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Simultaneous Total Endoscopic Bilateral Nephroureterectomy with Bladder Cuff Excision for Native Kidneys in Renal Transplant Recipients:Initial Experience in A Single-center

Simultaneous Total Endoscopic Bilateral Nephroureterectomy w...

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2012中国器官移植大会

作者： hai bi,lulin ma,xiaofei hou,lei liu,hongxian zhang department of urology,Third hospital of Peking university

【Objective】We present our single-center initial experience and evaluate the feasibility of total endoscopic bilateral nephroureterectomy(BNU) with bladder cuff(BC) excision for native kidneys in renal transplant(RTx) recipients.【Methods】From August 2008 to January 2011,four RTx recipients underwent simultaneous retroperitoneal laparoscopic BNU(RPLBNU) with BC excision for clinically presumed native localized upper urinary tract urothelial carcinoma(UUT-UC) at our *** were four female recipients;the mean age was 50.5(45-58) years and the mean body mass index(BMI)

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Supercritical fluid technology:A game-changer for biomacromolecular nanomedicine preparation and biomedical application

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Chinese Chemical Letters 2024年第7期35卷 89-99页

作者： Yating Zheng Yulan Huang Jing Luo Xuqi Peng Xiran Gui Gang liu Yang Zhang State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine LaboratoryNational Innovation Platform for Industry-Education Integration in Vaccine ResearchState Key Laboratory of Molecular Vaccinology and Molecular DiagnosticsCenter for Molecular Imaging and Translational MedicineSchool of Public HealthXiamen UniversityXiamen 361102China Shen Zhen Research Institute of Xiamen university Shenzhen 518057China Division of urology and department of Surgery Brigham and Women's HospitalHarvard Medical SchoolBostonMA 02115United States Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361102China

Biomacromolecules are attractive in biomedical applications as therapeutic agents and potential drug carriers due to their natural active components,good biocompatibility,and high ***,their large relative molecular weight,complex structure,susceptibility to degradation,and poor stability limit their *** can address these issues by improving the therapeutic value,bioavailability,permeability,and absorption of biomacromolecules while regulating their retention time in the ***,compelling evidence has been reported that supercritical fluid(SCF)technology has emerged as an alternative that maintains the integrity of biomacromolecules and reduces environmental *** this review,we highlight a set of unique nanosizing strategies based on SCF technology for biomacromolecular nanomedicine,and extensively discuss their characteristics and *** particular,the protein-based,nucleic acid-based,and polysaccharide-based nanomedicine preparations via SCF technology and their biomedical applications are summarized,and the potential for industrial production of biomacromolecular drugs is also *** further provide perspectives on the opportunities and challenges in this excellent field of biomacromolecular drugs nanotechnology.

关键词： Biomacromolecules Supercritical fluid technology Therapeutic proteins Gene therapy Nanomedicine

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Neodymium:Yttrium Aluminum Garnet Laser for Mini-Percutaneous Treatment of Upper Urinary Tract Stones

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Journal of Huazhong university of Science and Technology(medical Sciences) 2007年第2期27卷 197-199页

作者：罗洪波刘修恒吕胜启 department of urology Renmin Hospital of Wuhan University

To observe the efficacy and safety of mini-percutaneous nephrolithotomy with Neodymium：Yttrium Aluminum Garnet （Nd-YAG） laser in the treatment for upper urinary tract stones, from December 2005 to September 2006, 31 patients with renal stones, 15 patients with ureteral stones and 7 patients with renal and ureteral stones underwent mini-percutaneous nephrolithotomy with Nd-YAG laser by combination of rigid ureteroscope and flexible ureteroscope under B-ultrasound guidance. Clinical data including operation time, lithotripsy time, complications and stone-free rate were analyzed retrospectively. Our study showed that the percutaneous renal access （F14-F18） was successfully established under B-ultrasound guidance in all cases. Immediate phase Ⅰ lithotripsy was performed in 47 cases through single tract, and in one case through two tracts. Delayed phase Ⅱ lithotripsy was done in 5 cases of renal stones. Operation time ranged from 55 to 180 rain with an average time of 100±15 min. Lithotripsy time was from 25 to 135 min and the average lithotripsy time was 65±11 min. No severe complications occurred in our series. Complex renal stones were cleared in 34 of 38 cases （89.5 %）. All ureteral stones were completely removed in 15 cases （100 %）. It was concluded that mini-percutaneous nephrolithotomy with Nd：YAG laser for the treatment of upper urinary tract stones by combination of rigid ureteroscope and flexible ureteroscope has the advantages of effectiveness, mini-invasion, shorter operative time and safety.

关键词： percutaneous nephrolithotomy ureteroscope Nd:YAG laser urinary stones

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Management and nursing strategies for different patterns of adverse events in patients with urological cancer treated with immune checkpoint inhibitors

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Current urology 2024年第3期18卷 212-217页

作者： Xiaojuan Huang Xiaolei Li Lulin Ma Chunxia liu department of urology Peking University Third HospitalBejingChina

Background This study aimed to explore the patterns of treatment-related adverse events(AEs)associated with immune checkpoint inhibitor(ICI)monotherapy and in combination with chemotherapy or tyrosine kinase inhibitor(TKI)therapy and to summarize the corresponding management and nursing *** and methods A total of 69 patients with malignant urological tumors who received ICI treatment between June 2019 and October 2022 were retrospectively analyzed,and AEs that occurred during treatment were observed and *** on the different types of treatment,the patients were divided into ICI monotherapy,ICI plus chemotherapy,and ICI plus TKI therapy *** analysis was *** incidence,distribution,and severity of AEs in the different subgroups were *** A total of 138 AEs occurred in 69 patients,among which grade 1 plus 2,and grade 3 plus 4 AEs accounted for 78.99%and 21.01%,*** incidence of AEs per patient in the ICI-TKI therapy group was the highest(3.75 times/person),followed by the ICI-chemotherapy(2.33 times/person)and ICI monotherapy(0.82 times/person)*** AEs,such as fatigue,nausea,and myelosuppression,were much more common in the ICI-gemcitabine and cisplatin group,whereas renal injury,skin lesions,and diarrhea were most common ones in the ICI-TKI *** Immune checkpoint inhibitors are new treatment options for advanced urological tumors and renal cell *** AE patterns were observed among the different treatment ***,strict and meticulous clinical management and nursing measures are required to ensure the safety of patients receiving ICI treatment.

关键词： Immune checkpoint inhibitor Immunotherapy Adverse events Nursing Urological tumor

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CBioProfiler:A Web and Standalone Pipeline for Cancer Biomarker and Subtype Characterization

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Genomics, Proteomics & Bioinformatics 2024年第3期22卷 153-165页

作者： Xiaoping liu Zisong Wang Hongjie Shi Sheng Li Xinghuan Wang department of urology Zhongnan Hospital of Wuhan UniversityWuhan 430071China department of Pathology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Cancer Precision Diagnosis and Treatment and Translational Medicine Hubei Engineering Research Center Zhongnan Hospital of Wuhan UniversityWuhan 430071China department of Biological Repositories Zhongnan Hospital of Wuhan UniversityWuhan 430071China

Cancer is a leading cause of death worldwide,and the identification of biomarkers and subtypes that can predict the long-term survival of cancer patients is essential for their risk stratification,treatment,and ***,there are currently no standardized tools for exploring cancer biomarkers or *** this study,we introduced Cancer Biomarker and subtype Profiler(CBioProfiler),a web server and standalone application that includes two pipelines for analyzing cancer biomarkers and *** cancer biomarker pipeline consists of five modules for identifying and annotating cancer survival-related biomarkers using multiple survival-related machine learning *** cancer subtype pipeline includes three modules for data preprocessing,subtype identification using multiple unsupervised machine learning methods,and subtype evaluation and *** also includes CuratedCancerPrognosisData,a novel R package that integrates reviewed and curated gene expression and clinical data from 268 *** studies cover 43 common blood and solid tumors and draw upon 47,686 clinical *** web server is available at https://***/and https://***/CBioProfiler/,and the standalone app and source code can be found at https://***/liuxiaoping2020/CBioProfiler.

关键词： CBioProfiler Cancer biomarker Cancer subtype Machine learning Web app

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