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Highly fluorescent,photostable,and biocompatible silicon theranostic nanoprobes against Staphylococcus aureus infections

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Nano Research 2018年第12期11卷 6417-6427页

作者： Xia Zhai Bin Song binbin chu Yuanyuan Su Houyu Wang Yao He Laboratory of Nanoscale Biochemical Analysis lnstitute of Functional Nano &Soft Materials (FUNSOM)and Collaborative Innovation Center of Suzhou Nano Science and Technology (NANO-CIC)Soochow UniversitySuzhou 215123China

Human health is severely threatened by bacterial infections, which fuel urgent demand for the development of novel theranostic agents that are suitable for diagnosing and combating bacterial infections. To meet this goal, we synthesized a new kind of theranostic probes, made of vancomycin (Van)-modified fluorescent silicon nanoparticles (SiNPs-Van). The new probes feature good selectivity for Gram-positive bacterial infections, favorable fluorescence, strong resistance to photobleaching (e.g., 12% loss of fluorescence intensity during 40 min continuous laser excitation in the presence of Staphylococcus aureus (S. aureus)), and good biocompatibility (e.g., cell viability > 95% during 24 h treatment). Because of these benefits, the probes were effective at prolonged (i.e., 8-day) fluorescence tracking of S. aureus infections in vivo, thus providing a visible and accurate way to evaluate treatment efficacy. Moreover, the resultant SiNPs-Van with a minimum inhibitory concentration (MIC) of ca. 0.5 μg/mL exhibited high antibacterial efficiency of 92.5%, superior to that (76.5%) of free Van with higher MIC of ca. 1 μg/mL.

关键词： fluorescent silicon nanoparticles Gram-positive bacteria Staphylococcus aureus prolonged extended period

Photostable and Biocompatible Fluorescent Silicon Nanoparticles for Imaging-Guided Co-Delivery of siRNA and Doxorubicin to Drug-Resistant Cancer Cells

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Nano-Micro Letters 2019年第2期11卷 127-139页

作者： Daoxia Guo Xiaoyuan Ji Fei Peng Yiling Zhong binbin chu Yuanyuan Su Yao He Laboratory of Nanoscale Biochemical Analysis Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesInstitute of Functional Nano and Soft Materials (FUNSOM)Soochow University

The development of effective and safe vehicles to deliver small interfering RNA(siRNA) and chemotherapeutics remains a major challenge in RNA interference-based combination therapy with chemotherapeutics,which has emerged as a powerful platform to treat drug-resistant cancer ***,we describe the development of novel all-in-one fluorescent silicon nanoparticles(SiNPs)-based nanomedicine platform for imaging-guided co-delivery of siRNA and doxorubicin(DOX).This approach enhanced therapeutic efficacy in multidrug-resistant breast cancer cells(i.e.,MCF-7/ADR cells).Typically,the SiNP-based nanocarriers enhanced the stability of siRNA in a biological environment(i.e.,medium or RNase A) and imparted the responsive release behavior of siRNA,resulting in approximately 80% down-regulation of P-glycoprotein ***-delivery of P-glycoprotein siRNA and DOX led to>35-fold decrease in the half maximal inhibitory concentration of DOX in comparison with free DOX,indicating the pronounced therapeutic efficiency of the resultant nanocomposites for drug-resistant breast cancer *** intracellular time-dependent release behaviors of siRNA and DOX were revealed through tracking the strong and stable fluorescence of *** data provide valuable information for designing effective RNA interference-based co-delivery carriers.

关键词： Fluorescent silicon nanoparticles Drug resistance Gene therapy Bioimaging

Traditional Chinese medicine molecule-assisted chemical synthesis of fluorescent anti-cancer silicon nanoparUcles

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Nano Research 2018年第10期11卷 5629-5641页

作者： Xiaoyuan Ji Daoxia Guo Bin Song Sicong Wu binbin chu Yuanyuan Su Yao He Laboratory of Nanoscale Biochemical Analysis Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Institute of Functional Nano and Soft Materials (FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou 215123 China

Fluorescent silicon （Si） nanopartides （SiNPs） hold great promise for innumerable biological and biomedical applications owing to their unique optical properties and negligible toxicity. In this article, we present a new traditional Chinese medicine （TCM） molecule-assisted chemical synthetic strateg36 suitable for the production of multifunctional small-sized （diameter： - 3.7 nm） SiNPs in a facile and rapid （- 10 min） manner. Of particular significance, the resultant SiNPs simultaneously exhibited robust and stable fluorescence （photoluminescence quantum yield （PLQY）： ~ 15%）, as well as intrinsic anti-cancer efficacy with excellent selectivity toward cancer cells. Taking advantage of these unique merits, we further employed these novel fluorescent anti-cancer SiNPs （AC-SiNPs） for the fluorescence tracking and treatment of tumors, demonstrating long-term （~ 18 days） inhibition of tumor growth in tumor-bearing mice. Consequently, we believe this new TCM-assisted chemical synthetic method is highly attractive for designing silicon nanostructures featuring multiple functionalities, and we suggest these AC-SiNPs as novel promising tools for providing visual evidence of TCM-based cancer treatment.

关键词： traditional Chinese medicine fluorescent silicon nanoparticles anti-cancer

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硅基纳米探针用于眼部疾病的成像检测与治疗

高等学校化学学报 2022年第12期43卷 124-137页

作者：储彬彬何耀苏州大学功能纳米与软物质研究院苏州市纳米技术与生物医学重点实验室苏州215123

快速精准的诊断和高效的治疗对于减轻眼部疾病造成的危害至关重要.在过去的几十年里,由于具有尺寸小、比表面积大、表面易修饰及独特的光/电子/机械性能等优点,纳米材料已被用于构建不同种类的高性能纳米探针.其中,基于其良好的生物相容... 详细信息

快速精准的诊断和高效的治疗对于减轻眼部疾病造成的危害至关重要.在过去的几十年里,由于具有尺寸小、比表面积大、表面易修饰及独特的光/电子/机械性能等优点,纳米材料已被用于构建不同种类的高性能纳米探针.其中,基于其良好的生物相容性,科学家们已经将硅纳米材料设计为可用于不同眼部疾病诊断与治疗的功能化纳米探针.本综述主要概述了将硅基纳米探针用于检测和治疗不同眼部疾病(如角膜疾病、视网膜疾病、青光眼等)的近期研究进展.首先,重点介绍了硅基纳米探针的设计制备及在角膜新生血管、细菌性角膜炎等角膜疾病的成像检测与治疗中的应用;然后,介绍了用于成像检测和治疗视网膜疾病(如色素性视网膜炎和视网膜新生血管)的硅基持续性给药系统的研究成果;随后,概述了多功能硅基纳米载药系统的构建及在青光眼治疗领域的应用研究进展;最后,简要讨论了将硅基纳米探针用于眼部疾病诊治面临的挑战并对未来的发展前景进行了展望.

关键词：硅纳米探针眼部疾病成像检测药物递送

Naked-eye visualization of lymph nodes using fluorescence nanoprobes in non-human primate-animal models

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Nano Research 2024年第8期17卷 7404-7414页

作者： Xiaoyuan Ji binbin chu Xiaofeng Wu Zhiming Xia Airui Jiang Chenyu Wang Zhiming Chen Danni Zhong Qiaolin Wei Bin Song Wanlin Li Yiling Zhong Houyu Wang Fenglin Dong Min Zhou Yao He Suzhou Key Laboratory of Nanotechnology and Biomedicine Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesInstitute of Functional Nano and Soft Materials(FUNSOM)Soochow UniversitySuzhou 215123China School of Public Health Shanghai Jiao Tong University School of MedicineShanghai 200025China Zhejiang University-University of Edinburgh Institute(ZJU-UoE Institute) Zhejiang UniversityHaining 314400China Department of Ultrasound the First Affiliated Hospital of Soochow UniversitySuzhou 215006China State Key Laboratory(SKL)of Biobased Transportation Fuel Technology Zhejiang UniversityHangzhou 310027China School of Pharmacy Hangzhou Normal UniversityHangzhou 311121China Macao Translational Medicine Center Macao University of Science and TechnologyTaipa 999078MacaoChina Macao Institute of Materials Science and Engineering Macao University of Science and TechnologyTaipa 999078MacaoChina

Despite sufficient studies performed in non-primate animal models,there exists scanty information obtained from pilot trials in non-human primate animal models,severely hindering nanomaterials moving from basic research into clinical *** herein present a pioneering demonstration of nanomaterials based optical imaging-guided surgical operation by using macaques as a typical kind of non-human primate-animal ***,taking advantages of strong and stable fluorescence of the small-sized(diameter:~5 nm)silicon-based nanoparticles(SiNPs),lymphatic drainage patterns can be vividly visualized in a real-time manner,and lymph nodes(LN)are able to be sensitively detected and precisely excised from small animal models(e.g.,rats and rabbits)to non-human primate animal models(e.g.,cynomolgus macaque(Macaca fascicularis)and rhesus macaque(Macaca mulatta)).Compared to clinically used invisible near-infrared(NIR)lymphatic tracers(i.e.,indocyanine green(ICG);etc.),we fully indicate that the SiNPs feature unique advantages for naked-eye visible fluorescence-guided surgical operation in long-term *** toxicological analysis in macaque models further provides confirming evidence of favorable biocompatibility of the SiNPs *** expect that our findings would facilitate the translation of nanomaterials from the laboratory to the clinic,especially in the field of cancer treatment.

关键词： fluorescent silicon nanoparticles lymph node real-time naked-eye visualization macaque models

国产石英反射体应用于全反射X射线荧光光谱分析中的性能评价

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冶金分析 2021年第8期41卷 1-6页

作者：刘晓储彬彬詹秀春国家地质实验测试中心

石英反射体是全反射X射线荧光光谱(TXRF)分析常用的样品载体。目前TXRF商用石英反射体均为进口产品,单价过高,成批购置时成本往往难以承受。为此,项目组优选国内加工单位,指定技术参数,定制了一批国产石英反射体,单价仅为进口产品的1/1... 详细信息

石英反射体是全反射X射线荧光光谱(TXRF)分析常用的样品载体。目前TXRF商用石英反射体均为进口产品,单价过高,成批购置时成本往往难以承受。为此,项目组优选国内加工单位,指定技术参数,定制了一批国产石英反射体,单价仅为进口产品的1/15以下。为考察两种石英反射体的性能差异,在相同条件下,利用TXRF对国产和进口两种空白石英反射体进行测试,通过对比两种反射体的不同元素感兴趣区(光谱背景(BG)、Si、Ar、Mo)、多种元素(V、Cr、Mn、Co、Ni、Cu、Zn、As、Sr、Ba、Pb、Bi)的仪器检出限,考察评价两种石英反射体的材质纯度、平整度、厚度等物理性能的差异;分别采用国产和进口石英反射体,对5种不同质量浓度的混合标准溶液进行TXRF测试,通过对比两种反射体得到的多种元素的灵敏度与测量值,考察评价两种石英反射体使用性能的差异。实验结果表明,两种石英反射体得到的各项结果几乎相同,证明了国产石英反射体的性能指标与进口产品非常相近,完全可以代替进口石英反射体。采用国产石英反射体,可以大大降低成本,方便野外现场的样品分析。

关键词：全反射X射线荧光光谱(TXRF) 石英反射体国产进口性能评价

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奥沙利铂致感音神经性耳聋和急性视神经炎

药物不良反应杂志 2020年第10期22卷 599-600页

作者：邬伟褚斌斌梁琳春浙江大学明州医院肿瘤内科宁波315100

1例59岁男性患者因胃癌伴多发淋巴结转移接受SOX方案化疗:奥沙利铂注射液200 mg入5%葡萄糖注射液250 ml静脉滴注2 h(第1天),替吉奥60 mg口服、2次/d(第1~14 d);每3周为1个周期。在第3周期治疗期间,输注奥沙利铂1周后,患者突然出现耳聋... 详细信息

1例59岁男性患者因胃癌伴多发淋巴结转移接受SOX方案化疗:奥沙利铂注射液200 mg入5%葡萄糖注射液250 ml静脉滴注2 h(第1天),替吉奥60 mg口服、2次/d(第1~14 d);每3周为1个周期。在第3周期治疗期间,输注奥沙利铂1周后,患者突然出现耳聋及视物模糊症状。经耳鼻喉科医师会诊,诊断为突发感音神经性耳聋和急性视神经炎。考虑患者突发感音神经性耳聋和急性视神经炎与奥沙利铂相关。停止化疗,并给予神经营养药物及改善微循环治疗,1周后,患者视力逐渐恢复正常,但是耳聋症状持续存在。

关键词：奥沙利铂听觉丧失,感音神经性视神经炎

特色办刊提升地质学科技期刊的影响力——以《岩矿测试》为例

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中国科技期刊研究 2022年第2期33卷 209-214页

作者：潘静徐书荣储彬彬中国地质科学院期刊处北京市100037 国家地质实验测试中心《岩矿测试》编辑部北京市100037

【目的】在数字化出版背景下,探索如何提升地质学专业性科技期刊的学术质量和影响力。【方法】以地质学科技期刊《岩矿测试》为例,结合近年来改革办刊举措,探讨专业学术期刊发展的可行性方案。【结果】通过提高论文学术质量、推进数字... 详细信息

【目的】在数字化出版背景下,探索如何提升地质学专业性科技期刊的学术质量和影响力。【方法】以地质学科技期刊《岩矿测试》为例,结合近年来改革办刊举措,探讨专业学术期刊发展的可行性方案。【结果】通过提高论文学术质量、推进数字化出版、利用大数据服务办刊、举办作者培训班等一系列期刊品牌建设举措,《岩矿测试》的行业认可度和学术影响力得到提升。【结论】寻求特色的办刊之路是提高专业性科技期刊核心竞争力和整体影响力的关键。

关键词：《岩矿测试》特色办刊学术影响力新媒体传播数字化出版

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腹腔镜子宫肌瘤剔除术患者的手术护理配合

中国医药指南 2021年第24期19卷 121-122页

作者：褚滨滨盘锦辽油宝石花医院妇婴院区手术麻醉科辽宁盘锦124010

目的分析腹腔镜子宫肌瘤剔除术患者的手术护理配合。方法于2018年1月至2019年1月间随机抽取122例手术治疗的子宫肌瘤剔除术患者,随机分为两组,对照组行常规护理,观察组增加手术护理配合。对比两组护理效果。结果观察组患者护理依从性为9... 详细信息

目的分析腹腔镜子宫肌瘤剔除术患者的手术护理配合。方法于2018年1月至2019年1月间随机抽取122例手术治疗的子宫肌瘤剔除术患者,随机分为两组,对照组行常规护理,观察组增加手术护理配合。对比两组护理效果。结果观察组患者护理依从性为95.08%(58/61)、护理满意度为96.72%(59/61),对照组患者护理依从性为85.25%(52/61)、护理满意度为83.61%(51/61),两组对比,差异具有统计学意义(P<0.05,χ^(2)=9.045、10.280)。观察组患者的自我护理能力得分平均为(7.80±0.90)分,焦虑评分(20.60±3.30)分,住院时间(4.40±0.80)d。对照组患者自我护理能力得分为(5.70±0.80)分,焦虑评分(27.40±4.60)分,住院时间(5.80±0.90)d。两组对比,差异具有统计学意义(P<0.05,t=8.147、12.933、6.289)。结论在腹腔镜子宫肌瘤剔除术患者的疗护中,可借助手术护理配合提升其护理依从性和满意度,改善患者心理态势、自我护理能力,缩短住院时间。

关键词：腹腔镜子宫肌瘤剔除术手术护理焦虑评分住院时间