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Changes of Leaf Morphological, Anatomical Structure and Carbon Isotope Ratio with the Height of the Wangtian Tree (Parashorea chinensis) in Xishuangbanna, China

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Journal of Integrative Plant Biology 2008年第2期50卷 168-173页

作者： chun-xia He Ji-Yue Li Ping Zhou Ming Guo Quan-Shui Zheng Key Laboratory for Silviculture and Conservation Ministry of Education Beijing Forestry University Beijing 100083 China Viikki Tropical Resources Institute University of Helsinki FIN-00014 Helsinki Finland Department of Engineering Mechanics of Tsinghua University Beijing 100084 China

Leaf morphological and anatomical structure and carbon isotope ratio （δ^13C） change with increasing tree height. To determine how tree height affects leaf characteristics, we measured the leaf area, specific leaf mass （ratio of leaf mass to leaf area [LMA]）, thickness of the total leaf, cuticle, epidermis, palisade and sponge mesophyll, stomata traits and δ^13C at different heights of Parashorea chinensis with methods of light and scanning electron microscopy （SEM） and isotope-ratio mass spectrometry. The correlation and stepwise regression between tree height and leaf structure traits were carried out with SPSS software. The results showed that leaf structures and δ^13C differed significantly along the tree height gradient. The leaf area, thickness of sponge mesophyll and size of stomata decreased with increasing height, whereas the thickness of lamina, palisade mesophyll, epidermis, and cuticle, ratios of palisade to spongy thickness, density of stomata and vascular bundles, LMA and δ^13C increased with tree height. Tree height showed a significant relationship with all leaf indices and the most significant relationship was with epidermis thickness, leaf area, cuticle thickness, δ^13C. The δ^13C value showed a significantly positive relationship with LMA （R = 0.934）. Our results supported the hypothesis that the leaf structures exhibited more xeromorphic characteristics with the increasing gradient of tree height.

关键词： δ^13C anatomy morphology Parashorea chinensis ratio of leaf mass to leaf area.

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Congenital hepatic cyst:Eleven case reports

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World Journal of Clinical Cases 2022年第25期10卷 9112-9120页

作者： chun-xia Du Chang-Gui Lu Wei Li Wei-Bing Tang Department of Paediatric Surgery Children’s Hospital of Nanjing Medical UniversityNanjing 210008Jiangsu ProvinceChina Department of Pediatric Surgery Children’s Hospital of Nanjing Medical UniversityNanjing 210008Jiangsu ProvinceChina

BACKGROUND Liver cysts in infants are *** modern diagnostic imaging,we can achieve an early diagnosis of congenital hepatic *** purpose was to investigate the clinical features,surgical treatment methods and prognosis of infants with congenital hepatic ***,we report a case series of congenital hepatic *** SUMMARY Eleven infants with hepatic cysts were retrospectively *** of them had simple hepatic cysts,and a girl with a large hepatic mass was diagnosed with a solitary intrahepatic biliary cyst accompanied by a choledochal *** the ten simple hepatic cysts,eight were solitary and two were multiple.A total of 87.5%(7 of 8)of infants with solitary hepatic cysts were detected before delivery,and 86%(6 of 7)of those cysts were located in the right lobe of the *** intervention was required for symptomatic hepatic *** resection or unroofing with fulguration of the cyst bed was *** recurrence of cysts was observed in these *** Congenital hepatic cyst is a condition with a narrow differential *** diagnosis is essential for appropriate *** is the favoured treatment in infants with symptomatic *** infants with congenital hepatic cysts have a good prognosis.

关键词： Hepatic cyst Infant Surgery Case series Case report

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Mathematical Modeling and Effect of Various Hot-Air Drying on Mushroom(Lentinus edodes)

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Journal of Integrative Agriculture 2014年第1期13卷 207-216页

作者： GUO xiao-hui xia chun-yan TAN Yu-rong CHEN Long MING Jian College of Food Science Southwest University Key Laboratory of Food Processing & Technology of Chongqing Laboratory of Quality & Safety Risk Assessment for Agro-products on Storage and Presevation (Chongqing) Ministry of Agriculture

An experimental study was performed to determine the characteristics and drying process of mushroom （Lentinus edodes） by 6 different hot-air drying methods namely isothermal drying, uniform raise drying, non-uniform raise drying, uniform intermittent drying, non-uniform intermittent drying and combined drying. The chemical composition （dry matter, ash, crude protein, crude fat, total sugars, dietary fiber, and energy）, color parameters （L, a＊, b＊, c＊, and h~） and rehydration capacities were determined. Among all the experiments, non-uniform intermittent drying reached a better comprehensive results due to the higher chemical composition, better color quality associated with high bright （26.381＋5.842）, high color tone （73.670＋2.975）, low chroma （13.349a：3.456） as well as the highest rehydration （453.76% weigh of dried body）. Nine kinds of classical mathematical model were used to obtained moisture data and the Midili-kucuk model can be described by the drying process with the coefficient （R2 ranged from 0.99790 to 0.99967）, chi-square （X2 ranged from 0.00003 to 0.00019） and root mean square error （RMSE ranged from 0.000486 to 0.0012367）.

关键词： Lentinus edodes hot-air drying mathematical model

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Effect of brain-derived neurotrophic factor on c-jun expression in the rd mouse retina

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International Journal of Ophthalmology(English edition) 2012年第3期5卷 266-271页

作者： Rui Chen xiao-Bei Yin chun-xia Peng and Gen-Lin Li Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Key Laboratory of Ophthalmology and Visual Sciences Beijing 100730 China

AIM: To determine the location of c-jun protein, dynamic changes in c-jun mRNA and protein expression, and ultrastructure characteristics in the rd mouse retina, following a single dose of brain-derived neurotrophic factor (BDNF) in a short period of time. METHODS: A single intravitreal injection of BDNF at two dosages (25 mu g/L or 50 mu g/L) was given to the right eye of the rd mouse at age 2 and 3 weeks respectively. Two weeks after injection, the location of c-jun protein in the retina was observed by immunofluorescence detection, c-jun mRNA and protein expression in retinas were detected by quantitative real time polymerase chain reaction (RT-PCR) and western immunoblotting analysis, ultrastructure characteristics of retinas were detected by transmission electron microscope (TEM) observation. RESULTS: c-jun protein was expressed in the inner nuclear layer (INL) of retina. BDNF at two dosages (25 mu g/L and 50 mu g/L) increased c-jun mRNA expression at PN-4 weeks respectively (P-1 =0.019, P-2=0.021). 50 mu g/L BDNF increased c-jun protein expression at PN-4 weeks (P =0.000). The retinal ultrastructure was improved. CONCLUSION: The effects of BDNF exerts on the c-jun expression in the retina are dose-dependent and time-dependent, which may mediate photoreceptor rescue indirectly in the pathological process of retinitis pigmentosa (RP)at early stage.

关键词： BDNF c-jun retina photoreceptor

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Identification of potential oxidative stress biomarkers for spinal cord injury in erythrocytes using mass spectrometry

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Neural Regeneration Research 2021年第7期16卷 1294-1301页

作者： Li-Jian Zhang Yao Chen Lu-Xuan Wang xiao-Qing Zhuang He-chun xia School of Clinical Medicine Ningxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina Department of Neurosurgery General Hospital of Ningxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina Ningxia Human Stem Cell Research Institute General Hospital of Ningxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina Department of Nuclear Medicine General Hospital of Ningxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina

Oxidative stress is a hallmark of secondary injury associated with spinal cord *** stable and specific oxidative biomarkers is of important significance for studying spinal cord injury-associated secondary *** erythrocytes do not contain nuclei and mitochondria and cannot be transcribed and ***, mature erythrocytes are highly sensitive to oxidative stress and may become a valuable *** the present study, we revealed the proteome dynamics of protein expression in erythrocytes of beagle dogs in the acute and subacute phases of spinal cord injury using mass spectrometry-based *** found 26 proteins that were differentially expressed in the acute(0–3 days) and subacute(7–21 days) phases of spinal cord *** analysis revealed that these differentially expressed proteins were involved in glutathione metabolism, lipid metabolism, and pentose phosphate and other oxidative stress *** blot assays validated the differential expression of glutathione synthetase, transaldolase, and *** result was consistent with mass spectrometry results, suggesting that erythrocytes can be used as a novel sample source of biological markers of oxidative stress in spinal cord *** synthetase, transaldolase, and myeloperoxidase sourced from erythrocytes are potential biomarkers of oxidative stress after spinal cord *** study was approved by the Experimental Animal Centre of Ningxia Medical University, China(approval No.2017-073) on February 13, 2017.

关键词： acute phase bioinformatic analysis biomarkers central nervous system dog erythrocytes mass spectrometry oxidative stress peripheral blood spinal cord injury subacute phase

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Sulfur Flow Analysis for New Generation Steel Manufacturing Process

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Journal of Iron and Steel Research International 2008年第4期15卷 12-15,37页

作者： HU Chang-qing ZHANG chun-xia HAN xiao-wei YIN Rui-yu College of Metallurgy and Energy Hebei Polytechnic University Tangshan 063009 Hebei China State KeyLaboratory of Advanced Steel Process and Products Central Iron and Steel Research Institute Beijing 100081 China

Sulfur flow for new generation steel manufacturing process is analyzed by the method of material flow analysis, and measures for SO2 emission reduction are put forward as assessment and target intervention of the results. The results of sulfur flow analysis indicate that 90 % of sulfur comes from fuels. Sulfur finally discharges from the steel manufacturing route in various steps, and the main point is BF and BOF slag desulfurization. In sintering process, the sulfur is removed by gasification, and sintering process is the main source of SO2 emission. The sulfur content of coke oven gas （COG） is an important factor affecting SO2 emission. Therefore, SO2 emission reduction should be started from the optimization and integration of steel manufacturing route, sulfur burden should be reduced through energy saving and consumption reduction, and the sulfur content of fuel should be controlled. At the same time, BF and BOF slag desulfurization should be optimized further and coke oven gas and sintering exhausted gas desulfurization should be adopted for SO2 emission reduction and reuse of resource, to achieve harmonic coordination of economic, social, and environmental effects for sustainable development.

关键词： material flow analysis sulfur flow analysis steel industry sustainable development SO2 emission

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Effect of Co on Microstructure and Interfacial Properties of Fe-Based Laser Cladding

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Journal of Iron and Steel Research International 2009年第4期16卷 84-88页

作者： GAO Li-li BIAN Xiu-fang TIAN Yong-sheng FU chun-xia Key Laboratory of Liquid Structure and Heredity of Materials of Ministry of Education Shandong University Jinan 250061 Shandong China

The coatings consisting of Fe0. 64 Ni0.36 dendrites as matrix and （Fe, Cr） 7 （C, B） 3 interdendritic compounds as reinforcement were fabricated on the medium steel substrate by laser cladding using the Fe-based powders with different Co content, and Co is uniformly dissolved in the coatings. Compared with the coatings containing 1 % and 5% Co, the coating containing 3 % Co increases in the area fraction of the interdendritic region by about 5 %, in the microhardness nearby the interface by about HV 55 and in the interracial bond strength by about 30 MPa. The interface fracture morphology exhibits the tear appearance, which can be characterized as the ductile fracture.

关键词： laser cladding microstructure microhardness bond strength fracture

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Risks of incident heart failure with preserved ejection fraction in Chinese patients hospitalized for cardiovascular diseases

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Journal of Geriatric Cardiology 2019年第12期16卷 885-893页

作者： Jun-xia ZHANG Yi-xian LIU chun-Lei xia Peng CHU Xin-Liang QU Lin-Lin ZHU Shao-Liang CHEN Department of Cardiology Nanjing First Hospital Nanjing Medical University

Background Endogenous aldehyde damages DNA and potentiates an ageing phenotype. The aldehyde dehydrogenase 2(ALDH2) rs671 polymorphism has a prevalence of 30%–50% in Asian populations. In this study, we aimed to analyze risk factors contributing to the development of heart failure with preserved ejection fraction(HFpEF) along with the genetic exposure in Chinese patients hospitalized with cardiovascular diseases(CVD). Methods From July 2017 to October 2018, a total of 770 consecutive Chinese patients with normal left ventricular ejection fractions(LVEF) and established CVD(hypertension, coronary heart diseases, or diabetes) were enrolled in this prospective cross-sectional study. HFpEF was defined by the presence of at least one of symptom(dyspnoea and fatigue) or sign(rales and ankle swelling) related to heart failure;N-terminal pro-B-Type natriuretic peptide(NT pro-BNP ≥ 280 pg/mL);LVEF ≥ 50%;and at least one criterion related to elevated ventricular filling pressure or diastolic dysfunction(left atrial diameter > 40 mm, E/E’ ≥ 13, E’/A’ < 1 or concurrent atrial fibrillation). Logistic regression was performed to yield adjusted odds ratios(ORs) for HFp EF incidence associated with traditional and/or genetic exposures. Results Finally, among 770 patients with CVD, 92(11.9%) patients were classified into the HFpEF group according to the diagnostic criteria. The mean age of the participants was 67 ± 12 years, and 278(36.1%) patients were females. A total of 303(39.4%) patients were ALDH2*2 variant carriers. In the univariate analysis, eight exposures were found to be associated with HFpEF: atrial fibrillation, ALDH2*2 variants, hypertension, age, anaemia, smoking, alcohol consumption and sex. Multivariable logistic regression showed that 4 ‘A’ variables(atrial fibrillation, ALDH2*2 variants, age and anaemia) were significantly associated with an increased risk of HFpEF. Atrial fibrillation was associated with a 3.8-fold increased HFpEF risk(95% CI: 2.21–6.61, P < 0.0

关键词： Aldehyde dehydrogenase 2 Cardiovascular diseases Diastolic dysfunction Heart failure with preserved ejection fraction Riskfactor

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Preparation and evaluation of a water-in-oil nanoemulsion drug delivery system loaded with salidroside

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Chinese Journal of Natural Medicines 2021年第3期19卷 231-240页

作者： LIANG chun-xia QI Dong-Li ZHANG Li-Na LU Peng LIU Zhi-Dong State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique Ministry of EducationTianjin University of Traditional Chinese MedicineTianjin 301617China

Salidroside(SAL)is a phenolic substance with high solubility and low permeability,which make it easy to cause the efflux effect of P-glycoprotein and degradation of intestinal flora,resulting in lower *** aim of this study was to develop and optimize a water-in-oil nanoemulsion of SAL(w/o SAL-N)to explore its suitability in oral drug delivery *** this work,SAL-N was successfully prepared by water titration method at K_(m)=1 to construct the pseudo-ternary phase *** characterization including the average viscosity,pH,refractive index,particle size,PDI,TEM,DSC,the content of SAL,and stability study were *** was evaluated for drug release in vitro and pharmacokinetic studies in *** optimized nanoemulsion formulation consisted of Labrafil M 1944 CS(63%),Span-80/Tween-80/EtOH(27%)and 200 mg·mL^(-1) SAL solution(SAL-SOL)(10%).Low viscosity and suitable pH were expected for the *** spherical morphology and nanoscale size of SAL-N enhanced the stability of the nanoemulsion *** vitro drug release showed that SAL-N had a better controlled release property than SAL-SOL at earlier time *** pharmacokinetic studies exhibited that SAL-N had significantly higher in t_(1/2)(2.11-fold),AUC_(0-48 h)(1.75-fold)and MRT0-48 h(2.63-fold)than SAL-SOL(P<0.01).The w/o SAL-N prepared in this work can be effectively delivered via the oral *** can be seen w/o nanoemulsion is a strategy for the drug with polyphenols to delay the release,enhance oral absorption and reduce metabolic rate.

关键词： Salidroside Water-in-oil nanoemulsion Polyphenol Drug release Pharmacokinetics Bioavailability

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Clinicians’prescription preferences for treating patients with Alzheimer’s disease in Shanghai

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Translational Neurodegeneration 2016年第1期5卷 67-74页

作者： chun-xia Ban Shi-Fu xiao xiang Lin Tao Wang Qi Qiu Min-Jie Zhu xia Li Alzheimer’s Disease and Related Disorders Center Department of Geriatric PsychiatryShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Mental Health Center of Jiading District in Shanghai ShanghaiChina

Background:China has more cases of Alzheimer’s disease(AD)than any other country in the *** training to recognize and manage dementia is in its early stage,it is important to study clinicians’current prescription preferences for treating patients with ***:This study surveyed neurologists,psychiatrists,and general physicians(GPs)in Shanghai who had outpatients with AD,using a questionnaire asking about their prescription preferences for these ***:Among the 148 clinicians in the study,26.4%were psychiatrists,44.6%were neurologists,and 29.1%were *** groups did not differ significantly in age,gender,or their monthly cases of new patients with mild or moderate AD(P>0.05).Most clinicians prescribed Cholinesterase inhibitors(ChEIs),including Huperzine A,but there were significant group-differences in prescribing specific ChEIs(P0.05),and all three groups prescribed piracetam,ergot,and ginkgo biloba *** three groups also tended to treat AD patients with a combination of antidepressants and anxiolytics,although psychiatrists were significantly more likely than neurologists to combine antipsychotics with other drugs(P<0.05).Conclusion:Clinicians in Shanghai prescribed low doses of ChEIs and Memantine for patients with AD.A relatively high proportion also prescribed cognitive enhancers,which lack evidence-based support of their use,and *** is a need for more training about treating patients with AD and for clinicians to standardize their clinical practice.

关键词： Alzheimer’s disease Clinicians Cognitive enhancers Prescriptions Survey research

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