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经皮椎间孔镜联合围手术期高压氧治疗对腰椎间盘突出症患者的疗效分析

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颈腰痛杂志 2024年第3期45卷 503-505,509页

作者：蒋传海吴成如陈然孙国荣史凤之顾庆陟中国人民解放军联勤保障部队第901医院骨二科安徽合肥230031

目的探讨经皮椎间孔镜联合围手术期高压氧治疗对腰椎间盘突出症患者的疗效分析。方法 2020年1月~2022年1月,对该科拟行椎间孔镜手术的60例腰椎间盘突出症患者采用随机数字表法进行随机分组:对照组30例,均单纯接受经皮椎间孔镜手术治疗... 详细信息

目的探讨经皮椎间孔镜联合围手术期高压氧治疗对腰椎间盘突出症患者的疗效分析。方法 2020年1月~2022年1月,对该科拟行椎间孔镜手术的60例腰椎间盘突出症患者采用随机数字表法进行随机分组:对照组30例,均单纯接受经皮椎间孔镜手术治疗;试验组30例,入院后即开始进行高压氧治疗,围手术期治疗疗程为10 d,每日1次高压氧治疗。测量并记录两组患者术前、术后3 d、术后7 d、术后2周的疼痛视觉模拟评分(visual analogue scale, VAS)和Oswestry功能障碍指数(Oswestry disability index, ODI)。术后2周时,采用改良Macnab标准评估患者是否出现神经根水肿症状。结果 60例患者均顺利完成手术。两组患者术后VAS评分及ODI指数均较术前明显改善(P<0.05);试验组患者术后3 d、术后7 d及术后2周的VAS评分及ODI较对照组明显改善(P<0.05)。试验组患者术后2周改良Macnab标准结果优良率为83.33%,对照组为63.33%,组间差异有统计学意义(P<0.05)。结论围手术期高压氧治疗,可有效减轻术后残留症状及降低神经根水肿发生率,对腰椎间盘突出症的治疗具有积极作用。

关键词：经皮脊柱内镜下腰椎间盘摘除术腰椎间盘突出症高压氧治疗

Modification of residual stress in Al-[AlBO]_w/Al compound plate

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中国有色金属学会会刊：英文版 2001年第2期11卷 275-277页

作者：姜传海吴建生王德尊上海交通大学教育部高温材料及高温测试重点实验室上海 200030 哈尔滨工业大学材料科学与工程学院黑龙江哈尔滨 150001

The application of compound parts of Al [AlBO] w/Al not only reduces the cost of the parts but also improves its properties. However, there is a large thermal residual stress between Al and [AlBO] w/Al, and it is harmful for practical application. From the theoretical analyses and experimental results, it was found that by the compressive pre plastic deformation perpendicular to the interface between Al and [AlBO] w/Al, the interlayer residual stress of compound parts can be reduced, while the mechanical properties of compound parts can be improved. [

关键词： Al [AlBO] w/Al compound plate residual stress

Patients Administered Neoadjuvant Chemotherapy Could be Enrolled into an Enhanced Recovery after Surgery Program for Locally Advanced Gastric Cancer

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Chinese Medical Journal 2018年第4期131卷 413-419页

作者： Jian Zhao Gang Wang Zhi-Wei jiang chuan-Wei jiang jiang Liu Can-Can Xia Jie-Shou Li Research Institute of General Surgery Jinling Hospital Medical School of Nanjing University Nanjing Jiangsu 210002 China

Background： Most studies on enhanced recovery after surgery （ERAS） for gastric cancer exclude patients who received neoadjuvant chemotherapy. Here, we aimed to evaluate whether patients who received neoadjuvant chemotherapy can be enrolled into the ERAS program for locally advanced gastric cancer. Methods： From April 2015 to July 2017, 114 patients who received neoadjuvant chemotherapy for locally advanced gastric cancer were randomized into ERAS and standard care （SC） groups. Postoperative length of stay, complications, bowel function, and nutritional status were recorded. Results： The postoperative length of stay of the ERAS group was shorter compared with that of the SC group （5.9 ± 5.6 vs. 8.1 ± 5.3 days, P=0.037）.The postoperative complication rate was 9.3% in the ERAS group and 11.5% in the SC group（P=0.700）.The time to first flatus （2.7 ± 2.0 vs. 4.5 ± 4.6 days, P = 0.010） and time to a semi-liquid diet （3.2 ± 2.1 vs. 6.3 ± 4.9 days, P 〈 0.001） in the ERAS group were shorter compared with those in the SC group. On the 10thday after surgery, the values of weight, total protein, albumin, and prealbumin of the ERAS group were lower compared with those of the SC group. Conclusions： Patients who received neoadjuvant chemotherapy could be enrolled into ERAS programs for locally advanced gastric cancer. The nutritional status of these patients was not adversely affected.

关键词： Advanced Gastric Cancer Enhanced Recovery after Surgery Gastrectomy Length of Stay Neoadjuvant Chemotherapy

Electroacupuncture at Feishu(BL13) and Zusanli(ST36) down-regulates the expression of orexins and their receptors in rats with chronic obstructive pulmonary disease

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Journal of Integrative Medicine 2014年第5期12卷 417-424页

作者： Xin-fang Zhang Ji Zhu Wen-ye Geng Shu-jun Zhao chuan-wei jiang Sheng-rong Cai Miao Cheng chuan-yun Zhou Zi-bing Liu Department of Physiology College of Integrated Chinese and Western Medicine Anhui University of Chinese Medicine The Third Clinical College of Zhejiang Chinese Medical University Department of Pharmacology Shanghai Medical College of Fudan University Institute of Acupuncture and Meridian College of Acupuncture and Osteology Anhui University of Chinese Medicine

Inflammation and lung function decline are the main pathophysiological features of chronic obstructive pulmonary disease （COPD）. Acupuncture can improve lung function in patients with COPD, but the underlying mechanisms are not well understood. Orexins （OXs）, which are found in peripheral plasma, are neuropeptides that regulate respiration and their levels are related to COPD. Therefore, we hypothesized that acupuncture might alter OXs, reduce lung inflammation and improve lung function in COPD. METHODS： COPD was induced in rats by exposure to cigarette smoke for 8 weeks and injecting with lipopolysaccharide twice. Electroacupuncture （EA） was performed at Feishu （BL13） and Zusanli （ST36） for 30 min/d for 2 weeks. Rat lung function and morphology were assessed after EA. The levels of tumor necrosis factor-α （TNF-a） and intedeukin-1β （IL-16） in bronchoalveolar lavage fluid （BALF） and orexin A and B levels in the lung tissue were detected by enzyme-linked immunosorbent assay. OX receptor mRNA levels and immunopositive cells were assessed with real-time polymerase chain reaction and immunohistochemical methods, respectively. The relationships among lung function, cell factors, and OX levels were analyzed by Pearson correlation analyses. RESULTS： Compared with the control group, lung function was significantly decreased in the rats with COPD （P〈0.05）. There were obvious increases in TNF-α and IL-1β levels in BALF （P〈0.05 and P〈0.01, respectively）, orexin A level in lung tissue （P〈0.01; but not orexin B） and mRNA expressions of OX 1 type receptor （OXR1） and OX 2 type receptor （OXR2） in lung tissue （P〈0.05 and P〈0.01, respectively）; the integrative optical densities （IODs） of both receptors were greater in the COPD group （P〈0.05）. For rats with COPD subjected to EA, lung function was improved （P〈0.05）. There were notable decreases in TNF-a and IL-1β levels （P〈0.05 and 〈0.01, respectively） in BALF. Orexin A, but not orexin B, levels in lung tissue also decreased （P〈0.01）, a

关键词： pulmonary disease,-chronic obstructive electroacupuncture Point BL13 (Feishu) Point ST36 (Zusanli) orexin anti-inflammation rats

铜代谢相关基因COX17与头颈部鳞状细胞癌不良预后相关

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广西医科大学学报 2024年第5期41卷 688-696页

作者：卢苇江川何馨露姚茜苏敬雅刘春磊谢莹韦正波广西医科大学附属肿瘤医院南宁530021 广西区域性高发肿瘤早期防治研究重点实验室南宁530021 广西医科大学生命科学研究院南宁530021

目的:探讨铜代谢相关基因细胞色素c氧化酶铜伴侣17(COX17)对头颈部鳞状细胞癌(HNSCC)发生发展及预后的影响。方法:运用生物信息学分析COX17在HNSCC与正常组织中的表达差异;通过构建列线图验证COX17在预测HNSCC预后中的作用;采用KEGG和G... 详细信息

目的:探讨铜代谢相关基因细胞色素c氧化酶铜伴侣17(COX17)对头颈部鳞状细胞癌(HNSCC)发生发展及预后的影响。方法:运用生物信息学分析COX17在HNSCC与正常组织中的表达差异;通过构建列线图验证COX17在预测HNSCC预后中的作用;采用KEGG和GO分析对COX17相关基因进行功能富集分析以及利用ssGSEA分析COX17表达与HNSCC组织中免疫细胞浸润丰度的关系;采用实时定量聚合酶链反应(RT-qPCR)验证COX17在HNSCC细胞系与永生化正常上皮细胞系中的表达差异;细胞活力试剂盒(CCK-8)和Transwell实验分别用于检测COX17对细胞增殖、侵袭能力的影响。结果:COX17在HNSCC中表达显著上调(P<0.05)。预后分析表明COX17与HNSCC患者总生存期(OS)密切相关(P<0.05)。免疫浸润相关性分析显示,COX17与多种免疫细胞浸润丰度呈负相关关系(均P<0.001)。敲低COX17可显著抑制HNSCC细胞SCC-9、SAS细胞的增殖及侵袭能力。结论:COX17的表达可影响HNSCC细胞的增殖和侵袭,并与HNSCC组织中免疫细胞浸润存在潜在关联;作为线粒体铜代谢分子标记物,COX17可能是评估HNSCC预后的有效指标和潜在治疗靶点。

关键词：细胞色素c氧化酶铜伴侣17 铜代谢头颈鳞癌生长侵袭预后

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改进分形图像编码的叉迹算法

计算机学报 2007年第12期30卷 2156-2163页

作者：何传江申小娜重庆大学数理学院重庆400030

分形图像编码具有好的视觉质量和高压缩比,然而,固有的编码耗时限制了它的应用范围.编码时间主要花费于在一个海量码本中搜索每个输入子块的最佳匹配块.针对这个问题,提出了一个限制搜索空间的算法,改进了原叉迹算法.具体说,它把子块叉... 详细信息

分形图像编码具有好的视觉质量和高压缩比,然而,固有的编码耗时限制了它的应用范围.编码时间主要花费于在一个海量码本中搜索每个输入子块的最佳匹配块.针对这个问题,提出了一个限制搜索空间的算法,改进了原叉迹算法.具体说,它把子块叉迹的定义修改为其规范子块主次对角元绝对值之和,并利用新叉迹把搜索范围限制在初始匹配块的邻域内;同时,引入误差阈值来控制以初始匹配块为中心的搜索邻域大小.实验显示,与叉迹算法比较,改进算法在编码时间和图像质量方面获得了更好的效果.

关键词：图像压缩分形迭代函数系统分形图像编码叉迹

Legumain-triggered aggregable gold nanoparticles for enhanced intratumoral retention

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Chinese Chemical Letters 2024年第7期35卷 388-393页

作者： Zhi Li Wenpei Li Shaoping jiang chuan Hu Yuanyu Huang Maxim Shevtsov Huile Gao Shaobo Ruan Advanced Research Institute of Multidisciplinary Sciences School of Life ScienceBeijing Institute of TechnologyBeijing 100081China Key Laboratory of Drug Targeting and Drug Delivery System West China School of PharmacySichuan UniversityChengdu 610041China Institute of Cytology of Russian Academy of Sciences(RAS) St.Petersburg 194064Russia

Insufficient intratumoral retention of nanomedicines remains the major challenge for broad implementation in clinical ***,we proposed a legumain-triggered aggregable gold nanoparticle(GNP)delivery platform(GNPs-A&C).GNPs-A&C could form intratumoral or intracellular aggregates in response to the overexpressed *** aggregates with size increase not only could reduce back-flow from interstitial space to peripheral bloodstream but also could restrict the cellular exocytosis,leading to enhanced intratumoral *** vitro studies demonstrated that GNPs-A&C possessed an excellent legumain responsiveness and the increased size was closely relevant with legumain *** vivo studies demonstrated GNPs-A&C possessed slower clearance rate and much higher intratumoral retention within legumain-overexpressed tumor compared to non-aggregable NPs,regardless of intravenous or intratumoral *** importantly,this delivery platform significantly improved the chemotherapeutic effect of doxorubicin(DOX)towards subcutaneous xenograft C6 *** effectiveness of this stimulus-responsive aggregable delivery system provides a thinking for designing more intelligent size-tunable nanomedicine that can substantially improve intratumoral retention.

关键词： Legumain Size-tunable Enhanced retention Stimulus-responsive Nanomedicine

Tenofovir amibufenamide vs tenofovir alafenamide for treating chronic hepatitis B:A real-world study

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World Journal of Gastroenterology 2023年第44期29卷 5907-5918页

作者： Wen-Ting Peng chuan jiang Fei-Lan Yang Nian-Qi Zhou Ke-Yu Chen Jin-Qing Liu Shi-Fang Peng Lei Fu Department of Infectious Diseases Xiangya Hospital Central South UniversityChangsha 410008Hunan ProvinceChina

BACKGROUND The efficacy and safety profile of tenofovir amibufenamide(TMF)in chronic hepatitis B(CHB)patients is not *** To compare the efficacy and safety of TMF and tenofovir alafenamide(TAF)over a 48-wk period in patients with *** A total of 215 subjects meeting the inclusion criteria were enrolled and divided into two groups:TMF group(n=106)and the TAF group(n=109).The study included a comparison of virological response(VR):Undetectable hepatitis B virus DNA levels,alanine transaminase(ALT)normalization rates,renal function parameters,and blood lipid *** At 24 and 48 wk,VR rates for the TMF group were 53.57%and 78.57%,respectively,compared with 48.31%and 78.65%for the TAF group(P>0.05).The VR rates were also similar in both groups among patients with low-level viremia,both hepatitis B e antigen(HBeAg)-positive and HBeAg-negative *** TMF cohort showed ALT normalization and renal safety profiles similar to the TAF *** was a notable increase in total cholesterol levels in the TAF group(P=0.045),which was not observed in the TMF group(P>0.05).In patients with liver cirrhosis,both groups exhibited comparable VR and ALT normalization rates and renal safety ***,the fibrosis 4 score at 48 wk showed a significant reduction in the TAF group as compared to the TMF group within the liver cirrhosis *** Our study found TMF is as effective as TAF in treating CHB and has a comparable safety ***,TAF may be associated with worsening lipid profiles.

关键词： Alanine transaminase normalization Chronic hepatitis B Renal safety Virological response Blood lipid Tenofovir

女性健康体检人群乳腺结节和甲状腺结节检出情况及相关影响因素分析

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中国疗养医学 2024年第3期33卷 109-112页

作者：关若萍戴国奎叶传江罗利利李丹娜广州市干部和人才健康管理中心广州市第十一人民医院医学检验科广东广州510530

目的研究在广州市干部和人才健康管理中心健康体检的女性人群中乳腺结节和甲状腺结节检出情况及影响因素,为乳腺和甲状腺疾病的早期防治提供科学依据。方法选取2020年在广州市干部和人才健康管理中心健康体检并行乳腺和甲状腺彩超检查的... 详细信息

目的研究在广州市干部和人才健康管理中心健康体检的女性人群中乳腺结节和甲状腺结节检出情况及影响因素,为乳腺和甲状腺疾病的早期防治提供科学依据。方法选取2020年在广州市干部和人才健康管理中心健康体检并行乳腺和甲状腺彩超检查的8175例女性受检人员作为研究对象,进行回顾性分析,了解女性健康体检人群中乳腺结节和甲状腺结节检出情况,采用SPSS 23.0统计学软件进行卡方检验和多分类Logistic回归分析,分析结节与年龄、体质量指数、血压、血糖、血脂、尿素、肌酐、尿酸等影响因素之间的关系。结果在8175例女性受检者中乳腺结节检出率为38.42%(3141/8175);甲状腺结节检出率为52.78%(4315/8175),且检出率随年龄增长升高;乳腺结节合并甲状腺结节检出率为21.44%(1753/8175)。多因素Logistic回归分析结果显示,乳腺结节的发生与身高(OR=1.011,P<0.05)、BMI(OR=0.980,P<0.05)、舒张压(OR=1.071,P<0.05)及甲状腺结节(OR=1.361,P<0.001)独立相关。而甲状腺结节的发生与年龄(OR=1.065,P<0.001)、身高(OR=1.013,P<0.01)、BMI(OR=1.033,P<0.01)、舒张压(OR=1.092,P<0.05)及乳腺结节(OR=1.327,P<0.001)独立相关。结论女性健康体检人群乳腺结节的发病年龄高峰为40~<50岁组,而甲状腺结节检出率随年龄增长而增加;较高身高、低BMI、高舒张压和甲状腺结节是发生乳腺结节的独立相关因素。年龄增加、较高身高、高BMI、高舒张压和乳腺结节是女性发生甲状腺结节的独立相关因素。

关键词：乳腺结节甲状腺结节健康体检影响因素