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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei Wu Ji-chuan liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

A Lattice Study of the Glueball Spectrum

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Chinese Physics Letters 2001年第2期18卷 187-189页

作者： liu chuan Department of Physics Peking UniversityBeijing 100871

The glueball spectrum is studied using an improved gluonic action on asymmetric lattices in the pure SU(3)lattice gauge *** smallest spatial lattice spacing is about 0.08fm which makes the extrapolation to the continuum limit more *** our lattice results to physical units using the scale set by the static quark potential,We obtain the following results for the glueball masses:MG(0^(++))=1730(90)MeV for the scalar glueball and MG(2^(++))=2400(95)MeV for the tensor glueball.

关键词： theory lattice smallest

Symmetry Breaking in Finite Volume

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Chinese Physics Letters 2000年第3期17卷 180-181页

作者： liu chuan Department of Physics Peking UniversityBeijing 100871

Spontaneous symmetry breaking is a cooperative phenomenon for systems with inGnitely many degrees of freedom and it plays an essential role in quantum Held *** O(N)model is studied within the Hamiltonian approach using an adiabatic *** is shown that the low-lying spectrum of the system in the broken phase can be understood by using the adiabatic^or Born-Oppenheimer approximation,which turns out to become an expansion in the inverse power of *** the infinite volume limit,the symmetry is broken while in the finite volume the slow rotation of the zero-momGntum mode restores the symmetry and gives rise to the rotator spectrumf which has been observed in realistic Monte Carlo simulations.

关键词： symmetry adiabatic spectrum

Simulating Strongly Correlated Electron Systems with Hybrid Monte Carlo

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Chinese Physics Letters 2000年第8期17卷 547-548页

作者： liu chuan Department of Physics Peking UniversityBeijing 100871

Using the path integral representation,the Hubbard and the periodic Anderson model on D-dimensional cubic lattice are transformed into field theories of fermions in D+1 *** theories at half-filling possess a positive ... 详细信息

关键词： method Strongly theories

Ergodic Retraction Theorem and Weak Convergence Theorem for Reversible Semigroups of Non-Lipschitzian Mappings

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Acta Mathematica Sinica,English Series 2006年第2期22卷 407-416页

作者： liu chuan ZENG Department of Mathematics Shanghai Normal University

Let G be a semitopological semigroup. Let C be a closed convex subset of a uniformly convex Banaeh space E with a Frechet differentiable norm, and T = {Tt ： t ∈ G} be a continuous representation of G as nearly asymptotically nonexpansive type mappings of C into itself such that the common fixed point set F（T） of T in C is nonempty. It is shown that if G is right reversible, then for each almost-orbit u（.） of T, ∩s∈G ^-CO{u（t）： t ≥ s} ∩ F（T） consists of at most one point. Furthermore, ∩s∈G ^-CO{Ttx ： t ≥ s} ∩ F（T） is nonempty for each x ∈ C if and only if there exists a nonlinear ergodic retraction P of C onto F（T） such that PTs - TsP = P for all s ∈ G and Px ∈^-CO{Ttx ： s ∈ G} for each x ∈ C. This result is applied to study the problem of weak convergence of the net {u（t）： t ∈ G} to a common fixed point of T.

关键词： Non Lipschitzian mapping Reversible semigroup Ergodic retraction Weak convergence

A Monte Carlo Study of the Half-Filled Two-Dimensional Hubbard Model

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Communications in Theoretical Physics 2001年第11期36卷 625-630页

作者： ZHU Xing liu chuan Department of Physics Peking UniversityBeijing 100871China Department of PhysicsPeking UniversityBeijing 100871China

Using the path integral representation,bulk thermodynamic properties of the two-dimensional Hubbard model on a square lattice are studied numerically using the hybrid Monte Carlo simulation *** for averaged energy,spin-spin correlation functions and Cooper pair correlation functions are *** these results suggest that the system exhibits an anti-ferromagnetic correlation at half-filling for a wide range of temperature.

关键词： strongly correlated electrons,bulk thermodynamic quantities,hybrid Monte Carlo

On the Countable Tightness of Product Spaces

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Acta Mathematica Sinica,English Series 2005年第4期21卷 929-936页

作者： chuan liu Shou LIN Department of Mathematics Ohio University Zanesville Campus Zanesville OH43701 USA Department of Mathematics Ningde Teachers' College Ningde 352100 P. R. China

In this paper, we discuss the countable tightness of products of spaces which are quotient simages of locally separable metric spaces, or k-spaces with a star-countable k-network. The main result is that the following conditions are equivalent：（1） b = ω1; （2） t（Sω×Sω1）〉 ω; （3） For any pair （X, Y）, which are k-spaces with a point-countable k-network consisting of cosmic subspaces, t（X×Y）≤ω if and only if one of X, Y is first countable or both X, Y are locally cosmic spaces. Many results on the k-space property of products of spaces with certain k-networks could be deduced from the above theorem.

关键词： Countable tightness k-spaces Cosmic spaces Product spaces k-networks Point-countablecollections Star-countable collections

ISHIKAWA ITERATIVE PROCESS FOR CONSTRUCTING SOLUTIONS OF m-ACCRETIVE OPERATOR EQUATIONS

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Applied Mathematics and Mechanics(English Edition) 2002年第6期23卷 686-693页

作者： ZENG liu-chuan(曾六川) Department of Mathematics Shanghai Normal University Shanghai 200234 P R China

The convergence of the Ishikawa iteration sequences with errors for constructing solutions of m-accretive operator equations is characterized. Moreover, the error estimates of approximate solutions for locally Lipschi... 详细信息

关键词： m-accretive operator Ishikawa iterative sequence uniformly smooth Banach space

Measurement of Random Surface Parameters of Weak Scatterers using the Speckle Contrast Method

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Chinese Physics Letters 2002年第9期19卷 1283-1286页

作者： Cheng chuan-Fu, liu Chun-Xiang Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Department of Physics Shandong Normal University Ji"nan 00 Shandong Institute of Architecture

Theoretical analysis shows that the deviation roughness w and the lateral correlation length ζ of a weak scattering object determine the different properties of the contrast of the speckles in the image plane of a 4f system. Experimentally, we have measured the data of the speckle contrast versus the radius R of the variable filtering aperture. By fitting the theoretical results to these data, we extract the parameters w and ζ of the random surfaces with Gaussian correlation. This method can determine the two parameters simultaneously and independently, and pre-calibrations are not needed

关键词： Speckle