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Multifaceted role of haptoglobin:Implications for disease development

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World Journal of Hematology 2024年第3期11卷 1-6页

作者： chun-han cheng Wen-Rui Hao Tzu-Hurng cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan 33305Taiwan China Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei 23561Taiwan China Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002Taiwan China Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404328Taiwan China

Haptoglobin,a protein primarily recognized for its role in sequestering free hemoglobin,has been identified as a molecule with diverse and underexplored functions in the pathophysiology of various *** editorial explores the multifaceted roles of haptoglobin,highlighting its involvement in inflammatory responses and immune regulation and its potential implications in chronic diseases such as diabetes,cardiovascular disorders,and *** a synthesis of recent research findings,this editorial reveals the importance of haptoglobin in disease mechanisms and underscores the need for further investigation to fully elucidate its therapeutic potential.A comprehensive understanding of haptoglobin’s novel functions may catalyze the development of innovative diagnostic and therapeutic modalities in clinical practice.

关键词： Haptoglobin Disease development Inflammation Immune modulation Therapeutic potential

Stem cell exosomes:New hope for recovery from diabetic brain hemorrhage

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World Journal of Diabetes 2024年第11期15卷 2264-2271页

Recent advancements in stem cell-derived exosome therapy for diabetic brain hemorrhage are discussed in this editorial,which highlights this therapy’s potential for revolutionizing diabetic brain hemorrhage *** paper offers compelling evidence that exosomes can effectively reduce neuroinflammation and promote recovery from diabetic brain *** these findings are promising,further research is warranted to fully understand the underlying mechanisms and to validate the therapeutic potential of exosomes in clinical *** findings of this study indicate that continued exploration should be conducted into exosome-based therapies as a novel approach to managing diabetic brain hemorrhage.

关键词： Stem cell exosomes Diabetic brain hemorrhage Neuroinflammation Exosome therapy Regenerative medicine

Addressing the alarming link between nonalcoholic fatty liver disease and cardiovascular mortality in men

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World Journal of Cardiology 2024年第9期16卷 502-507页

作者： Wen-Rui Hao chun-han cheng Tzu-Hurng cheng Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei 23561TaiwanChina Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002TaiwanChina Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan 33305TaiwanChina Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404328TaiwanChina

This editorial discusses the key findings presented in Batta and Hatwal’s recent paper titled“Excess cardiovascular mortality in men with non-alcoholic fatty liver disease:A cause for concern!”,which was published in the World Journal of *** original article highlights a notable correlation between nonalcoholic fatty liver disease(NAFLD)and increased cardiovascular mortality risk in *** present commentary explores the implications of their findings,discussing potential mechanisms,risk factors,and the urgent need for integrated clinical approaches to mitigate the dual burden of these *** should be placed on the importance of early detection,lifestyle modifications,and interdisciplinary collaboration for improving patient *** editorial aims to highlight the broad implications of NAFLD for cardiovascular health and to advocate for increased awareness and proactive management strategies within the medical community.

关键词： Non-alcoholic fatty liver disease Cardiovascular mortality Men's health Integrated clinical approaches Risk factors

Targeting neuronal PAS domain protein 2 and KN motif/ankyrin repeat domains 1:Advances in type 2 diabetes therapy

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World Journal of Diabetes 2024年第11期15卷 2173-2176页

This editorial summarizes the latest literature on the roles of neuronal PAS domain protein 2 and KN motif/ankyrin repeat domain 1 in type 2 diabetes(T2D).We highlight their involvement inβ-cell dysfunction,explore their potential as therapeutic targets,and discuss the implications for new treatment *** offer valuable insights into relevant gene regulation and cellular mechanisms relevant for the targeted management of T2D.

关键词： Type 2 diabetes Neuronal PAS domain protein 2 KN motif and ankyrin repeat domain 1 β-cell dysfunction Therapeutic target

Role of intestinal glucagon-like peptide-1 in hypoglycemia response impairment in type 1 diabetes

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World Journal of Diabetes 2024年第11期15卷 2237-2241页

作者： chun-han cheng Wen-Rui Hao Tzu-Hurng cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan City 33305Taiwan Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei City 23561Taiwan Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002Taiwan Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung City 404328Taiwan

This study critically examines the novel findings presented by Jin et al,which explores the role of intestinal glucagon-like peptide-1(GLP-1)in impaired counterregulatory responses to hypoglycemia in mice with type 1 *** study identifies intestinal GLP-1 as a significant determinant in the physiological responses to hypoglycemia,offering new insights into its potential implications for diabetes *** editorial synthesizes these findings,discusses their relevance in the context of current diabetes research,and outlines potential avenues for future investigation of intestinal GLP-1 as a therapeutic *** analysis underscores the need for continued research into the complex mechanisms underlying impaired hypoglycemia responses and highlights the potential of targeting intestinal GLP-1 pathways in therapeutic strategies for type 1 diabetes.

关键词： Intestinal glucagon-like peptide-1 Type 1 diabetes Hypoglycemia Counterregulatory response Mouse model

Managing uterine artery pseudoaneurysm post-hysteroscopic surgery:Clinical insights and future directions

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World Journal of Clinical Cases 2024年第32期12卷 6547-6550页

This editorial discusses the case report by Kakinuma et al,which details a rare occurrence of uterine artery pseudoaneurysm following hysteroscopic *** case highlights diagnostic challenges and management strategies for this uncommon *** editorial explores the implications for clinical practice,emphasizing the importance of early recognition and appropriate intervention to prevent potential severe *** research directions to increase the understanding and management of uterine artery pseudoaneurysm in similar clinical settings.

关键词： Uterine artery pseudoaneurysm Hysteroscopic surgery Vascular complications Intervention implications Case report

Investigating clubfoot in Saudi Arabia: Prevalence, factors, and future directions

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World Journal of Orthopedics 2024年第9期15卷 836-840页

This editorial discusses the significant findings and implications of the study conducted by Alomran et *** retrospective study,soon to be published,provides valuable insights into the epidemiology of and risk factors associated with clubfoot in a specific Saudi *** highlighting the study’s key outcomes and discussing its broader implications for public health and clinical practices,this editorial aims to underscore the importance of continued research and targeted interventions in addressing congenital deformities such as clubfoot.

关键词： Clubfoot prevalence Saudi Arabia Congenital deformities Retrospective study Orthopedic epidemiology

Innovative approaches beyond periprocedural hydration for preventing contrast-induced acute kidney injury

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World Journal of Radiology 2024年第9期16卷 375-379页

作者： chun-han cheng Wen-Rui Hao Tzu-Hurng cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan 33305Taiwan Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityTaipei 23561Taiwan Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002Taiwan Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404328Taiwan

Contrast-induced acute kidney injury(CI-AKI)is a major concern in clinical practice,particularly among high-risk patients with preexisting renal and cardiovascular *** periprocedural hydration has long been the primary approach for CI-AKI prevention,recent advancements have led to the development of novel approaches such as RenalGuard and contrast removal *** editorial explores these emerging approaches and highlights their potential for enhancing CI-AKI *** incorporating the latest evidence into clinical practice,health-care professionals can more effectively maintain renal function and improve outcomes for patients undergoing contrast-enhanced procedures.

关键词： Contrast-induced acute kidney injury Contrast-induced acute kidney injury prevention Periprocedural hydration RenalGuard Contrast removal systems

Unraveling the incompatibility mechanism of ethylene carbonate-based electrolytes in sodium metal anodes

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Journal of Energy Chemistry 2024年第7期94卷 560-567页

作者： Daomin Qin Fangyuan cheng Meilian Cao Feiyang Yan Qian Wang chun Fang Jiantao han State Key Laboratory of Material Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan430074HubeiChina

Ethylene carbonate(EC)is widely used in lithium-ion batteries due to its optimal overall performance with satisfactory conductivity,relatively stable solid electrolyte interphase(SEI),and wide electrochemical *** is also the most widely used electrolyte solvent in sodium ion ***,compared to lithium metal,sodium metal(Na)shows higher activity and reacts violently with EC-based electrolyte(NaPF_(6)as solute),which leads to the failure of sodium metal batteries(SMBs).Herein,we reveal the electrochemical instability mechanism of EC on sodium metal battery,and find that the com-bination of EC and NaPF_(6) is electrically reduced in sodium metal anode during charging,resulting in the reduction of the first coulombic efficiency,and the continuous consumption of electrolyte leads to the cell *** address the above issues,an additive modified linear carbonate-based electrolyte is provided as a substitute for EC based ***,ethyl methyl carbonate(EMC)and dimethyl carbon-ate(DMC)as solvents and fluoroethylene carbonate(FEC)as SEI-forming additive have been identified as the optimal solvent for NaFP_(6)based electrolyte and used in Na_(4)Fe_(3)(PO_(4))_(2)(P_(2)O_(7))/Na *** batter-ies exhibit excellent capacity retention rate of about 80%over 1000 cycles at a cut-off voltage of 4.3 V.

关键词： Na metal batteries Ethylene carbonate decomposition Na_(4)Fe_(3)(PO_(4))_(2)(P_(2)O_(7))cathode Interface engineering Ethylene carbonate-free electrolyte