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Interaction models of CYP1A1, GSTMl polymorphisms and tobacco smoking in intestinal gastric cancer

World Journal of Gastroenterology 2005年第38期11卷 6056-6060页

作者： Jing Shen Run-Tian Wang yao-chu Xu Li-Wei Wang Xin-Ru Wang Department of Epidemiology and Biostatistics School of Public Health Nanjing Medical University Nanjing 210029 Jiangsu Province China Department of Environmental Health Sciences Mailman School of Public Health Columbia University New York NY 10032USA Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing 100083China Yang Zhong Cancer Research Institute Yang Zhong City Municipal Hospital Yang Zhong 212200 China

AIM： To explore the interaction models of the cytochrome P-450 （CYP） 1A1 Valvariant and glutathione S-transferase （GST） M1 null polymorphisms with tobacco smoking in the occurrence of intestinal gastric cancer. METHODS： A community-based case-control study was conducted in Yangzhong. Subjects included 114 intestinal types of gastric cancer with endoscopic and pathological diagnosis during January 1997 and December 1998, and 693 controls selected from their spouse, siblings or siblingsin-law who had no history of digestive system cancer. Logistic regression was used to estimate the interaction models. RESULTS： The frequency of the CYPIA1 Valvariant allele in cases did not differ from that in controls. The OR of GSTM1 null genotype was 2.0 （95% confidence interval [95%CI]： 1.2-3.1, P〈0.01）. It showed a significant type 2 form of interaction model when both CYPIA1 Valvariant allele and former tobacco smoking existed （i.e., among the multiplicative effects, the disease risk is increased by the tobacco exposure alone but not by the CYPIA1 variant alone）. The interaction index y was 2.8, and OReg （95%CI） was 5.0 （1.9-13.4）. GSTM1 null genctype and former tobacco smoking were significant in a type 4 interaction model （i.e., the disease risk is increased by GSTM1 null genotype or tobacco exposure alone among the multiplicative effects）. The interaction index y and OReg （95%CI） were 3.4 and 8.4 （3.4-20.9）, respectively.CONCLUSION： Different interaction models of CYPIA1 Valvariant allele and GSTM1 null genotype with tobacco smoking will contribute to understanding carcinogenic mechanism, but there is a need to further investigate in larger scale studies.

关键词： Interaction models CYP1A1 GSTM1 Tobacco smoking Intestinal gastric cancer

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Human leukocyte antigen class II DQB1*0301, DRB1*1101 alleles and spontaneous clearance of hepatitis C virus infection: A meta-analysis

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World Journal of Gastroenterology 2005年第46期11卷 7302-7307页

作者： Xin Hong Rong-Bin Yu Nan-Xiong Sun Bin Wang yao-chu Xu Guan-Ling Wu Department of Epidemiology and Biostatistics School of Public Health Nanjing Medical University Nanjing 210029 Jiangsu Province China Research Laboraiory for infectious Diseases The First Affiliated Hospital Nanjing Medical University Nanjing 210029 Jiangsu Province China Department of Pharmacology Nanjing Medical University Nanjing 210029 Jiangsu Province China Department of-Microbiology Nanjing Medical University Nanjing 210029 Jiangsu Province China

AIM： To assess the associations of human leukocyte antigen （HI_A） class Ⅱ DQB1＊0301 and/or DRB1＊1101 allele with spontaneous hepatitis C virus （HCV） clearance by meta-analysis of individual dataset from all studies published till date. METHODS： To clarify the impact of HLA class Ⅱ polymorphisms on viral clearance, we performed a metaanalysis of the published data from 11 studies comparing the frequencies of DQB1＊0301 and DRB1＊1101 alleles in individuals with spontaneous resolution to those with persistent infection. As we identified the heterogeneity between studies, summary statistical data were calculated based on a random-effect model. RESULTS： Meta-analyses yielded summary estimatesodds ratio （OR） of 2.36 [95%CI （1.62, 3.43）, P〈0.00001] and 2.02 [95%CI （1.56, 2.62）, P〈0.00001] for the effects of DQB1＊0301 and DRB1＊1101 alleles on spontaneous clearance of HCV, respectively. CONCLUSION： These results support the hypothesis that specific HLA class Ⅱ alleles might influence the susceptibility or resistance to persistent HCV infection. Both DQB1＊0301 and DRB1＊1101 are protective alleles and present HCV epitopes more effectively to CD4^＋T lymphocytes than others, and subjects with these two alleles are at a lower risk of developing chronic HCV infection. Large, multi-ethnic confirmatory and welldesigned studies are needed to determine the host genetic determinants of HCV infection.

关键词： Human leukocyte antigen Genetic polymorphism DQB1*0301 DRB1*1101 Hepatitis C virus Spontaneous clearance Meta-analysis

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Role of intrinsic defects on carbon adsorbent for enhanced removal of Hg^(2+)in aqueous solution

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Chinese Journal of Chemical Engineering 2023年第9期61卷 129-139页

作者： Liu He Yiyang Qiu chu yao Guojun Lan Na Li Huacong Zhou Quansheng Liu Xiucheng Sun Zaizhe Cheng Ying Li Institute of Industrial Catalysis Zhejiang University of TechnologyHangzhou 310058China Inner Mongolia Key Laboratory of High-Value Functional Utilization of Low Rank Carbon Resources Huhhot 010051China

Carbon is a normally used adsorbent for removal of heavy metal ion in aqueous solutions,but the efficient adsorbent needs intensive modification by heteroatom doped or supported noble metals that cause severe pollution and easy leaching of active components during *** this paper,the role of intrinsic defects on Hg^(2+)adsorption for carbon adsorbent was *** maximum adsorbing capacity of defectrich carbon has been improved up to 433 mg·g^(-1)which is comparable to most of the modified carbon adsorbents via supported metal chloride or noble metal *** basicity is increased with the content of defective sites and the strong chemical bonding can be formed via electron transformation between the defect sites with adsorbed Hg^(2+).The present study gives a direction to explore cheap and easily scale-up high-performance mercury adsorbents by simply tuning the intrinsic defective structure of carbon without the necessity to support metal or other organic compounds.

关键词： Mercury-ion removal Adsorption Carbon adsorbent Defect sites

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Cross-shore suspended sediment flux in the salt marsh pioneer zone of Chongming eastern beach in the Chang- jiang Estuary in China

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Acta Oceanologica Sinica 2010年第6期29卷 62-72页

作者： WANG chu yao Dongjing HE Baogen ZHOU Naisheng XU Shiyuan Department of Geography Shanghai Normal University Shanghai 200234 China Department of Geography College of Resource and Environmental Science East China Normal University Shanghai 200062 China

Between April 2002 and April 2003,in situ measurements of water depth,current velocity and suspended sediment content were carried out in edge region of East Chongming salt marsh and neighboring bald flat in the Changjiang （Yangtze） Estuary under different weather ***-shore suspended sediment flux was calculated and *** results show that under calm weather conditions,the current velocity process in bald field and salt marsh area varied differently during semidiurnal tidal *** to current velocity asymmetry,mean SSC during flood tide phase was 1.8 times higher than that of ebb tide *** a result,net onshore sediment flux controlled cross-shore suspended sediment transport process and salt marsh pioneer zone was generally *** was significant positive correlation between total sediment flux and quartic power of maximum water *** indicates that tidal ranges dominate suspended sediment transport and sedimentation process in the salt marsh pioneer zone under the calm weather *** sedimentation rate on the adjacent mudflat was higher than the salt marsh,which induced stable accreting of salt marsh towards the *** wind events enhanced SSC and current velocity during the semidiurnal *** the remarkable onshore net sediment flux could occur on the high marsh and mudflat close to the marsh fringe during the short period under the rough weather condition.

关键词： current velocity suspended sediment content flux salt marsh eastern beach

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Variability of the Kuroshio in the East China Sea in 1995

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Acta Oceanologica Sinica 1999年第4期18卷 459-475页

作者： Liu Yong gang and Yuan yao chu (Second Institute of Oceanography, State Oceanic Administration, Hangzhou 310012, China) Second Institute of Oceanography State Oceanic Administration Hangzhou 310012 China

A modified inverse method is ed to compute the Kuroshio in the East China Sea with the CTD andwind data collected by R/V Chofu Maru during four cruises of 1995. The computed results show that: (1) The volume transport (hereafter VT) of the Kuroshio through fortion PN is 23. 3×106, 34. 1× 106,21. 1× 106 and 26. 7 ×106 m3/s, respectively , during winter, spring, summer and autumn, i. e., its VT is largest in spring but smallest inthe summer of 1995. However, from the statistical average results [e. g., Yuan et al. (1993) ], its VT is largest insummer but smallest in autumn. This means that the year 1995 is an anomalous year, which can also be shown from the T - S distributions. The heat transport (hereafter HT ) through Section PN is 1. 6×1015, 2. 5× 1015, 1. 7 x1015 and 2.1× 1015 W, respectively, during winter, spring, summer and autumn. This shows also that the year 1995is an anomalous year. VT through Section TK (at the Tokara Staik) is the largest in the spring of 1995. (2) Thereare two current cores at Section PN during winter, spring and summer, and three cores in autumn. (3) The Kuroshiovelocities at Section PN are stronger in spring and autumn than those in the winter and summer of 1995. (4) Thereare countercurrents under and east of the Kuroshio at Section PN. (5 ) The average rate of heat transfer in the computed area from the ocean to the atmosphere is 6.28×103, -0.83× 103, -2.09×103 and 2.49×103J/(cm2.d), respectively, during winter, spring, summer and autumn.

关键词： East China Sea Kuroshio seasonal variation

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Synergy of sodium doping and nitrogen defects in carbon nitride for promoted photocatalytic synthesis of hydrogen peroxide

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Chinese Chemical Letters 2024年第8期35卷 324-329页

作者： Fabrice Nelly Habarugira Ducheng yao Wei Miao Chengcheng chu Zhong Chen Shun Mao College of Environmental Science and Engineering State Key Laboratory of Pollution Control and Resource ReuseTongji UniversityShanghai 200092China Baowu Water Technology Co. Ltd.Research InstituteShanghai 201999China

Photocatalytic synthesis of hydrogen peroxide has gradually become a promising method for in-situ pro-duction of hydrogen peroxide,which relies on sustainable solar ***,the commonly used photocatalyst,i.e.,carbon nitride(CN),still suffers from the drawbacks of narrow light absorption range and fast charge ***,we report a facile method to introduce nitrogen defects into carbon nitride together with sodium *** adjusting the ratio of sodium dicyandiamide,the band gap of carbon nitride can be controlled,while the carrier separation and transfer ability of carbon nitride is *** modified CN with sodium doping and nitrogen defect(SD-CN)demonstrates outstanding H_(2)O_(2)pro-duction performance(H_(2)O_(2)yield rate of 297.2μmol L^(−1)h^(−1))under visible light irradiation,which is approximately 9.8 times higher than that of pristine *** work deepens the understanding of the coordinated effect of structural defect and element doping of carbon nitride on the photocatalytic H_(2)O_(2)production performance,and provides new insight into the design of photocatalytic system for efficient production of H_(2)O_(2).

关键词： Photocatalysis H_(2)O_(2)evolution Sodium doping Nitrogen defect Metal-free catalyst

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快速过滤净化-UPLC-MS/MS同时测定畜禽肉中12种兽药残留

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化学试剂 2024年第1期46卷 83-90页

作者：李楚瑶唐俊万亮郭雪梅陈春艳王姝南昌市检验检测中心南昌市保健食品及其接触材料质量安全风险评估重点实验室江西南昌330096

采用功能化聚苯乙烯/苯聚合物为填料的快速过滤净化柱萃取畜禽肉中的兽药,再结合超高效液相色谱-串联质谱(UPLC-MS/MS)高通量分析,建立了一种可同时测定12种兽药残留的方法。通过正交试验设计筛选前处理的最佳条件,样品经pH 4.0的EDTA-M... 详细信息

采用功能化聚苯乙烯/苯聚合物为填料的快速过滤净化柱萃取畜禽肉中的兽药,再结合超高效液相色谱-串联质谱(UPLC-MS/MS)高通量分析,建立了一种可同时测定12种兽药残留的方法。通过正交试验设计筛选前处理的最佳条件,样品经pH 4.0的EDTA-Mcllvaine缓冲液提取,按压式固相过滤柱快速净化,UPLC-MS/MS检测,外标法定量。结果表明,12种兽药在较宽的线性范围内拟合良好,相关系数均大于0.99,方法检出限0.3~3μg/kg,定量限1.0~10μg/kg。在3个不同添加水平下,猪肉、鸡肉、牛肉样品中的回收率分别为82.8%~110.4%、80.2%~108.4%、75.8%~107.1%,RSDs为0.51%~10.23%。该方法用于市售猪肉中的兽药检测,其中恩诺沙星、环丙沙星、金霉素、土霉素、四环素和强力霉素被检测出,与国标方法的测定结果相一致。该方法简单、快速、准确,适合多种兽药残留的同步筛查和准确定量。

关键词：超高液相色谱-串联质谱快速过滤净化兽药残留畜禽肉同步筛查

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A preliminary study on life history of marine red alga Stylonema alsidii(Zandardini)Drew *** Zheng et Li

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Journal of Oceanology and Limnology 2024年第3期42卷 915-922页

作者： Bingxin HUANG yao ZHANG Yue chu Youxuan GUO Junxia LIANG Jianan QIN Lanping DING Tianjin Key Laboratory of Animal and Plant Resistance College of Life SciencesTianjin Normal UniversityTianjin 300387China

Stylonema alsidii(Zandardini)Drew *** Zheng et Li is a common species in the genus Stylonema,but there are limited reports on morphological taxonomy and a lack of studies on life history and the regulation of early *** early development,discoid formation,and erect thallus growth of Stylonema alsidii *** were observed under laboratory *** addition,the influence of main environmental factors such as temperature and light intensity on its development was briefly studied,and various stages of its life history were *** result shows:(1)there are two reproductive modes:asexual reproduction and sexual reproduction;(2)the morphology of this species varies in different degrees under laboratory culture conditions;(3)sexual reproduction and asexual reproduction can coexist under suitable *** pathways of life history were inferred from experimental *** sporophytes form mature gametophytes by producing initially isolated or initially attached monospore,and mature gametophytes form mature sporophytes by fertilization of eggs and *** sexual and asexual reproduction processes of Stylonema alsidii *** were reported for the first time,and this is also the first report on sexual reproduction in the genus Stylonema.

关键词： Stylonema alsidii(Zandardini)Drew f.ramosum Zheng et Li life history environmental factor asexual reproduction sexual reproduction

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高大超长单层钢结构刚架温度分析及优化设计

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工程建设与设计 2024年第4期 19-21页

作者：孙必祥贝正其褚姚青郑益锋冉浚宏中机中联工程有限公司重庆400039 宁波方太厨具有限公司浙江宁波315336

通过对某高大超长单层钢结构厂房建筑的主刚架进行温度作用计算及对比分析,解决了高大超长刚架结构设计的温度影响问题,分析了温度作用、风荷载对高大超长单层钢结构刚架设计的主要影响,并根据主要影响因素探讨了不同的结构方案,提出了... 详细信息

通过对某高大超长单层钢结构厂房建筑的主刚架进行温度作用计算及对比分析,解决了高大超长刚架结构设计的温度影响问题,分析了温度作用、风荷载对高大超长单层钢结构刚架设计的主要影响,并根据主要影响因素探讨了不同的结构方案,提出了高大超长单层钢结构刚架的优化设计思路。

关键词：高大超长单层钢结构刚架温度分析优化设计

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Influence of rarefaction wave on premixed flame structure and propagation behavior

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Progress in Natural Science:Materials International 2007年第3期17卷 328-333页

作者： CHEN Xianfeng, SUN Jinhua, LU Shouxiang, chu Guanquan, yao Liyin and LIU Yi (State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei 230026, China) State Key Laboratory of Fire Science University of Science and Technology of China Hefei 230026 China

To explore the influence of rarefaction wave on the structure and propagation behavior of the premixed propane/air flame in a rectangle combustion pipe, the techniques of high speed Schlieren photograph method, pressure measurement and so on are used to study the interaction processes between rarefaction wave and flame. Two cases of rarefaction wave-flame interaction were performed in the experiment. The experimental result shows that both the rarefaction waves can cause the flame transition from laminar to turbulent combustion quickly. The cowflow rarefaction wave decreases the flame speed, while the counterflow rarefaction wave leads the flame propagation speed to increasing on the whole, accompanied with sharp vibration.

关键词： gas explosion rarefaction wave flame propagation laminar flame turbulent combustion.

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