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Chinese Journal of Polymer Science 2021年第11期39卷 1481-1488页

作者： Zhong-Zhu Liu Guo-Qiang Zheng Hong-Hui Shi chun-Tai Liu Li-Wei Mi Qian Li Xian-Hu Liu College of Material and Chemical Engineering Henan Key Laboratory of Functional Salt MaterialsCenter for Advanced Materials ResearchZhongyuan University of TechnologyZhengzhou 450007China National Center for International Joint Research of Micro-Nano Molding Technology School of Mechanics&Safety EngineeringZhengzhou UniversityZhengzhou 450002China College of Materials Science and Engineering National Engineering Research Center for Advanced Polymer Processing TechnologyZhengzhou UniversityZhengzhou 450001China

Herein,isotactic polypropylene films with smallβ-nucleating agent content were fabricated via a melt-extrusion-stretched technology with intended"shear-free"in barrel and *** with neat films,the tensile strength,elongation at break and strain energy density at break of i PP film with 0.05 wt%β-nucleating agent are significantly improved by 13.8%,39.6%and 90.6%,respectively,indicating the simultaneously enhanced toughness and ***,theβ-crystal content gradually increases with increasingβ-NA content,while the relative total daughter content ofα-andβ-crystal exhibits opposite ***,nucleation and crystal growth induced by variousβ-NA contents are *** work proves an efficient strategy to enhance mechanical properties of isotactic polypropylene film via controlling elongation flow and addition of appropriateβ-NA content.

关键词： Melt-extrusion Isotactic polypropylene β-Nucleating agent Crystallization Mechanical properties

Cobalt Porphyrin Catalyzed Carbon-Carbon Bond Transfer Hydrogenation with DMF

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Cobalt Porphyrin Catalyzed Carbon-Carbon Bond Transfer Hydro...

A cross-sectional study on compliance with topical glaucoma medication and its associated socioeconomic burden for a Chinese population

中国化学会第四届卟啉与酞菁学术研讨会

作者： chun Meng Tam Ching tat To Kin Shing Chan Department of Chemistry The Chinese University of Hong Kong

The Co(ttp) catalyzed carbon-carbon bond transfer hydrogenation of [2.2]paracyclophane(PCP) with DMF was *** investigation suggested that the benzylic carbon-carbon bond of PCP reacts with Co II(ttp) to generate 1,subsequent homolysis of Co-C bond and hydrogen atom abstraction yield 2 and regenerate the Co(ttp) *** mechanism of cobalt porphyrin catalysis is distinctly different from the rhodium and iridium catalyses.1,2

关键词： C-C bond hydrogenation transfer hydrogenation cobalt porphyrin N,N-dimethylformamide

来源： cnki会议评论

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International Journal of Ophthalmology(English edition) 2017年第2期10卷 293-299页

作者： Man-Hin lui Jason chun Ho Lam Yi Lee Kwong Tak Siu Wong Pak Long Cheung Sherri Shun Yan Lai Pak Lun Yuen Wai Yiu Lam Ho Yan Chan Yiu Fai Wong Jimmy Shiu Ming Lai Kendrick Co Shih Li Ka Shing Faculty of Medicine the University of Hong KongPokfulamHong KongChina Department of Ophthalmology Li Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHongKongChina Department of Ophthalmology Queen Mary HospitalPokfulamHong KongChina

AIM： To estimate the overall drug compliance for local Chinese glaucoma patients on long-term topical ***： This was a retrospective cross-sectional ***-seven primary glaucoma patients from the subspecialty clinic of a publicly-funded tertiary care hospital in Hong Kong completed a questionnaire on compliance with topical glaucoma medication,attitude towards glaucoma and therapy and vision related quality of *** was defined as reporting missing more than or equal to 10% of the prescribed topical glaucoma medication during the 2wk immediately prior to the *** between noncompliance and demographics,attitude,disease and treatment status was *** was estimated with quality of life and direct medical cost involved with *** logistic regression on noncompliance was performed on selected ***： Compliance was calculated as 75%（95% CI： 64%-87%） among 57 subjects（mean age 69 y,female 51%）.No statistical significant relationship was established between noncompliance and any single factors or ***（P=0.048） and forgetfulness（P=0.064） were found to be marginally significant predictive factors on noncompliance in multivariable logistic *** might be related（P=0.130） to poorer self-rated vision-associated quality of *** societal cost of noncompliance was estimated to be over 2510 life-years and US$ 3.7 million ***： The compliance of Chinese glaucoma patients in Hong Kong is comparable to other parts in the world,and carries detrimental impacts on individual and societal *** and forgetfulness are two possible independent predictors for noncompliance.

关键词： glaucoma eye drop compliance quality of life

中草药对良性前列腺增生的疗效及安个性：随机对照试验的系统回顾

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Asian Journal of Andrology 2013年第4期15卷 471-482,I0007页

作者： chun Ho Ma Wai Ling Lin Sing Leung lui Xun-Yuan Cai Vivian Taam Wong Kun-Yuan Cai Eric Zie Zhang-Jin Zhang The University of Hong Kong School of Chinese Medicine Hong Kong 852 China The University of Hong Kong Tung Wah Hospital Hong Kong China and 3Hospital Authority Chinese Medicine Section Hong Kong China

Chinese herbal medicine is commonly used as a treatment for benign prostatic hyperplasia （BPH）, but its efficacy and safety remain to be examined. To compare the efficacy and adverse events of Chinese herbal medicine alone or used adjuvantly with Western medications for BPH. Two independent reviewers searched the major electronic databases for randomized controlled trials comparing Chinese herbal medicine, either in single or adjuvant use with Western medication, with placebo or Western medication. Relevant journals and grey literature were also hand-searched. The outcome measures included changes in urological symptoms, urodynamic measures, prostate volume and adverse events. The frequency of commonly used herbs was also identified. Out of 13 922 identified citations of publications, 31 studies were included. Eleven studies with a Jadad score i〉 3 were selected for meta-analysis. Chinese herbal medicine was superior to Western medication in improving quality of life and reducing prostate volume. The frequency of adverse events in Chinese herbal medicine was similar to that of placebo and less than that of Western medication. The evidence is too weak to support the efficacy of Chinese herbal medicine for BPH due to the poor methodological quality and small number of trials included. The commonly used herbs identified here should provide insights for future clinical practice and research. Larger randomized controlled trials of better quality are needed to truly evaluate the efficacy of Chinese herbal medicine.

关键词： benign prostatic hyperplasia (BPH) meta-analysis review traditional Chinese medicine

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超偏载集中监控系统的研究

铁道学报 2010年第3期32卷 136-141页

作者：曹松马千里蒋荟刘春煌中国铁道科学研究院电子计算技术研究所北京100081 铁道部运输局装备部北京100844

近年来,中国铁路相继建设了超偏载检测监控系统和车辆运行品质动态监测系统(TPDS),强化了对铁路货车装载状态和运行状态的检测和监控,但是这两大系统分属不同部门、分别独立运行,货车超偏载检测信息资源没有共享。本文针对跨部门共享铁... 详细信息

近年来,中国铁路相继建设了超偏载检测监控系统和车辆运行品质动态监测系统(TPDS),强化了对铁路货车装载状态和运行状态的检测和监控,但是这两大系统分属不同部门、分别独立运行,货车超偏载检测信息资源没有共享。本文针对跨部门共享铁路货车超偏载信息,充分发挥超偏载仪检测装置、TPDS系统等既有安全监测系统的作用,提出建立统一的超偏载集中监控系统,在分析超偏载集中监控系统建设的原则和目标基础上,提出铁路超偏载集中监控系统的总体技术方案,包括系统服务对象、总体架构和逻辑架构;分析系统功能框架和基本功能;提出超偏载信息共享方案、路局确报接入和匹配方案、系统中web服务的封装获取以及系统数据处理的统一评判机制等关键技术。超偏载集中监控系统于2008年11月在北京铁路局投入正式运行。

关键词：超偏载 TPDS 集中监控安全监测

Soluble expression of recomb inant cMyc,Klf4,Oct4,and Sox2 proteins in bacteria and transduction into living cells

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International Journal of Ophthalmology(English edition) 2017年第4期10卷 560-566页

作者： Guo-Dan Liu Shi-Feng Zhou Xu-Chen Ding chun-Lai Fang Shu-Yong Mi Xiang-chun Gao Qing Han Department of Ophthalmology the Fourth Affiliated Hospital of Harbin Medical University Department of Emergency the First Affiliated Hospital of Harbin Medical University

AIM：To develop a new method to produce recombinant reprogramming proteins,c Myc,Klf4,Oct4,and Sox2,in soluble format with low cost for the generation of induced pluripotent stem cells（i PSCs）.METHODS：A short polypeptide sequence derived from the HIV trans-activator of transcription protein（tat） and the nucleus localization signal（NLS） polypeptide were fused to the N terminus of the reprogramming proteins and they were constructed into p Cold-SUMO vector which can extremely improve the solubility of recombinant *** these vector plasmids were transformed into *** BL21（DE3） Chaperone competent cells for *** solubility of these recombinant proteins was determined by SDS-PAGE and Coomassie brilliant blue *** recombinant proteins were purified by NiNTA resin and identified by Western *** transduction of these proteins into HEK 293 T cells were evaluated by immunofluorescence ***：These four reprogramming proteins could be produced in soluble format in p Cold-SUMO expression vector system with the assistance of chaperone proteins in *** proteins were purified successfully with a purity of over 70% with a relative high transduction rate into 293 ***：The results in the present study indicate the four important reprogramming proteins,c Myc,Klf4,Oct4,and Sox2,can be produced in soluble format in bacteria with low *** new method thus might be expected to greatly contribute to the future study of i PSCs.

关键词： reprogramming proteins induced pluripotent stem cells soluble expression protein transduction

Imipramine Inhibits Adipogenic Differentiation in Both 3T3-L1 Preadioocvtes and Mouse Marrow Stromal Cells

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Journal of Genetics and Genomics 2012年第4期39卷 173-180页

作者： Haifang Li Chi-chun Fong Yao Chen Guoping Cai Mengsu Yang Department of Biology and Chemistry City University of Hong Kong83 Tat Chee AvenueKowloonHong Kong SARChina Department of Biological Sciences and Biotechnology Tsinghua UniversityBeijing 100084China Shenzhen Key Laboratory of Biochip Research City University of Hong KongShenzhen 518057China

Imipramine （IM） has been widely used clinically for the treatment of mental disorders. Its actions on tissues or organs other than the nervous system also need to be understood for its proper clinical use. In this study, the effects of IM on adipogenic differentiation in both 3T3-L1 preadipocytes and mouse marrow stromal cells （MSCs） were investigated. The results showed that fewer adipocytic cells were developed from 3T3-L1 preadipocytes in the presence of 0.001 to 1 μmol/L of IM as compared to control. Similar inhibitory effect was also observed in mouse MSCs. The decrease in the formation of adipocytes was accompanied with significant down-regulation at mRNA expression of the early adipogenic transcription factor, peroxisome proliferator-activated receptor γ2 （PPARγ2）. Western blot analysis further revealed that the protein expression of PPARγ2 was reduced markedly in ceils treated with IM at concentrations of 0.01, 0.1 and 1 μmol/L, suggesting that the suppression on PPAR72 was involved in IM＇s inhibition on MSCs adipogenesis. Moreover, IM at the above concentrations could stimulate the mRNA expression of β2-adrenergic receptor （AR） and β3-AR, which implicated that the effect of IM on adipogenic differentiation was partially mediated by β-ARs. Our results demonstrated for the first time that the conventional antidepressive imipramine exerts accompanied inhibitory effect on adipocyte formation, which may have possible clinical implications.

关键词： Imipramine Adipogenic differentiation 3T3-L1 preadipocytes Marrow stromal cells (MSCs)

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矿用反冲洗过滤站换向阀芯动态特性仿真优化

煤炭技术 2014年第5期33卷 181-183页

作者：于洋刘世超付存银三一重型装备有限公司沈阳110027

介绍了液压支架系统中反冲洗过滤站换向阀芯的工作原理及结构特点,建立了反冲洗回路的AMESim模型,对回路模型进行仿真得出动态响应结果,并就换向阀芯主要结构参数对系统动态特性的影响进行了仿真和分析,为换向阀芯的优化设计提供依据。

关键词：反冲洗换向阀芯动态分析优化

Depletion of the IKBKAP ortholog in zebrafish leads to hirschsprung disease-like phenotype

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World Journal of Gastroenterology 2015年第7期21卷 2040-2046页

作者： William Wai-chun Cheng Clara Sze-Man Tang Hong-Sheng Gui Man-Ting So Vincent Chi-Hang lui Paul Kwong-Hang Tam Maria-Mercè Garcia-Barcelo Department of Surgery Li Ka Shing Faculty of Medicine the University of Hong Kong Department of Psychiatry Li Ka Shing Faculty of Medicine the University of Hong Kong Center for Genomic Sciences of the Li Ka Shing Faculty of Medicine the University of Hong Kong Centre for Reproduction Development and Growth Li Ka Shing Faculty of Medicine the University of Hong Kong

AIM:To investigate the role of IKBKAP(inhibitor of kappa light polypeptide gene enhancer in B-cells,kinase complexassociated protein)in the development of enteric nervous system(ENS)and Hirschsprung disease(HSCR).METHODS:In this study,we injected a morpholino that blocked the translation of ikbkap protein to 1-cell stage zebrafish *** phenotype in the ENS was analysed by antibody staining of the pan-neuronal marker Hu C/D followed by enteric neuron *** mean numbers of enteric neurons were compared between the morphant and the *** also studied the expressions of ret and phox2bb,which are involved in ENS development,in the ikbkap morpholino injected embryos by quantitative reverse transcriptase polymerase chain reaction and compared them with the ***:We observed aganglionosis(χ2,P<0.01)and a reduced number of enteric neurons(38.8±9.9 vs50.2±17.3,P<0.05)in the zebrafish embryos injected with ikbkap translation-blocking morpholino(morphant)when compared with the control *** of the morpholino was confirmed by similar results obtained using a second non-overlapping morpholino that blocked the translation of *** further studied the morphant by analysing the expression levels of genes involved in ENS development such as ret,phox2bb and sox10,and found that phox2bb,the ortholog of human PHOX2B,was significantly down-regulated(0.51±0.15 vs 1.00±0,P<0.05).Although we also observed a reduction in theexpression of ret,the difference was not ***:Loss of IKBKAP contributed to HSCR as demonstrated by functional analysis in zebrafish embryos.

关键词： Hirschsprung disease Enteric nervous system IKBKAP

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我国高校专利成果转化的立法完善研究

技术与创新管理 2010年第5期31卷 531-535页

作者：刘杨栾春娟大连理工大学人文社会科学学院辽宁大连116024

我国高校专利成果转化率较低和产业化水平不高的状况,很大程度上缘于我国高校专利成果转化立法建设的不完善。立法不足对高校专利成果转化造成了很大的制约。我国亟需通过对西方先进国家高校专利成果转化立法的研究和借鉴,加快我国高校... 详细信息

我国高校专利成果转化率较低和产业化水平不高的状况,很大程度上缘于我国高校专利成果转化立法建设的不完善。立法不足对高校专利成果转化造成了很大的制约。我国亟需通过对西方先进国家高校专利成果转化立法的研究和借鉴,加快我国高校专利成果转化方面的立法建设,为高校专利成果转化提供一个良好的法律环境。

关键词：高校专利成果转化立法完善