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Photoluminescent nickel(Ⅱ)carbene complexes with ligand-to-ligand charge-transfer excited states

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Chinese Chemical Letters 2024年第1期35卷 357-360页

作者： chun-liang Hou Jia-Xi Song Xiaoyong Chang Yong Chen Key Laboratory of Photochemical Conversion and Optoelectronic Materials&CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China

While nickel(II)complexes have been widely used as catalysts for carbon-carbon coupling reactions,the exploration of their photophysical and photochemical properties is still in the ***,a series of square-planar Ni(II)complexes[(diNHC)NiX2]bearing chelating benzimidazole-based bis(N-heterocyclic carbene)ligands and varying anionic coligands(1,X=Cl;2,X=Br;3,X=I)are synthesized and structurally *** solid state,both 1 and 2 exhibit orange-red photoluminescence under ambient *** photophysical and electrochemical measurements along with density functional theory(DFT)calculations reveal that the low-energy emissions can be attributed to singlet excited states with ligand-to-ligand charge-transfer(LLCT)*** work suggests that strong-field N-heterocyclic carbene ligands play a crucial role to achieve the luminescence of Ni(II)complexes.

关键词： Nickel(II)complexes N-Heterocyclic carbene Luminescence Ligand-to-ligand charge-transfer character Low-lying d-d excited states

Effects of Helicobacter pylori and Moluodan on the Wnt/β-catenin signaling pathway in mice with precancerous gastric cancer lesions

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 979-990页

作者： Yi-Mei Wang Zheng-Wei Luo Yu-Lin Shu Xiu Zhou Lin-Qing Wang chun-Hong liang Chao-Qun Wu Chang-Ping Li Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina

BACKGROUND Helicobacter pylori(***)is the primary risk factor for gastric cancer(GC),the Wnt/β-Catenin signaling pathway is closely linked to *** has a high mortality rate and treatment cost,and there are no drugs to prevent the progression of gastric precancerous lesions to ***,it is necessary to find a novel drug that is inexpensive and preventive to against *** To explore the effects of *** and Moluodan on the Wnt/β-Catenin signaling pathway and precancerous lesions of GC(PLGC).METHODS Mice were divided into the control,N-methyl-N-nitrosourea(MNU),***+MNU,and Moluodan *** first created an *** infection model in the ***+MNU and Moluodan groups.A PLGC model was created in the remaining three groups except for the control *** was fed to mice in the Moloudan group ad *** general condition of mice were observed during the whole experiment *** tissues of mice were grossly and microscopically *** quantitative real-time PCR(qRT-PCR)and Western blotting analysis,the expression of relevant genes were *** Mice in the ***+MNU group showed the worst performance in general condition,gastric tissue visual and microscopic observation,followed by the MNU group,Moluodan group and the control ***-PCR and Western blotting analysis were used to detect the expression of relevant genes,the results showed that the ***+MNU group had the highest expression,followed by the MNU group,Moluodan group and the control *** *** can activate the Wnt/β-catenin signaling pathway,thereby facilitating the development and progression of *** suppressed the activation of the Wnt/β-catenin signaling pathway,thereby decreasing the progression of PLGC.

关键词： Helicobacter pylori Gastric cancer Wnt/β-catenin signaling pathway Moluodan

Shugan Jieyu capsule effects on peripheral blood micro-124, micro- 132, and brain-derived neurotrophic factor in patients with mild to moderate depression

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World Journal of Psychiatry 2024年第9期14卷 1354-1363页

作者： Xian Zhang Yang Liu Hua-Fei Tang Feng Jiang chun-liang Chen Ting-Ting Wang Hui-Zhong Gu Qiang Zhao Rui Ma Department of Pharmacy The 305 Hospital of People’s Liberation ArmyBeijing 100017China

BACKGROUND To assess the effectiveness of Shugan Jieyu capsules on peripheral blood miR-124,miR-132,and brain-derived neurotrophic factor(BDNF)levels in patients with mild to moderate depression following coronary artery intervention[percuta-neous coronary intervention(PCI)]for coronary heart *** with mild-to-moderate depression of the liver-qi stagnation type after PCI for coronary heart disease at the 305th Hospital of the People’s Liberation Army were enrolled from June 2022 to November 2023 and randomly assigned to two groups:Experimental(treated with Shugan Jieyu capsules)and control(tr-eated with escitalopram oxalate tablets).This study compared the antidepressant effects of these treatments using 17-item Hamilton Rating Scale for Depression(HAMD-17)scores,metabolic equivalents,low-density lipoprotein cholesterol,BDNF,high-sensitivity C-reactive protein levels,miR-124 and miR-132 levels,distribution of immune-related lymphocyte subsets,and traditional Chinese me-dicine syndrome scores before and after 6 weeks of *** No significant difference was observed in any index between the two groups before treatment(P>0.05).After treatment,the total efficacy rates were 93.33%and 90.00%in the experimental and control groups,*** group had significantly lower scores for the main and secondary syndromes compared to the control group(P0.05).The levels of low-density lipoprotein cholesterol,high-sensitivity C-reactive pro-tein,and miR-132 were significantly lower,whereas those of miR-124,BDNF,CD3+T lymphocytes,CD3+CD4+T helper lymphocytes,and CD3+CD4+/CD3+CD8+cells were significantly higher in the experimental group com-pared to the control group(P<0.05).The incidence of adverse reactions during experimental group was signi-ficantly lower than that in control group(P<0.05).CONCLUSION Shugan Jieyu capsu

关键词： Shugan Jieyu capsule Coronary heart disease Depression Escitalopram oxalate tablet Micro-124 Micro-132 Brain-derived neurotrophic factor

SARS-CoV-2 breakthrough infections following inactivated vaccine vaccination induce few neutralizing antibodies against the currently emerging Omicron XBB variants

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Virologica Sinica 2024年第1期39卷 173-176页

作者： Fan Shen chun liang Cui-Xian Yang Ying Lu An-Qi Li Ying Duan Mi Zhang c Ren-Rong Tian a Xing-Qi Dong Yong-Tang Zheng Wei Pang Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunming650223China University of Chinese Academy of Sciences Beijing100049China Yunnan Provincial Infectious Disease Hospital Kunming650399China Department of Pathogen Biology and Immunology Faculty of Basic Medical ScienceKunming Medical UniversityKunming650500China

Dear Editor,COVID-19 inactivated vaccines have been extensively administered ***,the majority of the Chinese population has experiencedbreakthrough infections from SARS-CoV-2 ancestral,Delta or Omicronvariants over the past three years,particularly during the wave of Omicron BA.5 and BA.7 variants at the end of 2022(Zhu et al.,2023).Subsequently,new Omicron variants,such as BQ.1,BQ.1.1,XBB,XBB.1/XBB.1.9,and XBB.1.5/XBB.1.9.1,are emerging in China(Yueetal.,2023;Zhu et al.,2023).Therefore,it is an urgentneed and a publichealth imperative to assess the extent of the immunoprotection established in this population.

关键词： breakthrough neutral Omi

不同干燥方式对鸡屎藤中酚类代谢物及抗氧化活性的影响

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南方农业学报 2024年第7期55卷 1992-2005页

作者：黄泽杨春亮海南软件职业技术学院智慧旅游学院海南琼海571400

【目的】分析不同干燥方式处理鸡屎藤后酚类代谢物的变化和抗氧化活性差异,为鸡屎藤的开发利用提供理论依据。【方法】采用冷冻干燥和热烘干燥2种方式处理鸡屎藤,比较不同干燥方式处理鸡屎藤后酚类物质的抗氧化能力,并应用非靶向代谢组... 详细信息

【目的】分析不同干燥方式处理鸡屎藤后酚类代谢物的变化和抗氧化活性差异,为鸡屎藤的开发利用提供理论依据。【方法】采用冷冻干燥和热烘干燥2种方式处理鸡屎藤,比较不同干燥方式处理鸡屎藤后酚类物质的抗氧化能力,并应用非靶向代谢组学方法对鸡屎藤酚类化合物进行定性分析,采用偏最小二乘法判别分析(PLS-DA)筛选酚类差异代谢物后,对其进行层次聚类分析和KEGG代谢通路富集分析,同时分析不同干燥方式处理后鸡屎藤差异代谢物与抗氧化活性之间的相关性。【结果】冷冻干燥和热烘干燥2种方式对鸡屎藤总酚和总黄酮含量均无显著影响(P>0.05);冷冻干燥鸡屎藤的1,1-二苯基-2-三硝基苯肼(DPPH)自由基清除能力、2,2-联氮-双(3-乙基苯并噻唑啉-6-磺酸)二铵盐(ABTS)阳离子自由基清除能力和铜离子还原能力均高于热烘干燥。采用超高效液相色谱串联傅里叶变换质谱仪对2种干燥方式处理的鸡屎藤均鉴定出99种酚类化合物,其中黄酮类54种,香豆素及其衍生物15种,肉桂酸及其衍生物13种,酚类9种,异黄酮类6种,黄酮醇类2种。主成分分析和层次聚类分析结果表明不同干燥方式处理的鸡屎藤酚类代谢物具有显著差异(P<0.05,下同),且热烘干燥方式有15种差异代谢物表达量显著高于冷冻干燥方式。应用PLS-DA共筛出25种极显著差异代谢物(P<0.01),其中10种代谢物上调,15种代谢物下调,变化显著的主要有黄酮类、酚类和香豆素及其衍生物。KEGG代谢通路富集分析发现,不同干燥方式下鸡屎藤差异代谢物富集代谢通路有7条,富集程度最高的前5条通路分别为类黄酮生物合成、苯丙烷生物合成、多种次生代谢产物的生物合成1、酪氨酸代谢及二苯乙烯类、二芳基庚烷类和姜辣素生物合成。25种酚类差异代谢物与DPPH自由基清除能力和铜离子还原能力均表现出显著相关性,其中有10种酚类差异代谢物与这2个指标呈显著正相关,15种酚类差异代谢物呈显著负相关。【结论】不同干燥方式处理鸡屎藤未改变酚类化合物种类,但对酚类化合物的含量及抗氧化活性均有明显影响。鸡屎藤发挥功能活性不是单一代谢物作用,而是多种代谢物协同作用的结果。

关键词：鸡屎藤酚类干燥方式:代谢组学差异代谢物抗氧化活性

公平竞争审查制度能否缩小企业内部薪酬差距?

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财经问题研究 2024年第1期 44-56页

作者：于良春姜娜娜山东大学经济学院山东济南250100

缩小企业内部薪酬差距对缓解收入不平等和实现共同富裕具有重要意义。本文基于2010—2020年中国A股上市公司数据,运用双重差分模型实证检验了公平竞争审查制度对企业内部薪酬差距的影响及其作用机制。研究结果显示:公平竞争审查制度缩... 详细信息

缩小企业内部薪酬差距对缓解收入不平等和实现共同富裕具有重要意义。本文基于2010—2020年中国A股上市公司数据,运用双重差分模型实证检验了公平竞争审查制度对企业内部薪酬差距的影响及其作用机制。研究结果显示:公平竞争审查制度缩小了企业内部薪酬差距,其对高管平均薪酬有显著负向影响,而对普通员工平均薪酬的影响不显著;公平竞争审查制度对企业内部薪酬差距的影响在非国有企业、高管持股比例较高企业和产业政策扶持行业的企业更明显;公平竞争审查制度通过促进市场竞争、规范政府补贴和规范税收优惠缩小企业内部薪酬差距;公平竞争审查制度对企业内部薪酬差距的影响是通过缩小超额薪酬差距实现的。本文丰富了企业内部薪酬差距影响因素方面的研究,也为进一步探索企业内部薪酬差距的治理机制提供了新视角。

关键词：公平竞争审查制度企业内部薪酬差距市场竞争政府补贴税收优惠

A multicenter prospective study on the management of hepatoblastoma in children:a report from the Chinese Children's Cancer Group

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World Journal of Pediatrics 2024年第6期20卷 590-601页

作者： Meng-Jie Tang Xiao-Li Ma Xiang-Ling He Wei-Hua Pan Xiao-Hong Zhang Sha-Yi Jiang Ju Gao Fu Li Wei Yao Song Gu Wei-Ling Zhang Qiang Zhao Shi-Hao Huang Yong-Jun Fang Wei Liu Hui-Zhong Niu chun-Mei Wang Li-Rong Sun Hui Gao Yun-Peng Dai Shun-Gen Huang Zhi-Yong Zhong Xi-Ge Wang Zhong-Rong Li liang-chun Yang Ye-Ming Wu Huan-Min Wang Xin Sun Xiao-Jun Yuan Department of Pediatric Hematology/Oncology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNo.1665Kongjiang RoadYangpu DistrictShanghai 200092China Medical Oncology Department Pediatric Oncology CenterBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Hematology/Oncology Children's Medical CenterHunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 41005China Department of Pediatric Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Hematology/Oncology Guangzhou Women and Children's Medical CenterNational Children's Medical Center for South Central RegionGuangzhou 510623China Department of Hematology Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200062China Department of Pediatrics West China Second University HospitalSichuan UniversityChengdu 610041China Department of Hematology/Oncology Qilu Children's Hospital of Shandong UniversityJinan 250022China Department of Pediatric Surgery Children's Hospital of Fudan UniversityShanghai 201102China Department of General Surgery Shanghai Children's Medical Center(National Children's Medical Center-Shanghai)Shanghai Jiao Tong University School of MedicineShanghai 200127China Department of Pediatrics Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Pediatric Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of Hematology/Oncology Children's Hospital of Nanjing Medical UniversityNanjing 210008China Department of Hematology/Oncology Henan Children's HospitalZhengzhou 450018China Department of Pediatric General Surgery Hebei Children's Hospital of Hebei Medical UniversityShijiazhuang City 050031China Children's Hospital the First Affliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Paediatric

Background This study aimed to identify survival risk factors in Chinese children with hepatoblastoma(HB)and assess the effectiveness of the new treatment protocol proposed by the Chinese Children's Cancer Group(CCCG)in *** A multicenter,prospective study that included 399 patients with HB from January 2015 to June 2020 was *** demographics,treatment protocols,and other related information were *** regression models and Kaplan-Meier curve methods were *** The 4-year event-free survival(EFS)and overall survival(OS)were 76.9 and 93.5%,*** 4-year EFS rates for the very-low-risk,low-risk,intermediate-risk,and high-risk groups were 100%,91.6%,81.7%,and 51.0%,*** 4-year 0S was 100%,97.3%,94.4%,and 86.8%,*** regression analysis found that age,tumor rupture(R+),and extrahepatic tumor extension(E+)were independent prognostic factors.A total of 299 patients had complete remission,and 19 *** with declining alpha-fetoprotein(AFP)>75%after the first two cycles of neoadjuvant chemotherapy had a better EFS and OS than those≤75%.Conclusions The survival outcome of HB children has dramatically improved since the implementation of CCCG-HB-2016 ***≥8 years,R+,and E+were independent risk factors for *** with a declining AFP>75%after the first two cycles of neoadjuvant chemotherapy had better EFS and OS.

关键词： Alpha-fetoprotein Hepatoblastoma Multicenter Prospective study Survival

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心理赋能在社区矫正中的应用

广西政法管理干部学院学报 2024年第1期39卷 13-19页

作者：连春亮河南司法警官职业学院河南郑州450018

心理赋能是以人为本的具体化,以社区矫正对象的终身发展为目标,在接纳与尊重社区矫正对象的前提下,社区矫正对象所产生的一种内在认知和心理感知,包括社区矫正对象的自我意义感知、自我效能感知、自我决策感知及自我影响感知,是提高矫... 详细信息

心理赋能是以人为本的具体化,以社区矫正对象的终身发展为目标,在接纳与尊重社区矫正对象的前提下,社区矫正对象所产生的一种内在认知和心理感知,包括社区矫正对象的自我意义感知、自我效能感知、自我决策感知及自我影响感知,是提高矫正教育效能的工作范式。对社区矫正对象而言,心理赋能可以提升认知,增进情感,强化意志,激励行为,提高矫正教育的自我效能。心理赋能的类型包括组织赋能、个人赋能、社区赋能、自我赋能等。通过对社区矫正对象开发智识赋能、关怀心灵赋能、角色承担赋能等赋能方式,使社区矫正对象获取自我矫正教育的心理能量,促进社区矫正对象的自我成长。

关键词：社区矫正心理赋能自我赋能智识赋能角色赋能

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罪犯心理控制源对改造行为的影响研究

司法警官职业教育研究 2024年第2期5卷 1-9页

作者：连春亮河南司法警官职业学院河南与郑州450018

罪犯服刑中的改造行为与罪犯心理控制源密切相关。不同类型心理控制源会对罪犯改造态度、心理认知、健康状况、自我改造效能、情绪情感等罪犯的改造行为要素产生不同的影响。根据罪犯心理控制源的不同形态,可以预测罪犯的心理健康、自... 详细信息

罪犯服刑中的改造行为与罪犯心理控制源密切相关。不同类型心理控制源会对罪犯改造态度、心理认知、健康状况、自我改造效能、情绪情感等罪犯的改造行为要素产生不同的影响。根据罪犯心理控制源的不同形态,可以预测罪犯的心理健康、自我意识、自我效能、自我价值、监狱适应状况等罪犯心理行为的发展方向。因此,强化罪犯的归因训练,引导罪犯心理控制源由外控型向内控型转化,确立罪犯改造的主体性地位,建构罪犯主体性改造模式,培育罪犯的自控行为,提升改造行为的自我效能感等,是规制罪犯改造行为的有效措施。

关键词：罪犯心理控制源外控型罪犯内控型罪犯自我效能感