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金属卟啉二维纳米晶的制备及其光电性能

物理化学学报 2016年第10期32卷 2447-2461页

作者：石乃恩宋传远张俊黄维南京邮电大学信息材料与纳米技术研究院江苏省有机电子与信息显示重点实验室南京210023 南京工业大学先进材料研究院江苏-新加坡有机/生物电子与信息显示联合研究中心南京211816

金属卟啉是一种重要的金属-有机复合物,在光电转换器件、催化、传感、医学等领域有着广阔的应用前景。对无机二维纳米材料(石墨烯或过渡金属硫属化合物等)的广泛研究促使金属-有机二维纳米材料成为当前的研究热点之一。本文针对金属-有... 详细信息

金属卟啉是一种重要的金属-有机复合物,在光电转换器件、催化、传感、医学等领域有着广阔的应用前景。对无机二维纳米材料(石墨烯或过渡金属硫属化合物等)的广泛研究促使金属-有机二维纳米材料成为当前的研究热点之一。本文针对金属-有机以及卟啉二维纳米材料的研究现状,在简要回顾金属-有机二维纳米材料发展历史的基础上,详细总结了金属卟啉单分散二维纳米晶和二维薄膜的制备方法,综述了其当前在太阳能电池、光电催化以及光学传感等方面的应用,最后讨论了金属卟啉二维纳米材料当前面临的研究问题及未来可能的发展方向。

关键词：卟啉二维材料纳米片纳米薄膜光电性质

Transplantation of RADA16-BDNF peptide scaffold with human umbilical cord mesenchymal stem cells forced with CXCR4 and activated astrocytes for repair of traumatic brain injury

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Transplantation of RADA16-BDNF peptide scaffold with human u...

Systematical identification of regulatory GPCRs by single-cell trajectory inference reveals the role of ADGRD1 and GPR39 in adipogenesis

中国神经科学学会第十二届全国学术会议

作者： Wei Shi chuan-jun huang Xi-De Xu Yi-Nan Chen Qian-Qian Liu Jian Chen Department of Neurosurgery Affiliated Hospital of Nantong University

Objective Due to the poor self-regeneration of brain tissue, stem cell transplantation therapy is purported to enable the replacement of lost neurons after traumatic brain injury（TBI）. The main challenge of brain regeneration is whether the transplanted cells can survive and carry out neuronal functions in the lesion area. Methods We co-cultured human umbilical cord mesenchymal stem cells（h UC-MSCs） directly with the activated astrocytes and seeded in a biomaterial scaffold for the cell transplantation. We further specifically linked a functional peptide derived from BDNF, to the C-terminal of RADARADARADARADA（RADA16） to structure a functional self-assembling peptide hydrogel scaffold, RADA16-BDNF（R-B-SPH scaffold） for the better transplantation of the double cell unit（h UC-MSCs/astrocyte）. Also, the novel scaffold was used as cell-carrier for transplantation double cell unit for treating traumatic brain injury. Results（1） We found that co-culturing human umbilical cord mesenchymal stem cells（h UC-MSCs） directly with the activated astrocytes benefited to the proliferation and neuron differentiation of h UC-MSCs in vitro.（2）We first designed the RADA16-BDNF peptide scaffold such that it could not only flatten the injured brain cavity and reduce the surrounding reactive gliosis but could also provide neurotrophic factors.（3）We first specifically transferred CXCR4 to h UC-MSCs to improve the migratory ability of the transplanted h UC-MSCs *** presence of h UC-MSCs/activated astrocytes in the co-culturing unit also promoted better neuronal differentiation of the NSCs.（4）Both h UC-MSCs CXCR4 and activated astrocytes transplanted in the R-B-SPH scaffolds proliferate in the transplantation area and the presence of activated astrocytes increased the proliferation of h UCMSCs CXCR4 in vivo.（5）SDF-1 induces the migration of transplanted h UC-MSCs and showed this process can be enhanced by transferring CXCR4 to h UC-MSCs.（6） We found that the moderate-sized lesion cavity

关键词： Human umbilical cord mesenchymal stem cells BDNF hydrogel SDF1/CXCR4 axis Neural differentiation tissues engineering

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Science China Life Sciences 2025年

作者： chuan Ye Xuemei Wang jun Lin Chenyang Wu Yuhua Gao Chenghao Guo Yunxi Liao Ziyan Rao Shaodong huang Weixuan Chen Ying huang Jinpeng Sun Dongyu Zhao Changtao Jiang Center of Basic Medical Research Institute of Medical Innovation and ResearchPeking University Third Hospital Department of Physiology and Pathophysiology School of Basic Medical SciencesPeking University Department of Biomedical Informatics School of Basic Medical SciencesPeking University State Key Laboratory of Vascular Homeostasis and Remodeling Peking University Center for Obesity and Metabolic Disease Research School of Basic Medical SciencesPeking University State Key Laboratory of Female Fertility Promotion Center for Reproductive MedicineDepartment of Obstetrics and GynecologyPeking University Third Hospital National Clinical Research Center for Obstetrics and Gynecology Peking University Third Hospital Department of Endocrinology and Metabolism Peking University Third Hospital Key Laboratory Experimental Teratology of the Ministry of Education Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesCheeloo College of MedicineShandong University Department of Immunology School of Basic Medical SciencesPeking University

Adipogenesis is the healthy expansion of white adipose tissue (WAT),serving as a compensatory response to maintain metabolic homeostasis in the presence of excess energy in the ***,the identification of novel regulatory molecules in adipogenesis,specifically membrane receptors such as G protein-coupled receptors (GPCRs),holds significant clinical *** receptors can serve as viable targets for pharmaceuticals,offering potential for restoring metabolic homeostasis in individuals with *** utilized trajectory inference methods to analyze three distinct single-nucleus sequencing (sNuc-seq) datasets of adipose tissue and systematically identified GPCRs with the potential to regulate *** verification in primary adipose progenitor cells (APCs) of mice,we discovered that ADGRD1 promoted the differentiation of APCs,while GPR39 inhibits this *** the obese mouse model induced by a high-fat diet(HFD),both gain-of-function and loss-of-function studies validated that ADGRD1 promoted adipogenesis,thereby improving metabolic homeostasis,while GPR39 inhibited adipogenesis,leading to metabolic ***,through the analysis of 2,400 ChIP-seq data and 1,204 bulk RNA-seq data,we found that the transcription factors (TFs) MEF2D and TCF12 regulated the expression of ADGRD1and GPR39,*** study revealed the regulatory role of GPCRs in adipogenesis,providing novel targets for clinical intervention of metabolic dysfunction in obese patients.

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多循环脉冲爆震发动机概念化设计

推进技术 2003年第6期24卷 500-504页

作者：张群严传俊范玮黄希桥王治武西北工业大学航空动力与热力工程系陕西西安710072

为发展一种基于多循环爆震试验的新的脉冲爆震发动机结构设计方法,以汽油为燃料、空气为氧化剂,在内径为50mm的脉冲爆震发动机模型内产生了充分发展的脉冲爆震,根据试验结果对脉冲爆震发动机的结构参数进行了设计,设计结果更接近工程实... 详细信息

为发展一种基于多循环爆震试验的新的脉冲爆震发动机结构设计方法,以汽油为燃料、空气为氧化剂,在内径为50mm的脉冲爆震发动机模型内产生了充分发展的脉冲爆震,根据试验结果对脉冲爆震发动机的结构参数进行了设计,设计结果更接近工程实际。研究发现,当发动机结构尺寸一定时,决定推力壁压力等效作用时间的经验常数K不是一个定值,而是随爆震频率的增大按一定函数关系减小,当爆震频率增大到一定程度时,经验常数的变化幅度逐渐减小并最终趋于常值3 90。根据得到的经验性的函数关系计算出单次爆震的经验常数K为5 35。

关键词：脉冲爆震发动机结构参数设计

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang Jiali Wu Yu Wang Hanlin huang jun Ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： Zhao-jun Zhang Wen-Wei Wang Jing-Shui Zhen Bo-Cheng Li De-Cheng Cai Yang-Yang Du Hui huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

Reverse modulation of defect density of Ce-MOF-808 by solventassisted ligand exchange for dicyclopentadiene hydrogenation

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Science China Chemistry 2025年

作者： Danfeng Zhao Fajie Hu Rushuo Li Xinmeng Xu Zhaokun Wang Zuoshuai Xi jun Tong Xiubing huang Ge Wang Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory of Function Materials for Molecule & Structure Construction School of Materials Science and Engineering University of Science and Technology Beijing

Defect engineering is a pivotal strategy for tailoring the electronic structure and physicochemical properties of catalysts, yet the straightforward manipulation of defect density in porous materials presents a current challenge. In this work, we achieved precise control over the coordination unsaturated site（CUS） content and pore architecture of Ce-MOF-808 by employing 2-fluorobenzoic acid（2-FBA） as a modifier. Leveraging the p Kadisparities among three ligands（1,3,5-tricarboxylic benzoic acid,formic acid, and 2-FBA）, we preserved the spn topology of Ce-MOF within an aqueous system, while realizing partial substitution of the auxiliary ligands and saturation of the CUS. The amount of 2-FBA was negatively correlated with the number of ligand defects, and the consequent decrease in Ce3+content and the increase in the number of ligand linkages also induced crystal structure transformation. The modulation of the defect structure was correlated with the catalytic performance of dicyclopentadiene（DCPD） hydrogenation reaction, in which Ce-MMF0.15, constructed by the modulation of 0.15 mol amount of 2-fluorobenzoic acid, exhibited an optimal ligand defect density and micro-mesoporous structure, enabling almost complete conversion of DCPD at 100 ℃ and 2 MPa. This article also elucidates the correlation between the regulation of defect density and the accessibility of frustrated Lewis pair（FLP） active sites, guiding the application of novel porous intrinsic FLP materials in hydrogenation catalysis.

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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying Liu Bei Peng Xiaoyan Zhou Lixia Qin Lingyan Liang Yichen Wei Qingping Zhang Xiaocheng Li Haixia Qin Yinqi Lai Yian Lu Yan Zhang Jiazhu huang Jinli huang Yinfei Ouyang Bolin Bin Mingming Zhao jun Liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

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动态称量技术在发射药称重过程中的应用

兵器装备工程学报 2017年第2期38卷 70-74页

作者：伍凌川李全俊黄权中国兵器工业第五八研究所弹药中心四川绵阳621000

为了提高弹药发射药装药生产过程中发射药称量的精度和速度,设计一种改进型的动态称重系统,采用粗-中-细3级给料方式,建立发射药动态称重系统数学模型,通过称重信号处理和称重给料控制算法克服现有模式存在的效率低、精度不高等缺陷;20... 详细信息

为了提高弹药发射药装药生产过程中发射药称量的精度和速度,设计一种改进型的动态称重系统,采用粗-中-细3级给料方式,建立发射药动态称重系统数学模型,通过称重信号处理和称重给料控制算法克服现有模式存在的效率低、精度不高等缺陷;200次的发射药称量试验,都稳定在7.0±0.1g范围内,表明改进后的称重系统满足弹药生产过程中发射药快速精确称量的需求。

关键词：动态称量发射药称重弹药生产