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World Journal of Clinical Cases 2021年第30期9卷 9211-9217页

作者： Cheng-Xin Weng Shu-Min Wang Tie-Hao Wang Ji-chun zhao Ding Yuan Department of Vascular Surgery West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Indwelling inferior vena cava(IVC)filters might cause various complications,including filter penetration,filter fracture,filter migration,and thrombosis of the *** and migration complications are common,while a caudal migrated double-basket filter with associated infected iliac pseudoaneurysm has seldom been *** SUMMARY We report a 64-year-old female admitted for sudden onset of severe right abdominal pain after IVC filter placement for 3 *** patient had a history of failed endovascular IVC filter *** tomography showed that the retrieval hook of the filter penetrated the right common iliac artery and vein,leading to right iliac artery pseudoaneurysm accompanied by right ureteral obstruction with ipsilateral hydronephrosis,and bilateral iliac veins were *** open repair was performed to remove the IVC filter,the right iliac pseudoaneurysm,and the compromised segments of the iliac veins and IVC with right common iliac artery *** aureus was isolated from the tissue *** patient was discharged on postoperative day 12 with anticoagulation therapy and antibiotic therapy after ***-month follow-up computed tomography revealed that the right common iliac artery was patent,and only mild hydronephrosis was *** An indwelling IVC filter,even‘embedded’within organized thrombus,could still cause life-threatening *** procedures remain the last resort for IVC filters with severe complications.

关键词： Inferior vena cava filter Infected pseudoaneurysm Hydronephrosis Filter migration Open repair Antibiotic therapy Case report

Unusual case of digestive hemorrhage: Celiac axis-portal vein arteriovenous fistula

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World Journal of Gastroenterology 2015年第4期21卷 1362-1364页

作者： Yi-Ren Liu Bin Huang Ding Yuan Zhou-Peng Wu Ji-chun zhao Department of vascular surgery West China HospitalSichuan University

A case of intractable upper gastrointestinal-hemorrhage was reported in a patient with portal hypertension caused by an arterioportal fistula(APF), namely, celiac axis-portal vein arteriovenous fistula. Portal hypertension caused by extrahepatic-APFs is extremely rare. Trauma, malignancy, and hereditary causes are the common etiology of APFs; but were absent in our patient. Our patient represents an unusualcase of unexplained APF who presented with portal hypertension and was successfully managed through endovascular aortic repair.

关键词： Arterioportal fistula Portal hypertension Endovasc

miR-532-3p inhibits the progression of tongue squamous cell carcinoma by targeting podoplanin

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Chinese Medical Journal 2021年第24期134卷 2999-3008页

作者： Zhi-Yun Liu chun-Guang zhao Department of Stomatology The Sixth Hospital of WuhanAffiliated Hospital of Jianghan UniversityWuhanHubei 430015China

Background:The association between miR-532-3p and tongue squamous cell carcinoma(TSCC)has been examined in the literature to improve the survival rate of patients with this ***,further studies are needed to confirm the regulatory roles of this microRNA(miRNA)in *** objective of this study was to investigate the roles played by and the underlying mechanism used by the miR-532-3p/podoplanin(PDPN)axis in TSCC ***:Western blotting and quantitative real-time reverse transcription-polymerase chain reaction(RT-qPCR)were performed to evaluate the PDPN expression level in TSCC tissues and *** proliferative,adhesive,and migratory capabilities of TSCC cells(CAL-27 and CTSC-3)were examined using cell counting kit-8(CCK-8),cell adhesion,and wound-healing assays,*** dual-luciferase reporter(DLR)assay was later conducted to confirm the relationship between miR-532-3p and ***:The results indicated that PDPN expression was enriched in TSCC tissues and cells,and that the expression of PDPN was associated with some clinicopathological parameters of TSCC,including lymph node metastasis(P=0.001),tumor-node-metastasis(TNM)staging(P=0.010),and grading(P=0.010).Further analysis also showed that PDPN knockdown inhibited the viability,adhesive ability,and migratory capacity of CAL-27 and CTSC-3 cells,effects that could be reversed by the application of a miR-532-3p ***,PDPN was found to be a direct target of ***:This research suggested that by targeting PDPN,miR-532-3p could inhibit cell proliferation viability,adhesion,and migration in *** also revealed that the miR-532-3p/PDPN axis might provide more insights into the prognosis and treatment of TSCC.

关键词： Tongue squamous cell carcinoma Podoplanin miR-532-3p

Model Analysis of the Anthropogenic Aerosol Effect on Clouds over East Asia

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Atmospheric and Oceanic Science Letters 2012年第1期5卷 1-7页

作者： GAO Yi ZHANG Mei-Gen LIU Xiao-Hong zhao chun State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China Pacific Northwest National Laboratory Richland Washington 99352 USA

A coupled meteorology and aerosol/chemistry model WRF-Chem （Weather Research and Forecast model coupled with Chemistry） was used to conduct a pair of simulations with present-day （PD） and preindustrial （P1） emissions over East Asia to examine the aerosol indirect effect on clouds. As a result of an increase in aerosols in January, the cloud droplet number increased by 650 cm-3 over the ocean and East China, 400 cm-3 over Central and Southwest China, and less than 200 cm-3 over North China. The cloud liquid water path （LWP） increased by 40-60 g m-2 over the ocean and Southeast China and 30 g m-2 over Central China; the LWP in- creased less than 5 g m-2 or decreased by 5 g m2 over North China. The effective radius （Re） decreased by more than 4 pm over Southwest, Central, and Southeast China and 2 pm over North China. In July, variations in cloud properties were more uniform; the cloud droplet number increased by approximately 250400 cm-3, the LWP increased by approximately 30-50 g m 2, and Re decreased by approximately 3 μm over most regions of China. In response to cloud property changes from PI to PD, shortwave （SW） cloud radiative m-2 over the ocean and 10 forcing strengthened by 30 W W m-2 over Southeast China, and it weakened slightly by approximately 2-10 W m-2 over Central and Southwest China in January. In July, SW cloud radiative forcing strengthened by 15 W m-2 over Southeast and North China and weakened by l0 W m-2 over Central China. The different responses of SW cloud radiative forcing in different regions was related to cloud feedbacks and natural variability.

关键词： WRF-Chem aerosol indirect effect cloud properties cloud radiative forcing

Functional Marker Development and Effect Analysis of Grain Size Gene GW2 in Extreme Grain Size Germplasm in Rice

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Rice science 2015年第2期22卷 65-70页

作者： ZHANG Ya-dong ZHENG Jia LIANG Yan-li zhao chun-fang CHEN Tao zhao Qing-yong ZHU Zhen ZHOU Li-hui YAO Shu zhao Ling YU Xing WANG Cai-lin Institute of Food Crops Jiangsu Academy of Agricultural SciencesJiangsu High Quality Rice R & D CenterNanjing Branch of China National Center for Rice Improvement

GW2 is an important gene that regulates grain width and weight. We used cDNA clone to obtain the sequences of GW2 from large- and small-grained rice varieties, TD70 and Kasalath, respectively. Then, we developed a dCAPS （derived cleaved amplified polymorphic sequence） marker on the basis of the sequence difference between functional and nonfunctional GW2 genes to analyze the genotypes and phenotypes of recombinant inbred lines. Results showed that the sequence of GW2To7~ had a single nucleotide deletion at site 316 that generates a termination codon. This codon terminated the GW2 protein in advance. By contrast, the sequence of GW2Kasalath encoded an intact protein. A novel dCAPS marker was designed in accordance with a base A deletion at site 316 of the sequence. After the PCR product was digested by Apol, TD70 showed 21 and 30 bp fragments, and Kasalath showed a 51 bp fragment. Up to 82 lines contained GW2TDTO, and 158 lines contained GW2Kasalath. The lines that contained TD70 alleles displayed substantial increases in width and 1000-grain weight. This result suggested that GW2 played a critical role in rice breeding.

关键词： rice grain size GW2 gene derived cleaved amplified polymorphic sequence phenotype

Synthesis and Biological Evaluation of Novel Tricyclic Oximino Derivatives as Antitumor Agents

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Chemical Research in Chinese Universities 2008年第1期24卷 47-53页

作者： GUO Shu-chun zhao Yan-fang LI Rong-dong XIE Li-jun YANG You-bin GONG Ping School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 P. R. China

A series of novel alkylthio/sulfinyl-8H-thieno[2,3-b]pyrrolizin-8-oximino derivatives Ⅴ1--Ⅷ15 were designed and synthesized as antitumor agents. Their structures were confirmed using IR, ^1H NMR, elemental analysis, and MS. The antitumor activities of all the target compounds were tested by the MTT method in vitro against Bel-7402, HT-1080, SGC-7901, and A549 Cell Lines. Among them, compound Ⅵ9 displayed a promising antitumor activity superior to that of Cisplatin.

关键词： Thieno[2,3-b] pyrrolizine Synthesis Antitumor activity

Hot Rolled Strip Re-reddening Temperature Changing Law during Ultra-fast Cooling

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Journal of Iron and Steel Research International 2015年第8期22卷 694-702页

作者： Lian-yun JIANG chun-jiang zhao Jian-hui SHI Guo YUAN Xue-qiang WANG Qing-xue HUANG State Key Laboratory of Rolling and Automation Northeastern University School of Mechanical Engineering Taiyuan University of Science and Technology Shougang Qian'an Iron and Steel Co. Ltd.

Temperature deviation between surface and the center of hot rolled strip is formed during ultra-fast cooling （UFC）. Surface temperature would rise when temperature deviation goes up to an extent, and strip re-reddening phenomenon will appear. Strip re-reddening affects the stability of strip microstructure, property and temperature control precision. Thus, it is necessary to conduct research on re-reddening temperature changing law to improve strip property and temperature control precision. Strip temperature trends for various strip thicknesses and ultra-fast cooling rates were obtained by numerical calculation method. Re-reddening temperature, temperature deviation between surface and center, and boundary layer position changing law were obtained. By comparison, some conclusions were obtained： UFC re-reddening temperature and laminar cooling （LC） re-reddening temperature were linear to ultra-fast cooling rate respectively. Ultra-fast cooling rate affected UFC re-reddening temperature greatly, but it had little effect on LC re-reddening temperature. Equations which were used to calculate UFC re-reddening temperature, LC re-reddening temperature and maximum temperature deviation were obtained. The position of boundary layer stayed in 1/4 strip thickness.

关键词： ultra-fast cooling laminar cooling cooling rate re-reddening temperature

Measurement of residual stress in a multi-layer semiconductor heterostructure by micro-Raman spectroscopy

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Acta Mechanica Sinica 2016年第5期32卷 805-812页

作者： Wei Qiu Cui-Li Cheng Ren-Rong Liang chun-Wang zhao Zhen-Kun Lei Yu-Cheng zhao Lu-Lu Ma Jun Xu Hua-Jun Fang Yi-Lan Kang Tianjin Key Laboratory of Modern Engineering Mechanics Department of Mechanics Tianjin UniversityTianjin 300072China Institute of Microelectronics Tsinghua UniversityBeijing 100084China College of Art and Sciences Shanghai Maritime UniversityShanghai 201306China State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of TechnologyDalian 116024China Graduate School of the Chinese Academy of Sciences Beijing 100049China

Si-based multilayer structures are widely used in current microelectronics. During their preparation, some inhomogeneous residual stress is induced, resulting in competition between interface mismatching and surface energy and even leading to structure failure. This work presents a methodological study on the measurement of residual stress in a multi-layer semiconductor heterostructure. Scanning electron microscopy（SEM）, micro-Raman spectroscopy（MRS）, and transmission electron microscopy（TEM） were applied to measure the geometric parameters of the multilayer structure. The relationship between the Raman spectrum and the stress/strain on the [100] and [110] crystal orientations was determined to enable surface and crosssection residual stress analyses, respectively. Based on the Raman mapping results, the distribution of residual stress along the depth of the multi-layer heterostructure was successfully obtained.

关键词： Residual stress Multi-layer semiconductor heterostructure Micro-Raman spectroscopy(MRS) Strained silicon Germanium silicon

Biocompatible microcapsules with a water core templated from single emulsions

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Chinese Chemical Letters 2017年第9期28卷 1897-1900页

作者： Linlin Kong Esther Amstad Mingtan Hai Xinyou Ke Dong Chen chun-Xia zhao David A.Weitz Institute of Process Equipment. College of Energy Engineering. Zhejiang University Hangzbou 310027 China State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang University Hangzhou 310027 China John A. Panlson School of Engineer and Applied Science Harvard University Cambridge MA 02138 USA Australian Institute for Bioengineering and Naaotechnology The University of Queensland St Lucia. OLD 4072 Australia

Biocompatible microcapsules with a water core are widely used to encapsulate hydrophilic ***,a facile method to fabricate monodisperse biocompatible microcapsules with a water core in large quantity is *** technology is utilized to emulsify the inner aqueous phase containing the shell polymer into monodisperse drops in the outer oil *** the cosolvent in the inner aqueous phase diffuses into the outer oil phase,the solubility of the shell polymer decreases,which eventually *** the shell polymer,shellac,contains both hydrophilic and hydrophobic groups,it tends to wet both the inner aqueous phase and the outer oil phase,thus forming a solid shell at the periphery of the *** show that the diffusion rate of hydrophilic molecules encapsulated in the water core decreases as their molecular weight increases and the property of the microcapsules could further be modified by polyelectrolyte multilayer *** microcapsules are fabricated using FDA-approved polymer and non-toxic solvents and are of great use in drugs,cosmetics and foods.

关键词： Microcapsule Microfluidic Biocompatible Single emulsion Hydrophilic actives

Seasonal Characteristics of Forecasting Uncertainties in Surface PM_(2.5)Concentration Associated with Forecast Lead Time over the Beijing-Tianjin-Hebei Region

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Advances in Atmospheric Sciences 2024年第5期41卷 801-816页

作者： Qiuyan DU chun zhao Jiawang FENG Zining YANG Jiamin XU Jun GU Mingshuai ZHANG Mingyue XU Shengfu LIN Deep Space Exploration Laboratory/School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Comparative Planetology University of Science and Technology of ChinaHefei 230026China

Forecasting uncertainties among meteorological fields have long been recognized as the main limitation on the accuracy and predictability of air quality ***,the particular impact of meteorological forecasting uncertainties on air quality forecasts specific to different seasons is still not well *** this study,a series of forecasts with different forecast lead times for January,April,July,and October of 2018 are conducted over the Beijing-Tianjin-Hebei(BTH)region and the impacts of meteorological forecasting uncertainties on surface PM_(2.5)concentration forecasts with each lead time are *** increased lead time,the forecasted PM_(2.5)concentrations significantly change and demonstrate obvious seasonal *** general,the forecasting uncertainties in monthly mean surface PM_(2.5)concentrations in the BTH region due to lead time are the largest(80%)in spring,followed by autumn(~50%),summer(~40%),and winter(20%).In winter,the forecasting uncertainties in total surface PM_(2.5)mass due to lead time are mainly due to the uncertainties in PBL heights and hence the PBL mixing of anthropogenic primary *** spring,the forecasting uncertainties are mainly from the impacts of lead time on lower-tropospheric northwesterly winds,thereby further enhancing the condensation production of anthropogenic secondary particles by the long-range transport of natural *** summer,the forecasting uncertainties result mainly from the decrease in dry and wet deposition rates,which are associated with the reduction of near-surface wind speed and precipitation *** autumn,the forecasting uncertainties arise mainly from the change in the transport of remote natural dust and anthropogenic particles,which is associated with changes in the large-scale circulation.

关键词： PM_(2.5) forecasting uncertainties forecast lead time meteorological fields Beijing-Tianjin-Hebei region