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Science China Materials 2024年第10期67卷 3151-3159页

作者： Baichao Zhang Xuchuan Cao Chao Suo Jing cui Xiaochuan Duan Shaohui Guo Xian-ming Zhang Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of EducationCollege of ChemistryCollege of Chemical Engineering and TechnologyTaiyuan University of TechnologyTaiyuan 030024China

Utilizing plasmonic non-noble metal nanoparticles(NPs)for photocatalytic hydrogen evolution reaction is a significant step toward green energy ***,optimizing the interface between non-noble metal NPs and semiconducting materials in metal-semiconductor composites remains challenging owing to the inevitable surface oxide layers of non-noble metal NPs because the surface oxide layers of non-noble metal NPs can suppress the transfer of photoinduced carriers,leading to poor photocatalytic ***,we propose a photoinduced interface activation strategy to reduce the number of oxide layers based on a dynamic charge-transfer mechanism under illumination conditions,with Bi NPs and a Ni-based metal-organic framework(MOF)selected as model *** light illumination,the photoinduced charges and plasmonic hot electrons heavily pooled at the interface between the Bi NPs and Ni-MOF,resulting in the reduction of the oxide layer on the surface of Bi,thus attenuating its hindering effect on charge *** phenomenon led to a dynamically enhanced carrier concentration in the Bi/Ni-MOF composite,with an outstanding photocatalytic hydrogen evolution rate of 5822μmol g^(−1)h^(−1)achieved with the *** results of this study indicate that our strategy provides a new method for optimizing plasmonic non-noble metal Bi NPs with oxide layers.

关键词： plasmonic non-noble metal interface activation metal-organic framework charge transfer photocatalytic hydrogen

Disaster effects of climate change in High Mountain Asia:State of art and scientific challenges Disaster effects of climate change in High Mountain Asia:State of art and scientific challenges

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Advances in Climate Change Research 2024年第3期15卷 367-389页

作者： Hao WANG Bin-Bin WANG Peng cui Yao-ming MA Yan WANG Jian-Sheng HAO Yu WANG Ya-Mei LI Li-Jun SUN Jiao WANG Guo-Tao ZHANG Wei-Mo LI Yu LEI Wen-Qing ZHAO Jin-Bo TANG Chao-Yue LI Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China China‒Pakistan Joint Research Center on Earth Sciences Chinese Academy of SciencesIslamabad 45320Pakistan College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China College of Atmospheric Science Lanzhou UniversityLanzhou 730000China National Observation and Research Station for Qomolongma Special Atmospheric Processes and Environmental Changes Dingri 858200China

High Mountain Asia(HMA)shows a remarkable warming tendency and divergent trend of regional precipitation with enhanced meteorological *** rapid thawing of the HMA cryosphere may alter the magnitude and frequency of nature *** reviewed the influence of climate change on various types of nature hazards in HMA region,including their phenomena,mechanisms and *** reveals that:1)the occurrences of extreme rainfall,heavy snowfall,and drifting snow hazards are escalating;accelerated ice and snow melting have advanced the onset and increased the magnitude of snowmelt floods;2)due to elevating trigger factors,such as glacier debuttressing and the rapid shift of thermal and hydrological regime of bedrock/snow/ice interface or subsurface,the mass flow hazards including bedrock landslide,snow avalanche,ice-rock avalanches or glacier detachment,and debris flow will become more severe;3)increased active-layer detachment and retrogressive thaw slumps slope failures,thaw settlement and thermokarst lake will damage many important engineering structures and infrastructure in permafrost region;4)multi-hazards cascading hazard in HMA,such as the glacial lake outburst flood(GLOF)and avalanche-induced mass flow may greatly enlarge the destructive power of the primary hazard by amplifying its volume,mobility,and impact force;and 5)enhanced slope instability and sediment supply in the highland areas could impose remote catastrophic impacts upon lowland regions,and threat hydropower security and future water *** future,ongoing thawing of HMA will profoundly weaken the multiple-phase material of bedrock,ice,water,and soil,and enhance activities of nature *** and cascading hazards of high magnitude will prevail in *** the glacier runoff overpasses the peak water,low flow or droughts in lowland areas downstream of glacierized mountain regions will became more frequent and *** escalating hazards in the HMA region requires tackling s

关键词： High Mountain Asia Climate change Cryosphere degradation Nature hazards Disaster risk

Comprehensive assessment of the association between tumorinfiltrating immune cells and the prognosis of renal cell carcinoma

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World Journal of Clinical Oncology 2024年第10期15卷 1280-1292页

作者： Guo-Hao Wei Xi-Yi Wei Ling-Yao Fan Wen-Zheng Zhou ming Sun chuan-Dong Zhu Department of Oncology The Second Hospital of NanjingAffiliated to Nanjing University of Chinese MedicineNanjing 210003Jiangsu ProvinceChina The State Key Laboratory of Reproductive Department of UrologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210003Jiangsu ProvinceChina

BACKGROUND According to current statistics,renal cancer accounts for 3%of all cancers *** cell carcinoma(RCC)is the most common solid lesion in the kidney and accounts for approximately 90%of all renal *** evi-dence has shown an association between immune infiltration in RCC and clinical *** discover possible targets for the immune system,we investigated the link between tumor-infiltrating immune cells(TIICs)and the prognosis of *** To investigate the effects of 22 TIICs on the prognosis of RCC patients and iden-tify potential therapeutic targets for RCC *** The CIBERSORT algorithm partitioned the 22 TIICs from the Cancer Genome Atlas cohort into *** regression analysis was employed to evaluate the impact of 22 TIICs on the probability of developing RCC.A predictive model for immunological risk was developed by analyzing the statistical relationship between the subpopulations of TIICs and survival ***,multi-variate Cox regression analysis was used to investigate independent factors for the prognostic prediction of RCC.A value of P<0.05 was regarded as statistically *** Compared to normal tissues,RCC tissues exhibited a distinct infiltration of im-mune *** immune risk score model was established and univariate Cox regression analysis revealed a significant association between four immune cell types and the survival risk connected to ***-risk individuals were correlated to poorer outcomes according to the Kaplan-Meier survival curve(P=1E-05).The immunological risk score model was demonstrated to be a dependable predictor of survival risk(area under the curve=0.747)via the receiver operating characteristic *** to multivariate Cox regression analysis,the immune risk score model independently predicted RCC patients'prognosis(hazard ratio=1.550,95%CI:1.342–1.791;P<0.001).Finally,we established a nomogram that accurately and comprehensively fore

关键词： Renal cell carcinoma Tumor-infiltrating immune cells Prognosis Immune risk score model Nomogram

SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2285-2297页

作者： Hui Qian Chen-Hong Ding Fang Liu Shi-Jie Chen Chen-Kai Huang Meng-Chao Xiao Xia-Lu Hong ming-Chen Wang Fang-Zhi Yan Kai Ding Ya-Lu cui Bai-Nan Zheng Jin Ding Cheng Luo Xin Zhang Wei-Fen Xie Department of Gastroenterology Changzheng HospitalNaval Medical UniversityShanghaiChina Department of Gastroenterology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Drug Discovery and Design Center CAS Key Laboratory of Receptor ResearchState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina Department of Gastroenterology First Affiliated Hospital of Nanchang UniversityNanchangChina Clinical Cancer Institute Center for Translational MedicineNaval Medical UniversityShanghaiChina

The translocation of YAP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor ***,the precise molecular mechanisms governing the nuclear import of YAP are not fully *** this study,we have uncovered a crucial role of SOX9 in the activation of ***9 promotes the nuclear translocation of YAP by direct ***,we have identified that the binding between Asp-125 of SOX9 and Arg-124 of YAP is essential for SOX9-YAP interaction and subsequent nuclear entry of ***,we have discovered a novel asymmetrical dimethylation of YAP at Arg-124(YAP-R124me2a)catalyzed by ***-R124me2a enhances the interaction between YAP and SOX9 and is associated with poor prognosis in multiple ***,we disrupted the interaction between SOX9 and YAP using a competitive peptide,S-A1,which mimics anα-helix of SOX9 containing Asp-125.S-A1 significantly inhibits YAP nuclear translocation and effectively suppresses tumor *** study provides the first evidence of SOX9 as a pivotal regulator driving YAP nuclear translocation and presents a potential therapeutic strategy for YAP-driven human cancers by targeting SOX9-YAP interaction.

关键词： interaction interaction precise

基于CREB信号通路的脑卒中治疗中药研究进展

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药学学报 2024年第6期59卷 1538-1545页

作者：成翠翠梁雨娟李星吕明朱彦天津中医药大学组分中药国家重点实验室天津301617 贵州百灵企业集团制药股份有限公司贵州贵阳550000

cAMP反应元件结合蛋白(cAMP response element binding protein,CREB)是一种真核细胞生物核内蛋白质,在各种器官中广泛表达,其被激活后增加下游基因的转录活性,促进相关基因的表达。CREB在神经元中的功能与许多细胞内过程有关,如增殖、... 详细信息

cAMP反应元件结合蛋白(cAMP response element binding protein,CREB)是一种真核细胞生物核内蛋白质,在各种器官中广泛表达,其被激活后增加下游基因的转录活性,促进相关基因的表达。CREB在神经元中的功能与许多细胞内过程有关,如增殖、分化、生存、长期突触电位、神经发生和神经元可塑性。越来越多的研究结果证明,CREB功能影响脑卒中的发生和发展,具有作为防治脑卒中新靶点的巨大潜力,且部分中药及有效成分可以促进CREB的表达。因此,本文将梳理归纳CREB信号通路在脑卒中病理生理学中的作用以及调节CREB表达的中药及有效成分的研究进展,以期为未来天然药物防治脑卒中研发提供依据和参考。

关键词：脑卒中 cAMP反应元件结合蛋白突触可塑性凋亡中药

电动汽车动力电池制造商混合渠道回收模式选择与碳减排决策

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中国管理科学 2024年第6期32卷 184-195页

作者：张川田雨鑫崔梦雨东北大学工商管理学院辽宁沈阳110169

本文研究电动汽车动力电池制造商在碳配额交易政策下的回收模式选择与碳减排策略,提出了四种混合渠道回收模式:(1)制造商和零售商共同回收;(2)制造商和第三方回收商共同回收;(3)零售商和第三方回收商共同回收;(4)制造商、零售商和第三... 详细信息

本文研究电动汽车动力电池制造商在碳配额交易政策下的回收模式选择与碳减排策略,提出了四种混合渠道回收模式:(1)制造商和零售商共同回收;(2)制造商和第三方回收商共同回收;(3)零售商和第三方回收商共同回收;(4)制造商、零售商和第三方回收商共同回收。运用Stackelberg博弈模型求解不同模式下各成员最优定价决策、最优利润和制造商碳减排决策,并对均衡结果进行分析。研究结果表明,制造商最优碳减排水平随初始碳排放量增加而降低,随碳减排投资成本系数增加而降低,随单位碳交易价格的增加呈现先上升后下降再上升的趋势;当回收价格敏感系数高于特定阈值且回收竞争系数低于特定阈值时,制造商最优回收模式为制造商、零售商和第三方回收商共同回收,否则,制造商最优回收模式为制造商与零售商共同回收或者制造商与第三方回收商共同回收。

关键词：碳限额与交易政策动力电池闭环供应链碳减排混合渠道回收

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基于边缘增强和特征融合的伪装目标分割

液晶与显示 2024年第1期39卷 48-58页

作者：李明岩吴川朱明中国科学院长春光学精密机械与物理研究所吉林长春130033 中国科学院大学北京100049

伪装目标分割的任务是使用像素级分割掩码将与背景高度相似的目标进行准确分类和定位,与传统的目标分割任务相比更具挑战性。针对目标与周围环境高度相似、边界模糊、对比度低等问题,构建了一种基于边缘增强和特征融合的伪装目标分割方... 详细信息

伪装目标分割的任务是使用像素级分割掩码将与背景高度相似的目标进行准确分类和定位,与传统的目标分割任务相比更具挑战性。针对目标与周围环境高度相似、边界模糊、对比度低等问题,构建了一种基于边缘增强和特征融合的伪装目标分割方法。首先,设计了一组边缘提取模块,能够更准确地分割有效的边缘先验。之后,引入了多尺度特征增强模块和跨层级特征聚合模块,分别挖掘层内与层间的多尺度上下文信息。提出了一种简单的层间注意力模块,利用相邻层级间的差异有效滤除融合后存在的干扰信息。最后,通过将各级特征图与边缘先验逐级结合的方式,获得准确的预测结果。实验结果表明,在4个伪装目标基准数据集上,该模型的表现都优于其他算法。其中加权F值提升了2.4%,平均绝对误差减少了7.2%,在RTX 2080Ti硬件环境下分割速度达到了44.2 FPS。与现有方法相比,该算法能够更准确地分割伪装目标。

关键词：深度学习伪装目标图像分割边缘特征特征融合

Subcutaneous daratumumab in Chinese patients with relapsed or refractory multiple myeloma:an open-label,multicenter,phase 1 study(MMY1010)

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Blood Science 2024年第3期6卷 42-47页

作者： Gang An Zheng Ge Hongmei Jing Jing Liu Guoping Yang Ru Feng Zhongyuan Xu ming Qi Jianping Wang Juanjuan Song Wei Zhou Binbin Sun Dian Zhu Xi Chen Canchan cui Lugui Qiu National Clinical Research Center for Hematological Disorders State Key Laboratory of Experimental HematologyInstitute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300020China Department of Hematology Zhongda Hospital Southeast UniversityNanjing 210009China Peking University Third Hospital Beijing 100191China Department of Hematology The Third Xiangya Hospital of Central South UniversityChangsha 410013China Department of Hematology Nanfang Hospital of Southern Medical UniversityGuangzhou 510515China Phase 1 Clinical Trial Department Nanfang Hospital of Southern Medical UniversityGuangzhou 510515China Janssen Research&Development LLCSpring HousePA 19477USA Janssen Research&Development LLCBeijing 100025China Janssen Research&Development LLCShanghai 200231Chin

Despite recent progress in multiple myeloma(MM)treatments,most patients will relapse and require additional *** daratumumab,a human IgGκmonoclonal antibody targeting CD38,has shown good efficacy in the treatment of MM.A subcutaneous version of daratumumab was formulated to reduce the burden of intravenous *** aimed to investigate the efficacy and safety of subcutaneous daratumumab in Chinese patients with relapsed/refractory MM based on the demonstrated noninferiority of subcutaneous daratumumab to intravenous daratumumab,with a shorter administration time and reduced infusion-related reaction rate in global *** phase 1,multicenter study(MMY1010;*** Identifier:NCT04121260)evaluated subcutaneous daratumumab in Chinese patients with relapsed/refractory MM after 1 prior line(n=1)or≥2 prior lines(n=20)of therapy,including a proteasome inhibitor and an immunomodulatory *** endpoints were pharmacokinetics and ***(standard deviation)maximum trough concentration of daratumumab was 826(335)μg/mL,which was consistent with prior studies of subcutaneous daratumumab and intravenous *** was consistent with safety profiles observed in other daratumumab studies,with no new safety concerns *** of infusion-related reactions and injection-site reactions were low and consistent with other subcutaneous daratumumab *** a median follow-up of 7.5 months,the overall response rate was 57.1%,with a very good partial response or better rate of 38.1%and complete response or better rate of 19.0%.Our results demonstrate a favorable benefit/risk profile of subcutaneous daratumumab in Chinese patients with relapsed/refractory MM,potentially impacting clinical administration of daratumumab in this population.

关键词： Chinese Daratumumab Multiple myeloma Pharmacokinetic Relapse/refractory Safety Subcutaneous

Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor

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Science China(Life Sciences) 2024年第7期67卷 1502-1513页

作者： Luo-Yuan Xia Xue-Feng Wang Xiao-ming cui Yi-ming Zhang Zhen-Fei Wang En-Tao Li Chang-Fa Fan Ke Song Yuan-Guo Li Run-Ze Ye Fang-Xu Li Dai-Yun Zhu Jie Zhang Zhuang-Zhuang Shi ming-Zhu Zhang Liang-Jing Li Shi-Jing Shen Song Jin Ya-Wei Zhang Wei-Guang Fu Lin Zhao Wen-Hao Wang Tie-Cheng Wang You-Chun Wang Jia-Fu Jiang Yan-Ling Hu Na Jia Yu-Wei Gao Wu-Chun Cao Institute of EcoHealth School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Changchun Veterinary Research Institute Changchun 130122China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug ControlBeijing 102629China National Institutes for Food and Drug Control Beijing 102629China Life Sciences Institute Guangxi Medical UniversityNanning 530020China College of Life Sciences Shandong Normal UniversityJinan 250014China Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical SciencesBeijing 100071China

Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins,showing a potential threat to *** we report the infectivity and pathogenicity of the SARS-CoV-2-related virus,PCoV-GX/P2V,which was isolated from a Malayan pangolin(Manis javanica).PCoV-GX/P2V could grow in human hepatoma,colorectal adenocarcinoma cells,and human primary nasal epithelial *** replicated more efficiently in cells expressing human angiotensin-converting enzyme 2(hACE2)as SARS-CoV-2 *** intranasal inoculation to the hACE2-transgenic mice,PCoV-GX/P2V not only replicated in nasal turbinate and lungs,but also caused interstitial pneumonia,characterized by infiltration of mixed inflammatory cells and multifocal alveolar *** population immunity established by SARS-CoV-2 infection and vaccination may not protect people from PCoV-GX/P2V *** findings further verify the hACE2 utility of PCoV-GX/P2V by in vivo experiments using authentic viruses and highlight the importance for intensive surveillance to prevent possible cross-species transmission.

关键词： pangolin SARS-CoV-2-related virus infectivity pathogenicity human cell lines human ACE2 receptor hACE2-transgenic mice

Inhibitory effect of saffron on head and neck squamous cell carcinoma via targeting of ESR1 and CCND1 by its active compound crocetin

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Traditional Medicine Research 2024年第7期9卷 25-34页

作者： Xiao-Jie Wang ming-Jun Zhang Li-Mei cui Zhe-Ying Song Ya-Qi Wang Yu-Teng Yang Xiang-Kun Zhao Ya-Kui Mou Yu-Mei Li Xi-Cheng Song School of Clinical Medicine Weifang Medical UniversityWeifang 261042China. Department of Otorhinolaryngology Head and Neck SurgeryYantai Yuhuangding HospitalQingdao UniversityYantai 264000China. Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases Yantai 264000China. Yantai Key Laboratory of Otorhinolaryngologic Diseases Yantai Yuhuangding HospitalYantai 264000China. The 2nd Medical College of Binzhou Medical University Yantai 264000China.

Background:Traditional Chinese medicine is promising for managing challenging and complex disorders,including cancer,and in particular,saffron is applied in treating various cancer ***,its potential therapeutic efficacy and active components in managing squamous cell carcinoma of the head and neck(HNSCC)remain unclear ***:Using network pharmacology approaches,active ingredients of saffron,their target genes,and HNSCC-related genes were *** analyses were conducted for determining molecular functions and pathways enriched by genes that overlapped between the saffron target gene set and the HNSCC gene *** the four known active ingredients of saffron,crocetin was found to have the strongest inhibitory impact on HNSCC,based on the findings of cell viability and migration ***,the potential target genes of crocetin in HNSCC cells were examined using molecular docking experiments and were confirmed by *** s:Four active ingredients of saffron and 184 of their target genes were ***,a total of 34 overlapping saffron-/HNSCC-associated targets related to the four active ingredients were screened,and crocetin was chosen for further investigation because it had the strongest inhibitory effect on HNSCC *** docking experiments indicated that ESR1 and CCND1 were the target genes of *** results were confirmed through qPCR analysis,in which crocetin was found to lower the expression of the ESR1 and CCND1 genes in AMC-HN-8 and FaDu ***:According to our results,crocetin is a primary active anti-cancer component of saffron that may have potential in the development of novel HNSCC-treating ***,more thorough molecular research is necessary for confirming these results and elucidating the anti-cancer mechanism underlying saffron.

关键词： saffron hub genes crocetin network pharmacology analysis HNSCC ESR1 CCND1