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中国医药导报 2024年第9期21卷 16-21页

作者：袁廷申李秀勤邹明方勇马成才梁盼盼方英磊华长城安徽省亳州市人民医院骨科安徽亳州236800

目的探讨近端滑动加压技术在股骨转子间骨折(IFF)并外侧壁骨折患者股骨近端抗旋髓内钉(PFNA)术中的应用价值。方法选取安徽省亳州市人民医院骨科2019年8月至2021年8月收治的IFF并外侧壁骨折患者50例,按随机数字表法将其分成试验组、... 详细信息

目的探讨近端滑动加压技术在股骨转子间骨折(IFF)并外侧壁骨折患者股骨近端抗旋髓内钉(PFNA)术中的应用价值。方法选取安徽省亳州市人民医院骨科2019年8月至2021年8月收治的IFF并外侧壁骨折患者50例,按随机数字表法将其分成试验组、对照组,各25例。两组均行PFNA术,试验组在PFNA术中使用近端滑动加压技术,对照组行常规PFNA术。比较两组围手术期恢复情况与骨折复位效果,分别在术前及术后3、6个月采血,检测两组血清骨形态生成蛋白-2(BMP-2)、骨碱性磷酸酶(BALP)水平。分别在术后当日及术后3、6、12个月对两组进行髋关节功能Harris评分,并比较两组股骨颈干角的变化,记录并发症发生情况。另选取30份人工股骨标本,编号后采用随机数字表法分为PFNA术组和近端滑动加压技术联合PFNA术组,每组15份。进行相应干预后进行扭转荷载试验与压缩荷载试验,比较两组扭转1.5°时的扭转刚度、扭矩,以及荷载800 N时的压缩刚度、位移情况。结果试验组骨折愈合时间短于对照组(P0.05)。近端滑动加压技术联合PFNA术组扭转1.5°时扭转刚度、扭矩高于PFNA术组,荷载800 N时的压缩刚度高于PFNA术组,压缩位移低于PFNA术组(P<0.05)。结论在PFNA术中近端采用滑动加压技术,能促进IFF并外侧壁骨折患者的骨折愈合及功能恢复,生物力学性能更好。

关键词：外侧壁骨折股骨转子间骨折股骨近端抗旋髓内钉滑动加压技术

水化学和环境同位素对济南东源饮用水源地地下水演化过程的指示

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环境科学 2019年第6期40卷 2667-2674页

作者：张雅苏春利马燕华刘伟江中国地质大学环境学院武汉430074 海南省环境科学研究院海口570026 生态环境部环境规划院长江经济带生态环境联合研究中心北京100012

济南东源水源地属于岩溶裂隙水,是济南市的主要供水水源.以济南市东源水源地为研究区,通过对研究区地下水和地表水的主要离子含量、氢氧同位素比值分析,揭示了东源饮用水源地地下水的补给来源、地表水的影响及水岩作用过程.结果表明,区... 详细信息

济南东源水源地属于岩溶裂隙水,是济南市的主要供水水源.以济南市东源水源地为研究区,通过对研究区地下水和地表水的主要离子含量、氢氧同位素比值分析,揭示了东源饮用水源地地下水的补给来源、地表水的影响及水岩作用过程.结果表明,区内地下水水化学类型相似,阳离子以Ca^(2+)为主,阴离子以HCO_3^-和SO_4^(2-)离子为主;大气降水是该地区地下水和河水的主要补给来源,且经历了不同程度的蒸发作用.地下水化学组分主要受水-岩作用的控制,方解石和石膏等贫镁矿物的溶解沉淀以及上覆第四系地层硅酸盐矿物的水解是区内地下水水化学组分的主要来源;部分地段河水污染渗漏补给地下水,造成地下水污染,主要超标指标为总硬度、NO_3^-、NH_4^+、SO_4^(2-)、Fe和Mn.

关键词：地下水水化学特征环境同位素水岩作用东源水源地

Clinical and laboratory features,treatment,and outcomes of macrophage activation syndrome in 80 children:a multi-center study in China

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World Journal of Pediatrics 2020年第1期16卷 89-98页

作者： Li-Xia Zou Yun Zhu Li Sun Hui-Hui ma Si-Rui Yang hua-Song Zeng Ji-Hong Xiao Hai-Guo Yu Li Guo Yi-Ping Xu Mei-Ping Lu Department of Rheumatology Immunology and Allergy Children's HospitalZhejiang University School of Medicine57 Zhugan LaneHangzhou 310003China Department of Nephrology and Immunology Children's Hospital of Soochow University92 Zhongnan StreetSuzhou 215003China Department of Rheumatology Children's Hospital of Fudan University399 Wanyuan RoadShanghai 201102China Department of Rheumatology and Immunology Children's Hospital of Nanjing Medical University72 Guangzhou RoadNanjing 210008China Department of Pediatric Rheumatology and Allergy The First Hospital of Jilin University71 Xinming StreetChangchun 130021China Pediatric Allergy Immunology and Rheumatology DepartmentGuangzhou Children's HospitalGuangzhou Women and Children's Medical CenterGuangzhou Medical University318 Renminzhong RoadGuangzhou 510120China Department of Pediatric The First Affiliated Hospital of Xiamen University55 Zhenhai RoadXiamen 361003China

Background macrophage activation syndrome(maS)is a major cause of morbidity and mortality in pediatric *** aimed to further understand the clinical features,treatment,and outcome of maS in *** A multi-center cohort study was performed in seven hospitals in China from 2012 to *** patients with maS were enrolled,including 53 cases with systemic juvenile idiopathic arthritis(SJIA-maS),10 cases of Kawasaki disease(KD-maS),and 17 cases of connective tissue disease(CTD-maS).The clinical and laboratory data were collected before(pre-),at onset,and during full-blown stages of *** compared the data among the SJIA-maS,KD-maS,and CTD-maS *** 51.2%of patients developed maS when the underlying disease was first *** patients with SJIA,22.6%(12/53)were found to have hypotension before the onset of *** patients were also found to have significantly increased aspartate aminotransferase(AST)and lactate dehydrogenase(LDH),as well as decreased albumin(PmaS when compared to pre-maS stages of the *** addition,ferritin and ratio of ferritin/ESR were significantly elevated in patients at full-blown stages of SJIA-maS compared to pre-maS *** increased ferritin and ratio of ferritin/ESR were also observed in patients with SJIA compared to in KD and ***-operating characteristic analysis showed that 12,217.5μg/L of ferritin and 267.5 of ferritin/ESR ratio had sensitivity(80.0%and 90.5%)and specificity(88.2%and 86.7%),respectively,for predicting full-blown *** majority of the patients received corticosteroids(79/80),while biologic agents were used in 12.5%(10/80)of *** was the most commonly selected biologic *** overall mortality rate was 7.5%.Conclusions About half of maS occurred when the underlying autoimmune diseases(SJIA,KD,and CTD)were

关键词： Connective tissue disease Kawasaki disease macrophage activation syndrome Systemic juvenile idiopathic arthritis

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古河道砂岩含水层水资源保护与水害防治方法

绿色矿山

绿色矿山 2024年第1期2卷 64-74页

作者：华照来范立民李增林孙魁王路吕扬马万超李强陕西陕煤曹家滩矿业有限公司陕西榆林719000 中国矿业大学(北京)国家煤矿水害防治工程技术研究中心北京100083 中国矿业大学矿业工程学院江苏徐州221116 陕西省地质环境监测总站陕西西安710054

鄂尔多斯盆地开采侏罗纪煤层的矿区有24个,原煤产量占全国的45%左右,随着开采深度的增加,煤层顶板直罗组古河道砂岩含水层成为煤矿突水的主要水源。直罗组砂岩含水层富水性相对较弱,但采动条件下释水效应显著,成为长期、持续提供煤矿矿... 详细信息

鄂尔多斯盆地开采侏罗纪煤层的矿区有24个,原煤产量占全国的45%左右,随着开采深度的增加,煤层顶板直罗组古河道砂岩含水层成为煤矿突水的主要水源。直罗组砂岩含水层富水性相对较弱,但采动条件下释水效应显著,成为长期、持续提供煤矿矿井水的主要突水水源。同时,该区属于生态脆弱区,水资源相对短缺,如何有效利用有限的水资源,无疑是矿区地下水系统保护和生态环境保护的重要基础。以榆神矿区及曹家滩煤矿为例,提出了古河道砂岩含水层研究技术路线、主要研究内容和研究方法。应综合运用沉积学、水文地质学和矿井防治水理论,辅助必要的野外地质调查、典型剖面实测、水文地质及环境地质典型要素专项调查、钻探、物探测井和采样测试、数值模拟等方法,重点开展古河道砂岩含水层沉积演化及物性特征、古河道砂岩含水层地下水系统特征、古河道砂岩含水层与煤层开采互馈机制等3个方面的研究。神府南区研究实践表明,直罗组下段古河道砂体规模巨大且具有良好的孔隙、裂隙结构特征,具有良好的地下水储存和运移性能,总体上以红碱淖—尔林兔—锦界一线为轴线,呈NW-SE向带状展布。延安组第四段、第五段遭受了直罗组古河道冲刷。主河道区域富水性强于分支河道和分流间湾区域,是矿井涌(突)水危险性较大区域,应做好水害防控。

关键词：古河道砂岩直罗组含水层水资源保护(保水采煤) 防治水鄂尔多斯盆地

Expression of insulin-like growth factor Ⅱ and its receptor in hepatocellular carcinogenesis

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World Journal of Gastroenterology 2001年第2期7卷 285-288页

作者： Zi Rong Fan Dong hua Yang Jun Cui Han Rong Qin chun Chi huang Department of Gastroenterology, Zhujiang Hospital. The First Military Medical University, Guangzhou 510282.Guangdong Province. China Department of Gastroenterology Zhujiang Hospital The First Military Medical University Guangzhou 510282 Guangdong Province China.

INTRODUCTIONInsulin-like growth factor Ⅱ(IGF-Ⅱ) is a mitogenic peptide of 74 kD and is mostly synthesized in fetal liver tissue .IGF-Ⅱ is believed to play an important role in fetal growth and development and is involved in cellular proliferation and differentiation[1-5]. Recently ,several researchers have reported increased expression of the IGF-Ⅱgene in human hepatocellular carcinoma (HCC) and adjacent non-cancerous liver tissues [6-10].

关键词： liver neoplasms/pathology insulin-like growth factor Ⅱ/biosynthesis receptors,somatomedin/biosynthesis RNA, messenger/biosynthesis in situ hybridization hepatitis,chronic/pathology

Disease Risks of Childhood Obesity in China

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Biomedical and Environmental Sciences 2005年第6期18卷 401-410页

作者： YAN-PING LI XIAO-GUANG YANG FENG-YING ZHAI JIAN-hua PIAO WEN-hua ZHAO JIAN ZHANG GUAN-SHENG ma National Institute for Nutrition and Food Safety Chinese Center for Disease Control and Prevention 29 Nanwei Road Beijing 100050 China

Objective To estimate the relative risks of dyslipidemia, hypertension, diabetes mellitus, and metabolic syndromes among overweight and obese Chinese children compared with their normal weight counterparts. Methods Overweight and obesity were defined by age- and sex-specific BMI classification reference for Chinese children and adolescents. Pediatric metabolic syndrome （MetS） and each risk factor for MetS were defined using the criteria for US adolescents. Definition of hyper-TC, LDL, and dyslipidemia for adults was applied as well. General linear model factor analysis and chi-square test were used to compare the difference in metabolic indicators among normal weight, overweight, and obese groups. Multiple logistic regression analysis was performed to estimate the odds ratio of metabolic abnormalities between obesity, overweight, and normal weight children, after adjustment for living area, family economic level, age, sex, and daily exercise time and TV watching time, as well as different dietary indices in the model. Results Significant increases in blood lipids, glucose, and blood pressure were found among overweight and obese children as compared with their counterparts with normal weight. By applying WGOC-recommended BMI classification, the risks for hypertriglyceridemia, low HDL and dyslipidemia among overweight children were 1.9, 1.4, and 1.5 times, and was 3.3, 1.5, and 1.8 times among obese groups compared to their counterparts with normal weight after adjustment for age, sex, region, socioeconomic status, physical activity, and dietary intakes. The overweight and obese children （15-17.9 years） had a high-risk of developing hypertension, which was 2.3 and 2.9 times higher than their counterparts with normal weight. Above 90% obese adolescents had abdominal obesity, while less than 1% normal weight ones had abdominal obesity. No obese adolescents were free from any risk factors for MetS, while 36.9% of normal weight adolescents were from the risk factors. 83.

关键词： Chinese obese children Metabolic syndrome (MetS) Hypertension Lipids Relative risk

Polarization of terahertz emission out of incident plane from laser interactions with solid targets

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Science China(Physics,Mechanics & Astronomy) 2012年第4期55卷 589-592页

作者： DU Fei LI chun ZHOU MuLin WANG WeiMin SU LuNing ZHENG Yi LI YuTong ma JingLong SHENG ZhengMing CHEN LiMing LU Xin WANG Zhaohua WEI ZhiYi ZHANG Jie Beijing National Laboratory of Condensed matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 China Key Laboratory for Laser Plasmas （Ministry of Education） and Department of Physics Shanghai Jiao Tong University Shanghai 200240 China

A powerful terahertz(THz) pulse was produced by a p-polarized,70 fs,800 nm laser interacting with solid targets at an incident angle of 45°.The polarization of the THz emission was measured out of the laser incident *** results showed that it was linearly *** established a surface current model to explain this phenomenon,assuming that the transient current moving along the plasma surface was responsible for the generation of the THz *** model expectation and the experimental result were in good agreement.

关键词： terahertz emission laser solid interactions polarization

Th17 cells and IL-17 are involved in the disruption of vulnerable plaques triggered by short-term combination stimulation in apolipoprotein E-knockout mice

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Cellular & Molecular Immunology 2013年第4期10卷 338-348页

作者： Tian ma Qi Gao Faliang Zhu chun Guo Qun Wang Fei Gao Lining Zhang Department of Immunology Shandong University School of Medicine and Jinan China Key Laboratory of Cardiovascular Remodeling and Function Research Qilu Hospital Shandong University .linan China

Considerable evidence indicates that type 1 T helper （Th 1）- and Th 17-mediated immune responses promote the formation of atherosclerotic plaques while that CD4＋CD25＋Foxp3＋ regulatory T cells （Tregs） have a protective effect. However, the functions of diverse CD4＋ lymphocyte subsets in plaque rupture remain poorly understood because of a shortage of satisfactory plaque rupture models. Here, we established a murine model of atherosclerotic plaque rupture using a high-fat diet and collar placement on the carotid artery, and triggered plaque rupture by short-term stimulation with a combination of lipopolysaccharide, phenylephrine injection and cold in apolipoprotein E-knockout （ApoE-/-） mice. We investigated the associations between Thl cells, Th17 cells and Tregs and plaque rupture by PCR, flow cytometry, ELISA and immunohistochemistry. In total, 75% （18/24） of vulnerable plaques, but no stable plaques, showed rupture characteristics. The proportion of Th17 cells was increased among splenocytes after treatment, but the changes in the levels of Thl ceils and Tregs were not related to rupture. Furthermore, the treatment resulted in high levels of interleukin- 17 （IL-17） in the serum and in the region of plaque rupture, in vitro, IL-17 increased the level of apoptosis, a major factor associated with plaque rupture, in cultured murine vascular smooth muscle cells. Th17 cells and IL-17 may be involved in the disruption of vulnerable plaques triggered by short-term stimulation with lipopolysaccharide, phenylephrine injection and cold in ApoE-/-mice.

关键词： atherosclerosis mice plaque rupture Th1 Th17

Mining chemodiversity from biodiversity:pharmacophylogeny of medicinal plants of Ranunculaceae

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Chinese Journal of Natural Medicines 2015年第7期13卷 507-520页

作者： HAO Da-Cheng XIAO Pei-Gen ma Hong-Ying PENG Yong HE chun-Nian Biotechnology Institute School of Environment and Chemical EngineeringDalian Jiaotong University Institute of Medicinal Plant Development Chinese Academy of Medical Sciences

This paper reports a pharmacophylogenetic study of a medicinal plant family,Ranunculaceae,investigating the correlations between their phylogeny,chemical constituents,and pharmaceutical ***,ethnopharmacological,and pharmacological data were integrated in the context of the systematics and molecular phylogeny of the *** chemical components of this family included several representative metabolic groups:benzylisoquinoline alkaloids,ranunculin,triterpenoid saponin,and diterpene alkaloids,among *** and magnoflorine were found to coexist in some *** pharmacophylogenetic analysis,integrated with therapeutic information,agreed with the taxonomy proposed previously,in which the family Ranunculaceae was divided into five sub-families:Ranunculoideae,Thalictroideae,Coptidoideae,Hydrastidoideae,and *** was plausible to organize the sub-family Ranunculoideae into ten *** chemical constituents and therapeutic efficacy of each taxonomic group were reviewed,revealing the underlying connections between phylogeny,chemical diversity,and clinical use,which should facilitate the conservation and sustainable utilization of the pharmaceutical resources derived from the Ranunculaceae.

关键词： Ranunculaceae Pharmacophylogeny Chemodiversity Ethnopharmacology Bioactivity Sustainability