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成年起病的甲基丙二酸血症1例报道

中华神经医学杂志 2024年第6期23卷 610-612页

作者：商笑姜川肖珍珍王宝洁李琪赵楠楠郝茂林冯建利山东省第二人民医院神经内科济南250022

甲基丙二酸血症(MMA)属常染色体隐性遗传性疾病,主要由甲基丙二酰辅酶A变位酶(MCM)缺陷及其辅酶钴胺素(维生素B_(12))代谢障碍导致机体三羧酸循环及氧化磷酸化障碍,使代谢产物甲基丙二酸、丙酸及甲基枸橼酸等异常蓄积,从而引起神经、肝... 详细信息

甲基丙二酸血症(MMA)属常染色体隐性遗传性疾病,主要由甲基丙二酰辅酶A变位酶(MCM)缺陷及其辅酶钴胺素(维生素B_(12))代谢障碍导致机体三羧酸循环及氧化磷酸化障碍,使代谢产物甲基丙二酸、丙酸及甲基枸橼酸等异常蓄积,从而引起神经、肝脏、肾脏等多系统损害^([1])。MMA多见于婴幼儿,成年起病罕见。山东省第二人民医院神经内科曾收治1例发病年龄为44岁的MMA患者,现总结其诊疗经过并进行文献复习,以期为临床同道提供参考借鉴。

关键词：甲基丙二酸血症同型半胱氨酸肌电图脊髓前角细胞

Laboratory investigation on hydraulic fracture propagation in sandstone-mudstone-shale layers

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Petroleum Science 2022年第4期19卷 1664-1673页

作者： jiang-chuan He Kuang-Sheng Zhang Han-Bin Liu Mei-Rong Tang Xue-Lin Zheng Guang-Qing Zhang PetroChina Changqing Oilfield Company Xi′an710018ShaanxiChina College of Petroleum Engineering China University of Petroleum(Beijing)Beijing102249China State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China

During the stimulating unconventional reservoirs, the vertical propagation of hydraulic fractures is crucial for enlarging the stimulated reservoir volume, especially in multi-layers of sandstone, mudstone and shale(sand-mud-shale). To investigate the effects of lithological interface and fracturing fluid viscosity on the fracture propagation vertically in the multi-layers, hydraulic fracturing experiments in laboratory were performed on the outcrop samples of 30 cm × 30 cm × 30 cm collected from Yanchang Formation in Ordos Basin. The results show that hydraulic fractures are multi-branched and zig-zagged when they initiate in shale, simple when they commence in sandstone or mudstone. Hydraulic fractures created with low-viscosity fracturing fluid can only cross sandstone from mudstone, but those induced by high-viscosity fracturing fluid can cross the sand-mud-shale layers. Furthermore, the high-viscosity fracturing fluid reduces the fractures complexity in shale, facilitating vertical fracture propagation. The injection pressure fluctuates slightly as the hydraulic fracture extends from shale to sandstone or mudstone, otherwise it fluctuates significantly. From the laboratory investigation, a hydraulic fracturing scheme for Chang 7 Member was proposed, with its feasibility proved in field tests.

关键词： Sandstone-mudstone-shale Multi-layers Hydraulic fracturing experiments Lithological interface

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废弃物处置协同制备水煤浆技术研究进展

煤炭加工与综合利用 2024年第6期 76-83页

作者：董岳李传江谢咏波刘霖刘钐国能新疆化工有限公司新疆乌鲁木齐830009 中国矿业大学(北京) 北京100083

阐述了近年来人们掺配不同废液与废固所制水煤浆的浆体性质,其中包括焦化废水、含油废水、印染废水、造纸黑液等废液所制水煤浆以及采用化工污泥、含油污泥、煤气化细渣、煤泥等固废所制水煤浆,分析了不同预处理与改性方式对浆体性能的... 详细信息

阐述了近年来人们掺配不同废液与废固所制水煤浆的浆体性质,其中包括焦化废水、含油废水、印染废水、造纸黑液等废液所制水煤浆以及采用化工污泥、含油污泥、煤气化细渣、煤泥等固废所制水煤浆,分析了不同预处理与改性方式对浆体性能的影响,并对掺配废弃物制浆的技术瓶颈与未来发展趋势进行了展望。

关键词：废水煤浆污泥水煤浆工业废水改性

香苏杂交猪KAT2B基因多态性与其生长性状的关联分析

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南方农业学报 2024年第5期55卷 1463-1470页

作者：李吉凤阮涌蒋传美肖美美黄家锦许家利许厚强高原山地动物遗传育种与繁殖教育部重点实验室/贵州省动物遗传育种与繁殖重点实验室/贵州大学动物科学学院贵州贵阳550025

【目的】了解香苏杂交猪组蛋白乙酰转移酶P300/CBP结合因子(KAT2B)基因在组织中的表达量,筛选其单核苷酸多态性(Single nucleotide polymorphism,SNP)位点,并分析基因多态性与生长性状的关联性,为香苏杂交猪新品系培育提供参考依据。【... 详细信息

【目的】了解香苏杂交猪组蛋白乙酰转移酶P300/CBP结合因子(KAT2B)基因在组织中的表达量,筛选其单核苷酸多态性(Single nucleotide polymorphism,SNP)位点,并分析基因多态性与生长性状的关联性,为香苏杂交猪新品系培育提供参考依据。【方法】以香苏杂交猪为研究对象,采用实时荧光定量PCR检测KAT2B基因在3日龄和6月龄不同组织中的相对表达量,通过直接测序检测KAT2B基因的SNP位点,统计SNP位点等位基因频率、基因型频率、观测杂合度(Ho)、期望杂合度(He)、有效等位基因数(Ne)及平均多肽信息含量(PIC)等,以卡方(χ^(2))检验分析基因型是否处于Hardy-Weinberg平衡状态,分析不同基因型与香苏杂交猪生长性状的关联性。【结果】实时荧光定量PCR结果显示,KAT2B基因在心脏、肝脏、脾脏、肺脏、肾脏和背最长肌6个组织中均有表达,与3日龄相比,6月龄KAT2B基因相对表达量在肝脏和脾脏组织中极显著升高(PA、g.104540G>T和g.106651A>G,3个SNPs位点PIC均处于中度多态性水平且Hardy-Weinberg平衡。g.36682G>A位点优势基因型为GA型,等位基因频率G>A;g.104540G>T位点优势基因型为GG型,等位基因频率G>T;g.106651A>G位点优势基因型为AA型,等位基因频率A>G。关联分析结果表明,g.36682G>A位点各基因型生长性状之间无显著差异(P>0.05),g.106651A>G位点AA基因型与AG基因型胸深存在显著差异(PA、g.104540G>T和g.106651A>G),KAT2B基因可作为与香苏杂交猪生长性状相关的候选基因。

关键词：香苏杂交猪 KAT2B基因实时荧光定量PCR SNPs 生长性状

Pt-Te alloy nanowires towards formic acid electrooxidation reaction

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Journal of Energy Chemistry 2023年第10期85卷 481-489,I0013页

作者： Bin Sun Yu-chuan jiang Qing-Ling Hong Xue Liu Fu-Min Li Dong-Sheng Li Yun Yang Yu Chen Key Laboratory of Macromolecular Science of Shaanxi Province School of Materials Science and EngineeringShaanxi Normal UniversityXi’an 710062ShaanxiChina Nanomaterials and Chemistry Key Laboratory Wenzhou UniversityWenzhou 325035ZhejiangChina School of Chemistry and Chemical Engineering Huazhong University of Science and TechnologyWuhan 430074HubeiChina College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002HubeiChina

The high-performance anodic electrocatalysts is pivotal for realizing the commercial application of the direct formic acid fuel *** this work,a simple polyethyleneimine-assisted galvanic replacement reaction is applied to synthesize the high-quality PtTe alloy nanowires(PtTe NW)by using Te NW as an efficient sacrificial *** existence of Te atoms separates the continuous Pt atoms,triggering a direct reaction pathway of formic acid electrooxidation reaction(FAEOR)at PtTe *** one-dimensional architecture and highly active sites have enabled PtTe NW to reveal outstanding electrocatalytic activity towards FAEOR with the mass/specific activities of 1091.25 mA mg^(-1)/45.34 A m^(-2)at 0.643 V potential,which are 44.72/23.16 and 20.26/11.75 times bigger than those of the commercial Pt and Pd nanoparticles,*** functional theory calculations reveal that Te atoms optimize the electronic structure of Pt atoms,which decreases the adsorption capacity of CO intermediate and simultaneously improves the durability of PtTe NW towards *** work provides the valuable insights into the synthesis and design of efficient Pt-based alloy FAEOR electrocatalysts.

关键词： Formic acid electrooxidation PtTe alloy nanowires Galvanic replacement reaction Reaction pathway Fuel cells

A Dual Closed-Loop Digital Twin Construction Method for Optimizing the Copper Disc Casting Process

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 581-594页

作者： Zhaohui jiang chuan Xu Jinshi Liu Weichao Luo Zhiwen Chen Weihua Gui IEEE the School of Automation Central South UniversityChangsha 410083China the Peng Cheng Laboratory Shenzhen 518000China

The copper disc casting machine is core equipment for producing copper anode plates in the copper metallurgy *** copper disc casting machine casting package motion curve(CPMC) is significant for precise casting and efficient ***,the lack of exact casting modeling and real-time simulation information severely restricts dynamic CPMC *** this end,a liquid copper droplet model describes the casting package copper flow pattern in the casting ***,a CPMC optimization model is proposed for the first *** top of this,a digital twin dual closed-loop self-optimization application framework(DT-DCS) is constructed for optimizing the copper disc casting process to achieve self-optimization of the CPMC and closed-loop feedback of manufacturing information during the casting ***,a case study is carried out based on the proposed methods in the industrial field.

关键词： Copper disc casting machine digital twin(DT) mechanism modeling self-optimization

八车道高速公路交通轴载与沥青路面使用性能指标的车道差异性

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公路 2024年第5期69卷 424-432页

作者：黄考取陈宇徐文军郝金海晏博智周献龙朱传江谷雨浙江交工集团股份有限公司设计院分公司公路数智养护浙江省工程研究中心杭州市310051 浙江沪杭甬高速公路股份有限公司宁波管理中心宁波市315016 浙江师范大学浙江省城市轨道交通智能运维技术与装备重点实验室金华市321004

为积极响应高速公路集约化施工的思想,实现高速公路车道级精准养护,以浙江省沪杭甬公路典型八车道路段交通轴载和沥青路面使用性能指标数据为基础,分析了其交通轴载的车道差异性,并采用多种拟合模型和集度分析相结合的方法,分析了历年... 详细信息

为积极响应高速公路集约化施工的思想,实现高速公路车道级精准养护,以浙江省沪杭甬公路典型八车道路段交通轴载和沥青路面使用性能指标数据为基础,分析了其交通轴载的车道差异性,并采用多种拟合模型和集度分析相结合的方法,分析了历年车辙深度RD、国际平整度指数IRI和路面破损率DR等3项使用性能指标的车道差异性,探讨了交通轴载与各使用性能指标的相关性及其车道差异性。结果表明:交通轴载和沥青路面各使用性能指标及其集度均与所在车道有关,各严重病害主要集中在第三、四车道,交通轴载与各使用性能指标的相关性分析结果在第一、二车道和第三、四车道也分别呈现不同的团聚。因此,建议在后续双向八车道高速公路养护工作中,充分考虑第一、二车道和第三、四车道的差异性。

关键词：沥青路面精准养护决策车道系数车辙深度国际平整度指数路面破损率集度拟合分析

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Timing issues in distributed testing

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第4期8卷 522-528页

作者： HUANG chuan-dong jiang Fan Department of Computer Science University of Science and Technology of China Hefei 230027 China

The objective of conformance testing is to determine whether an implementation under test (IUT) conforms to its specification. In distributed test architecture where there are multiple remote testers, the objective can be complicated by the fact that testers may encounter controllability and observability problems during the application of a test sequence. A certain amount of work has been done in the area of generating test sequence that is free from these problems. However, few researchers investigate them from the aspect of test execution. This work studies the test execution phase when test sequences are applied to the imple- mentation and it is pointed out that controllability and observability problems can be resolved if and only if the test system im- plements some timing constraints. When determining these constraints, the dynamic time information during test is taken into account, which reduces the test execution time and improves test efficiency further.

关键词：分布式系统检测定时问题可观测性可控制性

Severe tinnitus and migraine headache in a 37-year-old woman treated with trastuzumab for breast cancer:A case report

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World Journal of Clinical Cases 2022年第8期10卷 2491-2496页

作者： Yong-Zhi Liu Hai jiang Yong-Hua Zhao Qi Zhang Shi-Chao Hao Li-Ping Bao Wei Wu Zhao-Bo Jia Hui-chuan jiang Department of Breast Surgery General Hospital of Benxi Iron&Steel Industry Group of Liaoning Health Industry GroupBenxi 117000Liaoning ProvinceChina

BACKGROUND Trastuzumab is a generally safe agent prescribed in the systemic treatment of breast *** is not a currently known adverse event related to ***,we describe a rare case of severe tinnitus and a migraine headache induced by trastuzumab used for adjuvant *** SUMMARY A 37-year-old woman was diagnosed with hormone receptor-positive and human epidermal growth factor receptor 2-positive breast *** surgery,she was treated with four cycles of epirubicin and cyclophosphamide;she then received docetaxel and a loading dose of trastuzumab plus *** than half an hour after trastuzumab infusion,the patient complained of severe tinnitus and left-sided migraine *** monotherapy was discontinued immediately,and symptoms disappeared after 10 *** was readministered,and severe tinnitus and migraine headache *** was stopped,and severe tinnitus diminished after 10 *** and docetaxel therapy was then administered,and no adverse events were *** infusions of trastuzumab every three weeks did not show the same *** Although trastuzumab is well-tolerated in most patients,we should pay attention to the risk of severe tinnitus and migraine.

关键词： Breast cancer Tinnitus Adverse effects Trastuzumab Migraine headache Case report