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Plexin domain-containing 1 may be a biomarker of poor prognosis in hepatocellular carcinoma patients,may mediate immune evasion

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2091-2112页

作者： Ming-Yue Tang Xue Shen Run-Sheng Yuan Hui-Yuan Li Xin-Wei Li Yi-Ming Jing Yue Zhang Hong-Hong Shen Zi-Shu Wang Lei Zhou Yun-chuan yang He-Xin Wen Fang Su Department of Medical Oncology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Otolaryngology and Head and Neck Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Neurology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina

BACKGROUND For the first time,we investigated the oncological role of plexin domain-containing 1(PLXDC1),also known as tumor endothelial marker 7(TEM7),in hepatocellular carcinoma(HCC).AIM To investigate the oncological profile of PLXDC1 in *** Based on The Cancer Genome Atlas database,we analyzed the expression of PLXDC1 in *** immunohistochemistry,quantitative real-time polymerase chain reaction(qRT-PCR),and Western blotting,we validated our *** prognostic value of PLXDC1 in HCC was analyzed by assessing its correlation with clinicopathological features,such as patient survival,methylation level,tumor immune microenvironment features,and immune cell surface checkpoint ***,to assess the immune evasion potential of PLXDC1 in HCC,we used the tumor immune dysfunction and exclusion(TIDE)website and immunohistochemical staining *** Based on immunohistochemistry,qRT-PCR,and Western blot assays,overexpression of PLXDC1 in HCC was associated with poor *** and multivariate Cox analyses indicated that PLXDC1 might be an independent prognostic *** HCC patients with high methylation levels,the prognosis was worse than in patients with low methylation *** enrichment analysis of HCC tissues indicated that genes upregulated in the high-PLXDC1 subgroup were enriched in mesenchymal and immune activation signaling,and TIDE assessment showed that the risk of immune evasion was significantly higher in the high-PLXDC1 subgroup compared to the low-PLXDC1 *** high-risk group had a significantly lower immune evasion rate as well as a poor prognosis,and PLXDC1-related risk scores were also associated with a poor *** As a result of this study analyzing PLXDC1 from multiple biological perspectives,it was revealed that it is a biomarker of poor prognosis for HCC patients,and that it plays a role in determining immune evasion status.

关键词： Plexin domain-containing 1 Biomarker Immune evasion Prognosis Immunotherapy Hepatocellular carcinoma

Small-molecule agents for cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第3期14卷 905-952页

作者： Fang Wang Kai Fu Yujue Wang Can Pan Xueping Wang Zeyu Liu chuan yang Ying Zheng Xiaopeng Li Yu Lu Kenneth Kin Wah To Chenglai Xia Jianye Zhang Zhi Shi Zeping Hu Min Huang Liwu Fu State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Esophageal Cancer InstituteGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China School of Pharmaceutical Sciences Tsinghua-Peking Center for Life SciencesBeijing Frontier Research Center for Biological StructureTsinghua UniversityBeijing 100084China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Cell Biology&Institute of Biomedicine National Engineering Research Center of Genetic MedicineMOE Key Laboratory of Tumor Molecular BiologyGuangdong Provincial Key Laboratory of Bioengineering MedicineCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target&Clinical Pharmacology NMPA and State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences and the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436China School of Pharmacy The Chinese University of Hong KongHong Kong 999077China Affiliated Foshan Maternity and Child Healthcare Hospital Southern Medical UniversityFoshan 528000China

Cancer immunotherapy,exemplified by the remarkable clinical benefits of the immune checkpoint blockade and chimeric antigen receptor T-cell therapy,is revolutionizing cancer *** induce long-term tumor regression and overall survival benefit in many types of *** the advances in our knowledge about the tumor immune microenvironment,remarkable progress has been made in the development of small-molecule drugs for *** molecules targeting PRR-associated pathways,immune checkpoints,oncogenic signaling,metabolic pathways,cytokine/chemokine signaling,and immune-related kinases have been extensively *** of smallmolecule immunotherapeutic drugs and their combinations with other antitumor modalities are under active clinical investigations to overcome immune tolerance and circumvent immune checkpoint inhibitor ***,we review the latest development of small-molecule agents for cancer immunotherapy by targeting defined pathways and highlighting their progress in recent clinical investigations.

关键词： Cancer immunotherapy Small-molecule agents Immune checkpoints Oncogenic signaling Metabolic pathways Cytokine/chemokine signaling Antitumor immunity Tumor immune microenvironment

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亲油水泥浆界面封隔性能评价研究

西南石油大学学报（自然科学版） 2024年第1期46卷 115-125页

作者：黄盛周灿李早元杨川刘洋油气藏地质及开发工程全国重点实验室·西南石油大学四川成都610500 西南石油大学石油与天然气工程学院四川成都610500 中国石油川庆钻探工程有限公司井下作业公司四川成都610052

页岩气井油基钻井液条件下固井时,套管与井壁表面附着油膜或油基钻井液易导致水泥环界面封隔能力下降,形成窜流通道,影响后期增产改造作业。虽然前置液能有效提高界面润湿反转,但受用量、冲洗效率等因素限制,界面仍会出现油膜附着情况... 详细信息

页岩气井油基钻井液条件下固井时,套管与井壁表面附着油膜或油基钻井液易导致水泥环界面封隔能力下降,形成窜流通道,影响后期增产改造作业。虽然前置液能有效提高界面润湿反转,但受用量、冲洗效率等因素限制,界面仍会出现油膜附着情况。为此,在水泥浆中加入亲油表面活性剂,制备形成亲油水泥浆,赋予水泥环亲油能力。采用接触角、剪切胶结强度、界面水力封隔测试等评价了亲油水泥石的亲油能力及界面封隔效果。研究发现,非极性溶剂在亲油水泥石表面接触角远低于常规水泥石表面,具备良好的亲油性能;亲油水泥石与含白油、油基钻井液的套管、页岩岩芯胶结后,一、二界面抗流体窜流压力分别提升500%和400%,胶结强度分别提高205%和122%;亲油表面活性剂的加入不会对水泥水化程度、水泥浆工程性能及水泥石力学性能产生负面影响。结果表明,亲油表面活性剂掺入后可有效提高水泥环与含油界面的封隔能力,具备提高油基钻井液条件下水泥环套管地层界面胶结与封隔性能的潜力。

关键词：页岩气固井界面封隔油基钻井液表面活性剂

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城市快速路综合整治施工交通组织案例分析

市政设施管理 2024年第2期 37-40页

作者：杨川重庆市市政设施运行保障中心

以重庆市内环快速路综合整治二期工程一阶段施工为例,详细介绍了建成区道路更新项目施工期间交通组织研究、方案比选、成型过程及安全与应急保障措施等内容,为有类似施工交通组织困难的项目提供思路和借鉴。

关键词：快速路交通组织占道施工

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智能化防伪包装印刷技术的原理

丝网印刷 2024年第10期 36-39页

作者：杨川湖北楚天传媒印务有限责任公司

防伪包装技术利用商品的包装来达到防伪目的,借助于包装的各种要素,防止商品在流通与转移过程中被人为地、有意识地窃换和假冒。文章介绍了防伪包装印刷技术的基本情况,结合几种智能化防伪包装印刷技术,从其原理和应用技术上加以分析阐述。

关键词：智能化防伪包装印刷技术

基于“大食物观”的中国粮食安全水平评价与动态演进

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经济地理 2024年第2期44卷 166-174页

作者：杨川卢新海许进龙华中师范大学公共管理学院湖北武汉430070

立足“大食物观”构建了粮食安全评价指标体系,基于2010—2021年中国31个省份的面板数据,运用熵值法、核密度估计、空间自相关和Markov链对中国粮食安全水平进行评价并分析其时空演进特征。结果表明:①2010—2021年中国粮食安全水平总... 详细信息

立足“大食物观”构建了粮食安全评价指标体系,基于2010—2021年中国31个省份的面板数据,运用熵值法、核密度估计、空间自相关和Markov链对中国粮食安全水平进行评价并分析其时空演进特征。结果表明:①2010—2021年中国粮食安全水平总体上呈现增长态势,但增长速度缓慢,生产安全、生态安全、经济安全、消费安全、流通安全5个子系统存在发展不均衡的问题,生产安全对粮食安全水平的提升贡献率最高。②全国、粮食主产区、非主产区粮食安全水平均表现出“绝对水平提升、相对差异缩小”的特征,粮食主产区的粮食安全水平在空间上表现出更严重的多级分化现象,非粮食主产区初始粮食安全水平分布较为集中但后续发展速度存在较大差异。③中国的粮食安全水平分布具有显著的空间集聚特征,各省市粮食安全水平之间存在明显的空间正相关关系,但这种相关性正逐渐减小。④粮食安全水平存在俱乐部趋同现象,呈现稳态性,不同粮食安全水平类型之间转移概率较低,各地区在总体粮食安全水平中的分布位置比较稳定。基于研究结论,从重构粮食生产空间、培育农业特色产业、完善粮食流通体系等方面提出了政策建议。

关键词：粮食安全大食物观多元食物评价生产安全消费安全流通安全

Exploring Sulfur Chemistry in TMC-1 with NSRT

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Chinese Physics Letters 2024年第2期41卷 129-132页

作者： Wasim Iqbal Xiaohu Li Juan Tuo Ryszard Szczerba Yanan Feng Zhenzhen Miao Jiangchao yang Jixing Ge Gleb Fedoseev Donghui Quan Qiang Chang chuan-Lu yang Tao yang Gao-Lei Hou Yong Zhang Xuan Fang Xia Zhang Fangfang Li Rong Ma Xiaomin Song Zhiping Kou Yuxuan Sun Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Xinjiang Key Laboratory of Radio Astrophysics Urumqi 830011China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Nicolaus Copernicus Astronomical Center Rabia´nska 887-100 Toru´nPoland Research Laboratory for Astrochemistry Ural Federal UniversityKuibysheva St.48620026 EkaterinburgRussia Astronomical Computing Research Center Zhejiang LaboratoryHangzhou 311100China School of Physics and Optoelectronic Engineering Shandong University of TechnologyZibo 255000China School of Physics and Optoelectronic Engineering Ludong UniversityYantai 264025China State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200062China MOE Key Laboratory for Non-Equilibrium Synthesis and Modulation of Condensed Matter School of PhysicsXi’an Jiaotong UniversityXi’an 710049China School of Physics and Astronomy Sun Yat-sen UniversityGuangzhou 510275China Laboratory for Space Research Faculty of ScienceThe University of Hong KongHong KongChina National Astronomical Observatories Chinese Academy of SciencesBeijing 100012China

There have been several studies on sulfur depletion in dense cores like TMC-1(Taurus Molecular Cloud 1),employing updated reaction networks for sulfur species to explain the missing sulfur in the gas within dense *** of these studies used a C/O ratio of 0.7 or *** present NSRT(NanShan 26m Radio Telescope)observations of TMC-1 alongside results from time-dependent chemical simulations using an updated chemical *** findings highlight the impact of the C/O ratio on the gas-phase evolution of C2S and *** simulation results show that the C/O ratio is an important parameter,playing a fundamental role in determining the gas-phase abundances of sulfur species in dense cores.

关键词： sulfur Sulfur depletion

Cryogenian and Ediacaran integrative stratigraphy, biotas, and palaeogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年

作者： Lang SUN Malik Muhammad Saud Sajid KHAN chuan yang Zhixin SUN Bing PAN Shehryar AHMED Lanyun MIAO Weichen SUN Chunlin HU Xiaojuan SUN Cui LUO Bo CHEN Zongjun YIN Fangchen ZHAO Guoxiang LI Maoyan ZHU State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of Sciences College of Earth and Planetary Sciences University of Chinese Academy of Sciences

The complex evolutionary history of the Qinghai-Tibetan Plateau and its surrounding areas, including the continental blocks (Indian, Lhasa, South Qiangtang, Tarim, Olongbuluk, Central Qilian, Alxa, North China, yangtze, Central Iran and Oman) and the orogenic belts between them, has long been the frontier in Earth science research. The Cryogenian and Ediacaran strata are extensively distributed in these blocks. Specifically, relatively complete Cryogenian and Ediacaran successions have been discovered in Oman, Indian, yangtze, and Tarim blocks, while only the Ediacaran successions have been reported in Iran,the South Qiangtang, Central Qilian, Alxa, and North China blocks. Based on previous studies together with the integration of new materials and advancement obtained through the Second Tibetan Plateau Scientific Expedition and Research, this review aims to synthesize a correlative stratigraphic framework of the representative Cryogenian and Ediacaran sequences from the Qinghai-Tibetan Plateau and its surrounding areas. Furthermore, the Cryogenian and Ediacaran biotas and major geological events in these areas are comprehensively discussed in aspects of current research status. The results indicate that, in general,Ediacaran fossils of each area exhibit distinct features in preservation and assemblage composition, but the typical late Ediacaran fossils Cloudina and Shaanxilithes have been reported from most of these areas. In addition to the two global Cryogenian glaciations, late Ediacaran glaciogenic deposits are extensively recorded in the areas within and around the northern QinghaiTibetan Plateau (including the North China, Alxa, Central Qilian, Olongbuluk, and Tarim blocks, and the North Qilian Accretionary Belt), as well as central and southern Iran. However, further research is required to determine the age, distribution, and origin of these late Ediacaran glaciogenic deposits. Meanwhile, the middle Ediacaran DOUNCE/Shuram Excursion is widely documented in

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水力条件对供水管网微生物影响研究进展

给水排水 2024年第6期50卷 164-169页

作者：房志伟杨川徐强强志民中国科学院生态环境研究中心饮用水科学与技术重点实验室北京100085 中国科学院大学北京100049 北京市自来水集团水质监测中心北京100085

供水管网内微生物异常增殖会降低水质,威胁用户用水安全,因此控制管网微生物是保障饮用水安全的重要措施。管网微生物的生长和去除受到管网水力条件的影响,且在管网不同位置处所受影响程度不同。综述了水力停留时间和流速对管网微生物... 详细信息

供水管网内微生物异常增殖会降低水质,威胁用户用水安全,因此控制管网微生物是保障饮用水安全的重要措施。管网微生物的生长和去除受到管网水力条件的影响,且在管网不同位置处所受影响程度不同。综述了水力停留时间和流速对管网微生物生长的影响,以及水力冲刷对生物膜的去除作用,发现水力停留时间和流速对微生物量与群落结构有显著影响,水力冲刷对不同条件下形成的管壁生物膜去除效果不同,研究结果可为供水管网微生物控制的研究和应用提供重要参考。

关键词：供水管网水力条件微生物