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PHLDA1 deficiency limits microglia activation and protects dopaminergic neurons through attenuating auto-ubiquitination of TRAF6

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中国药理学与毒理学杂志 2018年第9期32卷 693-694页

作者： HAN chao-jun ZHEN Xue-chu Department of Pharmacology College of Pharmaceutical Sciences Soochow University Suzhou 215123 China

OBJECTIVE Pleckstrin homologylike domain family A member 1(PHLDA1),also known as TDAG51,was first identified as a potential transcription factor required for Fas expression and activation-induced apoptosis in mouse T cell *** research showed that PHILDA1 plays crucial roles in cell proliferation and apoptosis,PHLDA1 deficiency caused several phenotypic changes in macrophages that increased cytoprotection against oxidative and endoplasmic reticulum(ER) ***,little is known about the critical role of PHLDA1 in the neuroinflammation and neuronal *** Mouse Parkinson disease(PD) model was induced by intraperitoneal injection(ip) of MPTP for 7 *** staining was used to observe TH,Iba-1 and PHLDA1 in brain *** microglia and BV2 microglial cell lines were exposed to lipopolysacchrides(LPS) at different time points to determine PHLDA1 mRNA and protein level in ***2 cells with PHLDA1 knockdown using lentivirus experessing shRNA were exposed to LPS for the detection of proinflammatory genes expression by q-PCR or Western *** NF-κB and MAPK pathways were detected to reveal the underlying mechanisms of PHLDA1 regulate microglia ***,to determine the effect of PHLDA1 deletion in the substantia nigra(SN) on motor dysfunction,the mice were previously infected with AAV-GFP(control) or AAV-shP HLDA1 in the SN in PD model,then were administered with behavior *** PHLDA1 was expressed in ***1 was increased in primary microglia or BV2 microglia cell lines by LPS treatment,acted as a positive regulator of TLR4 ***1 deficiency suppressed LPS-induced microglia *** underlying mechanisms of PHLDA1 might be through directly interacting with TRAF6 to promote its auto-ubiquitination consequently enhanced *** PD model,PHLDA1 deletion in the SN limits microglial activation and protects dopaminergic ***1 deficiency mic

关键词： PHLDA1 TRAF6 microglia inflammation Parkinson disease

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基于SA-SVM的众筹违约风险预警模型

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统计与信息论坛 2018年第11期33卷 70-77页

作者：李杰马士豪靳孟宇 chao-hsien chu 河北工业大学经济管理学院天津300401 宾夕法尼亚州立大学信息科学与技术学院 pausa16802

随着中国众筹市场的不断发展,众筹出资人与众筹平台对违约风险的管控要求不断提升。由于众筹存在信息严重不对称、时间跨度长、违约损失大等特点,对高违约风险的众筹项目进行预警可有效规避风险,降低损失。通过分析众筹违约相关因素,结... 详细信息

随着中国众筹市场的不断发展,众筹出资人与众筹平台对违约风险的管控要求不断提升。由于众筹存在信息严重不对称、时间跨度长、违约损失大等特点,对高违约风险的众筹项目进行预警可有效规避风险,降低损失。通过分析众筹违约相关因素,结合众筹平台提供的公开信息,从众筹项目基本特征、发起人信用度、项目关联度、项目融资进展四个方面构建众筹违约风险预警指标体系;在上述分析的基础上,将模拟退火(SA)算法与支持向量机(SVM)相结合,构建众筹违约风险预警模型,实证研究结果表明该模型鲁棒性好、精度高,能有效预警众筹项目违约风险。

关键词：众筹违约预警模拟退火支持向量机随机森林

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新订单下基于资源共享差异性的作业成本系统计量误差建模

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管理评论 2016年第12期28卷 235-243页

作者：吴晓丹李娟刘丹岳殿民 chao-hsien chu 河北工业大学经济管理学院天津300130 美国宾西法尼亚州立大学UP分校 pa16801

通过对作业成本系统中计量误差的分析,建立基于作业成本法的考虑资源共享差异性因素的成本误差模型,研究新订单加入时不同资源共享下各种计量误差引发的总成本偏差以及对成本系统的稳健性的影响。结果发现通常资源共享差异性越大时,资... 详细信息

通过对作业成本系统中计量误差的分析,建立基于作业成本法的考虑资源共享差异性因素的成本误差模型,研究新订单加入时不同资源共享下各种计量误差引发的总成本偏差以及对成本系统的稳健性的影响。结果发现通常资源共享差异性越大时,资源动因、作业动因中存在计量误差时,整个成本系统的稳健性越强,资源成本池存在误差时,当每个成本池向所有成本对象分配动因百分比大小的平方和越接近于成本对象的个数时,成本系统的偏差就会越大,成本系统的稳健性越差,反之,成本系统的稳健性增强。本研究就具体情况为管理人员在间接成本分配时如何有效配置有限资源、提高成本精度提供依据。

关键词：成本系统设计作业成本资源共享计量误差

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A data-driven approach to RUL prediction of tools

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Advances in Manufacturing 2024年第1期12卷 6-18页

作者： Wei Li Liang-Chi Zhang chu-Han Wu Yan Wang Zhen-Xiang Cui chao Niu Department of Mechanical Engineering University College LondonLondonWC1E 7JEUK Shenzhen Key Laboratory of Cross-Scale Manufacturing Mechanics Southern University of Science and TechnologyShenzhen518055GuangdongPeople’s Republic of China SUSTech Institute for Manufacturing Innovation Southern University of Science and TechnologyShenzhen518055GuangdongPeople’s Republic of China Department of Mechanics and Aerospace Engineering Southern University of Science and TechnologyShenzhen518055GuangdongPeople’s Republic of China School of Mechanical and Manufacturing Engineering The University of New South WalesKensingtonNSW2052Australia Baoshan Iron&Steel Co. Ltd.Shanghai200941People’s Republic of China

An effective and reliable prediction of the remaining useful life(RUL)of a tool is important to a metal forming process because it can significantly reduce unexpected maintenance,avoid machine shutdowns and increase system *** study proposes a new data-driven approach to the RUL prediction for metal forming processes under multiple contact sliding *** data-driven approach took advantage of bidirectional long short-term memory(BLSTM)and convolutional neural networks(CNN).A pre-trained lightweight CNN-based network,WearNet,was re-trained to classify the wear states of workpiece surfaces with a high accuracy,then the classification results were passed into a BLSTM-based regression model as inputs for RUL *** experimental results demonstrated that this approach was able to predict the RUL values with a small error(below 5%)and a low root mean square error(RMSE)(around 1.5),which was more superior and robust than the other state-of-the-art methods.

关键词： Remaining useful life(RUL) Bidirectional long short-term memory(BLSTM) Data-driven approach Metal forming

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Denaturation behavior of inclusions in industrial pure iron by calcium treatment

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Journal of Iron and Steel Research International 2023年第2期30卷 249-258页

作者： Xin Liu Yan-ping Bao Cheng-jian Hua Jian-hua chu chao Gu Min Wang State Key Lab of Advanced Metallurgy University of Science and Technology BeijingBeijing100083China

Only a few Chinese enterprises can produce high-quality industrial pure iron,and studies on the smelting process of industrial pure iron were *** inclusions in a melting process were characterized by means of electron microscopy and an automatic inclusion analysis system,and the evolution mechanism of inclusion was studied using thermodynamic calculation to optimize the calcium alloy addition in liquid *** results show that during the smelting process,inclusions mainly composed of Al_(2)O_(3)and spinel are formed before calcium *** calcium treatment,they continuously react with[Ca],[S]and[Ti],grow up,and are removed during refining and tundish *** the end,there are more small-sized inclusions containing CaS,and the contents of Al_(2)O_(3)and spinel are *** to thermodynamic calculations,the appropriate calcium treatment liquid window for the molten steel composition is(10-38)×10^(-6).Calcium treatment has changed the main types of inclusions in industrial pure iron from Al_(2)O_(3)to small-sized inclusions containing CaS and effectively reduces the influence of Al_(2)O_(3)inclusions on the quality of industrial pure iron.

关键词： Industrial pure iron Calcium treatment Inclusion Thermodynamic CaS

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Thermal conductivity of diamond/copper composites with a bimodal distribution of diamond particle sizes prepared by pressure infiltration method

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Rare Metals 2011年第4期30卷 408-413页

作者： CHEN chao GUO Hong chu Ke YIN Fazhang ZHANG Ximing HAN Yuanyuan FAN Yeming The General Research Institute of Nonferrous Metals Beijing Beijing 100088 China

The thermal conductivity of diamond/copper composites with bimodal particle sizes was studied. The composites were prepared through pressure infiltration of liquid copper into diamond preforms with a mixture of 40 and 100 pm-size diamonds. The permeability of the preforms with different coarse-to-fine volume ratios of diamonds was investigated. The thermal conductivity of the diamond/copper composites with bimodal size distribution was compared to the theoretical value derived from an analytical model developed by chu. It is predicted that the diamond/copper composites could reach a higher thermal conductivity and their surface roughness could be improved by applying bimodal diamond particle sizes.

关键词： metallic matrix composites thermal conductivity diamonds copper size distribution pressure infiltration

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Characteristics of Ce-Mn film on 6061 alloys and its improved performance

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Rare Metals 2019年第10期38卷 971-978页

作者： Xue-Long Hao Wen Ma chu Luo Shi-chao Yang Hong Ji Kai Zhang GRIM AT Engineering Institute Co. Ltd.Beijing 101407China National Center of Analysis and Testing for Nonferrous Metals and Electronic Materials General Research Institute for Nonferrous MetalsBeijing 100088China China United Testing&Certification Co. Ltd.Beijing 101407China Guobiao(Beijing)Testing&Certification Co. Ltd..Beijing 101407China GRINM Bohan(Beijing)Publisher Co. LtdBeijing 101407China Guangdong Zhuhai Supervision Testing Institute of Quality and Metrology Zhuhai 519000China Guangdong Provincial Academy of Building Research Guangzhou 510500China

HF2- was applied to accelerate the Ce-Mn film formation on 6061A1 alloy in the Ce3+-*** process of film formation,the composition and structure of the film were analyzed by scanning electron microscopy(SEM) equipped with energy-dispersive spectroscopy(EDS),X-ray photoelectron spectroscopy(XPS)and X-ray diffractometer(XRD).The film formation process includes three *** the initial stage,a threedimensional(3D) skeleton was formed quickly,and then the skeleton was fully filled with cerium oxide and manganese oxide,resulting in a dense ***,a new skeleton was formed and also ***,Ce,O and Mn were detected in the *** existed mainly in the form of Ce4+(89%).The film existed in an amorphous form and was composed of ceria(cerium hydroxide),manganese dioxide and aluminum *** electrostatically spraying fluorocarbon powder,the resultant products satisfied the required mechanical performance and exhibited almost non-filament corrosion compared with commercially available chromium-free conversion *** corrosion resistant time to acetate spray can reach 2000 h,which is consistent with that of fluorocarbon *** results showed that Ce-Mn film can offer an attractive prospect to eliminate volatile organic compounds(VOC) problem arisen by using fluorocarbon paint in the process of industrial production.

关键词： Aluminumalloy Ce-Mn film Process of filmformation Amorphous

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Improved Breakdown Voltage in AlGaN/GaN High Electron Mobility Transistors by Employing Polyimide/Chromium Composite Thin Films as Surface Passivation and High-Permittivity Field Plates

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Chinese Physics Letters 2013年第9期30卷 145-148页

作者： chu Fu-Tong CHEN chao ZHOU Wei LIU Xing-Zhao State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of ChinaChengdu 610054

The breakdown voltage of AlGaN/GaN high electron mobility transistors(HEMTs)is enhanced by employing metal chromium(Cr)nanoparticle-embedded polyimide(PI)as a high-permittivity(high-𝐿)dielectric covering both the source-gate and gate-drain *** PI/Cr composite high-𝐿dielectrics acting as a field plate prevent the occurrence of strong electric fields produced at the drain side edge of the gate electrode to obtain an optimum lateral electric flux of *** breakdown voltage is improved by approximately 35%when using the PI/Cr thin film dielectric field plate while maintaining high performance,a high transconductance value of 122.4mS/mm,and a large saturated drain-current value of 748mA/mm.

关键词： AlGaN/GaN drain HEMTs

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A literature review of perishable medical resource management

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Frontiers of Engineering Management 2023年第4期10卷 710-726页

作者： chao Zhang Peifeng Li Qiao-chu He Fan Wang School of Business Southern University of Science and TechnologyShenzhen518055China Business School Sun Yat-sen UniversityGuangzhou 510275China

In recent decades,healthcare providers have faced mounting pressure to effectively manage highly perishable and limited medical *** article offers a comprehensive review of supply chain management pertaining to such resources,which include transplantable organs and healthcare *** review encompasses 93 publications from 1990 to 2022,illustrating a discernible upward trajectory in annual *** surveyed literature is categorized into three levels:Strategic,tactical,and *** problem attributes and methodologies are analyzed through the assessment of pertinent publications for each problem ***,research on service innovation,decision analytics,and supply chain resilience elucidates potential areas for future research.

关键词： perishable medical resources organ transplant healthcare products decision analytics operations management

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Corrosion resistance and hydrophobicity of myristic acid modified Mg-AI LDH/Mg(OH)2 steam coating on magnesium alloy AZ31

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Frontiers of Materials Science 2020年第1期14卷 96-107页

作者： Zai-Meng Qiu Fen Zhang Jun-Tong chu Yu-chao Li Liang Song Corrosion Laboratory for Light Metals College of Materials Science and EngineeringShandong University of Science and TechnologyQingdao266590China School of Materials Science and Engineering Liaocheng UniversityLiaocheng252059China

A hydrophobic surface was successfully fabricated on the Mg-Al-layered double hydroxide(Mg-Al LDH)/Mg(OH)2-coated AZ31 magnesium alloy via an in-situ steam coating(SC)process and a subsequent surface modification with environment-friendly myristic acid(MA).The microstructure,composition and hydrophobicity of SC/MA composite coating were investigated by XRD,SEM,EDS,FTIR,and contact angle(CA)*** corrosion behavior of the hybrid coating was evaluated by potentiodynamic polarization,EIS and hydrogen evolution test in 3.5 wt.%NaCl *** results showed that the LDH coating had nano-flake microstructure,which remained unchanged after modification with *** CA of the MA-modified coating surface reached up to 129°±3.5°,and the corrosion current density of SC/MA-2 coating decreased about three orders of the magnitude compared to that of the *** is proven that the modified surface has an effective anti-corrosion effect on AZ31 *** formation mechanism and the corrosion mechanism of the coating were also discussed.

关键词： magnesium alloy steam coating layered double hydroxide corrosion resistance hydrophobicity

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