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Planning the hepatitis C virus elimination in Cyprus:A modeling study

World Journal of Gastroenterology 2021年第31期27卷 5219-5231页

作者： Ilias Gountas Ioanna Yiasemi Evi Kyprianou christos mina Chrysanthos Georgiou Petros Katsioloudes Andri Kouroufexi Anna Demetriou Elena Xenofontos Georgios Nikolopoulos Medical School University of CyprusNicosia 1678Cyprus Cyprus Monitoring Centre Cyprus National Addictions AuthorityNicosia 1678Cyprus Nicosia General Hospital Nicosia 1678Cyprus Evangelistria Medical Centre Nicosia 1678Cyprus Ministry of Health Pharmaceutical ServicesNicosia 1678Cyprus Ministry of Health Health Monitoring UnitNicosia 1678Cyprus Department of Internal Medicine Limassol General HospitalLimassol 4131Cyprus

BACKGROUND Hepatitis C virus(HCV)infection is a major global public health *** the Republic of Cyprus,the estimated prevalence of chronic hepatitis C(CHC)among the general population is 0.6%,while the CHC prevalence among people who inject drugs(PWID)is estimated at 46%.Direct-acting antivirals that can eliminate HCV are not yet widely available in the Republic of ***,when direct-acting antivirals become available,a long-term strategic plan to guide elimination efforts will be needed to maximize the effect of *** To determine the programmatic targets to eliminate HCV in the Republic of *** A dynamic,stochastic,individual-based model of HCV transmission,disease progression,and cascade of care was calibrated to data from *** model stratifies the population into the infected general population and the PWID population.A variety of test,prevention,and treatment strategies concerning the general population,PWID,or both were *** time horizon of the analysis was until *** Under the status quo scenario,the model predicted that 75(95%confidence interval(CI):60,91)and 575(95%CI:535,615)liver-related deaths and new infections would occur by 2034,*** an expanded treatment program,without screening interventions,would cause modest outcomes regarding CHC prevalence(16.6%reduction in 2034 compared to 2020)and liverrelated deaths(10 deaths would be prevented compared to the status quo scenario by 2034).Implementing a test and treat strategy among the general population but without any intervention in the PWID population would suffice to meet the mortality target but not the incidence *** achieve HCV elimination in Cyprus,3080(95%CI:3000,3200)HCV patients need to be diagnosed and treated by 2034(2680 from the general population and 400 from PWID),and harm reduction coverage among PWID should be increased by 3%per year(from 25%in 2020 to 67%in 2034).CONCLUSION Elimination of HCV is a demanding pub

关键词： Mathematical modelling Projections Hepatitis C virus elimination Directacting antivirals Screening campaigns

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Prevalence of occult hepatitis B virus infection in haemodialysis patients from central Greece

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World Journal of Gastroenterology 2010年第2期16卷 225-231页

作者： Paraskevi mina Sarah P Georgiadou christos Rizos George N Dalekos Eirini I Rigopoulou Department of Medicine and Research Laboratory of Internal Medicine Medical School University of Thessaly41110 LarissaThessalyGreece Research Group of Investigational Medicine Institute of Biomedical Research and TechnologyCentre for Research and Technology-Thessaly(CE.RE.TE.TH)41222 LarissaThessalyGreece RE.TE.TH)41222 LarissaThessalyGreece Research Group of Investigational Medicine Institute of Biomedical Research and TechnologyCentre for Research and Technology-Thessaly(CE.RE.TE.TH)41222 LarissaThessalyGreece

AIM:To assess the hepatitis B virus(HBV)-DNA and the prevalence of occult HBV infection in end-stage renal failure(ESRF)patients from Central Greece. METHODS:Sera from 366 ESRF patients attending five out of six dialysis units from Central Greece were investigated for HBV-DNA by real-time polymerase chain *** serum samples with repeatedly detectable HBV-DNA were considered *** antibodies to hepatitis C virus(anti-HCV)were tested by a third generation enzyme linked immunosorbent assay(ELISA),while IgG antibodies to hepatitis E virus (anti-HEV)were tested by two commercially available ***:HBV-DNA was detected in 15/366 patient (4.1%)and HBsAg in 20/366(5.5%).The prevalenc of occult HBV infection was 0.9%(3/346 HBsAg negative patients).Occult HBV was not associate with a specific marker of HBV infection or anti-HCV o anti-HEV *** was no significant differenc in HBV-DNA titres,demographic and biochemica features,between patients with occult HBV infectio and those with HBsAg-positive chronic HBV infection. CONCLUSION:In central Greece,4%of ESRF patient had detectable HBV-DNA,though in this setting,th prevalence of occult HBV seems to be very low(0.9%).

关键词： Hepatitis B virus-DNA Occult hepatitis B virus infection Haemodialysis Hepatitis B Real-time polymerase chain reaction

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