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Targeting mitochondrial transcription factor A sensitizes pancreatic cancer cell to gemcitabine

国际肝胆胰疾病杂志:英文版 2023年第5期22卷 519-527页

作者： Wei Wang chun-fan jiang Hai-Sen Yin Shan Gao Bao-Ping Yu Department of Gastroenterology Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Gastroenterology Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441021China Department of Pathology Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441021China

Background:The survival of pancreatic cancer cells,particularly cancer stem cells which are responsible for tumor relapse,depends on mitochondrial *** transcription factor A(TFAM)is critical for the regulation of mitochondrial DNA and thus mitochondrial ***,the possible involvement of TFAM in pancreatic cancer is ***:Human samples were obtained from pancreatic cancers and their adjacent tissues;human pancreatic cell lines were cultured in RPMI1640 *** expressions in pancreatic tissues and cultured cells were determined using immunohistochemistry,ELISA,and reverse transcription polymerase chain reaction(RT-PCR).The effect of TFAM on cell growth,migration,colony formation and apoptosis were *** biogenesis in pancreatic cancer and normal cells were ***:The majority of pancreatic cancer tissues exhibited higher TFAM expression compared to the adjacent ***,TFAM mRNA and protein levels were higher in pancreatic cancer cell lines than in immortalized normal pancreatic epithelial *** was no difference on TFAM level between gemcitabine-sensitive and resistant pancreatic cancer *** analysis demonstrated that TFAM overexpression activated pancreatic normal and tumor cells whereas TFAM inhibition effectively inhibited the growth of pancreatic cancer *** inhibition enhanced gemcitabine’s cytotoxicity and suppressed growth,anchorage-independent colony formation and survival of gemcitabine-resistant pancreatic cancer *** studies showed that TFAM inhibition resulted in remarkable mitochondrial dysfunction and energy crisis followed by oxidative *** basal mitochondrial biogenesis level correlated well with TFAM level in pancreatic cancer ***:TFAM played essential roles in pancreatic cancer via regulating mitochondrial functions which highlighted the therapeutic value of inhibiting TFAM to overcome gemcitabine resist

关键词： TFAM Mitochondrial respiration and biogenesis Pancreatic cancer Gemcitabine

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不同剂量异维A酸联合超分子水杨酸治疗对中重度痤疮患者治疗安全性和负性情绪的影响

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中国现代医学杂志 2024年第15期34卷 76-81页

作者：袁波钱昕妤宋丹丹范春江江南大学附属无锡五院皮肤科江苏无锡214001 无锡市康复医院皮肤科江苏无锡214000 江南大学附属医院皮肤科江苏无锡214062 无锡市康复医院呼吸科江苏无锡214000

目的探讨不同剂量异维A酸联合超分子水杨酸治疗对中重度痤疮患者的疗效、安全性和对负面情绪的影响。方法选取2019年8月-2023年8月江南大学附属无锡五院皮肤科和无锡市康复医院皮肤科接收的中重度痤疮患者93例。根据不同治疗方式将患者... 详细信息

目的探讨不同剂量异维A酸联合超分子水杨酸治疗对中重度痤疮患者的疗效、安全性和对负面情绪的影响。方法选取2019年8月-2023年8月江南大学附属无锡五院皮肤科和无锡市康复医院皮肤科接收的中重度痤疮患者93例。根据不同治疗方式将患者分为对照组、联合A组和联合B组,每组31例。对照组仅接受30%超分子水杨酸治疗,联合A组在对照组的基础上口服0.2 mg/(kg·d)的低剂量异维A酸,联合B组在对照组的基础上口服0.5 mg/(kg·d)的常规剂量异维A酸;3组均治疗8周。比较3组患者治疗8周后的临床疗效,以及治疗前、治疗1、4、8周后的皮损数量,通过VISIA数字皮肤分析仪评估患者治疗前后的皮肤生理指标,通过一般自我效能感量表(GSES)和积极情感消极情感量表(PANAS)评估患者治疗前后的心理状态,比较两组患者的不良反应。结果3组治疗前、治疗1、4、8周后皮损数量比较,结果:①不同时间点的皮损数量比较,差异有统计学意义(F=2539.401,P=0.000);②3组的皮损数量比较,差异有统计学意义(F=50.171,P=0.000),联合A组、联合B组的皮损数量少于对照组;③3组皮损数量的变化趋势比较,差异有统计学意义(F=4.986,P=0.000)。与对照组比较,联合A组和联合B组的治疗总有效率均更高(P<0.05)。联合A组和联合B组治疗前、治疗8周后皮肤生理指标(红色区、紫质、斑点、毛孔、纹理)评分的差值均高于对照组(P<0.05)。联合A组治疗前、治疗8周后心理状态评分(GSES、积极情绪评分、消极情绪评分)的差值高于对照组和联合B组(P<0.05)。与联合B组比较,对照组和联合A组的不良反应总发生率均更低(P<0.05)。结论低剂量异维A酸联合超分子水杨酸有助于提高中重度痤疮患者的治疗效果,并降低患者的负性情绪。

关键词：中重度痤疮异维A酸超分子水杨酸负性情绪

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Experimental Study on Wire Melting Control Ability of Twin-Body Plasma Arc

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 184-194页

作者： Ruiying Zhang fan jiang Long Xue School of Mechanical Engineering Beijing Institute of Petrochemical TechnologyBeijing 102617China Beijing Academy of Safety Engineering and Technology Beijing 102617China College of Mechanical and Energy Engineering Beijing University of TechnologyBeijing 100124China

The twin-body plasma arc has the decoupling control ability of heat transfer and mass transfer,which is beneficial to shape and property control in wire arc additive *** this paper,with the wire feeding speed as a characteristic quantity,the wire melting control ability of twin-body plasma arc was studied by adjusting the current separation ratio(under the condition of a constant total current),the wire current/main current and the position of the wire in the arc axial *** results showed that under the premise that the total current remains unchanged(100 A),as the current separation ratio increased,the middle and minimum melting amounts increased approximately synchronously under the effect of anode effect power,the first melting mass range remained constant;the maximum melting amount increased twice as fast as the middle melting amount under the effect of the wire feeding speed,and the second melting mass range was *** the wire current increased,the anode effect power and the plasma arc power were both factors causing the increase in the wire melting amount;however,when the main current increased,the plasma arc power was the only factor causing the increase in the wire melting *** average wire melting increment caused by the anode effect power was approximately 2.7 times that caused by the plasma arc *** minimum melting amount was not affected by the wire-torch distance under any current separation ratio *** the current separation ratio increased and reached a threshold,the middle melting amount remained constant with increasing wire-torch *** the current separation ratio continued to increase and reached the next threshold,the maximum melting amount remained constant with the increasing wire-torch *** effect of the wire-torch distance on the wire melting amount reduced with the increase in the current separation *** this study,the decoupling mechanism and ability of this innovative

关键词： Twin-body plasma arc Melting control ability Melting amount Current separation ratio

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A Robust Framework for Multimodal Sentiment Analysis with Noisy Labels Generated from Distributed Data Annotation

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2965-2984页

作者： Kai jiang Bin Cao Jing fan School of Computer Science and Technology Zhejiang University of TechnologyHangzhou310023China

Multimodal sentiment analysis utilizes multimodal data such as text,facial expressions and voice to detect people’s *** the advent of distributed data collection and annotation,we can easily obtain and share such multimodal ***,due to professional discrepancies among annotators and lax quality control,noisy labels might be *** research suggests that deep neural networks(DNNs)will overfit noisy labels,leading to the poor performance of the *** address this challenging problem,we present a Multimodal Robust Meta Learning framework(MRML)for multimodal sentiment analysis to resist noisy labels and correlate distinct modalities ***,we propose a two-layer fusion net to deeply fuse different modalities and improve the quality of the multimodal data features for label correction and network ***,a multiple meta-learner(label corrector)strategy is proposed to enhance the label correction approach and prevent models from overfitting to noisy *** conducted experiments on three popular multimodal datasets to verify the superiority of ourmethod by comparing it with four baselines.

关键词： Distributed data collection multimodal sentiment analysis meta learning learn with noisy labels

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Low H_(2)O_(2)consumption Fenton-like catalysts for pollutant cleavage based on the construction of a dual reaction center

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Journal of Environmental Sciences 2024年第11期145卷 107-116页

作者： Weixiang Liao Ziwen Zhao Lai Lyu chun Hu fan Li Key Laboratory for Water Quality and Conservation of the Pearl River Delta Ministry of EducationInstitute of Environmental Research at Greater BayGuangzhou UniversityGuangzhou 510006China Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China South China Institute of Environmental Sciences Ministry of Ecology and EnvironmentGuangzhou 510345China

High energy consumption has seriously hindered the development of Fenton-like reactions for the removal of refractory organic pollutants in *** solve this problem,we designed a novel Fenton-like catalyst(Cu-PAN3)by coprecipitation and carbon thermal *** catalyst exhibits excellent Fenton-like catalytic activity and stability for the degradation of various pollutants with low H_(2)O_(2)*** experimental results indicate that the dual reaction centers(DRCs)are composed of Cu-N-C and Cu-O-C bridges between copper and graphene-like carbon,which form electron-poor/rich centers on the catalyst surface.H_(2)O_(2)is mainly reduced at electron-rich Cu centers to free radicals for pollutant ***,pollutants can be oxidized by donating electrons to the electron-poor C centers of the catalyst,which inhibits the ineffective decomposition of H_(2)O_(2)at the electron-poor *** therefore significantly reduces the consumption of H_(2)O_(2)and reduces energy consumption.

关键词： Water purification Fenton-like Dual reaction centers Graphene-like carbon Low H_(2)O_(2)consumption

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Superior Anodic Lithium Storage in Core–Shell Heterostructures Composed of Carbon Nanotubes and Schiff-Base Covalent Organic Frameworks

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Energy & Environmental Materials 2024年第6期7卷 150-157页

作者： Nan jiang Mengpei Qi Yalong jiang Yin fan Shiwei Jin Yingkui Yang School of Chemistry and Materials Science South-Central Minzu UniversityWuhan 430074China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200China

Covalent organic frameworks(COFs)after undergoing the superlithiation process promise high-capacity anodes while suffering from sluggish reaction kinetics and low electrochemical utilization of redox-active ***,integrating carbon nanotubes(CNTs)with imine-linked covalent organic frameworks(COFs)was rationally executed by in-situ Schiff-base condensation between 1,1′-biphenyl]-3,3′,5,5′-tetracarbaldehyde and 1,4-diaminobenzene in the presence of CNTs to produce core–shell heterostructured composites(CNT@COF).Accordingly,the redox-active shell of COF nanoparticles around one-dimensional conductive CNTs synergistically creates robust three-dimensional hybrid architectures with high specific surface area,thus promoting electron transport and affording abundant active functional groups accessible for electrochemical utilization throughout the whole ***,upon the full activation with a superlithiation process,the as-fabricated CNT@COF anode achieves a specific capacity of 2324 mAh g^(−1),which is the highest specific capacity among organic electrode materials reported so ***,the superior rate capability and excellent cycling stability are also *** redox reaction mechanisms for the COF moiety were further revealed by Fourier-transform infrared spectroscopy in conjunction with X-ray photoelectron spectroscopy,involving the reversible redox reactions between lithium ions and C=N groups and gradual electrochemical activation of the unsaturated C=C bonds within COFs.

关键词： heterostructured anode core-shell nanostructures carbon nanotubes polymeric Schiff-bases covalent organic frameworks

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Assembly of peptide nanostructures with controllable sizes

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Nano Research 2024年第1期17卷 151-161页

作者： Dan Cheng fan Jia Yun-Bao jiang Vincent P.Conticello Tao jiang The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China Department of Chemistry Emory UniversityAtlanta 30033USA

Controlled peptide assembly offers significant promise to develop synthetic supramolecular nanostructures to display material and biological properties that mimic protein assemblies in *** the progress in forming peptide nanostructures of various morphology,there exists a distinct gap between natural and synthetic assembly systems in terms of size *** nanostructures with a narrow size distribution that can be tuned over a wide range of length-scales is essential for applications that require precise spacing between *** approach provides the opportunity to correlate materials and biological properties of interest with assembly *** this review,we discuss representative endeavors over the past two decades for design of size-controllable peptide nanostructures using tunable building *** mechanisms for size control,e.g.,molecular frustration,template-directed peptide assembly,and multi-component peptide co-assembly,will also be *** also demonstrate the applicable scopes of these strategies and suggest potential future avenues for scientific advances in this field.

关键词： peptide assembly controllable size template multi-component

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Bioinspired metal-organic framework nanozyme reinforced with thermosensitive hydrogel for regulating inflammatory responses in Parkinson’s disease

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Nano Research 2024年第2期17卷 858-865页

作者： Xiaowan fan Tao Zhang Xin Ding Yushuo Gu Qing Li Wei jiang Kelong fan Nanozyme Medical Center Academy of Medical ScienceZhengzhou UniversityZhengzhou 450001China Department Central-China Branch of National Center for Cardiovascular DiseasesHean Cardiovascular Disease CenterFuwai Central-China HospitalCentral China Fuwai Hospital of Zhengzhou UniversityZhengzhou 450046China Application Center for Precision Medicine the Second Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalsInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 101408China Department of General Surgery Strategic Support Force Medical CenterBeijing 100101China Department of Anesthesiology Pain and Perioperative MedicineThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Parkinson’s disease(PD)is a prevalent neurodegenerative disorder accompanied by movement disorders and neuroinflammatory ***-inflammatory intervention to regulate oxidative stress in the brain is beneficial for managing ***,traditional natural antioxidants have failed to meet the clinical treatment demands due to insufficient activity and ***,Cu-doping zeolite imidazolate framework-8(ZIF-8)nanozyme is designed to simulate Cu/Zn superoxide dismutase(SOD)by biomimetic *** nanozyme composite is then integrated into thermosensitive hydrogel(poly(lactic-co-glycolic acid)-poly(ethylene glycol)-poly(lactic-co-glycolic acid)(PLGA-PEG-PLGA))to form an effective antioxidant system(Cu-ZIF@Hydrogel).The thermosensitive hydrogel incorporating nanozymes demonstrate distinct viscoelastic properties aimed at enhancing local nanozyme adhesion,prolonging nanozyme retention time,and modulating antioxidant activity,thus significantly improving the bioavailability of *** the cellular and animal levels of PD,we find that Cu-ZIF@Hydrogel bypass the blood-brain barrier and efficiently accumulate in the nerve ***,the Cu-ZIF@Hydrogel significantly alleviate the PD’s behavioral and pathological symptoms by reducing the neuroinflammatory levels in the lesion ***,the hydrogel-incorporating nanozyme system holds great potential as a simple and reliable avenue for managing PD.

关键词： bioinspired nanozyme thermosensitive hydrogel Parkinson’s disease oxidative stress neuroinflammatory

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Anion-hosting cathodes for current and late-stage dual-ion batteries

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Science China Chemistry 2024年第5期67卷 1485-1509页

作者： Miao Zhang Wenyong Zhang fan Zhang chun-Sing Lee Yongbing Tang School of Chemistry and Materials Science Guangdong University of EducationGuangzhou 510303China Advanced Energy Storage Technology Research Center Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Center of Super-Diamond and Advanced Film(COSDAF) City University of Hong KongKowloon 999077China

Anion-hosting cathodes capable of reversibly storing large-size anions play a leading role in dual-ion batteries(DIBs). The purpose of the present review is to summarize the most promising anion-hosting cathodes for current and late-stage DIBs. This review first summarizes the developments in conventional graphite cathodes, especially the latest advances in the graphiterelated research. Next, organic cathodes for the anion storage are discussed, including aromatic amine polymers, heterocyclic polymers, bipolar compounds, and all-carbon-unsaturated compounds. Then, the review focuses on the conversion-type cathodes with high theoretical specific capacities. Finally, the future research directions of the cathodes of DIBs are proposed.

关键词： dual-ion batteries organic cathodes graphite cathodes conversion-type cathodes

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Associative Tasks Computing Offloading Scheme in Internet of Medical Things with Deep Reinforcement Learning

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China Communications 2024年第4期21卷 38-52页

作者： jiang fan Qin Junwei Liu Lei Tian Hui School of Communications and Information Engineering Xi’an University of Posts and TelecommunicationsXi’an 710121China State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing 100876China

The Internet of Medical Things(Io MT) is regarded as a critical technology for intelligent healthcare in the foreseeable 6G era. Nevertheless, due to the limited computing power capability of edge devices and task-related coupling relationships, Io MT faces unprecedented challenges. Considering the associative connections among tasks, this paper proposes a computing offloading policy for multiple-user devices(UDs) considering device-to-device(D2D) communication and a multi-access edge computing(MEC)technique under the scenario of Io MT. Specifically,to minimize the total delay and energy consumption concerning the requirement of Io MT, we first analyze and model the detailed local execution, MEC execution, D2D execution, and associated tasks offloading exchange model. Consequently, the associated tasks’ offloading scheme of multi-UDs is formulated as a mixed-integer nonconvex optimization problem. Considering the advantages of deep reinforcement learning(DRL) in processing tasks related to coupling relationships, a Double DQN based associative tasks computing offloading(DDATO) algorithm is then proposed to obtain the optimal solution, which can make the best offloading decision under the condition that tasks of UDs are associative. Furthermore, to reduce the complexity of the DDATO algorithm, the cacheaided procedure is intentionally introduced before the data training process. This avoids redundant offloading and computing procedures concerning tasks that previously have already been cached by other UDs. In addition, we use a dynamic ε-greedy strategy in the action selection section of the algorithm, thus preventing the algorithm from falling into a locally optimal solution. Simulation results demonstrate that compared with other existing methods for associative task models concerning different structures in the Io MT network, the proposed algorithm can lower the total cost more effectively and efficiently while also providing a tradeoff between delay and energy co

关键词： associative tasks cache-aided procedure double deep Q-network Internet of Medical Things(IoMT) multi-access edge computing(MEC)

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