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Global trends in COVID-19

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Infectious Medicine 2022年第1期1卷 31-39页

作者： chuan-min zhou Xiang-Rong Qin Li-Na Yan Yuan Jiang Xue-Jie Yu Department of Infectious Diseases Zhongnan HospitalWuhan UniversityWuhan430071Hubei ProvinceChina State Key Laboratory of Virology School of Health SciencesWuhan UniversityWuhan430071Hubei ProvinceChina Department of Clinical Laboratory the Second Hospital of Shandong UniversityJinan250033Shandong ProvinceChina

The pandemic COVID-19 is certainly one of the most severe infectious diseases in human *** the last 2 years,the COVID-19 pandemic has caused over 418.6 million confirmed cases and 5.8 million deaths *** people make up the majority of all infected COVID-19 cases,but the mortality rate is relatively lower compared to older age ***,about 55.04%individuals have been fully vaccinated rapidly approaching to herd immunity *** challenge is that new SARS-CoV-2 variants with potential to evade immunity from natural infection or vaccine continue to *** infections have occurred in both SARS-CoV-2 naturally infected and vaccinated individuals,but breakthrough infections tended to exhibit mild or asymptomatic symptoms and lower mortality ***,immunity from natural infection or vaccination can reduce SARS-CoV-2 pathogenicity,but neither can completely prevent SARS-CoV-2 infection/***,the morbidity and mortality of COVID-19 continue to *** 7-day average cumulative case fatality of COVID-19 has decreased from 12.3%on the February 25,2020,to 0.27%on January 09,2022,which could be related to a decreased SARS-CoV-2 variant virulence,vaccine immunization,and/or better treatment of *** conclusion,elimination of SARS-CoV-2 in the world could be impossible or at least an arduous task with a long way to *** best strategy to prevent COVID-19 pandemic is to expand inoculation rate of effective *** the population reaches herd immunity,the mortality rate of COVID-19 may continue to decrease,and COVID-19 could eventually become another common cold.

关键词： COVID-19 SARS-CoV-2 Herd immunity Case fatality rate Breakthrough infection Delta variant Omicron variant Vaccine

Reactivation of Epstein-Barr virus in SFTSV infected patients

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Infectious Medicine

Infectious Medicine 2023年第3期2卷 195-201页

作者： Li-Zhu Fang Yu-Hong Dong Zhi-Jian Yan chuan-min zhou Xue-Jie Yu Xiang-Rong Qin Qingdao City Center for Disease Control and Prevention Qingdao 266033China Sixth People’s Hospital Qingdao 266033China State Key Laboratory of Virology School of Public HealthWuhan UniversityWuhan 430071China Department of Clinical Laboratory the Second Hospital of Shandong UniversityJinan 250033China

Background:Severe fever with thrombocytopenia syndrome(SFTS)is an emerging hemorrhagic fever caused by a tick-borne bunyavirus SFTSV with case fatality up to 30%.The reactivation of Epstein-Barr virus(EBV)has been proven to occur in individuals with various immune suppression ***:Here,we diagnosed 22 SFTSV infected patients with PCR in a hospital in Shandong Province,China in *** understand the consequences of SFTSV infection leading to EBV reactivation,we examined EBV reactivation in SFTSV-infected patients with PCR and ***:We found that EBV was reactivated in 18.2%(4/22)of SFTS patients,suggesting that EBV reactivation is common in SFTS *** with SFTS patients without EBV reactivation,SFTS patients with EBV-reactivation had a significantly lower median level of serum albumin(32.45 g/L vs.26.95 g/L,p=0.03)and a significantly higher median number of urine red blood cells(0 cells/μL vs.9 cells/μL,p=0.04).Conclusion:SFTS infection can reactivate EBV in patients,which may make the clinical condition of patients worsen.

关键词： Severe fever with thrombocytopenia syndrome virus Epstein-Barr virus Reactivation Glomerular injury

Hybrid Dynamic Variables-Dependent Event-Triggered Fuzzy Model Predictive Control

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 723-733页

作者： Xiongbo Wan Chaoling Zhang Fan Wei chuan-Ke Zhang min Wu IEEE the School of Automation China University of Geosciencesthe Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systemsand the Engineering Research Center of Intelligent Technology for Geo-ExplorationMinistry of EducationWuhan 430074China

This article focuses on dynamic event-triggered mechanism(DETM)-based model predictive control(MPC) for T-S fuzzy systems.A hybrid dynamic variables-dependent DETM is carefully devised,which includes a multiplicative dynamic variable and an additive dynamic *** addressed DETM-based fuzzy MPC issue is described as a “min-max” optimization problem(OP).To facilitate the co-design of the MPC controller and the weighting matrix of the DETM,an auxiliary OP is proposed based on a new Lyapunov function and a new robust positive invariant(RPI) set that contain the membership functions and the hybrid dynamic variables.A dynamic event-triggered fuzzy MPC algorithm is developed accordingly,whose recursive feasibility is analysed by employing the RPI *** the designed controller,the involved fuzzy system is ensured to be asymptotically *** examples show that the new DETM and DETM-based MPC algorithm have the advantages of reducing resource consumption while yielding the anticipated performance.

关键词： Dynamic event-triggered mechanism(DETM) hybrid dynamic variables model predictive control(MPC) robust positive invariant(RPI)set T-S fuzzy systems

Oral and ocular transmission of severe fever with thrombocytopenia syndrome virus

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Infectious Medicine 2022年第1期1卷 2-6页

作者： chuan-min zhou Rui Qi Xiang-Rong Qin Li-Zhu Fang Hui-Ju Han Xiao-Ying Lei Xue-Jie Yu State Key Laboratory of Virology School of Public HealthWuhan UniversityWuhanChina School of Public Health Lanzhou UniversityLanzhouGansu ProvinceChina Department of Clinical Laboratory the Second Hospital of Shandong UniversityJinanShandong ProvinceChina Department of Microbiological Laboratory Technology School of Public HealthCheeloo College of MedicineShandong UniversityJinanShandongChina

Background:Severe fever with thrombocytopenia syndrome virus(SFTSV)is a tick-borne bunyavirus that could cause a severe hemorrhagic fever termed SFTS with a high fatality rate of up to 30%.Importantly,SFTSV is frequently transmitted from person-to-person and patients’blood or excreta are considered as the risk factors for transmission of ***,the mechanism of person-to-person transmission of SFTSV is still ***:In this study,wild-type(WT)C57BL/6 J mice and a lethal SFTSV mouse model IFNAR−/−A129 mice were utilized to evaluate whether SFTSV could be transmitted via oral or ocular routes.C57BL/6 J mice were inoculated with cell-cultured SFTSV via oral and ocular ***−/−A129 mice were inoculated with cell-cultured SFTSV or SFTSV infected mouse acute sera via oral and ocular ***:We found that SFTSV antibody positive rates in C57BL/6 J mice were 70%(7/10)and 30%(3/10)in the oral inoculation group and ocular inoculation group,respectively on day 21 post SFTSV *** mortality rates of IFNAR−/−mice with oral and ocular inoculation of cell-cultured SFTSV were 100%and 83.33%(5/6),respectively on day 6 post *** mortality rates of IFNAR−/−mice with oral and ocular inoculation of SFTSV infected mouse acute serum were 100%and 66.67%(4/6),respectively on day 9 post ***:Together,our results show that SFTSV can be transmitted effectively through oral and ocular mem-brane,suggesting exposure to SFTS positive excreta may be a high-risk factor of nosocomial transmission of SFTSV in hospitals and/or *** members and healthcare workers should be protected properly during taking care of SFTS patients to prevent SFTSV nosocomial infection.

关键词： SFTSV Nosocomial infection Person-to-person transmission Fecal-oral Fecal-ocular

A mixed-valence polyoxometalate-based 3D inorganic framework cathode material for high-efficiency rechargeable AZIBs

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Rare Metals 2024年第8期43卷 3677-3691页

作者： Qing Han Hao-Ran Xiao Tao zhou Bing-chuan Li Liu Yang Ling-Ling Xie Xue-Jing Qiu Xian-Yong Wu Li-min Zhu Xiao-Yu Cao School of Chemistry and Chemical Engineering Henan University of TechnologyZhengzhou 450001China Key Laboratory of High Specific Energy Materials for Electrochemical Power Sources of Zhengzhou City Zhengzhou 450001China College of Materials Engineering Henan University of EngineeringZhengzhou450007China School of Environmental Engineering Henan University of TechnologyZhengzhou 450001China Department of Chemistry University of Puerto Rico-Rio Piedras CampusSan JuanPR 00925USA

The global trend towards new energy storage systems has stimulated the development of electrochemical energy storage *** these technologies,rechargeable aqueous zinc-ion batteries(AZIBs)have attracted considerable interest as a potential alternative to lithium-ion batteries(LIBs)due to their affordable cost,environmental compatibility and high safety *** this study,a high-quality electrode for AZIBs has been successfully developed using a dehydrated mixed-valence polyoxometalate-based three-dimensional(3D)inorganic framework material known as[H_6Mn_(3)V^Ⅳ_(15)V-^Ⅴ_(4O)_(46)(H_2O)_(12)](3D-MnVO).This innovative 3D-MnVO material is built from the alternate connections of{V_(19)O_(46)}"sphere-shaped"clusters andμ_(2)-{Mn(H_(2)O)_(4)}bridges,where each{V_(19)O_(46)}cluster is surrounded by three pairs of vertically distributed{Mn(H_(2)O)_(4)}units,thus resulting in the 3D interpenetrating grid-like network from the infinite[-{V_(19)O_(46)}-μ_(2)-Mn(H_(2)O)_(4)-{V_(19)O_(46)}]_∞chains in three mutually perpendicular *** 3D framework structure of 3D-MnVO possesses abundant oxygen vacancies,spacious and multi-level interconnected channels for ion transport,which facilitates the efficient intercalation/deintercalation of hydrated Zn^(2+)into the pores of the primary structure via the intercalation capacitance *** a result,the 3D-MnVO electrode exhibits excellent diffusion rates and minimal interfacial *** a current density of 0.1 A·g^(-1),the 3D-MnVO cathode delivers a commendable discharge capacity of170.5 mAh·g^(-1)with 81.6%capacity retention after100 charge/discharge ***,even at a high current density of 1.0 A·g^(-1),the 3D-MnVO electrode delivers a remarkable reversible capacity of198.9 mAh·g^(-1).Our research results provide valuable insights into the development of advanced polyoxometalate-based 3D inorganic framework electrode materials for high-performance rechargeable AZIBs.

关键词： Cathode Polyoxometalate 3D inorganic framework Zinc-ion batteries Energy storage mechanism

Construction of daily precipitation series and the observational characteristics of extreme precipitation in Tianjin,China during 1888-2022

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Advances in Climate Change Research 2024年第1期15卷 52-61页

作者： Peng SI Qing-Xiang LI Xiao-Yang CHEN min WANG chuan-Jun LUO Tianjin Meteorological Information Center Tianjin Meteorological BureauTianjin 300074China Research Centerfor Ecology and Environment of Central Asia Chinese Academy of SciencesWulumuqi 830011China School of Atmospheric Sciences Sun Yat-sen UniversityZhuhai 528478China Key Laboratory of Tropical Amosphere-Ocean System Ministry of EducationZhuhai 528478China Shaoguan Meteorological Service Shaoguan 512028China

Given the difficulties in rescuing and ensuring the quality of long-term climate data,current studies on century-scale climate change are usually limited to annual and monthly data,resulting in the poor detection of extreme climate events and their changes before *** this study,we reconstructed a daily precipitation series for Tianjin from 15 September 1887 to 31 December 2022 on the basis of the most comprehensive daily precipitation records collected from the Tianjin Meteorological Archive,China,and in reference to the precipitation analysis results based on the datasets developed by the Climatic Research Unit Time-Series version 4.06,Global Precipitation Climatology Centre and University of Delaware along with the application of various homogenisation methods for climate *** approach provides a complete and reliable century-long daily precipitation series for the study of regional or local extreme weather and climate *** reconstructed daily dataset reveals that the annual precipitation amount and R95 intensity in Tianjin during 1888-2022 lack significant trends and have values of 0.74±6.99 and-1.84±3.22 mm per decade,*** the annual and seasonal scales,the precipitation amount and R95 intensity,particularly those in autumn,have increased since the latter half of the 20th century relative to those in ***,the increase in precipitation amount and R95 intensity is relatively limited compared with that in atmospheric water vapour content due to surface warming,indicating the highly sensitive response of extreme precipitation events to *** addition,the estimates for the return periods of 5,10,20,50 and 100 years covering 1888-2022,1888-1950 and 1951-2022 depict that the intensity of heavy rain and above magnitude was highest in 1888-1950 and decreased in 1951-2022.

关键词： Over a century-long timescale Daily precipitation series Extreme precipitation Return period

Demonstration of controlled high-dimensional quantum teleportation

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 1-6页

作者： min-Yu Lv Xiao-min Hu Neng-Fei Gong Tie-Jun Wang Yu Guo Bi-Heng Liu Yun-Feng Huang chuan-Feng Li Guang-Can Guo CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Centerfor Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China State Key Laboratory of Information Photonics and Optical Communications School of ScienceBeijing University of Posts and TelecommunicationsBeijing 100876China

Controlled quantum teleportation(CQT), which is regarded as the prelude and backbone for a genuine quantum internet, reveals the cooperation, supervision, and control relationship among the sender, receiver, and controller in the quantum network within the simplest unit. Compared with low-dimensional counterparts, high-dimensional CQT can exhibit larger information transmission capacity and higher superiority of the controller's authority. In this article, we report a proof-of-principle experimental realization of three-dimensional(3D) CQT with a fidelity of 97.4% ± 0.2%. To reduce the complexity of the circuit, we simulate a standard 4-qutrit CQT protocol in a 9×9-dimensional two-photon system with high-quality operations. The corresponding control powers are 48.1% ± 0.2% for teleporting a qutrit and 52.8% ± 0.3% for teleporting a qubit in the experiment, which are both higher than the theoretical value of control power in 2-dimensional CQT protocol(33%). The results fully demonstrate the advantages of high-dimensional multi-partite entangled networks and provide new avenues for constructing complex quantum networks.

关键词： high dimension quantum information quantum teleportation quantum nonlocality

Apolipoprotein E4 interferes with lipid metabolism to exacerbate depression-like behaviors in 5xFAD mice

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Animal Models and Experimental Medicine 2024年第3期7卷 347-361页

作者： Yanju Gong mingfeng Li min Liu Xinghan Wu Yanhong Li chuan Qin Ling Zhang iNHC Key Laboratory of Human Disease Comparative Medicine Beijing Engineering Research Center for Experimental Animal Models of Human Critical DiseasesInternational Center for Technology and lnnovation of Animal ModelComparative Medicine CenterInstitute of Laboratory Animal SciencesChinese Academy of Medical Sciences(CAMS)and Peking Union Medical College(PuMC)BeijingChina Changping National Laboratory(CPNL) BeijingChina

Background:Apolipoprotein E4(ApoE4)allele is the strongest genetic risk factor for late-onset Alzheimer's disease,and it can aggravate depressive symptoms in non-AD ***,the impact of ApoE4 on AD-associated depression-l ike behaviors and its underlying pathogenic mechanisms remain ***:This study developed a 5xFAD mouse model overexpressing human ApoE4(E4FAD).Behavioral assessments and synaptic function tests were conducted to explore the effects of ApoE4 on cognition and depression in 5xFAD *** in peripheral and central lipid metabolism,as well as the levels of serotonin(5-HT)andγ-aminobutyric acid(GABA)neurotransmitters in the prefrontal cortex,were *** addition,the protein levels of 24-dehydrocholesterol reductase/glycogen synthase kinase-3 beta/mammalian target of rapamycin(DHCR24/GSK3β/m TOR)and postsynaptic density protein 95/calmodulin-dependent protein kinase II/brain-derived neurotrophic factor(PSD95/CaMK-II/BDNF)were measured to investigate the molecular mechanism underlying the effects of ApoE4 on AD ***:Compared with 5xFAD mice,E4FAD mice exhibited more severe depressionlike behaviors and cognitive *** mice also exhibited increased amyloid-beta deposition in the hippocampus,increased astrocyte numbers,and decreased expression of depression-related neurotransmitters 5-HT and GABA in the prefrontal ***,lipid metabolism disorders were observed in E4FAD,manifesting as elevated low-density lipoprotein cholesterol and reduced high-density lipoprotein cholesterol in peripheral blood,decreased cholesterol level in the prefrontal cortex,and reduced expression of key enzymes and proteins related to cholesterol synthesis and *** expression of proteins related to the DHCR24/GSK3β/m TOR and PSD95/CaMK-II/BDNF pathways was also ***:This study found that ApoE4 overexpression exacerbates depressionlike behaviors in 5xFAD mice and confirmed that ApoE4 reduces co

关键词： 5xFAD mice Alzheimer's disease ApoE4 allele depression like

Constructing highly safe and long-life calcium ion batteries based on hydratedvanadium oxide cathodes featuring a pillar structure

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Rare Metals 2024年第6期43卷 2597-2612页

作者： Chun-Fang Wang Shi-Wei Zhang Lan Huang Yuan-min Zhu Feng Liu Jian-chuan Wang Li-ming Tan Chun-Yi Zhi Cui-Ping Han Powder Metallurgy Research Institute Central South UniversityChangsha410083China Songshan Lake Materials Laboratory Dongguan 523808China Research Institute of Interdisciplinary Science and School of Materials Science and Engineering Dongguan University of TechnologyDongguan 523808China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China Faculty of Materials Science and Energy Engineering/Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Calcium-ion batteries(CIBs)have generated intense interest due to the growing demand for safer,cheaper,and large-scale energy storage ***,their development is still in its infancy,owing to the lack of suitable cathodes for sustaining reversiblc Ca^(2+)intercalation/***,layered H_(2)V_(3)O_(8)(HVO)with Zn^(2+)pre-insertion(ZHVO)is reported as a high-rate and highly durable cathode material for *** existence of Zn^(2+)and H_(2)O pillars could expand the interlayer spacing up to 1.8 nm,which is favorable for the diffusion of bulky Ca^(2+).The formation of Zn-O bonds facilitates electron transfer and enhances electrical ***,the ZHVO cathode achieves superior capacity performance(213.9 mAh·g^(-1)at 0.2 A·g^(-1))and long lifespan(78.3%for 1,000 cycles at 5 A·g^(-1))compared to pristine *** functional theory(DFT)calculations revealed that Zn^(2+)moved during Ca^(2+)intercalation,thereby reducing the diffusion energy barrier and facilitating Ca^(2+)***,a safe aqueous calcium ion cell was successfully assembled.

关键词： Multivalent batteries Calcium-ion batteries Layered structure Vanadium oxide Cathode materials