Taiwan Department of Medicine MacKay Medical CollegeNew Taipei City 25245Taiwan Division of Gastroenterology and Hepatology Department of Internal MedicineMacKay Memorial HospitalTaipei City 10449Taiwan Department of Anesthesiology Taipei Medical University HospitalTaipei City 110301Taiwan Heroic Faith Medical Science Company Taipei 11493Taiwan

The incidence of liver injury after coronavirus disease 2019(COVID-19)infection ranged from 15%-53%.The mechanism includes direct viral cytopathic effect,cytokinesis,and treatment drug-induced liver *** symptoms include nausea,vomiting,diarrhea,and loss of *** laboratory results include increased liver enzyme levels,decreased monocyte count,and longer prothrombin *** most common imaging findings are hepatomegaly on ultrasound,ground-glass opacity on chest computed tomography(CT),and liver hypodensity and pericholecystic fat stranding on abdominal *** may also have different presentations and poor outcomes of different liver diseases concomitant with COVID-19 *** function test(LFT)results should be monitored,and all factors known to cause or predispose liver injury should be investigated while managing the *** risks of transfer to an intensive care unit,need for mechanical ventilator support,and acute kidney injury is higher in COVID-19 patients with than without abnormal *** mortality and length of hospital stay are both observed.

关键词： COVID-19 Fatty liver Liver cirrhosis Hepatitis Hypoalbuminemia Hepatic injury