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Prognostic value of circulating tumor cells combined with neutrophil-lymphocyte ratio in patients with hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 372-385页

作者： jia-Li Chen Lu Guo Zhen-Ying Wu kun He Han Li Chi Yang Yun-Wei Han Department of Oncology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Ophthalmology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Clinical Research Institute The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Plastic Surgery Meguiar's Medical Beauty HospitalChengdu 610000Sichuan ProvinceChina

BACKGROUND Circulating tumor cell(CTC)count and neutrophil-to-lymphocyte ratio(NLR)are both closely associated with the prognosis of hepatocellular carcinoma(HCC).AIM To investigate the prognostic value of combining these two indicators in *** Clinical data were collected from patients with advanced HCC who received im-mune therapy combined with targeted therapy at the Department of Oncology,the Affiliated Hospital of Southwest Medical University,Sichuan,China,from 2021 to *** optimal cutoff values for CTC programmed death-ligand 1(PD-L1)(+)>1 or CTC PD-L1(+)≤1 and NLR>3.89 or NLR≤3.89 were evaluated using X-Tile *** were categorized into three groups based on CTC PD-L1(+)counts and NLR:CTC-NLR(0),CTC-NLR(1),and CTC-NLR(2).The relationship between CTC-NLR and clinical variables as well as survival rates was *** Patients with high CTC PD-L1(+)expression or NLR at baseline had shorter median progression-free survival(m-PFS)and median overall survival(mOS)than those with low levels of CTC PD-L1(+)or NLR(P<0.001).Mean-while,patients in the CTC-NLR(2)group showed a significant decrease in mPFS and *** regression analysis revealed that alpha-fetoprotein(AFP),CTC PD-L1(+),and CTC-NLR were independent predictors of *** time-dependent receiver operating characteristic curve showed that the area under the curve of CTC-NLR at 12 months(0.821)and 18 months(0.821)was superior to that of AFP and CTC PD-L1(+).CONCLUSION HCC patients with high CTC PD-L1(+)or NLR expression tend to exhibit poor prognosis,and a high baseline CTC-NLR score may indicate low ***-NLR may serve as an effective prognostic indicator for patients with advanced HCC receiving immunotherapy combined with targeted therapy.

关键词： Circulating tumor cells Neutrophil–lymphocyte ratio Hepatocellular carcinoma Prognosis Survival Marker

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Late-onset Cholestasis with Paucity of Portal Area Secondary 􀁗􀁒􀀃􀀫􀀱􀀩􀀔􀈕􀀃􀀧􀁈􀁉􀁌􀁆􀁌􀁈􀁑􀁆􀁜􀀃􀁌􀁑􀀃􀀤􀁇􀁘􀁏􀁗􀁋􀁒􀁒􀁇􀀝􀀃􀀤􀀃􀀦􀁄􀁖􀁈􀀃􀀵􀁈􀁓􀁒􀁕􀁗

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Journal of Clinical and Translational Hepatology 2024年第3期12卷 327-331页

作者： Xuemei Zhang kun Liu Xiaona Lu Wenlan Zheng jia Shi Shihan Yu Hai Feng Zhuo Yu Department of Hepatopathy Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Pathology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina Institute of Infectious Disease Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina

Hepatocyte nuclear factor 1β(HNF1β)is essential for biliary development,while its genetic defect triggers the dysplasia of interlobular bile ducts,leading to life-threatening hepatitis and *** date,this disorder has mainly been docu-mented in ***,we report a case of cholestasis in an adult patient caused by a de novo HNF1β mutation.A liver biopsy revealed remarkable shrinkage of the portal area accompanied by a decrease or absence of interlobular bile ducts,veins,and arteries in the portal *** case showed that an HNF1β defect could induce late-onset cholestasis with paucity of the portal area in adulthood.

关键词： HNF1β Cholestasis Adult patient Paucity of the portal area Renal cysts Case report

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Iron-based layered double hydroxide packed with metal-organic frameworks for enhanced overall water-splitting electrocatalysis

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Tungsten 2024年第4期6卷 859-868页

作者： Long Chen Yun Luo Zhi-Peng Yu Yi-kun Cheng Yang Zheng Li He jia-Hao Xiong Wen-Wen Kong Key Laboratory for Green Process of Chemical Engineering of Xinjiang Bingtuan School of Chemistry and Chemical Engineering Shihezi University Institute of Scientific Research Luzhou North Chemistry Industry Co.Ltd International Iberian Nanotechnology Laboratory (INL) CAS Key Laboratory of Functional Materials and Devices for Special Environments Xinjiang Key Laboratory of Electronic Information Materials and Devices Center of Materials Science and Optoelectronics Engineering Xinjiang Technical Institute of Physics and Chemistry of CAS

Designing hybrid materials with numerous catalytic active sites,high specific surface area,and interfacial interactions is an effective strategy to improve electrocatalytic *** this work,iron-based metal organic frameworks（Fe-MOFs）@（Co,Ni）Fe-layered double hydroxide（LDH） is successfully constructed using the similar "MOF growing on LDH" strategy for oxygen evolution reaction and hydrogen evolution reaction in the alkaline *** synthesized hybrid materials in this particular way show excellent electrochemical overall water-splitting performance with the cell voltage of 1.62 V at10 mA·cm-2in the alkaline environment due to the optimized adsorption/desorption properties of metal ions on oxygencontaining species and interfacial effects of hybrid ***-MOFs@（Co,Ni）Fe-LDH also exhibits excellent hydrogen and oxygen production efficiency of 370 and 175 μL·min-1,*** work draws on an effective approach to the fabrication of MOF@LDH structures and provides new insights into overall water-splitting in alkaline conditions.

关键词： Electrocatalysis Interfacial interactions Layered double hydroxide Metal–organic frameworks (MOFs) Water splitting

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Impact of water table on hierarchically nested groundwater flow system

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Journal of Groundwater Science and Engineering 2024年第2期12卷 119-131页

作者： Jun Zhang Rong-zhe Hou kun Yu jia-qiu Dong Li-he Yin Key Laboratory of Groundwater and Ecology in Arid and Semi-arid Areas Xi'an Center of Geological SurveyChina Geological SurveyXi'an 710054China

Water table configuration gives rise to hierarchically nested groundwater flow ***,there remains a lack of comprehensive understanding regarding the controlling factors of water table and its impact on flow ***,it remains challenging to identify characteristics of water table space variation through limited groundwater observations at the regional *** on two ideal two-dimensional cross-section analytical models,this study presents a simplified approach to preliminarily assess the nonlinear interactions between water table variation and three driving factors:Topography,geol-ogy and *** criteria,C1 and C2,are utilized to address issues at different scales ranging from basin to local:(i)the influence of various factors on water table configuration;and(ii)the influence of water table on groundwater flow ***,the Ordos Plateau is taken as an example to explore the role of the water table in nested groundwater systems using the provided approach and *** applica-tion of this approach in the Ordos Plateau demonstrates its appropriateness as a practical method for prelim-inarily determining the characteristics of water table configuration and its impact on flow *** study explores the mechanism influencing spatial variation in the water table and improves understanding of the interaction between topography,geology,and climate on groundwater flow patterns.

关键词： Water table configuration Groundwater flow pattern Analytical models Top boundary condi-tions Ordos Plateau

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Decadal shifts in Qingzang Plateau lake carbon dynamics (1970-2020): From predominant carbon sources to emerging sinks

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Environmental Science and Ecotechnology 2024年第5期21卷 123-132页

作者： Di Shen Yu Li Yafeng Wang Shouliang Huo Yong Liu Junjie jia Shuoyue Wang kun Sun Yang Gao College of Earth and Environment Science Lanzhou UniversityLanzhou730000PR China State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing100101PR China Chinese Research Academy of Environmental Sciences Beijing100012PR China College of Environmental Sciences and Engineering Peking UniversityBeijing1008714PR China Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing100101PR China College of Resources and Environment University of Chinese Academy of SciencesBeijing100049PR China

The evasion of carbon dioxide(CO_(2))from lakes significantly influences the global carbon *** global climatic transformations,the role of Qingzang Plateau(QZP)lakes as carbon(C)sources or sinks remains a subject of ***,accurately quantifying their contribution to the global carbon budget presents a formidable ***,spanning half a century(1970e2020),we utilize a synthesis of literature and empirical field data to assess the CO_(2) exchange flux of QZP *** find markedly higher CO_(2) exchange flux in the southeast lakes than that in the northern and western regions from 1970 to *** this time,both freshwater and saltwater lakes served primarily as carbon *** annual CO_(2) exchange flux was estimated at 2.04±0.37 Tg(Tg)C yr1,mainly influenced by temperature *** CO_(2) exchange flux patterns underwent a geographical inversion between 2000 and 2020,with increased levels in the west and decreased levels in the ***,CO_(2) emissions from freshwater lakes diminished,and certain saltwater lakes in the QTP transitioned from carbon sources to *** 2000 to 2020,the annual CO_(2) exchange flux from QZP lakes is estimated at 1.34±0.50 Tg C yr1,with solar radiation playing a more pronounced role in carbon ***,over the past five decades,QZP lakes have generally functioned as carbon ***,the total annual CO_(2) emissions have declined since the year 2000,indicating a potential shift trend from being a carbon source to a sink,mirroring broader patterns of global climate *** findings not only augment our understanding of the carbon cycle in plateau aquatic systems but also provide crucial data for refining China's carbon budget.

关键词： Carbon source Carbon sink Carbon exchange flux Qingzang Plateau Global climate change

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Unveiling the next generation of MRI contrast agents:current insights and perspectives on ferumoxytol-enhanced MRI

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National Science Review 2024年第5期11卷 385-404页

作者： Guangxiang Si Yue Du Peng Tang Gao Ma Zhaochen jia Xiaoyue Zhou Dan Mu Yan Shen Yi Lu Yu Mao chuan Chen Yan Li Ning Gu jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical EngineeringSoutheast University Key Laboratory for Bio-Electromagnetic Environment and Advanced Medical Theranostics School of Biomedical Engineering and InformaticsNanjing Medical University Department of Radiology the First Affiliated Hospital of Nanjing Medical University MR Collaboration Siemens Healthineers Ltd. Department of Radiology Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School School of Mathematical Sciences Capital Normal University Nanjing Key Laboratory for Cardiovascular Information and Health Engineering Medicine Institute of Clinical Medicine Nanjing Drum Tower HospitalMedical SchoolNanjing University

Contrast-enhanced magnetic resonance imaging(CE-MRI) is a pivotal tool for global disease diagnosis and management. Since its clinical availability in 2009, the off-label use of ferumoxytol for ferumoxytol-enhanced MRI(FE-MRI) has significantly reshaped CE-MRI practices. Unlike MRI that is enhanced by gadolinium-based contrast agents, FE-MRI offers advantages such as reduced contrast agent dosage, extended imaging windows, no nephrotoxicity, higher MRI time efficiency and the capability for molecular imaging. As a leading superparamagnetic iron oxide contrast agent, ferumoxytol is heralded as the next generation of contrast agents. This review delineates the pivotal clinical applications and inherent technical superiority of FE-MRI, providing an avant-garde medical-engineering interdisciplinary lens, thus bridging the gap between clinical demands and engineering innovations. Concurrently, we spotlight the emerging imaging themes and new technical breakthroughs. Lastly, we share our own insights on the potential trajectory of FE-MRI, shedding light on its future within the medical imaging realm.

关键词： ferumoxytol contrast agent contrast-enhanced MRI ferumoxytol-enhanced MRI

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Nutritional Assessment Tools for Patients with Cancer:A Narrative Review

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Current Medical Science 2024年第1期44卷 71-80页

作者： Peng-peng WANG Kim Lam Soh Huzwah binti Khazaai chuan-yi NING Xue-ling HUANG jia-xiang YU Jin-lian LIAO Faculty of Medicine and Health Sciences Universiti Putra MalaysiaSerdang 43400Malaysia NursingCollege of Guangxi Medical University Nanning 530021China Department of Biomedical Sciences Universiti Putra MalaysiaSerdang 43400Malaysia Department of Nursing The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China

Cancer patients are at high risk of malnutrition,which can lead to adverse health outcomes such as prolonged hospitalization,increased complications,and increased *** and timely nutritional assessment plays a critical role in effectively managing malnutrition in these ***,while many tools exist to assess malnutrition,there is no universally accepted *** different tools have their own strengths and limitations,there is a lack of narrative reviews on nutritional assessment tools for cancer *** address this knowledge gap,we conducted a non-systematic literature search using PubMed,Embase,Web of Science,and the Cochrane Library from their inception until May 2023.A total of 90 studies met our selection criteria and were included in our narrative *** evaluated the applications,strengths,and limitations of 4 commonly used nutritional assessment tools for cancer patients:the Subjective Global Assessment(SGA),Patient-Generated Subjective Global Assessment(PG-SGA),Mini Nutritional Assessment(MNA),and Global Leadership Initiative on Malnutrition(GLIM).Our findings revealed that malnutrition was associated with adverse health *** of these 4 tools has its applications,strengths,and *** findings provide medical staff with a foundation for choosing the optimal tool to rapidly and accurately assess malnutrition in cancer *** is essential for medical staff to be familiar with these common tools to ensure effective nutritional management of cancer patients.

关键词： cancer malnutrition nutrition nutritional assessment tool

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Three-dimensional reconstruction of Late Miocene Trapa from eastern Zhejiang Province,China:Insights into its phytogeography and evolution

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Journal of Palaeogeography 2024年第4期13卷 954-970页

作者： Liang Xiao Man Yuan De-Shuang Ji Li-Yan Guo Xiang-chuan Li Xing Wang jia-Nan Wang jia-Qi Liang Mei-Ting Wang School of Earth Science and Resources and Key Laboratory of Western Mineral Resources and Geological Engineering of the Ministry of EducationChang'an University State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of Sciences Shaanxi Key Laboratory of Early Life and Environments Northwest University State Key Laboratory of Continental Dynamics Northwest University

Abundant plant fossils were found in the Upper Miocene Shengxian Formation,eastern Zhejiang Province,China,among which Trapa belongs to a dominant *** fossil fruits of Trapa were well preserved with abundant ***,due to compaction during fossilization,Trapa fruits were often flattened,leading to the loss of some characteristic ***,a bias in taxonomic and phylogenetic studies would occur when such studies were based on these fruit *** this study,we present the first quantitative three-dimensional reconstruction of compressed Trapa fruit fossils to restore their original morphology prior to *** approach provides a novel perspective for the identification and classification of compressed fruit *** three-dimensional reconstruction of Trapa fruit fossils enabled accurate comparisons with extant *** subsequently identified it as a new species,named Trapa radiatiformis *** ***.,revealing differences from previously known taxa of ***,our comparison suggests that the long lower horns and residual stalk may represent inherent characteristics of early Trapa ***,these traits gradually degenerated during fruit evolution,resulting in morphological simplification during geological *** with primitive features exhibits good resemblance to Trapa natans fruit characteristics,which means it may be an ancestor of *** summarize the palaeogeographic distribution of fossil Trapa using previously published literature and demonstrate that the genus was mostprosperous in the Miocene and exhibited the same distribution as that at ***,through detailed morphological comparisons between Trapa and Hemitrapa fruits,along with phylogenetic analysis within the Primotrapa genus itself,we propose a homology between Trapa and Hemitrapa,suggesting that they could have a common ancestor.

关键词： Trapa Late Miocene Shengxian Formation Three-dimensional reconstruction Phytogeographic history Evolutionary history

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Manganese oxide and derivative-modified materials in advanced oxidation processes:A review of modification enhancement and activation mechanisms

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Chinese Chemical Letters 2024年第3期35卷 40-51页

作者： Si Sun Shuang Song Shuai Yang Yong-Li He Yang Shi Peng Zhou Zhao-kun Xiong Yang Liu Heng Zhang Ye Du chuan-Shu He Bo Lai State Key Laboratory of Hydraulics and Mountain River Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China Sino-German Centre for Water and Health Research Sichuan UniversityChengdu 610065China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaSichuanChengdu 610054China

Manganese oxides(MNO_(x)),as low-toxicity and high-abundance catalysts,have been demonstrated to hold great promise for application in advanced oxidation processes(AOPs).However,further application of this material is restricted due to its unsatisfactory oxidant activation ***,recently remarkable research on deep activation mechanisms and modification of MNO_(x)have been undertaken to improve its ***,modification enhancement mechanisms of MNO_(x)to efficiently degrade various organic contaminants were discussed and highlighted,including metal doping,coupling with other metal oxides,composite with carbonaceous material,and compounding with other *** activation mechanisms of different MNO_(x)and derivative-modified material(such as doped MNO_(x),metal oxide-MNO_(x)hybrids,and MNO_(x)-carbonaceous material hybrids)were summarized in great details,which was specifically categorized into both radical and non-radical *** effects of pH,inorganic ions,and natural organic matter on degradation reactions are also ***,future research directions and perspectives are presented to provide a clear interpretation on the MNO_(x)initiated AOPs.

关键词： Manganese oxide Derivative-modified materials Modification enhancement mechanisms Advanced oxidation process Activation mechanism

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Higher palaeoelevation in the Baoshan Basin:Implications for landscape evolution at the southeastern margin of the Tibetan Plateau

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Journal of Palaeogeography 2024年第3期13卷 563-580页

作者： Yong-jiang Huang Hao-Ran Zong Shi-Tao Zhang Arata Momohara Jin-Jin Hu Lin-Bo jia Yun-Heng Ji Zhe-kun Zhou Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201Yunnan ProvinceChina College of Forestry Shandong Agricultural UniversityTai'an 271018Shandong ProvinceChina Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming 650093Yunnan ProvinceChina Graduate School of Horticulture Chiba UniversityChiba 271-8510Japan Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303Yunnan ProvinceChina

Surface uplift at the southeastern margin of the Tibetan Plateau has been widely studied,but more palaeoaltimetry data are required to better understand the elevation history of this geologically complex *** this study,fossil leaves of Abies(Pinaceae),a cool-temperate element,recovered from the latest Miocene-Pliocene Yangyi Formation of the southern Baoshan Basin,were used as a proxy to estimate the local *** on the regional modern altitude range(2100-4280 m)of the genus as well as regional temperature discrepancy(1.5℃)between the past and present,the palaeoelevation of the study area was calculated to be>2360 m above sea level as compared to 1670 m at *** result suggests that the southern Baoshan Basin experienced pronounced uplift prior to the time of fossil deposition,probably as a result of crustal shortening and thickening of the northern Baoshan Terrane during the *** infer that surface growth in areas south of the Dali Basin may have been greater than previously interpreted,and that a widespread plateau or plateau patches higher than 2000 m probably extended southwards into at least the Baoshan Basin by the latest *** also infer that the elevation of the southern Baoshan Basin has decreased by at least 690 m since then,in contrast to most other scenarios in which the elevation of the southeastern margin of the Tibetan Plateau has increased or remained close to modern levels since the late *** major cause of the inferred altitude decline is likely tectonic *** a transtensional graben basin,the Baoshan Basin has experienced pull-apart and base-fall movement since the late Miocene,which would reduce the altitude of its southern part located on the hanging *** erosion associated with the increased summer rainfall might also have played a role especially in reducing the local relief,although its contribution can be *** study provides one of the few palaeoelevation

关键词： Abies Lapse rate Palaeoaltimetry Surface uplift Tectonic movement Tibetan plateau

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