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Treatment of liver fibrosis:Past,current,and future

World Journal of Hepatology 2023年第6期15卷 755-774页

作者： chun-ye Zhang Shuai Liu Ming Yang Bond Life Sciences Center University of MissouriColumbiaMO 65211United States Department of Radiology The First Affiliated HospitalZhejiang UniversityHangzhou 310006Zhejiang ProvinceChina Department of Surgery University of MissouriColumbiaMO 65211United States

Liver fibrosis accompanies the progression of chronic liver diseases independent of etiologies,such as hepatitis viral infection,alcohol consumption,and metabolicassociated fatty liver *** is commonly associated with liver injury,inflammation,and cell *** fibrosis is characterized by abnormal accumulation of extracellular matrix components that are expressed by liver myofibroblasts such as collagens and alpha-smooth actin *** hepatic stellate cells contribute to the major population of *** treatments for liver fibrosis have been investigated in clinical trials,including dietary supplementation(e.g.,vitamin C),biological treatment(e.g.,simtuzumab),drug(e.g.,pegbelfermin and natural herbs),genetic regulation(e.g.,non-coding RNAs),and transplantation of stem cells(e.g.,hematopoietic stem cells).However,none of these treatments has been approved by Food and Drug *** treatment efficacy can be evaluated by histological staining methods,imaging methods,and serum biomarkers,as well as fibrosis scoring systems,such as fibrosis-4 index,aspartate aminotransferase to platelet ratio,and non-alcoholic fatty liver disease fibrosis ***,the reverse of liver fibrosis is slowly and frequently impossible for advanced fibrosis or *** avoid the lifethreatening stage of liver fibrosis,anti-fibrotic treatments,especially for combined behavior prevention,biological treatment,drugs or herb medicines,and dietary regulation are *** review summarizes the past studies and current and future treatments for liver fibrosis.

关键词： Liver fibrosis Molecular mechanism Therapeutic targets Treatments Clinical trials

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Effects of Nitrogen Application on Chlorophyll Fluorescence Parameters and Leaf Gas Exchange in Naked Oat

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Journal of Integrative Agriculture 2013年第12期12卷 2164-2171页

作者： LIN ye-chun HU Yue-gao REN Chang-zhong GUO Lai-chun WANG chun-long JIANG Ying WANG Xue-jiao Phendukani Hlatshwayo ZENG Zhao-hai College of Agronomy and Biotechnology China Agricultural University Baicheng Academy of Agricultural Sciences KZN Department of Agriculture

Naked oat（Avena nuda L.） was originated from China,where soil nitrogen（N） is low *** responses of chlorophyll（Chl.） fluorescence parameters and leaf gas exchange to N application were analysed in this *** the N application rate ranged from 60 to 120 kg ha-1,variable fluorescence（F v）,the maximal fluorescence（F m）,the maximal photochemical efficiency（F v /F m）,quantum yield（Φ PS II） of the photosynthetic system II（PS II）,electron transport rate（ETR）,and photochemical quenching coefficient（qP） increased with N application level,however,non-photochemical quenching coefficient（qN） ***,there was no difference in initial fluorescence（F o） with further more N *** maximum net photosynthetic rate（P max）,apparent dark respiration rate（R d） and light saturation point（LSP） were improved with 40-56 kg N ha-1as basal fertilizer and 24-40 kg N ha-1as top dressing fertilizer applied at jointing *** quantum yield（α） was decreased with 24 kg N ha-1as basal fertilizer and 56 kg N ha-1as top dressing ***-leaf net photosynthetic rate（P n） was significantly enhanced at the jointing and heading stages with 40-56 kg N ha-1as basal fertilizer; in addition,increased at grain filling stage of naked oat with 40-56 kg N ha-1as top dressing fertilizer.90 kg N ha-1（50-70% as basal fertilizer and 30-50% as top dressing fertilizer） application is recommended to alleviate photodamage of photosystem and improve the photosynthetic rate in naked oat.

关键词： Avena nuda nitrogen fertilizer nitrogen application chlorophyll fluorescence gas exchange

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Enhanced performance of a solar cell based on a layer-by-layer self-assembled luminescence down-shifting layer of core–shell quantum dots

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Chinese Physics B 2018年第12期27卷 461-465页

作者： Ni Liu Shu-Xin Li Ying-chun ye Yan-Li Yao College of Aeronautical Engineering Binzhou UniversityBinzhou 256603China Anhui Key Laboratory of Nanomaterials and Technology and Key Laboratory of Materials Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China

In this paper, core–shell quantum dots(QDs) with two polar surface functional groups(ZnSe/ZnS–COOH QDs and ZnSe/ZnS–NH_2 QDs) are synthesized in an aqueous phase. Photoluminescence(PL) and absorption spectra clearly indicate luminescence down-shifting(LDS) properties. On the basis of QDs, surface functional group multilayer LDS films(MLDSs) are fabricated through an electrostatic layer-by-layer(LBL) self-assembly method. The PL intensity increases linearly with the number of bilayers, showing a regular and uniform film growth. When the M-LDS is placed on the surface of a Si-based solar cell as an optical conversion layer for the first time, the external quantum efficiency(EQE) and shortcircuit current density(Jsc) notably increases for the LDS process. The EQE response improves in a wavelength region extending from the UV region to the blue region, and its maximum increase reaches more than 15% between 350 nm and 460 nm.

关键词： two-surface functional group LBL self-assembly LDS

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Shock-Timing Experiment Using a Two-Step Radiation Pulse with a Polystyrene Target

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Chinese Physics Letters 2011年第8期28卷 194-197页

作者： WANG Feng PENG Xiao-Shi JIAO chun-ye LIU Shen-ye JIANG Xiao-Hua DING Yong-Kun Research Center of Laser Fusion China Academic of Engineering and PhysicsP.O.Box 919-986Mianyang 621900

A shock-timing experiment plays an important role in inertial confinement fusion studies,and the timing of multiple shock waves is crucial to the performance of inertial confinement fusion ignition *** present an experimental observation of a shock wave driven by a two-step radiation pulse in a polystyrene *** experiment is carried out at Shen Guang III Yuan Xing(SGIIIYX)laser facility in China,and the generation and coalescence of the two shock waves,originating from each of the two radiation steps,is clearly seen with two velocity *** two-shock-wave coalescence is also simulated by the radioactive hydrodynamic code of a multi-1D *** experimental measurements are compared with the simulations and quite good agreements are found,with relatively small discrepancies in shock timing.

关键词： shock steps polystyrene

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Neuroprotective effect of angiotensin Ⅱ type 2 receptor during cerebral ischemia/reperfusion

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Neural Regeneration Research 2016年第7期11卷 1102-1107页

作者： chun-ye Ma Lin Yin Department of Neurology the Second Hospital of Dalian Medical University Dalian Liaoning Province China

Angiotensin Ⅱ type 2 receptor（AT2R） activation has been shown to protect against stroke,but its precise mechanism remains poorly *** investigated whether the protective effect of AT2 R against ischemia/reperfusion injury is mediated by the suppression of immune and inflammatory *** models of middle cerebral artery occlusion were intraperitoneally injected with physiological saline,the AT2 R agonist CGP42112（1 mg/kg per day） or antagonist PD123319（1 mg/kg per day）.In the CGP42112 group,AT2 R expression increased,the infarct area decreased,interleukin-1β and tumor necrosis factor-α expression decreased,and interleukin-10 expression increased compared with the saline *** AT2 R using PD123319 produced the opposite *** results indicate that AT2 R activation suppresses immune and inflammatory responses,and protects against cerebral ischemia/reperfusion injury.

关键词： interleukin protective saline occlusion infarct understood suppression injected poorly physiological

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Experimental Analysis of the Flow Characteristics of an Adjustable Critical-Flow Venturi Nozzle

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Fluid Dynamics & Materials Processing 2023年第3期19卷 754-765页

作者： chun ye Jingjing Gao Zhihui Wang Weibiao Zheng Yibei Wang Xingkai Zhang Ming Liu Cooperative Innovation Center of Unconventional Oil and Gas(Ministry of Education&Hubei Province) Yangtze UniversityWuhan430100China Hubei Oil and Gas Storage and Transportation Engineering Technology Research Center Wuhan430100China Key Laboratory of Drilling and Production Engineering for Oil and Gas Wuhan430100China Siji Petroleum Machinery Company SINOPECJingzhou434000China Petroleum Engineering Technology Research Institute of Shengli Oilfield Company SINOPECDongying257000China

The response of an adjustable critical-flow Venturi nozzle is investigated through a set indoor experiments aimed to determine the related critical flow rate,critical pressure ratio,and discharge *** effect of a variation in the cone displacement and liquid content on the critical flow characteristics is examined in detail and it is shown that the former can be used to effectively adjust the critical flow *** critical pressure ratio of the considered nozzle is above 0.85,and the critical flow control deviation of the gas flow is within±3%.Liquid flow can reduce the gas critical mass flow rate accordingly,especially for the cases with larger liquid volume and lower inlet *** set of results and conclusions provided are intended to support the optimization of steam injection techniques in the context of heavy oil recovery processes.

关键词： Adjustable critical flow venturi nozzle critical pressure ratio critical mass flow rate gas-liquid two-phase critical flow

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Distributions of Electromagnetic Fields and Forced Flow and Their Relevance to the Grain Refinement in Al–Si Alloy Under the Application of Pulsed Magneto-Oscillation

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Acta Metallurgica Sinica(English Letters) 2022年第2期35卷 254-274页

作者： Yan-Yi Xu Jing Zhao chun-Yang ye Yan-Ping Shen Xin-Cheng Miao Yun-Hu Zhang Qi-Jie Zhai Center for Advanced Solidification Technology Shanghai UniversityShanghai 200072China Key Lab of Intelligent Equipment Digital Design and Process Simulation Tangshan UniversityTangshan 063000Hebei ProvinceChina School of Materials Science and Engineering University of Science and Technology LiaoningAnshan 114051China

Distributions of electromagnetic fields and induced forced flow inside a metal melt are crucial to understand the grain refinement of the metal driven by pulsed magneto-oscillation(PMO).In the present study,PMO-induced electromagnetic fields and forced flow in Ga-20 wt%In-12 wt%Sn liquid metal have been systematically investigated by performing numerical simulations and corresponding experimental *** numerical simulations have been confirmed by magnetic and melt flow *** to the simulated distribution of electromagnetic fields under the application of PMO,the strongest magnetic field,electric eddy current and Lorentz force with inward radial direction inside the melt are concentrated adjacent the sidewall of cylindrical melt at the cross section of middle height of *** a result,a global forced flow throughout the whole cylindrical column filled with Ga-20 wt%In-12 wt%Snmelt is initiated with a flow structure of two pair of symmetric *** PMO-induced electromagnetic fields and forced flow in Al-7 wt%Si melt have been numerically *** contribution of electromagnetic fields and forced flow to the grain refinement of Al-7 wt%Sialloy under the application of PMO is *** indicates that the forced flow may play a key role in the grain size reduction.

关键词： Pulsed magneto-oscillation(PMO) Electromagnetic field Forced flow Solidification Grain refinement

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Readout electronics for a high-resolution soft X-ray spectrometer based on silicon drift detector

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Nuclear Science and Techniques 2017年第1期28卷 94-99页

作者： Er-Lei Chen Chang-Qing Feng Shu-Bin Liu chun-Feng ye Dong-Dong Jin Jian Lian Hui-Jun Hu State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026 China Department of Modern Physics University of Science and Technology of China Hefei 230026 China 705 Research Division Electronic Engineering InstituteHefei 230037 China Shandong Aerospace Electro-technology Institute Yantai 264670 China

The readout electronics for a prototype soft X-ray spectrometer based on silicon drift detector(SDD),for precisely measuring the energy and arrival time of X-ray photons is presented in this *** system mainly consists of two parts,i.e.,an analog electronics section(including a pre-amplifier,a signal shaper and filter,a constant fraction timing circuit,and a peak hold circuit)and a digital electronics section(including an ADC and a TDC).Test results with X-ray sources show that an energy dynamic range of 1-10 keV with an integral nonlinearity of less than 0.1%can be achieved,and the energy resolution is better than 160 eV @ 5.9 keV *** a waveform generator,test results also indicate that time resolution of the electronics system is about 3.7 ns,which is much less than the transit time spread of SDD(<100 ns)and satisfies the requirements of future applications.

关键词： Energy and time measurement Soft X-ray detection Silicon drift detector Readout electronics

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Dry Reforming of Ethane over FeNi/Al-Ce-O Catalysts:Composition-Induced Strong Metal-Support Interactions

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Engineering 2022年第11期18卷 173-185页

作者： Tao Zhang Zhi-Cheng Liu Ying-chun ye Yu Wang He-Qin Yang Huan-Xin Gao Wei-Min Yang State Key Laboratory of Green Chemical Engineering and Industrial Catalysis Sinopec Shanghai Research Institute of Petrochemical TechnologyShanghai 201208China

Dry reforming of ethane(DRE)has received significant attention because of its potential to produce chemical raw materials and reduce carbon ***,a composition-induced strong metal-support interaction(SMSI)effect over FeNi/Al-Ce-O catalysts is revealed via X-ray photoelectron spectroscopy(XPS),H_(2)-temperature programmed reduction(TPR),and energy dispersive X-ray spectroscopy(EDS)elemental *** introduction of Al into Al-Ce-O supports significantly influences the dispersion of surface active components and improves the catalytic performance for DRE over supported FeNi catalysts due to enhancement of the SMSI *** catalytic properties,for example,C_(2)H_(6) and CO_(2) conversion,CO selectivity and yield,and turnover frequencies(TOFs),of supported FeNi catalysts first increase and then decrease with increasing Al content,following the same trend as the theoretical effective surface area(TESA)of the corresponding *** FeNi/Ce-Al_(0.5) catalyst,with 50%Al content,exhibits the best DRE performance under steady-state conditions at 873 *** observed by with in situ Fourier transform infrared spectroscopy(FTIR)analysis,the introduction of Al not only increases the content of surface Ce3+and oxygen vacancies but also promotes the dispersion of surface active components,which further alters the catalytic properties for DRE over supported FeNi catalysts.

关键词： Dry reforming of ethane Strong metal-support interaction Carbon dioxide Ceria Oxygen vacancy Reaction mechanism

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Reporter Gene Assay for Detection of Shellfish Toxins

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Biomedical and Environmental Sciences 2009年第5期22卷 419-422页

作者： WEI-DONG YANG MIN-YI WU JIE-SHENG LIU XI-chun PENG HONG-ye LI School of Life Science and Technology Jinan UniversityGuangzhou 510632GuangdongChina

Objective To explore the potential reporter gene assay for the detection of sodium channel-specific toxins in shellfish as an alternative for screening harmful algal bloom (HAB) toxins, considering the fact that the existing methods including HPLC and bioassay are inappropriate for identifying HAB toxins which poses a serious problem on human health and shellfish industry. Methods A reporter plasmid pEGFP-c-fos containing c-fos promoter and EGFP was constructed and transfected into T24 cells using LipofectAMINE 2000. Positive transfcctants were screened by G418 to produce a pEGFP-c-fos-T24 cell line. After addition of increasing neurotoxic shellfish poison (NSP) or GTX2,3, primary components of paralytic shellfish poison (PSP), changes in expression of EGFP in the cell line were observed under a laser scanning confocal microscope and quantified with Image-pro Plus software. Results Dose-dependent changes in the intensity of green fluorescence were observed for NSP in a range from 0 to 10 ng/mL and for GTX2,3 from 0 to 16 ng/mL. Conclusion pEGFP-c-fos-T24 can be applied in detecting HAB toxins, and cell-based assay can be used as an alternative for screening sodium channel-specific HAB toxins.

关键词： Shellfish poisoning Green fluorescent protein Harmful algal bloom toxins

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