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Nano Research 2019年第10期12卷 2568-2575页

作者： Jin Hee Lee Hack-Keun Lee Dong Hyun Chun Hyunkyung Choi Geun Bae Rhim Min Hye Youn Heondo Jeong Shin Wook Kang Jung-ll Yang Heon Jung chui sung kim Ji Chan Park Clean Fuel Laboratory Korea Institute of Energy ResearchDaejeon 34129Republic of Korea Department of Chemical Engineering University of SeoulSeoul 02504Republic of Korea Advanced Energy and System Technology University of Science and TechnologyDaejeon 34113Republic of Korea Department of Physics Kookmin UniversitySeoul 02707Republic of Korea

Iron-based nan oparticles with un iform and high particle dispersi on,which are supported on carb on structures,have been used for various ***,their preparation still suffers from complicated synthesis involving multiple steps and from the high price of precursors and solve *** the prese nt work,a new carbon en capsulated iron-carbide nano particle supported on n itroge rvdoped porous carbon(Fe5C2@C/NPC)structure was *** was made using a simple solid-state reaction with sequential thermal ***5C2@C/NPC is a highly active and stable catalyst for the high-temperature Fischer-Tropsch synthesis *** showed very high hydrocarbon productivity(4.71 gHc gcat^-1·h^-1)with high CO conversions(up to 96%).

关键词： iron-carbide one-pot synthesis nitrogen-doped graphene Fischer-Tropsch synthesis Mdssbauer spectroscopy

Analysis of piezoelectric ceramic multilayer actuators based on an electro-mechanical coupled meshless method

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Acta Mechanica Sinica 2006年第1期22卷 34-39页

作者： Xianghua Guo Daining Fang Ai Kah Soh Hyun chui kim Jung Ju Lee Department of Engineering Mechanics Tsinghua UniversityBeijing 100084 China Department of Mechanical Engineering The University of Hong KongHong Kong China Department of Mechanical Engineering KAISTTaejon 305-701 Korea

This paper presents an efficient meshless method for analyzing cracked piezoelectric structures subjected to mechanical and electrical loading. In this method, an element free Galerkin （EFG） formulation, an enriched basic function and some special shape functions that contain discontinuous derivatives are employed. Based on the moving least squares （MLS） interpolation approach, the EFG method is one of the promising methods for dealing with problems involving progressive crack growth. Since the method is meshless and no element connectivity data are needed, the burdensome remeshing procedure required in the conventional finite element method （FEM） is avoided. The numerical results show that the proposed method can yield an accurate near-tip stress field in an infinite piezoelectric plate containing an interior hole. In another example studying a ceramic multilayer actuator, the proposed model was found to be accurate in the simulation of stress and electric field concentrations arround the abrupt end of an internal electrode.

关键词： Meshfree method Ceramic multilayeractuator Electro-mechanical coupling

A novel chitosan nanocapsule for enhanced skin penetration of cyclosporin A and effective hair growth in vivo

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Nano Research 2019年第12期12卷 3024-3030页

作者： Jin Sil Lee Youngmin Hwang Hyeryeon Oh sunghyun kim Jin-Hwa kim Jeung-Hoon Lee Yong chui Shin Giyoong Tae Won II Choi Center for Convergence Bioceramic Materials Convergence R&D DivisionKorea Institute of Ceramic Engineering and Technology202Osongsaengmyeong l-rof Osong-eupHeungdeok-guCheongjuChungbuk 28160Republic of Korea School of Materials Science and Engineering Gwangju Institute of Science and Technology123 Cheomdan-gwagiroBuk-guGwangju 61005Republic of Korea SKINMED Co. Ltd.Daejeon 34028Republic of Korea Amicogen Inc.64 Dongburo 1259JinsungJinju 52621Republic of Korea

Hair loss due to medical conditions,such as alopecia,male pattern baldness,and cancer chemotherapy treatment,has been a comm onproblem for many in *** n A(CsA),a fungal metabolite,has been reported to be a hair growth modulatory agent and is apotential drug for hair ***,the effect of topical application of CsA is limited by its poor water *** deliverysystems developed to enhance its solubility still showed poor skin *** overcome these limitations,in this study,we have developed a novel chitosan nanocapsule platform using Pluro nic F127 and chitosan without any chemical crosslinking or complicated preparati on steps for the enhanced water solubility and high tran sdermal penetration of *** chitosan nanocapsules(ChiNCs)optimized in terms of structural stability by using chitosan with various molecular weights ranging from 3 to 100 kDa enhanced the skin permeation of CsA through humancadaver skin in *** administration of the CsA loaded ChiNCs in creased the hair follicles by c.a.7 times higher than that of thecontrol group,and effectively induced hair growth in C57BL/6 mice in *** results suggest that ChiNCs could be used as a platform foreffective transdermal delivery of various hydrophobic drugs.

关键词： chitosan nanocapsule cyclosporin A transdermal delivery hair growth

The current status of hormone treatment for prostate cancer patients in Korean real-world practice:a multi-institutional observational study

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Asian Journal of Andrology 2019年第2期21卷 115-120页

作者： Jung Kwon kim Jung Jun kim Taek Won Gang Tae Kyun Kwon Hong Sup kim Seung chui Park Jae-Shin Park Jong-Yeon Park Seok Joong Yoon Youn-Soo Jeon Jin Seon Cho Kwan Joong Joo sung-Hoo Hong Seok-Soo Byun the Korean Urological Oncology Society Department of Urology Seoul National University Bundang HospitalSeongnam 13620Korea Department of Urology Hallym University Sacred Heart HospitalAnyang 14068Korea Department of Urology Kangbuk Samsung HospitalSeoul 03181Korea Department of Urology Seoul St.Mary HospitalSeoul 06591Korea 不详 Department of Urology Chonnam National University HospitalGwangju 61469Korea School of Medicine Kyungpook National University Medical CenterDaegu 41404Korea Department of Urology Konkuk University Medical CenterSeoul 05080Korea Department of Urology Wonkwang University HospitalIksan 54538Korea Department of Urology Daegu Catholic University Medical CenterDaegu 41911Korea Department of Urology Ulsan UniversityGangneung Asan HospitalGangneung 25440Korea Department of Urology Chungbuk National University HospitalCheongju 28644Korea Department of Urology Soonchunhyang University HospitalCheonan 31151Korea

We aimed to evaluate the current nationwide trend,efficacy,safety,and quality of life(QoL)profiles of hormone treatment in real-world practice settings for prostate cancer(PCa)patients in Korea.A total of 292 men with any biopsy-proven PCa(TanyNanyMany)from 12 institutions in Korea were included in this multi-institutional,observational study of prospectively collected *** luteinizing hormone-releasing hormone(LHRH)agonists were allowed to be investigational *** was defined as(1)the rate of castration(serum testosterone≤50 ng dl^-1)at 4-week visit and(2)breakthrough(serum testosterone>50 ng dl^-1 after castration).Safety assessments included routine examinations for potential adverse events,laboratory tests,blood pressure,body weight,and bone min era I density(BMD,at baseli ne and at the last follow-up visit).QoL was assessed using the Expa nded Prostate Cancer Index Composite-26(EPIC-26).The most comm on initial therapeutic regimen was LHRH agonist with an ti-androge n(78.0%),and the most commonly used LHRH agonist for combination and mono therapy was leuprolide(64.0%for combi natio n and 58.0%for monotherapy).The castration and breakthrough rates were 78.4%and 6.6%,*** laboratory results related to dyslipidemia worsened after 4 weeks of hormone *** addition,the mean BMD T-score was significantly lower at the last follow-up(mean:-1.950)compared to baseline(mean:-0.195).The mean total EPIC-26 score decreased from 84.8(standard deviation[s.d.]:12.2)to 78.3(s.d.:8.1),with significant deterioration only in the urinary domain(mean:23.5 at baseli ne and 21.9 at the 4-week visit).These findi ngs dem on strate the n ationwide trend of current practice setti ngs in hormone treatment for PCa in Korea.

关键词： efficacy hormonal treatment Korean population prostate cancer safety trend

The effects of single versus combined therapy using LIM-kinase 2 inhibitor and type 5 phosphodiesterase inhibitor on erectile function in a rat model of cavernous nerve injury-induced erectile dysfunction

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Asian Journal of Andrology 2019年第5期21卷 493-500页

作者： Min chui Cho Junghoon Lee Juhyun Park Sohee Oh Ji Sun Chai Hwancheol Son Jae-Seung Paick Soo Woong kim Department of Urology Seoul National University College of MedicineSMG-SNU Boramae Medical CenterSeoul 07061Korea Department of Urology Seoul National University College of MedicineSeoul National University HospitalSeoul 03080Korea Department of Biostatistics Seoul National University College of MedicineSMG-SNU Boramae Medical CenterSeoul 07061Korea

We aimed to determine whether combination of LIM-kinase 2 inhibitor(LIMK2i)and phosphodiesterase type-5 inhibitor(PDE5i)could restore erectile function through suppressing cavernous fibrosis and improving caver nous apoptosis in a rat model of cavernous nerve crush injury(CNCI).Seventy 12-week-old Sprague-Dawley rats were equally distributed into five groups as follows:(1)sham surgery(Group S),(2)CNCI(Group I),(3)CNCI treated with daily intraperitoneal administration of 10.0 mg kg^-1 LIMK2i(Group I+L),(4)daily oral administration of 20.0 mg kg-1 udenafil,PDE5i(Group I+U),and(5)combined administration of 10.0 mg kg^-1 LIMK2i and 20.0 mg kg^-1 udenafil(Group I+L+U).Rats in Groups I+L,I+U,and I+L+U were treated with respective regimens for 2 weeks after *** 2 weeks after surgery,erectile response was assessed using *** tissues were processed for histological studies and western *** I showed lower intracavernous pressure(ICP)/mean arterial pressure(MAP),lower area under the curve(AUC)/MAP,decreased immunohistochemical staining for alpha-smooth muscle(SM)actin,higher apoptotic index,lower SM/collagen ratio,increased phospho-LIMK2-positive fibroblasts,decreased protein kinase B/endothelial nitric oxide synthase(Akt/eNOS)phosphorylation,increased LIMK2/cofilin phosphorylation,and increased protein expression of fibronectin,compared to Group *** all three treatment groups,erectile responses,protein expression of fibronectin,and SM/collagen ratio were *** I+L+U showed greater improvement in erectile response than Group I+*** content and apoptotic index in Groups I+U and I+L+U were improved compared to those in Group ***,Group I+L did not show a significant improvement in SM content or apoptotic *** number of phospho-LIMK2-positive fibroblasts was normalized in Groups I+L and I+L+U,but not in Group I+***/eNOS phosphorylation was improved in Groups I+U and I+L+U,but not in Group I+***2/cofilin phosphorylation was i

关键词： apoptosis erectile dysfunction fibrosis LIM kinase phosphodiesterase

Novel N-heteroaromatic dyes for textile substrates

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Chinese Chemical Letters 2014年第8期25卷 1165-1168页

作者： kim-Hung Lam Sarah Sze-Wah Ho Pik-Ling Lam Johnny Cheuk-On Tang Zhao-Xiang Bian Albert Sun-Chi Chan Hua Li Wai-Yeung Wong Chung-Hin chui Department of Applied Biology and Chemical Technology Institute of Textile and Clothing The Hong Kong Polytechnic University Clinical Division School of Chinese Medicine Hong Kong Baptist University Institute of Molecular Functional Materials Department of Chemistry and Institute of Advanced Materials Hong Kong Baptist University College of Life and Environmental Sciences Minzu University of China HKBU Institute of Research and Continuing Education Shenzhen Virtual University Park

This study reports the synthesis and characterization of quinoline derivatives. The synthesized quinoline compounds were applied to the dyeing treatment of acrylic fabrics. The color fastness to washing and light of quinoline compound-dyed fabrics was examined. Human skin HaCaT cell line was also used for the skin cytotoxicity evaluation of the quinoline compound-dyed acrylic fabrics.

关键词： Acrylic fabrics Fluorescent Quinoline dyes Skin cytotoxicity

A Current Bleeding CMOS Mixer Featuring <i>LO</i>Amplification Based on Current-Reused Topology

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Circuits and Systems 2013年第1期4卷 58-66页

作者： Wah Ching Lee kim Fung Tsang Yi Shen Kwok Tai chui Department of Electronic & Information Engineering The Hong Kong Polytechnic University Hong Kong China&Department of Electronic Engineering City University of Hong Kong Hong Kong China Department of Electronic Engineering City University of Hong Kong Hong Kong China

A double balanced Gilbert-cell class-A amplifier bleeding mixer (DBGC CAAB mixer) is proposed and implemented. The injection current is utilized to amplify the local oscillator (LO) signal to improve the performance of the transconductor stage. The DBGC CAAB mixer achieves a conversion gain of 17.5 dB at -14 dBm LO power, and the noise figure is suppressed from 45 dB to 10.7 dB. It is important to stress that the new configuration will not drain additional power in contrast to the former current bleeding mixers. This topology dramatically relieves the requirement of the LO power. The DBGC CAAB mixer is implemented by using 0.18-μm RFCMOS technology and operates at the 2.4 GHz ISM application with 10 MHz intermediate frequency. The power consumption is 12 mA at 1.5 V supply voltage. The DBGC CAAB mixer features the highest FOM figure within a wide range of LO power.

关键词： Mixer Gilbert-Cell Current Bleeding Noise Conversion Gain Current-Reuse Class-A Amplifier

A WiFi-ZigBee Building Area Network Design of High Traffics AMI for Smart Grid

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Smart Grid and Renewable Energy 2012年第4期3卷 324-333页

作者： Hoi Yan Tung kim Fung Tsang Hoi Ching Tung Veseline Rakocevic Kwok Tai chui Yat Wah Leung 1Department of Electronic Engineering City University of Hong Kong Hong Kong China Department of Electronic Engineering City University of Hong Kong Hong Kong China Department of SEEM City University of Hong Kong Hong Kong China. School of Engineering & Mathematical Science City University London London UK

A WiFi-ZigBee hybrid BAN solution, namely WiZBAN, is proposed and implemented to cater for the development of high traffic AMI for smart grid application. It is important to highlight that the major challenge of WiZBAN is to handle the high density environment which results in heavy traffic loading and weak signal propagation. To overcome the captioned problem, Vertical Backbone Communication (VBC) and Horizontal Floor Communication (HFC) are defined for WiZBAN. The WiZBAN consists of WiZBAN Gateway (WiZGW), WiZBAN Meter Hub (WiZBAN) and WiZBAN In Home Display (WiZIHD) which caters for the smart grids services including smart metering and demand response. The WiZGW is the entrance of WiZBAN and connects WiZBAN to utilities. The WiZGW also teams up with WiZMH to enables VBC. On the other hand, WiZMH serves as the interception point of VBC and HFC. It interacts with smart meters and sets up the HFC together with WiZIHD to provide the user interface for end users. To shorten the transmission time, WiFi is adopted for VBC while ZigBee is applied to HCF to overcome the weak signal propagation. To investigate the performance of WiZBAN, a case study has been conducted based on an existing 23 floor residential building. From the measured and simulated results, the average round trip delay of demand response and smart metering are found to be 0.6 s and 9 s respectively.

关键词： Advance Metering Infrastructure Building Area Network WiFi ZigBee Delay

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乳牙根折后非典型牙根吸收

中国口腔医学继续教育杂志 2019年第5期22卷 282-285页

作者： Ok Hyung Nam Mi Sun kim Gyu-Tae kim sung chui Choi 刘佳(译) 黄徐静(译) 赵玮(审) 不详中山大学光华口腔医学院·附属口腔医院儿童口腔科广东省广州市510055

非典型牙根吸收(ARR)是指出现在上颌乳切牙牙根侧面和/或根尖表面的浅层环状吸收。本病例报告对6例乳切牙根折后出现非典型牙根吸收的患者进行了纵向观察。非典型牙根吸收与病理性牙根吸收具有不同的特点。

关键词：牙根吸收非典型牙根折上颌乳切牙病例报告 ARR 病理性

The complex of Fas-associated factor 1 with Hsp70 stabilizes the adherens junction integrity by suppressing RhoA activation

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Journal of Molecular Cell Biology 2022年第6期14卷 14-29页

作者： Soonhwa Song Joon Kyu Park Sang chui Shin Jae-Jin Lee Seung Kon Hong In-Kang Song Bokyung kim Eun Joo Song Kong-Joo Lee Eunice EunKyeong kim Graduate School of Pharmaceutical Sciences College of PharmacyEwha Womans UniversitySeoul 03760Republic of Korea Biomedical Research Institute Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Technology Support Center Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

Fas-associated factor 1 (FAF1) is a scaffolding protein that plays multiple functions, and dysregulation of FAF1 is associated withmany types of diseases such as cancers. FAF1 contains multiple ubiquitin-related domains (UBA, UBL1, UBL2, UAS, and UBX), eachdomain interacting with a specific partner. In particular, the interaction of UBL1 with heat shock protein 70 (Hsp70) is associatedwith tumor formation, although the molecular understanding remains unknown. In this study, the structural analysis revealed thatHis160 of FAF1 is important for its interaction with Hsp70. The association of Hsp70 with FAF1 is required for the interaction withIQGAP1. FAF1 negatively regulates RhoA activation by FAF1–Hsp70 complex formation, which then interacts with IQGAP1. Thesesteps play a key role in maintaining the stability of cell-to-cell junction. We conclude that FAF1 plays a critical role in the structureand function of adherens junction during tissue homeostasis and morphogenesis by suppressing RhoA activation, which induces theactivation of Rho-associated protein kinase, phosphorylation of myosin light chain, formation of actin stress fiber, and disruptionof adherens junction. In addition, depletion of FAF1 increased collective invasion in a 3D spheroid cell culture. These results provideinsightinto how the FAF1–Hsp70 complex acts as a novelregulator ofthe adherens junction integrity. The complex can be a potentialtherapeutic target to inhibit tumorigenesis and metastasis.

关键词： human Fas-associated factor 1(FAF1) heat shock protein 70(Hsp70) adherens junction RhoA activation IQGAP1 X-ray crystallography FAF1–Hsp70 complex