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Programmed death 1 and programmed death ligand 1 expressions in patients with chronic hepatitis B

hepatobiliary & Pancreatic Diseases International 2013年第4期12卷 394-399页

作者： Wen-Jin Zhang chuan-Hui Peng shu-Sen Zheng Division of hepatobiliary Pancreatic Surgery First Affiliated Hospital Zhejiang University School of Medicine

BACKGROUND: The role of programmed death 1 (PD-1) and programmed death ligand 1 (PD-L1) in persistent HBV infection is controversial. Increasing PD-1 and PD-L1 expression has been found in hepatitis B patients during immune clearance phase, but not in HBV-tolerant patients. We investigated PD-1 and PD-L1 expression and inflammation in chronic hepatitis B. METHODS: Twenty patients with chronic hepatitis B participated in this study. Fifteen patients were in the immune clearance phase, and 5 were in the immune inactive phase. Circulating HBV-specific T cells were analyzed by flow cytometric detection of major histocompatibility complex (MHC) class I peptide complexes, known as pentamers. Intra-hepatic PD-1 and PD-L1 expressions were analyzed by immunostaining. RESULTS: The frequency of pentamers, including core 18-27 (1.88%±0.36%), env 335-343 (1.85%±0.37%), and pol 575-583 (1.56%±0.29%) was 8.30-, 7.71- and 8.48-fold greater during immune clearance phase than those during the immune inactive phase. In addition, more than 70% of circulating pentamers were PD-1 positive. During immune clearance phase, the numbers of intra-hepatic PD-1 and PD-L1 positive cells were 108±23/HPF and 97±20/HPF respectively, in contrast, there was a paucity of PD-1 and PD-L1 positive cells in the immune inactive phase. The numbers of intra-hepatic PD-1 and PD-L1 positive cells were positively correlated with serum alanine aminotransferase and the number of intra-hepatic CD8 + T cells. Immunofluorescence showed that almost all of the intra- hepatic CD8 + T cells were PD-1 and CCR6 positive. These cells aggregated around macrophage inflammatory protein-3 alpha (MIP3α) positive cells and mixed with PD-L1 positive ***: PD-1 and PD-L1 expressions were significantly correlated with inflammation. CCR6 and PD-1 co-expressed in the same cells; these cells were increased both in circulation and the inflamed liver and aggregated around MIP3α positive cells. The mixture of CCR6 and PD-1, M

关键词： programmed death 1 receptor hepatitis B, chronic liver

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Electro-deoxidation of V_2O_3 in molten CaCl_2-NaCl-CaO

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International Journal of Minerals,Metallurgy and Materials 2012年第3期19卷 212-216页

作者： shu-lan Wang Shi-chao Li Long-fei Wan chuan-hua Wang School of Science Northeastern UniversityShenyang 110004China

The electro-deoxidation of V2O3 precursors was studied. Experiments were carried out with a two-terminal electrochemical cell, which was comprised of a molten electrolyte of CaCl2 and NaC1 with additions of CaO, a cathode of compact V2O3, and a graphite anode under the potential of 3.0 V at 1173 K. The phase constitution and composition as well as the morphology of the samples were studied by X-ray diffraction （XRD） and scanning electron microscopy （SEM）. 3 g of V2O3 could be converted to vanadium metal powder within the processing time of 8 h. The kinetic pathway was investigated by analyzing the product phase in samples prepared at different reduction stages. CaO added in the reduction path of V2O3 formed the intermediate product CaV2O4.

关键词： vanadous oxide electro-deoxidation vanadium molten salt electrochemical cells

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深水高温高压气井环空圈闭压力下油管柱安全评价方法

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科学技术与工程 2024年第12期24卷 4959-4968页

作者：刘书杰罗鸣马传华吴艳辉唐龙张智丁剑中海油(中国)有限公司海南分公司海口570100 中海油能源发展股份有限公司工程技术深水钻采技术中心海口570100 西南石油大学油气藏地质及开发工程国家重点实验室成都610500

深水高温高压气井普遍存在环空带压现象,而深水井通常采用水下井口,使得B、C环空无法进行泄压操作,从而导致井下油管柱承受高环空圈闭压力载荷,同时附加高温、腐蚀多因素耦合影响,使得油管柱存在失效风险。针对深水高温高压气井环空圈... 详细信息

深水高温高压气井普遍存在环空带压现象,而深水井通常采用水下井口,使得B、C环空无法进行泄压操作,从而导致井下油管柱承受高环空圈闭压力载荷,同时附加高温、腐蚀多因素耦合影响,使得油管柱存在失效风险。针对深水高温高压气井环空圈闭压力下油管柱安全问题,基于深水井特性,综合考虑热膨胀和鼓胀效应引起的环空温度、环空体积、流体体积以及环空压力变化的动态耦合作用,建立深水高温高压气井圈闭压力预测模型,同时,考虑高环空圈闭压力载荷,附加高温及腐蚀多因素耦合影响,建立深水高温高压气井油管柱安全评价方法,开展了环空圈闭压力多因素影响下油管柱安全评价,并对模型进行了验证。结果表明:考虑环空圈闭压力影响后,环空圈闭压力随服役时间逐渐降低幅度远小于地层压力降低幅度,管柱抗外挤安全系数随服役时间降低幅度增大。同时,管柱内外流体压差随井深增加而逐渐增大,在井底管柱更易发生失效风险;在井筒高温及腐蚀耦合影响下,管柱抗内压、抗外挤及抗拉安全系数均呈现出不同程度的降低,特别井底段管柱受苛刻高温及腐蚀环境,附加高环空圈闭压力,使其更易发生失效风险,在设计及实际生产过程中,应重点管柱井底管柱安全风险。

关键词：深水井高温高压圈闭压力油管柱安全评价

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Research on Stress and Strength of High Strength Reinforced Concrete Drilling Shaft Lining in Thick Top Soils

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Journal of China University of Mining and Technology 2007年第3期17卷 432-435页

作者： YAO Zhi-shu CHANG Hua RONG chuan-xin Department of Civil Engineering Anhui University of Science and Technology Huainan Anhui 232001 China

High strength reinforced concrete drilling shaft linings have been adopted to solve the difficult problem of supporting coal drilling shafts penetrating through thick top soils. Through model experiments the stress and strength of such shaft linings are studied. The test results indicate that the load beating capacity of the shaft lining is very high and that the main factors affecting the load bearing capacity are the concrete strength, the ratio of lining thickness to inner radius and the reinforcement ratio. Based on the limit equilibrium conditions and the strength theory of concrete under multi-axial compressive stressed state, a formula for calculating the load-beating capacity of a high strength reinforced concrete shaft lining was obtained. Because the concrete in a shaft lining is in a multi-axial compressive stress state the compressive strength increases to a great extent compared to uni-axial loading. Based on experiment a formula for the gain factor in compressive strength was obtained： it can be used in the structural design of the shaft lining. These results have provided a basis for sound engineering practice when designing this kind of shaft lining structure.

关键词： shaft sinking by drilling method shaft lining highstrength concrete strength designing method

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Intermittency of Wind Wave Group Breaking

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China Ocean Engineering 2013年第5期27卷 605-614页

作者：类淑河薛川田文婧管长龙 Department of Mathematics Ocean University of China Physical Oceanography Laboratory Ocean University of China

Knowledge on intermittency of wave breaking is so far limited to a few summary statistics, while the probability distribution of time interval between breaking events can provide a full view of intermittency. Based on a series of experiments on wind wave breaking, such probability distributions are investigated. Breaking waves within a wave group were taken as a single breaking event according to recent studies. Interval between successive wave groups with breaker is the focus of this paper. For intervals in our experiments with different fetch and wind conditions, their distributions are all skewed and weighted on small intervals. Results of Kolmogorov-Smirnov tests on time series of these intervals indicate that they all follow gamma distribution, and some are even exponential type. Average breaking-group-interval decreases with friction velocity and significant steepness until the wind is strong enough;most of them are more than 10 times the dominant wave period. Group breaking probability proposed by Babanin recently and the average number of breaking waves in wave groups are also discussed, and they are seemingly more reasonable and sensitive than traditional breaking probability defined in terms of single wave.

关键词： wave breaking wave group group breaking probability breaking group interval gamma distribution

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Deposition Morphology of Non-homogeneous Debris Flow and Its Energy Characteristics

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Journal of Mountain Science 2015年第5期12卷 1157-1168页

作者： shu An-ping TANG chuan ZHANG Xin SHAO Song-dong YANG Kai Key Laboratory of Water and Sediment Sciences of Ministry of Education School of Environment Beijing Normal University State Key Laboratory of Geo-hazard Prevention and Geo-environment Protection Chengdu University of Technology School of Environment Beijing Normal University Department of Civil and Structural Engineering University of Sheffield State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University Hydrochina Huadong Engineering Corporation

Non-homogeneous two-phase debris flows are widely found in the western mountainous regions of China. To investigate the characteristics of the debris flow deposition process related to the morphology and extent of the debris fan, a series of physical experiments were carried out using an experimental flume. Some useful relationships were obtained to link the flow velocity with the geometric characteristics of deposition morphology and the corresponding area or volume. Based on these, some expressions about energy dissipation process in both the transport-deposition zone and deposition zone are presented, and improved equations describing solidliquid two-phase energy transformations in the specific deposition zone are also established. These results provide a basis for further investigating the underlying mechanisms of non-homogeneous debris flows, based upon which effective disaster control measures can be undertaken.

关键词： Non-homogeneous debris flow Deposition morphology Debris flow velocity Energydissipation

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Diabetes mellitus and hepatocellular carcinoma:Comparison of Chinese patients with and without HBV-related cirrhosis

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World Journal of Gastroenterology 2010年第35期16卷 4467-4475页

作者： Chun Gao Hong-chuan Zhao Jing-Tao Li shu-Kun Yao Graduate School Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100730 China Department of Gastroenterology China-Japan Friendship Hospital Ministry of Health Beijing 100029China

AIM:To determine the role of diabetes mellitus(DM) and other associated factors in Chinese hepatocellular carcinoma(HCC) patients with cirrhosis,compared with those HCC patients without cirrhosis,in the single setting of hepatitis B virus(HBV) infection,after other known concomitant diseases were ***:A total of 482 patients,treated at the China-Japan Friendship Hospital,Ministry of health(Beijing,China),in the period January 2003 to June 2009,and with a hospital discharge diagnosis of HCC,were ***,clinical,laboratory,metabolic and instrumental features were ***:Of the total,310 patients were diagnosed with HBV infection and,following the inclusion and exclusion criteria,224 were analyzed,including 122 patients(54.5%) with cirrhosis(the case group) and 102 patients without cirrhosis(the control group).Twentyseven patients(12.1%) were diabetic,including 19 in the case group and 8 in the control group(19/122=15.6% vs 8/102=7.8%,P=0.077).Thirty-one possible relevant parameters were compared by univariate analysis,and 9 variables were selected for multivariable analysis,including DM(P=0.077),past history of HBV infection(P=0.005),total bilirubin(Phe three cirrhosis-related parameters,DM was found to be the sole independent factor associated with HCC in patients with HBV-related cirrhosis,compar

关键词： Diabetes mellitus hepatocellular carcinoma hepatitis B virus Cirrhosis Chinese patients

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AlN-based surface acoustic wave resonators on platinum bottom electrodes for high-temperature sensing applications

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Rare Metals 2016年第5期35卷 408-411页

作者： chuan Li Xing-Zhao Liu Bin Peng Lin shu Yan-Rong Li School of Microelectronics and Solid-State Electronics University of Electronic Science and Technology of China State Key Laboratory of Electronic Thin Film and Integrated Devices University of Electronic Science and Technology of China

Surface acoustic wave（SAW） resonators with Pt/AlN/Si and Pt/AlN/Pt/Si configurations were fabricated by lift-off photolithography techniques. High-temperature performances of both configurations were investigated for temperature sensor applications. AlN films grown on Ptcoated Si substrates exhibit a lower（002） preferred orientation than those grown on Si substrates. The center frequencies of Pt/AlN/Si and Pt/AlN/Pt/Si configurations at room temperature are 424.1 and 456.4 MHz, *** SAW was limited by Pt bottom electrodes to propagate in AlN layer. The temperature coefficient of frequency（TCF） values of Pt/AlN/Si and Pt/AlN/Pt/Si configurations are-51.6 × 10^-6 and-69.2 × 10^-6℃^-1, *** with that of Pt/AlN/Si configuration, the TCF value of Pt/AlN/Pt/Si configuration decreases by 34.1 %.AlN resonator with the Pt floating bottom electrodes provides a large, quasi-constant temperature sensitivity which is suitable for temperature sensor applications.

关键词： AlN film High temperature Platinum Temperature coefficient of frequency Surface acoustic wave

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Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang Yong-Hao Chen Jing-Yu Tang Rui-Rui Fan Qiang Li Gong Li Dong Liu Zheng-Yao Jin Xing-Zhu Cui Tian-Xiang Chen Yi-Wei Yang Rong Liu Han Yi Yang Li Zhen Yang Qi An Hao-Fan Bai Jiang-Bo Bai Jie Bao Ping Cao Qi-Ping Chen Zhen Chen Zeng-Qi Cui An-chuan Fan Chang-Qing Feng Fan-Zhen Feng Ke-Qing Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu he Yong-Cheng he Yang Hong Yi-Wei Hu Han-Xiong Huang Wei-Hua Jia Hao-yu Jiang Wei Jiang Zhi-jie Jiang Ling Kang Bo Li Chao Li Jia-Wen Li Xiao Li Jie Liu shu-Bin Liu Guang-Yuan Luan Chang-Jun Ning Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Xin Tan Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Yong-Ji Yu Guo-Hui Zhang Lin-Hao Zhang Mo-Han Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Yue Zhang Zhi-Yong Zhang Mao-Yuan Zhao Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the China Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

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Quantum learning control using differential evolution with equally-mixed strategies

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Control Theory and Technology 2017年第3期15卷 226-241页

作者： Hailan MA Daoyi DONG chuan-Cun shu Zhangqing ZHU Chunlin CheN School of Management and Engineering Nanjing University Nanjing Jiangsu 210093 China School of Engineering and Information Technology University of New South Wales Canberra ACT 2600 Australia

Learning control has been recognized as a powerful approach in quantum information technology. In this paper, we extend the application of differential evolution （DE） to design optimal control for various quantum systems. Various DE methods are introduced and analyzed, and EMSDE featuring in equally mixed strategies is employed for quantum control. Two classes of quantum control problems, including control of four-level open quantum ensembles and quantum superconducting systems, are investigated to demonstrate the performance of EMSDE for learning control of quantum systems. Numerical results verify the effectiveness of the FMSDE method for various quantum systems and show the potential for complex quantum control problems.

关键词： Differential evolution with equally-mixed strategies (EMSDE) quantum learning control superconducting circuits quantum control

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