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Antifouling and antimicrobial cobaltocenium-containing metallopolymer double-network hydrogels

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Biomaterials Translational 2022年第2期3卷 162-171页

作者： Hui Li Peng Yang JiHyeon Hwang Parasmani Pageni Alan W.Decho chuanbing tang Department of Chemistry and Biochemistry University of South CarolinaColumbiaSCUSA School of Chemistry and Chemical Engineering University of JinanJinanShandong ProvinceChina Department of Environmental Health Sciences Arnold School of Public HealthUniversity of South CarolinaColumbiaSCUSA

Compared with single-network hydrogels,double-network hydrogels offer higher mechanical strength and *** useful functions into double-network hydrogels can expand the portfolios of the *** report the preparation of double-network metallopolymer hydrogels with remarkable hydration,antifouling,and antimicrobial *** cationic hydrogels are composed of a first network of cationic cobaltocenium polyelectrolytes and a second network of polyacrylamide,all prepared via radical *** were further installed into the hydrogels via ion-complexation with metal *** hydrogels exhibited significantly enhanced hydration,compared with polyacrylamide-based hydrogels,while featuring robust mechanical *** metallopolymer hydrogels exhibited strong antifouling against oppositely charged *** antibiotic-loaded hydrogels demonstrated a synergistic effect on the inhibition of bacterial growth and antifouling of bacteria,as a result of the unique ion complexation of cobaltocenium cations.

关键词： antimicrobial cobaltocenium double network hydrogel metallopolymer

Facially amphiphilic polyionene biocidal polymers derived from lithocholic acid

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Bioactive Materials 2018年第2期3卷 186-193页

作者： Mitra S.Ganewatta Md Anisur Rahman Louis Mercado Tinom Shokfai Alan W.Decho Theresa M.Reineke chuanbing tang Department of Chemistry and Biochemistry University of South CarolinaColumbiaSC 29208USA Department of Environmental Health Sciences Arnold School of Public HealthUniversity of South CarolinaColumbiaSC 29208USA Department of Chemistry University of Minnesota-Twin Cities207 Pleasant Street SEMinneapolisMN 55455USA

Bacterial infections have become a global issue that requires urgent attention,particularly regarding to emergence of multidrug resistant *** developed quaternary amine-containing antimicrobial poly(bile acid)s that contain a hydrophobic core of lithocholic acid in the ***,by choosing appropriate monomers,these cationic polymers can form core-shell *** polymers exhibited biocidal activity against both Gram-positive and Gram-negative bacterial *** is demonstrated that the micelles can deliver hydrophobic antibiotics that functionally have dual antimicrobial *** assays against HeLa cells showed dosage-dependent toxicity for polymers with longer linkers.

关键词： Antimicrobial polymers Bile acid Quaternary ammonium Lithocholic acid Polyionene Facial amphiphilicity

Facial amphiphilicity index correlating chemical structures with antimicrobial efficacy

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Bioactive Materials 2023年第2期20卷 519-527页

作者： Leman Buzoglu Kurnaz Yuanyuan Luo Xiaoming Yang Amjed Alabresm Ryan Leighton Rani Kumar JiHyeon Hwang Alan W.Decho Prakash Nagarkatti Mitzi Nagarkatti chuanbing tang Department of Chemistry and Biochemistry University of South CarolinaColumbiaSC29208United States Department of Pathology Microbiology and ImmunologyUniversity of South CarolinaSchool of MedicineColumbiaSC29209United States Department of Environmental Health Sciences University of South CarolinaColumbiaSC29208United States

Facial amphiphilicity is an extraordinary chemical structure feature of a variety of antimicrobial peptides and *** efforts have been dedicated to small molecular,macromolecular and dendrimer-like systems to mimic this highly preferred structure or conformation,including local facial amphiphilicity and global *** work conceptualizes Facial Amphiphilicity Index(FAI)as a numerical value to quantitatively characterize the measure of chemical compositions and structural features in dictating antimicrobial *** is a ratio of numbers of charges to rings,representing both compositions of hydrophilicity and *** derivatives of multicyclic compounds were evaluated as model systems for testing antimicrobial selectivity against Gram-negative and Gram-positive *** monocyclic and bicyclic compounds are non-antimicrobial regardless of *** efficacy was observed with systems having larger cross-sectional areas including tricyclic abietic acid and tetracyclic bile *** low and high FAIs respectively lead to higher and lower antimicrobial efficacy,in consideration of cytotoxicity,the sweet spot is typically suited with intermediate FAIs for each specific *** can be well explained by the synergistic hydrophobic-hydrophobic and electrostatic interactions with bacterial cell membranes and the difference between bacterial and mammalian cell *** adoption of FAI would pave a new avenue toward the design of next-generation antimicrobial macromolecules and peptides.

关键词： Antimicrobial Facial amphiphilicity Chemical structure Peptide

Facial Amphiphilicity as a Robust Chemical Feature for Antimicrobials

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Facial Amphiphilicity as a Robust Chemical Feature for Antim...

ASTF2023（第五届）抗菌科学与技术论坛

作者： Leman B.Kurnaz Swagatam Barman chuanbing tang Department of Chemistry and Biochemistry University of South Carolina

Facial amphiphilicity is a chemical structure feature of many antimicrobial *** structure manifests with a global segregation of cationic moieties and lipophilic components,a highly preferred conformation for peptides to interact with *** we conceptualized Facial Amphiphilicity Index(FAI) as a numerical value to quantitatively characterize the measure of chemical compositions and structural features in dictating antimicrobial *** have dedicated efforts to make various(macro)molecular systems to mimic this highly preferred structure or conformation,including local facial amphiphilicity and global *** this presentation,I will discuss the design of facial amphiphilicity for small molecules and polymers for the treatment of both Gram-negative bacteria and *** of action will be *** facial amphiphiles are potentially a new class of potent antimicrobial agents to tackle the antimicrobial resistance for both planktonic and biofilm-related infections.

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茂金属基侧链高分子:可控合成与应用

茂金属基侧链高分子:可控合成与应用

南京国民政府初期农村高利贷研究——以河北省为例（1927—1937年）

中国化学会第30届学术年会-第二十四分会：超分子组装与软物质材料

作者：闫毅 chuanbing tang 西北工业大学理学院应用化学系陕西省西安市长安区西北工业大学 Department of Chemistry and Biochemistry University of South Carolina

金属高分子([Metal-containing Polymers,MCPs)是指结构中含有金属原子/离子的一类大分子。由于金属元素优异的氧化还原、变色、生物活性、催化等性质,[MCPs吸引了越来越多研究者的关注。一般而言,MCPs的构筑方法有两种:一是通过超分子... 详细信息

金属高分子([Metal-containing Polymers,MCPs)是指结构中含有金属原子/离子的一类大分子。由于金属元素优异的氧化还原、变色、生物活性、催化等性质,[MCPs吸引了越来越多研究者的关注。一般而言,MCPs的构筑方法有两种:一是通过超分子相互作用构筑MCPs的超分子高分子;另外一种就是可聚合基团修饰的金属配合物的直接聚合。对于后者,研究较多的就是含茂金属,尤其是二茂铁的聚合物(如Figure 1所示)。这类聚合物不仅表现出有趣的超分子组装行为,而且在生物、光电、医药等领域有着潜在的应用。然而,由于茂金属/茂金属离子合成化学方面的限制,其他含茂金属(比如二茂钌)和茂金属离子(比如二茂钴离子和二茂铑离子)聚合物的研究鲜见报道。在本报告中,我们将详细介绍含二茂钌、二茂钴离子、二茂铑离子以及半茂金属MCPs的可控聚合制备,并将介绍其在刺激响应自组装、非均相催化和生物医学等方面的应用。

关键词：可控聚合金属高分子茂金属茂金属离子

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金融理论探索 2019年第4期 73-80页

作者：唐传炳安徽大学历史系

南京国民政府初期,河北省战乱迭起、土匪肆虐,地主租税盘剥、政府苛捐杂税,婚丧嫁娶礼俗的铺张浪费,以及家庭副业的衰落都造成了高利贷在农村广泛存在。借贷手段大致分为信用借贷与抵押借贷两种,尽管信用借贷与抵押借贷各有差别,但都与... 详细信息

南京国民政府初期,河北省战乱迭起、土匪肆虐,地主租税盘剥、政府苛捐杂税,婚丧嫁娶礼俗的铺张浪费,以及家庭副业的衰落都造成了高利贷在农村广泛存在。借贷手段大致分为信用借贷与抵押借贷两种,尽管信用借贷与抵押借贷各有差别,但都与农民日常生产生活产生了细微的联系,一方面农民离不开高利贷,另一方面高利贷又迫使农民日益贫困。

关键词：高利贷南京国民政府农村

南京国民政府时期环巢湖地区匪患及其治理问题探究

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淮南师范学院学报 2017年第6期19卷 123-127页

作者：唐传炳安徽大学历史系安徽合肥230039

民国以来,各路军阀互相征战,导致民不聊生,百姓身在水深火热之中。一些地区土匪伺机猖獗,环巢湖南京国地区水运便利,交通发达,更是成为了土匪的"安乐窝",土匪最多时达到3000之众,为害一方,给当地居民、过往商船都造成了巨大的危害。民... 详细信息

民国以来,各路军阀互相征战,导致民不聊生,百姓身在水深火热之中。一些地区土匪伺机猖獗,环巢湖南京国地区水运便利,交通发达,更是成为了土匪的"安乐窝",土匪最多时达到3000之众,为害一方,给当地居民、过往商船都造成了巨大的危害。民国初年,原巢湖水师改为巢湖水上警察局,负责治理巢湖匪患及其他社会问题,对保护居民人身及财产安全,维护当地的社会稳定起到了重要作用。

关键词：民政府时期巢湖匪患水上警察局

高固含量多分散粒径分布乳液的研究 2.二元种子法制备二元分散粒径分布乳液

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粘接 2000年第2期21卷 1-3,9页

作者：储富祥唐传兵 Alain Guyot 中国林科院林产化学工业研究所南京市210042 LCPP/CNRS-CPE

通过在聚合过程中加入第 2种子乳液 ,制备出了具有二元分散粒径分布的乳液 ,研究了第 2种子乳液量对乳液粒径及粒径分布的影响。实验结果表明 ,通过改变第 2种子乳液的量可以调节乳液的粒径及粒径分布。当大粒子质量分数为 80 %时 ,乳... 详细信息

通过在聚合过程中加入第 2种子乳液 ,制备出了具有二元分散粒径分布的乳液 ,研究了第 2种子乳液量对乳液粒径及粒径分布的影响。实验结果表明 ,通过改变第 2种子乳液的量可以调节乳液的粒径及粒径分布。当大粒子质量分数为 80 %时 ,乳液粘度最小。通过粒径分布的多分散化。

关键词：粒径分布成膜温度二元种子法乳液聚合胶粘剂

最长尿道长度保存对腹腔镜前列腺癌根治术后尽快恢复尿控的意义研究

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临床泌尿外科杂志 2017年第3期32卷 232-235页

作者：王琦许传兵汤凯赵宁王彤郑建波淄博市中心医院泌尿外科山东淄博255036

目的:研究最长尿道长度保存(maximal urethral length preservation,MULP)对腹腔镜前列腺癌根治术后尽快恢复尿控的临床意义。方法:回顾性分析我院2013年2月~2015年3月80例行腹腔镜前列腺癌根治术的临床资料,随访至2016年3月。其中40例... 详细信息

目的:研究最长尿道长度保存(maximal urethral length preservation,MULP)对腹腔镜前列腺癌根治术后尽快恢复尿控的临床意义。方法:回顾性分析我院2013年2月~2015年3月80例行腹腔镜前列腺癌根治术的临床资料,随访至2016年3月。其中40例进行MULP腹腔镜前列腺癌根治术患者为治疗组,另外40例非行MULP腹腔镜前列腺癌根治术患者为对照组,在手术前两组患者年龄、平均BMI、既往史(糖尿病)、术前NHT、前列腺体积、术前前列腺特异性抗原(PSA)、术前Gleason评分、术前病理T分期均无统计学意义(P>0.05)。比较治疗组与对照组手术时间、切缘阳性率、前列腺尖部切缘阳性率、术后PSA(ng/ml)、术后Gleason评分、并发症率及两组患者术后1、3、6、12个月尿控恢复情况、国际尿失禁咨询委员会尿失禁问卷表简表(ICI-QSF)评分情况。结果:两组患者手术都成功完成,两组术后3、6、12个月并发症发生率、切缘阳性率、前列腺尖部切缘阳性率及PSA0.05)。两组术后1、3个月尿控恢复人数和ICIQ-SF评分情况差异均有统计学意义(P0.05)。结论:行MULP的腹腔镜前列腺癌根治术有利于术后早期尽快恢复尿控,且不增加切缘阳性率。

关键词：最长尿道长度保存腹腔镜前列腺根治术尿控