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Decoding the fish genome opens a new era in important trait research and molecular breeding in China

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Science China(Life Sciences) 2024年第10期67卷 2064-2083页

作者： Qian Zhou Jialin Wang Jiongtang Li Zhangfan Chen Na Wang ming Li Lei Wang Yufeng Si Sheng Lu Zhongkai cui Xuhui Liu Songlin Chen State Key Laboratory of Mariculture Biobreeding and Sustainable Goods Yellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesQingdaoShandong 266071China Laboratory for Marine Fisheries Science and Food Production Processes Qingdao Marine Science and Technology CenterQingdaoShandong 266237China Key Laboratory of Aquatic Genomics Ministry of Agriculture and Rural AffairsBeijing Key Laboratory of Fishery BiotechnologyChinese Academy of Fishery SciencesBeijing 100041China

Aquaculture represents the fastest-growing global food production sector,as it has become an essential component of the global food *** has the world's largest aquaculture industry in terms of production ***,the sustainable development of fish culture is hindered by several concerns,including germplasm degradation and disease *** practice of genomic breeding,which relies heavily on genome information and genotypephenotype relationships,has significant potential for increasing the efficiency of aquaculture *** 2014,the completion of the genome sequencing and annotation of the Chinese tongue sole signified the beginning of the fish genomics era in *** then,domestic researchers have made dramatic progress in functional genomic *** date,the genomes of more than 60 species of fish in China have been assembled and *** on these reference genomes,evolutionary,comparative,and functional genomic studies have revolutionized our understanding of a wide range of biologically and economically important traits of fishes,including growth and development,sex determination,disease resistance,metamorphosis,and ***,genomic tools and breeding techniques such as SNP arrays,genomic selection,and genome editing have greatly accelerated genetic improvement through the incorporation of functional genomic information into breeding *** review aims to summarize the current status,advances,and perspectives of the genome resources,genomic study of important traits,and genomic breeding techniques of fish in *** review will provide aquaculture researchers,fish breeders,and farmers with updated information concerning fish genomic research and breeding *** summary will help to promote the genetic improvement of production traits and thus will support the sustainable development of fish aquaculture.

关键词： fish genomics economic traits genomic selection genome editing genomic breeding

Multilocular thymic cysts can be easily misdiagnosed as malignant tumor on computer tomography:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1474-1480页

作者： Jun Sun Qing-Ning Yang Yi Guo Ping Zeng Long-Yan Ma Ling-Wen Kong Bo-Ying Zhao chuan-ming Li Department of Radiology Chongqing University Central HospitalChongqing Emergency Medical CenterChongqing 400014China Department of Pathology Chongqing University Central HospitalChongqing Emergency Medical CenterChongqing 400014China Department of Cardiothoracic Surgery Chongqing University Central HospitalChongqing Emergency Medical CenterChongqing 400014China

BACKGROUND Multilocular thymic cyst(MTC)is a rare mediastinal lesion which is considered to occur in the process of acquired *** is usually characterized by well-defined cystic density and is filled with transparent *** SUMMARY We report on a 39-year-old male with a cystic-solid mass in the anterior *** tomography(CT)imaging showed that the mass was irregular with unclear *** injection of contrast agent,there was a slight enhancement of stripes and *** to CT findings,it was diagnosed as thymic *** After surgery,MTC accompanied by bleeding and infection was confirmed by pathological *** main lesson of this case was that malignant thymic tumor and MTC of the anterior mediastinum sometimes exhibit similar CT *** is necessary in clinical work to avoid misdiagnosis.

关键词： Multilocular thymic cyst Computer tomography Misdiagnosis Hemorrhage Infection Case report

A hybrid machine learning optimization algorithm for multivariable pore pressure prediction

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Petroleum Science 2024年第1期21卷 535-550页

作者： Song Deng Hao-Yu Pan Hai-Ge Wang Shou-Kun Xu Xiao-Peng Yan Chao-Wei Li ming-Guo Peng Hao-Ping Peng Lin Shi Meng cui Fei Zhao School of Petroleum and Natural Gas Engineering Changzhou UniversityChangzhou213164JiangsuChina Tubular Goods Research Institute of CNPC Beijing102249China CNPC Engineering Technology R&D Company Limited Beijing102206China

Pore pressure is essential data in drilling design,and its accurate prediction is necessary to ensure drilling safety and improve drilling *** methods for predicting pore pressure are limited when forming particular structures and *** this paper,a machine learning algorithm and effective stress theorem are used to establish the transformation model between rock physical parameters and pore *** study collects data from three *** 1 had 881 data sets for model training,and Wells 2 and 3 had 538 and 464 data sets for model *** this paper,support vector machine(SVM),random forest(RF),extreme gradient boosting(XGB),and multilayer perceptron(MLP)are selected as the machine learning algorithms for pore pressure *** addition,this paper uses the grey wolf optimization(GWO)algorithm,particle swarm optimization(PSO)algorithm,sparrow search algorithm(SSA),and bat algorithm(BA)to establish a hybrid machine learning optimization algorithm,and proposes an improved grey wolf optimization(IGWO)*** IGWO-MLP model obtained the minimum root mean square error(RMSE)by using the 5-fold cross-validation method for the training *** the pore pressure data in Well 2 and Well 3,the coefficients of determination(R^(2))of SVM,RF,XGB,and MLP are 0.9930 and 0.9446,0.9943 and 0.9472,0.9945 and 0.9488,0.9949 and *** achieves optimal performance on both training and test data,and the MLP model shows a high degree of *** indicates that the IGWO-MLP is an excellent predictor of pore pressure and can be used to predict pore pressure.

关键词： Pore pressure Grey wolf optimization Multilayer perceptron Effective stress Machine learning

Plexin domain-containing 1 may be a biomarker of poor prognosis in hepatocellular carcinoma patients,may mediate immune evasion

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2091-2112页

作者： ming-Yue Tang Xue Shen Run-Sheng Yuan Hui-Yuan Li Xin-Wei Li Yi-ming Jing Yue Zhang Hong-Hong Shen Zi-Shu Wang Lei Zhou Yun-chuan Yang He-Xin Wen Fang Su Department of Medical Oncology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Otolaryngology and Head and Neck Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Neurology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina

BACKGROUND For the first time,we investigated the oncological role of plexin domain-containing 1(PLXDC1),also known as tumor endothelial marker 7(TEM7),in hepatocellular carcinoma(HCC).AIM To investigate the oncological profile of PLXDC1 in *** Based on The Cancer Genome Atlas database,we analyzed the expression of PLXDC1 in *** immunohistochemistry,quantitative real-time polymerase chain reaction(qRT-PCR),and Western blotting,we validated our *** prognostic value of PLXDC1 in HCC was analyzed by assessing its correlation with clinicopathological features,such as patient survival,methylation level,tumor immune microenvironment features,and immune cell surface checkpoint ***,to assess the immune evasion potential of PLXDC1 in HCC,we used the tumor immune dysfunction and exclusion(TIDE)website and immunohistochemical staining *** Based on immunohistochemistry,qRT-PCR,and Western blot assays,overexpression of PLXDC1 in HCC was associated with poor *** and multivariate Cox analyses indicated that PLXDC1 might be an independent prognostic *** HCC patients with high methylation levels,the prognosis was worse than in patients with low methylation *** enrichment analysis of HCC tissues indicated that genes upregulated in the high-PLXDC1 subgroup were enriched in mesenchymal and immune activation signaling,and TIDE assessment showed that the risk of immune evasion was significantly higher in the high-PLXDC1 subgroup compared to the low-PLXDC1 *** high-risk group had a significantly lower immune evasion rate as well as a poor prognosis,and PLXDC1-related risk scores were also associated with a poor *** As a result of this study analyzing PLXDC1 from multiple biological perspectives,it was revealed that it is a biomarker of poor prognosis for HCC patients,and that it plays a role in determining immune evasion status.

关键词： Plexin domain-containing 1 Biomarker Immune evasion Prognosis Immunotherapy Hepatocellular carcinoma

Remote ischemic conditioning prevents ischemic cerebrovascular events in children with moyamoya disease:a randomized controlled trial

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World Journal of Pediatrics 2024年第9期20卷 925-934页

作者： Shuang-Feng Huang Jia-Li Xu Chang-Hong Ren Nathan Sim Cong Han Yi-Qin Han Wen-Bo Zhao Yu-chuan Ding Xun-ming Ji Si-Jie Li Department of Neurology Xuanwu HospitalCapital Medical UniversityNo 45Changchun StreetXicheng DistrictBeijing100053China Department of Rehabilitation Medicine Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Capital Medical UniversityNo.10XitoutiaoYou’anmenwaiFengtai DistrictBeijing100053China Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Wayne State UniversityDetroitMIUSA Department of Neurosurgery The Fifth Medical CentreChinese PLA General HospitalBeijingChina Department of Emergency Xuanwu HospitalCapital Medical UniversityBeijingChina

Background Moyamoya disease(MMD)is a significant cause of childhood stroke and transient ischemic attacks(TIAs).This study aimed to assess the safety and efficacy of remote ischemic conditioning(RIC)in children with *** In a single-center pilot study,46 MMD patients aged 4 to 14 years,with no history of reconstructive surgery,were randomly assigned to receive either RIC or sham RIC treatment twice daily for a *** primary outcome measured was the cumulative incidence of major adverse cerebrovascular events(MACEs).Secondary outcomes included ischemic stroke,recurrent TIA,hemorrhagic stroke,revascularization rates,and clinical improvement assessed using the patient global impression of change(PGIC)scale during ***-related adverse events were also recorded,and cerebral hemodynamics were evaluated using transcranial *** All 46 patients completed the final follow-up(23 each in the RIC and sham RIC groups).No severe adverse events associated with RIC were ***-Meier analysis indicated a significant reduction in MACEs frequency after RIC treatment[log-rank test(Mantel-Cox),P=0.021].At 3-year follow-up,two(4.35%)patients had an ischemic stroke,four(8.70%)experienced TIAs,and two(4.35%)underwent revascularization as the qualifying *** clinical improvement rate in the RIC group was higher than the sham RIC group on the PGIC scale(65.2%vs.26.1%,P<0.01).No statistical difference in cerebral hemodynamics post-treatment was *** RIC is a safe and effective adjunct therapy for asymptomatic children with *** was largely due to the reduced incidence of ischemic cerebrovascular events.

关键词： Asymptomatic moyamoya disease Children Remote ischemic conditioning Stroke

Cryogenian and Ediacaran integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年第4期67卷 919-949页

作者： Lang SUN Malik Muhammad Saud Sajid KHAN chuan YANG Zhixin SUN Bing PAN Shehryar AHMED Lanyun MIAO Weichen SUN Chunlin HU Xiaojuan SUN cui LUO Bo CHEN Zongjun YIN Fangchen ZHAO Guoxiang LI Maoyan ZHU State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

The complex evolutionary history of the Qinghai-Tibetan Plateau and its surrounding areas,including the continental blocks(Indian,Lhasa,South Qiangtang,Tarim,Olongbuluk,Central Qilian,Alxa,North China,Yangtze,Central Iran and Oman)and the orogenic belts between them,has long been the frontier in Earth science *** Cryogenian and Ediacaran strata are extensively distributed in these ***,relatively complete Cryogenian and Ediacaran successions have been discovered in Oman,Indian,Yangtze,and Tarim blocks,while only the Ediacaran successions have been reported in Iran,the South Qiangtang,Central Qilian,Alxa,and North China *** on previous studies together with the integration of new materials and advancement obtained through the Second Tibetan Plateau Scientific Expedition and Research,this review aims to synthesize a correlative stratigraphic framework of the representative Cryogenian and Ediacaran sequences from the Qinghai-Tibetan Plateau and its surrounding ***,the Cryogenian and Ediacaran biotas and major geological events in these areas are comprehensively discussed in aspects of current research *** results indicate that,in general,Ediacaran fossils of each area exhibit distinct features in preservation and assemblage composition,but the typical late Ediacaran fossils Cloudina and Shaanxilithes have been reported from most of these *** addition to the two global Cryogenian glaciations,late Ediacaran glaciogenic deposits are extensively recorded in the areas within and around the northern QinghaiTibetan Plateau(including the North China,Alxa,Central Qilian,Olongbuluk,and Tarim blocks,and the North Qilian Accretionary Belt),as well as central and southern ***,further research is required to determine the age,distribution,and origin of these late Ediacaran glaciogenic ***,the middle Ediacaran DOUNCE/Shuram Excursion is widely documented in the Qinghai-Tibetan Plateau and its surroundi

关键词： Qinghai-Tibetan Plateau Cryogenian Ediacaran Stratigraphy Palaeogeography Biota Gondwana

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红色记忆空间的育人机理与营造

思想理论教育 2024年第6期 62-67页

作者：崔明兰州大学马克思主义学院甘肃兰州730000

红色记忆空间是传播红色文化的重要物质媒介,它通过对历史的全景式呈现、象征性建筑的运用、空间的重新赋义、记忆媒介的综合使用等空间营造技术,有效形塑了参观者的集体记忆,进而建构了参观者的政治认同。所以,红色记忆空间成为最常被... 详细信息

红色记忆空间是传播红色文化的重要物质媒介,它通过对历史的全景式呈现、象征性建筑的运用、空间的重新赋义、记忆媒介的综合使用等空间营造技术,有效形塑了参观者的集体记忆,进而建构了参观者的政治认同。所以,红色记忆空间成为最常被利用的思想政治教育空间。但红色记忆空间自身的物理衰变和多义特质也不断消解着其思想政治教育功能的有效性。为了提升红色记忆空间传播、传承红色文化和建构政治认同的有效性,红色文化记忆空间需要多路径开展空间生产,完善成为多意义空间、超时空的记忆空间、长时段的学习空间。

关键词：红色记忆空间记忆媒介政治认同

Changes of the trace metals in ice core during 1915-2016 in coastal eastern Antarctica

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Advances in Climate Change Research 2024年第4期15卷 596-608页

作者： Jing-Wen LIU chuan-Jin LI Gui-Tao SHI Yan LIU Zhi-Heng DU ming-Hu DING Shao-Peng GAO Cun-De XIAO Shi-Chang KANG Bo SUN State Key Laboratory of the Cryosphere Science Northwest Institute of the Eco-Environment and ResourcesChinese Academy of SciencesLanzhou730000China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory for Polar Science of State Oceanic Administration Polar Research Institute of ChinaShanghai 200136China Key Laboratory of Geographic Information Science(Ministry of Education) School of Geographic Sciences and Institute of Eco-ChongmingEast China Normal UniversityShanghai 200241China Institute of Tibetan Plateau and Polar Regions Meteorology Chinese Academy of Meteorological SciencesBeijing 100081China Key Laboratory of Tibetan Environment Changes and Land Surface Processes Instituie of the Tibetan PlateauChinese Academy of SciencesBeijing 100101China State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityBeijing 100875China

Antarctic trace metal records provide important information for grasping the influence of human activities on the environment over the last *** CA2016-75 ice core is located along the East Antarctic Zhongshan Station-Dome A,enhances the record of metals research in the East Antarctic region,and its high-resolution supplies data support for the study of high-frequency climatic drivers and the effect of human activities on the Antarctic environment.A thorough dataset on seven trace metals(Al,Fe,Mn,Cu,Zn,Ba and Pb)in a coastal ice core in eastern Antarctica during the previous 102 years(1915-2016)is presented in this *** has the lowest concentration(9.51±20.95 pg g^(-1)),and Ba has the highest concentration(36.57±51.35 ng g^(-1)).Notable variations are observed between the pre-1968 AD and post-1968 AD phases for Mn,Zn and *** abrupt,remarkable increase in the concentrations coincided with the change of metal smelting production in the southern *** addition to this,it may also be related to local Antarctic scientific research *** and Fe,the primary crustal elements,are essentially obtained from soil dust;Cu shows high crustal enrichment factors(EFc,>10),indicating that it is notably affected by anthropogenic ***,the anthropogenic activities in the Southern Hemisphere have had an impact on lead deposition in *** study not only enriches the trace metal historical record along the Zhongshan Station-Dome A but also provides a high-resolution ice core record,which is very crucial for the reconstruction of trace metal concentration changes in the last 100 years.

关键词： Eastern Antarctica Ice core Trace metals Human activities

A review on DFACS(II):Modeling and analysis of disturbances and noises

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Chinese Journal of Aeronautics 2024年第5期37卷 120-147页

作者： Chenglei YUE Bohan JIAO Zhaohui DANG Xiaokui YUE Yonghe ZHANG Yuanqing XIA Li DUAN Qinglei HU Qifan LIU Pengcheng WANG ming GUO Zhansheng DUAN Bing cui Chu ZHANG Xiaodong SHAO School of Astronautics Northwestern Polytechnical UniversityXi’an 710072China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 710699China School of Automation Beijing Institute of TechnologyBeijing 100081China Institute of Mechanics Chinese Academy of SciencesBeijing 710043China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China School of Automation Science and Engineering Xi’an Jiaotong UniversityXi’an 710049China

This paper presents Part II of a review on DFACS,which specifically focuses on the modeling and analysis of disturbances and noises in *** Part I,the system composition and dynamics model of the DFACS were *** this paper,we discuss the effects of disturbance forces and noises on the system,and summarize various analysis and modeling methods for these interferences,including the integral method,frequency domain analysis method,and magnitude evaluation *** analyzing the impact of disturbances and noises on the system,the paper also summarizes the system’s performance under slight ***,we highlight current research difficulties in the field of DFACS noise ***,this paper provides valuable insights into the modeling and analysis of disturbances and noises in DFACSs,and identifies key areas for future research.

关键词： Drag-free DFACS Disturbance Analysis Noise Analysis Frequency Domain Analysis Performance Evaluation