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Hyperinsulinemic hypoglycemia due to diffuse nesidioblastosis in adults:A case report

World Journal of Gastroenterology 2008年第1期14卷 140-142页

作者： Ran hong Dong-Youl choi Sung-chul Lim Department of Pathology College of Medicine Chosun University GwangiuKorea Research Center for Resistant Cells College of Medicine Chosun University Gwangju Korea

Persistent hyperinsulinemic hypoglycemia is caused most commonly by an insulinoma in adults or by nesidioblastosis in neonates. In adults, nesidioblastosis is a rare disorder characterized by diffuse or disseminated proliferation of islet cells. We recently encountered a case of nesidioblastosis in an adult. A 71-year-old man was admitted due to intermittent general weakness, abdominal pain, and mild dyspnea. The patient underwent a subtotal gastrectomy for a gastric adenocarcinoma two years ago. After 5 d of admission, the patient showed symptoms of cold sweating, chilling, and hypotension 30 min after eating. Thereafter, he frequently showed similar symptoms accounting for hypoglycemia regardless of food consumption. Laboratory findings revealed a low fasting blood glucose level （25 mg/dL）, and a high insulin level （47 μIU/mL）. Selective intra-arterial calcium stimulation with hepatic venous sampling （ASVS） was performed to localize a mass and revealed an increased insulin level about fourfold that of the normal fasting level at 60 s in the splenic artery, which suggested the presence of an insulinoma in the tail of pancreas. A distal pancreatectomy was performed. Neither intraoperative exploration nor a frozen biopsy specimen detected any mass-forming lesion. On the histological examination, many of the islets were enlarged and irregularly shaped in all specimens, the arrangement of which was a Iobulated islet pattern. Cytologically, a considerable subpopulation of endocrine cells showed enlarged and hyperchromatic nuclei. By immunohistochemistry, the cells were identified as p-cells. These clinical, radiological, microscopic and immuno-histochemical findings are consistent with diffuse nesidioblastosis in adults.

关键词： Hyperinsulinemic hypoglycemia Nesidioblastosis Adult

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Food intolerance and skin prick test in treated and untreated irritable bowel syndrome

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World Journal of Gastroenterology 2006年第15期12卷 2382-2387页

作者： Dae-Won Jun Oh-Young Lee ho-Joo Yoon Seok-Hwa Lee Hang-Lak Lee ho-Soon choi Byung-chul Yoon Min-ho Lee Dong-hoo Lee Sang-hoen Cho Department of Internal Medicine College of Medicine Hanyang UniversitySeoulKorea Department of Food and Nutrition College of Human Ecology Hanyang UniversitySeoulKorea Department of Internal Medicine College of Medicine Seoul National UniversitySeoulSouth Korea

AIM： To correlate the clinical features of treated and untreated patients with irritable bowel syndrome （IBS） to the results of skin prick test （SPT） for food and inhalant allergens. METhoDS： We recruited 105 subjects to form three different target groups： treated group （n=44） undergoing treatment for IBS, untreated group （n =31） meeting the Rome Ⅱ criteria without treatment for IBS, control group （n = 30） with no IBS symptoms. RESULTS： SPT results were different among the three groups in which SPT was positive in 17 （38.6%） treated patients, in 5 （16.1%） untreated patients and in 1 （3.3%） control （P〈0.01）. The number of positive SPTs was greater in the IBS group than in the control group （P〈 0.001）. The number of positive food SPTs was higher in the treated IBS group than in the untreated IBS group （P= 0.03）. CONCLUSION： Positive food SPT is higher in IBS patients than in controls.

关键词： Irritable bowel syndrome Skin prick test Food allergy

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Retraction control of motorized seat belt system with linear state observer

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Journal of Central South University 2013年第2期20卷 385-392页

作者： LEE Kang-seok choi Chin-chul LEE Woo-taik Department of Control and Instrumentation Engineering Changwon National University

A design and verification of linear state observers which estimate state information such as angular velocity and load torque for retraction control of the motorized seat belt (MSB) system were described. The motorized seat belt system provides functions to protect passengers and improve passenger's convenience. Each MSB function has its own required belt tension which is determined by the function's purpose. To realize the MSB functions, state information, such as seat belt winding velocity and seat belt tension are required. Using a linear state observer, the state information for MSB operations can be estimated without sensors. To design the linear state observer, the motorized seat belt system is analyzed and represented as a state space model which contains load torque as an augmented state. Based on the state space model, a linear state observer was designed and verified by experiments. Also, the retraction control of the MSB algorithm using linear state observer was designed and verified on the test bench. With the designed retraction control algorithm using the linear state observer, it is possible to realize various types of MSB functions.

关键词： motorized seat belt system motorized seat belt (MSB) system linear state observer state space model augmented state retraction control

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Development of vehicle-recognition method on water surfaces using LiDAR data:SPD^(2)(spherically stratified point projection with diameter and distance)

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Defence Technology（防务技术） 2024年第6期36卷 95-104页

作者： Eon-ho Lee Hyeon Jun Jeon Jinwoo choi Hyun-Taek choi Sejin Lee The Department of Mechanical Engineering Kongju National University1223-24 Cheonan-daeroCheonan 31080Republic of Korea Ocean System Engineering Research Division Korea Research Institute of Ships and Ocean Engineering(KRISO)Daejeon 34103Republic of Korea The Division of Mechanical&Automotive Engineering Kongju National University1223-24 Cheonan-daeroCheonan 31080Republic of Korea

Swarm robot systems are an important application of autonomous unmanned surface vehicles on water *** monitoring natural environments and conducting security activities within a certain range using a surface vehicle,the swarm robot system is more efficient than the operation of a single object as the former can reduce cost and save *** is necessary to detect adjacent surface obstacles robustly to operate a cluster of unmanned surface *** this purpose,a LiDAR(light detection and ranging)sensor is used as it can simultaneously obtain 3D information for all directions,relatively robustly and accurately,irrespective of the surrounding environmental *** the GPS(global-positioning-system)error range exists,obtaining measurements of the surface-vessel position can still ensure stability during platoon *** this study,a three-layer convolutional neural network is applied to classify types of surface *** aim of this approach is to redefine the sparse 3D point cloud data as 2D image data with a connotative meaning and subsequently utilize this transformed data for object classification ***,we have proposed a descriptor that converts the 3D point cloud data into 2D image *** use this descriptor effectively,it is necessary to perform a clustering operation that separates the point clouds for each *** developed voxel-based clustering for the point cloud ***,using the descriptor,3D point cloud data can be converted into a 2D feature image,and the converted 2D image is provided as an input value to the *** intend to verify the validity of the proposed 3D point cloud feature descriptor by using experimental data in the ***,we explore the feasibility of real-time object classification within this framework.

关键词： Object classification Clustering 3D point cloud data LiDAR(light detection and ranging) Surface vehicle

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Enhanced photocatalytic degradation of lindane using metal–semiconductor Zn@ZnO and ZnO/Ag nanostructures

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Journal of Environmental Sciences 2018年第12期30卷 107-115页

作者： Hyeon Jin Jung Ravindranadh Koutavarapu Seulki Lee Ju Hyun Kim Hyun chul choi Myong Yong choi Department of Chemistry (BK21+) and Research Institute of Natural Science Gyeongsang National University Department of Chemistry Chonnam National University

To achieve enhanced photocatalytic activity for the degradation of lindane, we prepared metal–semiconductor composite nanoparticles（NPs）. Zn@ZnO core–shell（CS） nanocomposites, calcined ZnO, and Ag-doped ZnO（ZnO/Ag） nanostructures were prepared using pulsed laser ablation in liquid, calcination, and photodeposition methods, respectively, without using surfactants or catalysts. The as-prepared catalysts were characterized by using X-ray diffraction（XRD）, field-emission scanning electron microscopy, high-resolution transmission electron microscopy, ultraviolet–visible（UV–vis） spectroscopy, and photoluminescence spectroscopy. In addition, elemental analysis was performed by energy dispersive X-ray spectroscopy. The obtained XRD and morphology results indicated good dispersion of Zn and Ag NPs on the surface of the ZnO nanostructures. Investigation of the photocatalytic degradation of lindane under UV–vis irradiation showed that Zn@ZnO CS nanocomposites exhibit higher photocatalytic activity than the other prepared samples. The maximum degradation rate of lindane was 99.5% in 40 min using Zn@ZnO CS nanocomposites. The radical trapping experiments verified that the hydroxyl radical（·OH） was the main reactive species for the degradation of lindane.

关键词： Zn@ZnO ZnO/Ag Lindane Pulsed laser ablation in liquid Photocatalysis

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Promoter hypermethylation and loss of CD133 gene expression in colorectal cancers

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World Journal of Gastroenterology 2010年第25期16卷 3153-3160页

作者： You-Kyung Jeon Sung-Hee Kim Seung-ho choi Kyung-Hee Kim Byong-chul Yoo Ja-Lok Ku Jae-Gahb Park Laboratory of Cell Biology Cancer Research Institute Seoul National University College of Medicine Seoul 110-799 South Korea Colorectal Cancer Branch Research Institute National Cancer Center Goyang 411-764 Gyeonggi South Korea

AIM: To understand CD133 promoter hypermethyl-ation and expression in 32 colorectal cancer cell lines. METhoDS: Nucleic acid was isolated from 32 colorectal cancer cell lines and CD133 expression levels were measured by reverse transcription-polymerase chain reaction (RT-PCR) and real-time PCR. Promoter methylation status of the CD133 gene was analyzed with a methylation-specific PCR after sodium-bisulfi te modification and by clonal sequencing analysis. The correlation between expression and promoter methylation of CD133 gene was confirmed with treatment of 5-aza-2’-deoxycytidine. RESULTS: We measured CD133 expression levels in 32 colorectal cancer cell lines. RT-PCR analysis showed undetectable or low levels of CD133 expression in 34.4%of cell lines. To verify the relation between CD133 expression and methylation status of the CD133 gene promoter in colorectal carcinogenesis, CD133 gene promoter hypermethylation was analyzed in 32 cancer cell lines. Promoter hypermethylation was detected in 13 (40.6%) of the cell lines using methylation specificPCR and confirmed by bisulfite sequencing analysis. Treatment of 11 of the cell lines with the demethylation agent 5-aza-2’-deoxycytidine recovered CD133 expression in most of them. CONCLUSION: Transcriptional repression of CD133 is caused by promoter hypermethylation of the CD133 CpG islands in some of colorectal cancer cell lines. The study may contribute to the understanding of the role of CD133 inactivation in the progression of colorectal cancers.

关键词： CD133 Promoter Hypermethylation Colorectal cancer Sodium bisulfite modification

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Interplay between Plants and Microbial Communities:Insights from holobionts and Environmental Interactions

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Phyton-International Journal of Experimental Botany 2024年第10期93卷 2519-2534页

作者： Sejin choi ho-Seok Lee Department of Biology College of SciencesKyung Hee UniversitySeoul02447Republic of Korea Center for Genome Engineering Institute for Basic ScienceDaejeon34126Republic of Korea

Plants interact with a complex network of microorganisms,forming a dynamic holobiont that is crucial for their health,growth,and *** interconnected system is deeply influenced by environmental factors,which modulate the relationships within the plant *** environmental drivers such as light,temperature,and moisture can alter the balance of these interactions,impacting plant immunity,resilience,and overall *** traditional disease triangle model,which emphasizes plant-pathogen-environment interactions,is enhanced by incorporating the role of the microbiome,revealing how microbial communities contribute to disease *** review highlights the importance of shifting focus from studying plants in isolation to embracing an integrated approach that accounts for the intricate interactions between plants,microbes,and their surrounding *** these interactions is pivotal as we explore new approaches,including advanced sequencing technologies and microbiome engineering,to optimize plant-microbe relationships for improved crop *** insights are vital for developing sustainable agricultural practices to address the impacts of climate change and other environmental challenges.

关键词： holobiont disease triangle plant-associated microbiome temperature moisture circadian clock

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Possibility of Solid Hydrometeor Growth Zone Identification Using Radar Spectrum Width

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Advances in Atmospheric Sciences 2023年第2期40卷 317-332页

作者： Sung-ho SUH Eun-ho choi hong-Il KIM Woonseon JUNG Flight Safety Technology Division NARO Space CenterKorea Aerospace Research Institute(KARI)508 Haban-roBongrae-myeonGoheung-gunJeollanam-do 59571Republic of Korea Research Applications Department National Institute of Meteorological Sciences33Seohobuk-roSeoqwipo-siJeju-do 63568Republic of Korea

In this study,the correlation between simulated and measured radar velocity spectrum width(σ_(v))is *** results show that the dendrites growth zones(DGZs)and needles growth zones(NGZs)mostly contain dendrites(DN)and needles(NE),***σ_(v) zones(1.11.2 m s^(-1),a differential reflectivity(ZDR)higher than 0 dB,and a cross-correlation coefficient(ρhv)less than *** contrast,prolate particles with relatively uniform shapes were observed in the NGZ withσ_(v)how that the DN exhibited a largerσ_(v) compared to the NE,and this observedσ_(v) was strongly dependent on the wind fluctuations(v’)due to turbulence or wind *** contrast,the NE exhibited a significantly smallσ_(v)~0.55 m s^(-1),which converges irrespective of v’.In addition,a strong correlation between the measuredσ_(v) values at five radar elevation angles(θ=6.2°,9.1°,13.1°,19°,and 80°)and those simulated in this study confirmed the significance of the analysis results.

关键词： spectrum width weather radar aerodynamic properties dendritic growth zone hydrometeor classifications

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Experience of limited pancreatic head resection for management of branch duct intraductal papillary mucinous neoplasm in a single center

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World Journal of Gastroenterology 2009年第23期15卷 2904-2907页

作者： Kwang Yeol Paik Seong ho choi Department of Surgery Kepco Medical Foundation Hanil General Hospital #388-1 Ssangmoon-Dong Dobong-Gu Seoul 132-033 South Korea Department of Surgery Samsung Medical Center College of Medicine Sungkyunkwan University #50 Irwon-Dong Gangnam-Gu Seoul 135-710 South Korea

AIM: To share our surgical experience and the outcome of limited pancreatic head resection for the management of branch duct intraductal papillary mucinous neoplasm (IPMN). METhoDS: Between May 2005 and February 2008, nine limited pancreatic head resections (LPHR) were performed for IPMN of the pancreatic head. We reviewed the nine patients, retrospectively. RESULTS: Tumor was located in the uncinate process of the pancreas in all nine patients. Three patients had stents inserted in the main pancreatic duct due to injury. The mean size of tumor was 28.4 mm. Postoperative complications were found in f ive patients: 3 pancreatic leakages, a pancreatitis, and a duodenal stricture. Pancreatic leakages were improved by external drainage. No perioperative mortality was observed and all patients are recorded alive during the mean follow-up period of 17.2 mo. CONCLUSION: In selected patients after careful evaluation, LPHR can be used for the treatment of branch duct type IPMN. In order to avoid pancreatic ductal injury, preand intra-operative defi nite localization and careful operative techniques are required.

关键词： Limited pancreatic head resection Branchduct type Intraductal papillary mucinous neoplasm

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3D printed energy devices:generation,conversion,and storage

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Microsystems & Nanoengineering 2024年第4期10卷 23-41页

作者： Jin-ho Son hongseok Kim Yoonseob choi howon Lee Department of Mechanical Engineering Institute of Advanced Machines and DesignSeoul National UniversitySeoulRepublic of Korea

The energy devices for generation,conversion,and storage of electricity are widely used across diverse aspects of human life and various ***-dimensional(3D)printing has emerged as a promising technology for the fabrication of energy devices due to its unique capability of manufacturing complex shapes across different length scales.3D-printed energy devices can have intricate 3D structures for significant performance enhancement,which are otherwise impossible to achieve through conventional manufacturing ***,recent progress has witnessed that 3D-printed energy devices with micro-lattice structures surpass their bulk counterparts in terms of mechanical properties as well as electrical *** existing literature focuses mostly on specific aspects of individual printed energy devices,a brief overview collectively covering the wide landscape of energy applications is *** review provides a concise summary of recent advancements of 3D-printed energy *** classify these devices into three functional categories;generation,conversion,and storage of energy,offering insight on the recent progress within each ***,current challenges and future prospects associated with 3Dprinted energy devices are discussed,emphasizing their potential to advance sustainable energy solutions.

关键词： 3D printing 3D-printed energy device Energy generation device Energy conversion device Energy storage device

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