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Polycystic ovary syndrome and intestinal flora

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Microenvironment & Microecology Research 2021年第2期3卷 7-8页

作者： ying-chun Sun Qingdao Hospital of Traditional Chinese Medicine(Qingdao Hiser hospital) 266034Qingdao ShandongChina

Polycystic ovary syndrome(PCOS)is a condition in which a woman has increased levels of male hormones(androgens).Many problems occur as a result of this increase of hormones,including:Menstrual irregularitiesInfertilit... 详细信息

关键词： Polycysticovary syndrome Hyperandrogenism

Deviation in the army political work effectiveness standards of performance and the reason

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中国国际财经（中英文版） 2015年第12期 30-33页

作者： ying-chun Yang

The Development of Asymmetric Reactions via Aminocatalysis

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The Development of Asymmetric Reactions via Aminocatalysis

Lower serum folate is associated with development and invasiveness of gastric cancer

手性中国2014学术研讨会

作者： ying-chun Chen West China School of Pharmacy Sichuan University

＜正＞Asymmetric aminocatalysis has attracted great interest over the past decade,and abundant reactions have been reported involving the activation of a-or P-site of carbonyl compounds via enamine or iminium ion *** it has demonstrated that enamine catalytic version could be easily expanded upon unsaturated C=C bond based on the principle of vinylogy,leading to the generation of diverse HOMO-raised dienamine or even trienamine *** are extremely useful as either dienes or

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World Journal of Gastroenterology 2014年第32期20卷 11313-11320页

作者： Teng-Yu Lee En-Pei Chiang Yin-Ting Shih Hsien-Yuan Lane Jaw-Town Lin chun-ying Wu Graduate Institute of Clinical Medical Science China Medical University Department of Medicine Chung Shan Medical University Division of Gastroenterology and Hepatology Taichung Veterans General Hospital Department of Food Science and Biotechnology National Chung Hsing University Chiang Agricultural Biotechnology Center National Chung-Hsing University Department of Psychiatry China Medical University HospitalTaichung 404 Taiwan School of Medicine Fu Jen Catholic University Faculty of Medicine School of Medicine National Yang-Ming University Department of Life Sciences National Chung Hsing University Department of Public Health China Medical University

AIM: To evaluate the associations of serum folate levelwith development, invasiveness and patient survival of gastric cancer. METHODS: In this nested case-control study, patients with newly diagnosed gastric cancer undergoing gastrectomy were enrolled, and patients receiving chemotherapy prior to surgery, with other concurrent malignancy, or of the aboriginal and alien populations were excluded. In total, 155 gastric cancer patients and 149 healthy controls were enrolled for determination of serum folate levels and their correlation with gastric cancer. Using the median value of serum folate computed among the overall population as the cutoff value, the associations between serum folate and gastric cancer in all cases and different age and gender subgroups were analyzed by multivariate logistic regression analysis. In the patient cohort of gastric cancer, receiver-operating characteristic analyses were performed to calculate the best cutoff values of serum folate, and the associations between serum folate levels and clinicopathological features were further analyzed by multivariate regression analysis. Survival analyses were conducted using the Cox proportional hazards ***: The mean serum folate level was significantly lower in gastric cancer patients than that in controls(3.71 ± 0.30 ng/mL vs 8.00 ± 0.54 ng/mL, P < 0.01), and folate levels were consistently lower in gastric cancer patients regardless of age and gender(all P < 0.01). Using the median serum folate value as the cutoff value, low serum folate was significantly associated with gastric cancer risk in the whole population(OR = 19.77, 95%CI: 10.54-37.06, P < 0.001) and all strata(age < 60 years OR = 17.39, 95%CI: 7.28-41.54, age ≥ 60 years(OR = 21.67, 95%CI: 8.27-56.80), males(OR = 17.95, 95%CI: 7.93-40.62), and females(OR = 20.95, 95%CI: 7.66-57.31); all P < 0.001. In the patient cohort of gastric cancer, the respective cutoff values showed that low serum folate levels were significantly associa

关键词： Folic acid Folate Plasma Metastasis Invasion

Morbidity and mortality risk factors in emergency department patients with Acinetobacter baumannii bacteremia

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World Journal of Emergency Medicine 2020年第3期11卷 164-168页

作者： Rui-xue Sun Priscilla Song Joseph Walline He Wang ying-chun Xu Hua-dong Zhu Xue-zhong Yu Jun Xu Emergency Department Peking Union Medical College HospitalBeijing 100010China Department of Anthropology Washington University in Saint LouisSaint Louis 63101USA Division of Emergency Medicine Saint Louis UniversitySaint Louis 63101USA Laboratory Department Peking Union Medical College HospitalBeijingChina

BACKGROUND:Acinetobacter baumannii(AB)bacteremia is an increasingly common and often fatal nosocomial *** of morbidity and mortality risk factors for AB bacteremia in emergency department(ED)patients may provide ways to improve the clinical outcomes of these ***:The records for 51 patients with AB bacteremia and 51 patients without AB infection were collected and matched in a retrospective case-control study between 2013 and 2015 in a singlecenter *** factors were analyzed by Chi-square and multivariate logistic regression statistical ***:A significant risk factor for morbidity was the presence of a central venous catheter(CVC)(P<0.001).The mortality rate for the 51 patients with AB bacteremia was 68.6%.Risk factors for mortality were the presence of a CVC(P=0.021)and an ED stay longer than two weeks(P=0.015).CONCLUSION:AB infections lead to high morbidity and *** presence of a CVC was associated with higher morbidity and mortality in patients with AB *** CVC insertions may improve outcomes in ED patients with AB bacteremia.

关键词： Acinetobacter baumannii Bacteremia Morbidity Mortality

Comparative transcriptome analysis of the effect of different heat shock periods on the unfertilized ovule in watermelon(Citrullus lanatus)

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Journal of Integrative Agriculture 2020年第2期19卷 528-540页

作者： ZHU ying-chun SUN De-xi DENG Yun AN Guo-lin LI Wei-hua SI Wen-jing LIU Jun-pu SUN Xiao-wu College of Horticulture Hunan Agricultural UniversityChangsha 410128P.R.China Zhengzhou Fruit Research Institute Chinese Academy of Agricultural SciencesZhengzhou 450009P.R.China

In vitro gynogenesis is an important tool used in haploid or homozygous double-haploid plant ***,because of low repeatability,embryoid induction rate and quality,the molecular mechanisms remain poorly *** shock treatment can promote the transformation of the gametophytic pathway into the sporophyte pathway,which induces the occurrence of *** this study,unfertilized ovaries were heat shocked for 0 h(A0)before flowering and for 0 h(A1),4 h(A3),8 h(A5),12 h(A7),and 24 h(A8),respectively,at 37℃at the first day of the flowering *** ovule enlargement rate was increased from 0%at 25℃to 96.8%at 37℃(24 h treatment).Thus,we aimed to investigate the gene expression patterns in unfertilized ovules of watermelon after different periods of heat shock by using RNA-Seq *** results showed that compared with A3,A5,A7,and A8,the biosynthesis of amino acid,glycine,serine and threonine metabolic pathways in A1 has changed *** indicated that heat shock treatment affected the synthesis and transformation of amino acids during ovule *** transcriptome data suggested gene expressions of ovule growth were significantly changed by heat-specific *** results provide new information on the complex relationship between in vitro gynogenesis and *** provides a basis for further study of the mechanism of heat shock affecting the expansion of watermelon ovule.

关键词： watermelon heat shock unfertilized ovule ovule enlargement transcription factors

Efficacy and safety of short duration radiotherapy combined with chemotherapy for advanced rectal cancer

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World Journal of Clinical Cases 2021年第7期9卷 1524-1531页

作者： Shu-Quan Gao ying-chun Zhang Chao Zhang Sheng-Jie Wang Wei Ren Na Yuan Jun-Ye Wen Department of Hepatobiliary Surgery The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075061Hebei ProvinceChina Department of Interventional Medicine The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075061Hebei ProvinceChina The First Affiliated Hospital of Hebei North University Zhangjiakou 075061Hebei ProvinceChina Department of Radiotherapy The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075061Hebei ProvinceChina Department of General Surgery Hebei Provincial People’s HospitalShijiazhuang 050003Hebei ProvinceChina

BACKGROUND Radiotherapy or chemoradiotherapy is widely used for the treatment of rectal cancer *** the combination of radiotherapy and chemotherapy as an established preoperative neoadjuvant therapy shows high efficacy in the treatment of rectal cancer,some patients experience a response of poor tolerance and outcomes due to the long duration *** study compared short duration radiotherapy plus chemotherapy vs long duration radiotherapy plus chemotherapy for rectal cancer to determine whether short duration radiation treatment should be considered to diminish complications,reduce risk of recurrence and improve survival in patients with rectal *** To evaluate the efficacy and safety of short duration radiotherapy combined with chemotherapy for the treatment of advanced rectal *** One hundred patients with stage IIIB or higher severe rectal cancer were selected as the study subjects at The First Affiliated Hospital of Hebei North University between December 2018 and December *** patients were assigned to different groups based on the treatment *** patients who received preoperative short durations of radiotherapy plus chemotherapy were enrolled in an observation group and fifty patients who received conventional radiotherapy and chemotherapy were enrolled in a control *** biopsy was performed for all patients with pathological diagnosis of rectal *** expression of tumor-related factors such as RUNX3 and Ki-67 was quantitatively analyzed using immunohistochemistry in the tissues of the patients before and after ***,the duration of procedure,the amount of bleeding during the operation,the anus-conserving rate,the incidence of postoperative complications(wound infection,anastomotic leakage,postoperative intestinal obstruction,etc.)and postoperative pathology were compared between the two *** overall survival rate,recurrence rate and distant metastasis rate were a

关键词： Short course radiotherapy Chemotherapy Advanced rectal cancer Runx3 Ki-67

Clinicopathological characteristics in the differential diagnosis of hepatoid adenocarcinoma:A literature review

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World Journal of Gastroenterology 2013年第3期19卷 321-327页

作者： Jiann-Sheng Su Yu-Tso Chen Ren-Ching Wang chun-ying Wu Shou-Wu Lee Teng-Yu Lee Division of Gastroenterology and Hepatology Kuang Tien General Hospital Division of Gastroenterology and Hepatology Taichung VeteransGeneral Hospital Department of Pathology and LaboratoryMedicine Taichung Veterans General Hospital Graduate Institute of Clinical Medical Science China Medical University Department of Medicine Chung Shan Medical University Division of Gastroenterology and Hepatology Taichung Veterans General Hospital

Hepatoid adenocarcinoma (HAC) is a rare but important special type of extrahepatic adenocarcinoma with clinicopathological presentation mimicking hepatocellular carcinoma (HCC), and prompt and correct diagnosis can be a challenge, especially in endemic areas with a high incidence of HCC. To date, HAC has only been reported in case series or single case reports, so we aimed to review the clinicopathological characteristics of HAC to obtain a more complete picture of this rare form of extrahepatic adenocarcinoma. All the articles about HAC published from 2001 to 2011 were reviewed, and clinicopathological findings were extracted for analysis. A late middle-aged male with high serum α-fetoprotein and atypical image finding of HCC should raise the suspicion of HAC, and characteristic pathological immunohistochemical stains can help with the differential diagnosis. Novel immunohistochemical markers may be useful to clearly differentiate HAC from HCC. Once metastatic HAC is diagnosed, the primary tumor origin should be identified for adequate treatment. The majority of HAC originates from the stomach, so panendoscopy should be arranged first.

关键词： Hepatocellular carcinoma Alpha-fetopro-tein-producing tumor Alpha fetoprotein Gastric adeno-carcinoma Pathology

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基于边界元法的非均质薄板弯曲问题的解

计算力学学报 2011年第B4期28卷 25-28,48页

作者：董春迎北京理工大学宇航学院力学系北京100081

本文用边界元法研究非均质无限域弹性薄板弯曲问题。在数值实施过程中,对于夹杂和基体分别形成边界积分方程。通过离散边界积分方程,得到相应的方程组,然后结合界面条件,最终获得问题的求解方程组。在界面的相关量求得之后,可以根据需... 详细信息

本文用边界元法研究非均质无限域弹性薄板弯曲问题。在数值实施过程中,对于夹杂和基体分别形成边界积分方程。通过离散边界积分方程,得到相应的方程组,然后结合界面条件,最终获得问题的求解方程组。在界面的相关量求得之后,可以根据需要来求解基体和夹杂中的有关位置的弯矩。数值结果与已有的解做了对比。

关键词：薄板弯曲夹杂边界元