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Kaemtakols A-D,highly oxidized pimarane diterpenoids with potent anti-inflammatory activity from Kaempferia takensis

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Natural Products and Bioprospecting 2023年第1期13卷 1-13页

作者： Orawan Jongsomjainuk Jutatip Boonsombat Sanit Thongnest Hunsa Prawat Paratchata Batsomboon Sitthivut Charoensutthivarakul Saroj Ruchisansakun Kittipong Chainok Jitnapa Sirirak chulabhorn mahidol Somsak Ruchirawat Laboratory of Natural Products Chulabhorn Research InstituteBangkokThailand Laboratory of Medicinal Chemistry Chulabhorn Research InstituteBangkokThailand Program in Chemical Sciences Chulabhorn Graduate InstituteChulabhorn Royal AcademyBangkokThailand Center of Excellence on Environmental Health and Toxicology(EHT) OPSMHESIBangkokThailand Excellent Center for Drug Discovery(ECDD) School of Bioinnovation and Bio-Based Product Intelligenceand Center for NeuroscienceFaculty of ScienceMahidol UniversityBangkokThailand Department of Plant Science Faculty of ScienceMahidol UniversityBangkokThailand Thammasat University Research Unit in Multifunctional Crystalline Materials and Applications(TU-MCMA) Faculty of Science and TechnologyThammasat UniversityPathum ThaniThailand Department of Chemistry Faculty of ScienceSilpakorn UniversityNakhon PathomThailand

Four highly oxidized pimarane diterpenoids were isolated from Kaempferia takensis *** A-C pos-sess a tetracyclic ring with either a fused tetrahydropyran or tetrahydrofuran *** D has an unusual rearranged A/B ring spiro-bridged pimarane framework with a C-10 spirocyclic junction and an adjacent 1-methyltri-cyclo[3.***.1.02,7]octene *** characterization was achieved using spectroscopic analysis,DP4+and ECD calculations,as well as X-ray crystallography,and their putative biosynthetic pathways have been *** B showed significant potency in inhibiting nitric oxide production with an IC50 value of 0.69μ*** docking provided some perspectives on the action of kaemtakol B on iNOS protein.

关键词： Kaempferia takensis Diterpenoid Structure elucidation Anti-inflammatory DP4+ Molecular docking

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Pathway analysis of metabolic genes and serum metabolites in HCC reveal aberrations associated with fatty acid and lipid metabolism

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Cancer Biology & Medicine 2018年第S1期15卷 12-13页

作者： Yotsawat Pomyen Anuradha Budhu Jittiporn Chaisaingmongkol Hien Dang Siritida Rabibhadana Benjarath Pupacdi Marshonna Forgues Vajarabhongsa Bhudhisawasdi Nirush Lertprasertsuke Chirayu Auewarakul Thaniya Sricharunrat Kannika Phornphutkul Suleeporn Sangrajrang chulabhorn mahidol Mathuros Ruchirawat Xinwei Wang The Liver Carcinogenesis Section Laboratory of Human CarcinogenesisCenter for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA chulabhorn Research Institute BangkokThailand Khon Kaen University Khon KaenThailand Chiang Mai University Chiang MaiThailand chulabhorn Hospital BangkokThailand Rajavej Hospital and Lampang Cancer Center Chiang MaiThailand National Cancer Institute BangkokThailand

Objective:Hepatocellular carcinoma(HCC)is among the deadliest cancers in *** Thailand Initiative in Genomics and Expression Research for Liver Cancer(TIGER-LC)cohort was established to discover molecular markers that can be used for early detection and diagnosis and to understand possible molecular mechanisms underlying the disease.

关键词： Pathway analysis metabolic

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Global tissue and serum metabolomics reveals altered tumor biochemical activity in molecular subtypes of hepatocellular carcinoma and cholangiocarcinoma

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Cancer Biology & Medicine 2018年第S1期15卷 13-14页

作者： Xinwei Wang Thaniya Mathuros Ruchirawat Anuradha Budhu Yotsawat Pomyen Jittiporn Chaisaingmongkoll Hien Dang Siritida Rabibhadana Benjarath Pupacdi Marshonna Forgues Vajarabhongsa Bhudhisawasdi Nirush Lertprasertsuke Anon Chotirosniramit Chawalit Pairojkul Chirayu Auewarakul Thaniya Sricharunrat Kannika Phornphutkul Suleeporn Sangrajrang chulabhorn mahidol The Liver Carcinogenesis Section Laboratory of Human CarcinogenesisCenter for Cancer ResearchNational Cancer InstituteBethesdaMDUSA chulabhorn Research Institute BangkokThailand Khon Kaen University Khon KaenThailand Chiang Mai University Chiang MaiThailand chulabhorn Hospital BangkokThailand Rajavej Hospital and Lampang Cancer Center Chiang MaiThailand

Objective:Cancer metabolite profiling(or cancer metabolomics),the global view of the biochemical end products of cellular processes,is a promising approach to identify biomarkers and tumor subgroups,and to understand ... 详细信息

关键词： Global tissue metabolomics

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Hepatocellular carcinoma screening and surveillance in 2293 chronic hepatitis B patients in an endemic area

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World Journal of Gastroenterology 2016年第34期22卷 7806-7812页

作者： Teerapat Ungtrakul chulabhorn mahidol Pattra Chun-on Charlie Laohapand Surachate Siripongsakun Akeanong Worakitsitisatorn Sirachat Vidhayakorn Wariya Boonchuay Jiraporn Dechma Gaidganok Sornsamdang Kamonwan Soonklang Tassanee Sriprayoon Tawesak Tanwandee Chirayu U Auewarakul chulabhorn Hospital Laksi Bangkok 10210 Thailand chulabhorn Research Institute Laksi Bangkok 10210 Thailand Faculty of Medicine Siriraj HospitalMahidol University Bangkoknoi Bangkok 10700 Thailand

AIM To determine the role of screening and surveillance of hepatocellular carcinoma(HCC) in treatment-na?ve chronic hepatitis B(CHB) patients. METHODS We recruited 2293 CHB patients(both males and females; aged 20-65 years). All patients were screened and underwent surveillance using abdominal ultrasonography(AUS) and serum alpha-fetoprotein(AFP) assay every 6 mo. The diagnosis,staging and treatment of HCC followed the American Association for the Study of Liver Diseases practice guidelines and the Barcelona Clinic Liver Cancer guidelines. The exclusion criteria included: decompensated cirrhosis; a history of any cancer in the last 5 years; previous antiviral treatment for CHB; concurrent infection with hepatitis C virus or human immunodeficiency virus; a Karnofsky Performance Status score < 60%; or any medical condition preventing eligibility to complete the protocol. The prevalence and incidence rates of HCC were determined; survival rates were calculated at 3-year post HCC diagnosis. The sensitivity and specificity were calculated on a per-patient *** Among 2293 treatment-na?ve CHB patients,seven cases had HCC at initial screening,giving a prevalence rate of 305 per 100000 persons; 3.3% were diagnosed with liver cirrhosis,all of which were Child-Pugh class A. With a median follow-up time of 42(range,3-48) mo,10 additional cases were diagnosed with HCC,resulting in an incidence rate of 143 per 100000 persons per year. This burden was as high as that reported in other studies from East Asian countries. All HCC patients were aged ≥ 40 years. Most were at an early stage(Stage 0,A or B); 14/17 cases were successfully treated with surgical resection or radiofrequency ablation,with a high 3-year survival rate of 90%. Hemangioma was the most common focal liver lesion in CHB patients detected by AUS; the main causes of AFP elevation at the initial screening were cirrhosis,increased alanine aminotransferase level and HCC. AUS detected 16/17 HCC cases whereas AFP

关键词： Liver cancer Ultrasonography Alpha fetoprotein Early detection Hepatitis B

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Common molecular subtypes among Asian hepatocellular carcinoma and cholangiocarcinoma

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Cancer Biology & Medicine 2018年第S1期15卷 10-11页

作者： Jittiporn Chaisaingmongkol Anuradha Budhu Hien Dang Siritida Rabibhadana Benjarath Pupacdi So Mee Kwon Marshonna Forgues Yotsawat Pomyen Vajarabhongsa Bhudhisawasdi Nirush Lertprasertsuke Anon Chotirosniramit Chawalit Pairojkul Chirayu UAuewarakul Thaniya Sricharunrat Kannika Phornphutkul Suleeporn Sangrajrang Maggie Cam Ping He Stephen M.Hewitt Kris Ylaya Xiaolin Wu Jesper B.Andersen Snorri S.Thorgeirsson Joshua J.Waterfall Yuelin J.Zhu Jennifer Walling Holly S.Stevenson Daniel Edelman Paul S.Meltzer Christopher A.Loffredo Natsuko Hama Tatsuhiro Shibata Robert H.Wiltrout Curtis C.Harris chulabhorn mahidol Mathuros Ruchirawat Xinwei Wang Laboratory of Human Carcinogenesis Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA Laboratory of Chemical Carcinogenesis Chulabhorn Research InstituteBangkokThailand Center of Excellence on Environmental Health and Toxicology Office of Higher Education CommissionMinistry of EducationBangkokThailand Faculty of Medicine Khon Kaen UniversityKhon KaenThailand Faculty of Medicine Chiang Mai UniversityChiang MaiThailand HRH Princess chulabhorn College of Medical Science BangkokThailand chulabhorn Hospital BangkokThailand Rajavej Hospital Chiang MaiThailand National Cancer Institute BangkokThailand Center for Cancer Research National Cancer InstituteBethesdaMarylandUSA FDA Silver SpringMarylandUSA Laboratory of Pathology Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA Frederick National Laboratory for Cancer Research FrederickMarylandUSA Biotech Research and Innovation Center(BRIC) Department of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark Genetics Branch Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA Georgetown University Medical Center WashingtonDCUSA Division of Cancer Genomics National Cancer Center Research InstituteThe University of TokyoTokyoJapan Laboratory of Molecular Medicine Human Genome CenterThe Institute of Medical ScienceThe University of TokyoTokyoJapan Cancer Inflammation Program Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA

Objective:Intrahepatic cholangiocarcinoma(ICC)and hepatocellular carcinoma(HCC)are clinically disparate primary liver cancers with etiological and biological *** Thailand,both cancer types represent the primary cause ... 详细信息

关键词： Common molecular subtypes

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