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Echocardiographic mapping of left ventricular resynchronization during cardiac resynchronization therapy procedures

Chinese Medical Journal 2010年第13期123卷 1645-1651页

作者： CHAN Ngai-yin CHOY Chi-chung CHEUNG Kar-chun LAU chun-leung LO Ying-keung CHU Pui-shan YUEN Ho-chuen LAU Suet-ting CHOI Yuen-choi Department of Medicine & Geriatrics Princess Margaret Hospital 2-10 Princess Margaret Hospital Road Lai Chi Kok Kowloon Hong Kong China

Background Cardiac resynchronization therapy （CRT） is an effective electrical therapy for patients with moderate to severe heart failure and cardiac dyssynchrony. This study aimed to investigate the degree of acute left ventricular （LV） resynchronization with biventricular pacing （BVP） at different LV sites and to examine the feasibility of performing transthoracic echocardiography （TTE） to quantify acute LV resynchronization during CRT procedure. Methods Fourteen patients with NYHA Class Ⅲ-Ⅳ heart failure, LV ejection fraction 〈35%, QRS duration 〉120 ms and septal-lateral delay （SLD）〉60 ms on tissue Doppler imaging （TDI）, underwent CRT implant. TDI was obtained from three apical views during BVP at each accessible LV site and SLD during BVP was derived. Synchronicity gain index （Sg） by SLD was defined as （I＋（SLD at baseline - SLD at BVP）/SLD at baseline）. Results Seventy-two sites were studied. Positive resynchronization （R＋, Sg〉1） was found in 42 （58%） sites. R＋ was more likely in posterior or lateral than anterior LV sites （66% vs. 36%, P 〈0.001）. Concordance of empirical LV lead implantation sites and sites with R＋ was 50% （7/14）. Conclusions The degree of acute LV resynchronizaUon by BVP depends on LV lead location and empirical implantation of LV lead results in only 50% concordance with R＋. Performing l-rE during CRT implantation is feasible to identify LV sites with positive resynchronization.

关键词： echocardiography cardiac resynchronization therapy heart failure left ventricular lead device implantation optimization

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Lithographic patterning of ferromagnetic FePt nanoparticles from a single-source bimetallic precursor containing hemiphasmidic structure for magnetic data recording media

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Science China Materials 2019年第4期62卷 566-576页

作者： Zhengong Meng Cheuk-Lam Ho Hon-fai Wong Zhen-Qiang Yu Nianyong Zhu Guijun Li Chi-Wah leung Wai-Yeung Wong College of Chemistry and Environmental Engineering Shenzhen University Institute of Molecular Functional Materials and Department of Chemistry Hong Kong Baptist University HKBU Institute of Research and Continuing Education Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Department of Applied Physics The Hong Kong Polytechnic University

Patterning of L10 FePt nanoparticles(NPs) with high coercivity offers a promising route to develop bit-patterned media(BPM) for the next generation magnetic data recording system, but the synthesis of monodisperse FePt NPs and mass production of their nanopatterns has been a longstanding challenge. Here, highly efficient nanoimprint lithography was applied for large-scale universal patterning, which was achieved by imprinting the solution of a single-source bimetallic precursor. The rigid coplanar metallic cores and the surrounding flexible tails in the bimetallic complex permit the spontaneous molecular arrangements to form the highly ordered negative morphology replicated from the soft ***-situ pyrolysis study was then investigated by one-pot pyrolysis of the precursor under an Ar/H2 atmosphere, and the resultant NPs were fully characterized to identify the phase,morphology and magnetic properties. Finally, highly-ordered patterns on certain substrates were preserved perfectly after pyrolysis and could be potentially utilized in magnetic data recording media.

关键词： FePt nanoparticles single-source bimetallic precursors one-pot pyrolysis lithographic patterning magnetic data recording media

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Pharmacological efficacy of the traditional Chinese medicinal formula Kun-Tai-1A in the treatment of letrozole-induced polycystic ovary syndrome

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Traditional Medicine Research 2022年第3期7卷 44-54页

作者： Leanne Lee leung Jing Xie Ya-Cun Chen Kar-Ho Lam Hei Wan Su-Lan Yu Tzi-Bun Ng George Pak-Heng leung Jin Yu Ren-Min Yao Shu-Jia Sun Sydney Chi-Wai Tang Hai-Yong Chen Jia Zhao Zhang-Jin Zhang Calvin Kai-fai Lee Kalin Yan-Bo Zhang Li-Xing Lao Yun Feng Xiang Lin Wei Meng School of Chinese Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Department of Pharmacology and Pharmacy Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China Workstation for Training and Research(Hong Kong Branch) Distinguished Professor Yu Jin Gynaecology of Chinese Medicine&Integrative MedicineHong Kong 999077China Shanghai Taikuntang Chinese Medicine Hospital Shanghai 200023China Department of Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China Virginia University of Integrative Medicine Virginia 22031USA Department of Ophthalmology Peking University Third HospitalBeijing 100191China Workstation of Zhu Nansun National Master of Chinese MedicineHong Kong Branch of Zhu’s School of Gynaecology of Chinese Medicine from ShanghaiHong Kong 999077China

Background:Polycystic ovary syndrome(PCOS)is an endocrine disorder that occurs in women of child-bearing ***,PCOS patients have decreased pregnancy rates and clomiphene citrate *** traditional Chinese medicine formula Kun-Tai-1S(KT1S),consisting of the seahorse species hippocampus,has been reported to elicit therapeutic effects in patients with ***,given the limited resources and global demand for wild hippocampus,whether KT1S with or without hippocampus can elicit similar therapeutic effects has not been ***:KT1S and Kun-Tai-1A(KT1A,KT1S without dry hippocampus)were used to treat a letrozole-induced rat model of PCOS with an established *** serum levels of testosterone,luteinizing hormone,anti-Müllerian hormone,and estradiol were determined,the luteinizing hormone/follicle-stimulating hormone ratio was determined,and the ovarian pathology was ***:Similar to the therapeutic effects of cyproterone acetate,both the KT1S and KT1A treatments reduced the body weight and ovarian and uterine indices in the rats with *** serum levels of testosterone,anti-Müllerian hormone,and luteinizing hormone and the luteinizing hormone/follicle-stimulating hormone ratio were significantly lower in the KT1S and KT1A treatment groups compared to the model group(P<0.01 and P<0.05,respectively).Moreover,the histopathological assessment results suggested that both the KT1S and KT1A treatments significantly ameliorated the PCOS pathology in the rats with an established disease,with a reduced number of cystic and atretic follicles and an increased number of corpora lutea being observed in the ***,there was no obvious difference in the disease outcomes between the KT1S and KT1A-treated *** pharmacology analysis revealed that 4’,7-dihydroxyflavanone,sinpemine A,quercetin,8-isopentenyl-kaempferol,and luteolin in KT1A may promote estrogen signaling;furthermore,the nitric oxide regulation pathway is also cl

关键词： polycystic ovary syndrome traditional Chinese medicine ovulation Kun-Tai-1A seahorse endocrine disease

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黄河流域未来气候-水文变化的模拟研究

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气象学报 2015年第2期73卷 382-393页

作者：康丽莉 leung L Ruby 柳春王守荣浙江省气象科学研究所杭州310008 Pacific Northwest National Laboratory RichlandWA 99352USA 安徽省气象局合肥230031 中国气象局北京100081

将大尺度半分布式水文模型VIC应用到黄河上中游流域(花园口水文断面以上),并利用区域气候模式RegCM4.0单向嵌套全球气候模式BCC_CSM1.1,动力降尺度到黄河流域的模拟结果驱动VIC模型,开展在新的典型浓度路径下(RCP4.5和RCP8.5)黄河流域... 详细信息

将大尺度半分布式水文模型VIC应用到黄河上中游流域(花园口水文断面以上),并利用区域气候模式RegCM4.0单向嵌套全球气候模式BCC_CSM1.1,动力降尺度到黄河流域的模拟结果驱动VIC模型,开展在新的典型浓度路径下(RCP4.5和RCP8.5)黄河流域未来气候和水文变化的离线模拟。模拟结果显示,在RCP4.5和RCP8.5排放情景下,黄河流域21世纪平均地表气温相对于1971—2000年均呈显著上升趋势,2019—2048年上升1.2—1.5℃,2069—2098年上升2.19—3.9℃。未来年平均降水量有微弱的增大,2019—2048年增幅为6%左右,2069—2098年增幅为1.4%—5.6%。未来蒸发量增大明显,2069—2098年年平均蒸发量最大可增加9.6%。2019—2048年花园口水文站的年平均径流量增大3.4%—7.4%,2069—2098年年平均径流量转为减少,减幅为3.3%—5.3%。黄河上游地区未来气候和水文变化趋势与黄河流域基本一致,但未来年径流量变幅低于黄河流域,相对比较稳定。

关键词：黄河流域 VIC模型水文变化气候变化典型浓度路径

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Early-onset primary torsional dystonia in a 4-generation Chinese family with a mutation in the DYT1 gene

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Chinese Medical Journal 2005年第10期118卷 873-876页

作者： YEUNG Wai Lan LAM Ching Wan CHENG Wai Tsoi SIN Ngai Chuen WONG Wing Kin WONG chun Nei TSE Ka Ming FOK Tai fai Departments of Paediatrics Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina Chemical Patholog Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina Department of Paediatrics and Adolescent Medicine Queen Mary HospitalUniversity of Hong Kong Nuclear Medicine&PET Division Scanning DepartmentSt.Teresa’s HospitalHong KongChina

Primary torsion dystonia(PTD)is a clinically and genetically heterogeneous movement *** least thirteen different types of dystonia can be distinguished on a genetic basis.~1 The DYT1 gene was first mapped by Ozelius et al in 1989.~2(Kramer et)al^3 linked the same locus to PTD in 12 Ashkenazi Jewish families in *** patients with early-onset generalized PTD were caused by the same three base pair(GAG)deletion in the DYT1 gene on chromosome 9q34.^(1,4,5)The product of the gene is a protein called torsinA.~5(Although the)function of this protein is as yet uncertain,it is widely distributed throughout the brain with high levels in the substantia nigra compacta dopamine neurones.

关键词： DYT1 gene dystonia positron emission tomography

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The effects of stent porosity on the endovascular treatment of intracranial aneurysms located near a bifurcation

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Journal of Biomedical Science and Engineering 2013年第8期6卷 812-822页

作者： Abraham Yik-Sau Tang Hiu-Ning Chan Anderson chun-On Tsang Gilberto Ka-Kit leung Kar-Ming leung Alfred Cheuk-Hang Yu Kwok-Wing Chow Department of Mechanical Engineering University of Hong Kong Hong Kong China Department of Neurosurgery Kwong Wah Hospital Hong Kong China Division of Neurosurgery Department of Surgery Li Ka Shing Faculty of Medicine University of Hong Kong Queen Mary Hos-pital Hong Kong China Medical Engineering Program Department of Electrical and Electronic Engineering University of Hong Kong Hong Kong China

Intracranial aneurysm occurs when a cerebral artery develops an abnormal sac-like dilatation, and will cause massive bleeding in the subarachnoid space upon rupture. Endovascular stenting is a minimally invasive procedure in which a flow-diverting stent is deployed to cover the aneurysm neck, thereby restricting blood from entering the aneurysm and reducing the risk of rupture. The stent porosity, a crucial factor determining the intra-aneurysmal hemodynamics following treatment, is investigated by computational fluid dynamics techniques. Based on the computational results, a low porosity stent will dramatically reduce the flow velocity and the flow rate inside the side branch vessel. Conversely, a high porosity stent may not provide adequate flow reduction inside the aneurysm, possibly causing treatment failure. An advisable range of optimal stent porosity would be 60% to 75%, which can drastically reduce the flow rate into the aneurysm while preserving enough blood flow for the side branch vessel. Clinically, deployment of two or more flow-diverting stents may not increase treatment efficacy but can potentially lead to adverse effects due to side-branch hypoperfusion. The present quantitative analysis can also provide practical insight for future stent design.

关键词： Intracranial aneurysm Endovascular Treatment Stent Stent Porosity Computational Fluid Dynamics

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Plasmonic enhancement and polarization dependence of nonlinear upconversion emissions from single gold nanorod@SiO_(2)@CaF2:Yb^(3+),Er^(3+)hybrid core–shell–satellite nanostructures

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Light(Science & Applications) 2016年第1期5卷 224-234页

作者： Jijun He Wei Zheng Filip Ligmajer Chi-fai Chan Zhiyong Bao Ka-leung Wong Xueyuan Chen Jianhua Hao Jiyan Dai Siu-Fung Yu Dang Yuan Lei Department of Applied Physics The Hong Kong Polytechnic UniversityHong KongChina Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002China Central European Institute of Technology Brno University of TechnologyBrno 61669Czech Republic Department of Chemistry Hong Kong Baptist UniversityHong KongChina

Lanthanide-doped upconversion nanocrystals(UCNCs)have recently become an attractive nonlinear fluorescence material for use in bioimaging because of their tunable spectral characteristics and exceptional *** materials are often introduced into the vicinity of UCNCs to increase their emission intensity by means of enlarging the absorption cross-section and accelerating the radiative decay ***,plasmonic nanostructures(e.g.,gold nanorods,GNRs)can also influence the polarization state of the UC fluorescence—an effect that is of fundamental importance for fluorescence polarization-based imaging methods yet has not been discussed *** study this effect,we synthesized GNR@SiO_(2)@CaF2:Yb^(3+),Er^(3+)hybrid core–shell–satellite nanostructures with precise control over the thickness of the SiO_(2) *** evaluated the shell thicknessdependent plasmonic enhancement of the emission intensity in ensemble and studied the plasmonic modulation of the emission polarization at the single-particle *** hybrid plasmonic UC nanostructures with an optimal shell thickness exhibit an improved bioimaging performance compared with bare UCNCs,and we observed a polarized nature of the light at both UC emission bands,which stems from the relationship between the excitation polarization and GNR *** used electrodynamic simulations combined with Förster resonance energy transfer theory to fully explain the observed *** results provide extensive insights into how the coherent interaction between the emission dipoles of UCNCs and the plasmonic dipoles of the GNR determines the emission polarization state in various situations and thus open the way to the accurate control of the UC emission anisotropy for a wide range of bioimaging and biosensing applications.

关键词： Förster resonance energy transfer gold nanorods lanthanide-doped upconversion nanocrystals plasmon-enhanced nonlinear fluorescence polarization modulation

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A 5W UHF POWER AMPLIFIER WITH HARMONIC FILTERING FOR MOBILE PHONE

A 5W UHF POWER AMPLIFIER WITH HARMONIC FILTERING FOR MOBILE ...

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2nd International Symposium on Recent Advances in Microwave Technology(ISRAMT’89)

作者： leung chun-Kwan Chan Wing-Shing Yip Peter C.L. Department of Electronic Engineering City Polytechnic of Hong Kong

＜正＞Design at UHF is a compromise between size,performance and cost.A 5W amplifier operating in 470～520 MHz with harmonic filtering is presented that overcomes this by the use of lumped components and transmission ...

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Anterior perineal hernia after anterior exenteration

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Asian Journal of Urology 2017年第4期4卷 253-255页

作者： Ka Wing Wong Terence chun-ting Lai Ada Tsui-lin Ng Brian Sze-ho Ho James Hok-leung Tsu Chiu Fung Tsang W.K.Ma Ming Kwong Yiu Division of Urology Department of SurgeryQueen Mary HospitalUniversity of Hong KongHong KongChina

Perineal hernia is a rare complication of anterior *** reported this complication after an anterior exenteration for bladder cancer with bleeding complication requiring packing and second-look *** approach is a simple... 详细信息

关键词： Perineal hernia Anterior exenteration Bladder cancer Mesh repair

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Meteorin-β/Meteorin like/IL-41 attenuates airway inflammation in house dust mite-induced allergic asthma

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Cellular & Molecular Immunology 2022年第2期19卷 245-259页

作者： Xun Gao Ting-Fan leung Gary Wing-Kin Wong Wing-Hung Ko Mengyun Cai Ellie Jiayi He Ida Miu-Ting Chu Miranda Sin-Man Tsang Ben chung-Lap Chan Jiawei Ling Xiao Fan Liwei Lu Christopher Wai-Kei Lam chun-Kwok Wong Department of Chemical Pathology The Chinese University of Hong KongHong KongChina Department of Paediatrics The Chinese University of Hong KongHong KongChina School of Biomedical Sciences The Chinese University of Hong KongHong KongChina Emory College of Arts and Sciences Emory UniversityAtlantaGAUSA Institute of Chinese Medicine and State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of Pathology and Shenzhen Institute of Research and Innovation The University of Hong KongHong KongChina Faculty of Medicine and State Key Laboratory of Quality Research in Chinese Medicines Macao University of Science and TechnologyMacaoChina Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine The Chinese University of Hong KongHong KongChina

We sought to examine the regulatory effect of Meteorin-β(Metrnβ)/Meteorin like(Metrnl)/IL-41 on lung inflammation in allergic *** found that Metrnβwas elevated significantly in asthmatic patients and in mice with allergic asthma induced by house dust mite(HDM)*** exposure to HDM,Metrnβwas secreted predominantly by airway epithelial cells and inflammatory cells,including macrophages and *** increased Metrnβeffectively blocked the development of airway hyperreactivity(AHR)and decreased inflammatory cell airway infiltration and type 2 cytokine production,which was associated with downregulated DC-mediated adaptive immune ***,Metrnβimpaired the maturation and function of bone marrow-derived dendritic cells in *** mice adoptively transferred with dendritic cells isolated from Metrnβ-treated allergic mice displayed decreased AHR,airway inflammation,and lung ***βalso displayed anti-inflammatory properties in immunodeficient SCID mice with allergic asthma and in in vitro 3D ALI airway ***,blockade of Metrnβby anti-Metrnβantibody treatment promoted the development of allergic *** results revealed the unappreciated protective roles of Metrnβin alleviating DC-mediated Th2 inflammation in allergic asthma,providing the novel treatment strategy of therapeutic targeting of Metrnβin allergic asthma.

关键词： Metrnβ Eosinophils Dendritic cells Allergic asthma Air-liquid interface

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