检索结果-南通市图书馆

Soft monolithic infrared neural interface for simultaneous neurostimulation and electrophysiology

Light(Science & Applications) 2023年第6期12卷 1103-1116页

作者： Marcello Meneghetti Jaspreet Kaur Kunyang Sui Jakob F.Sørensen Rune W.Berg christos markos DTU Electro Department of Electrical and Photonics EngineeringTechnical University of DenmarkDK-2800 KgsLyngbyDenmark Department of Neuroscience University of CopenhagenBlegdamsvej 3BDK-2200 Kbh NCopenhagenDenmark NORBLIS ApS Virumgade 35DDK-2830 VirumDenmark

Controlling neuronal activity using implantable neural interfaces constitutes an important tool to understand and develop novel strategies against brain *** neurostimulation is a promising alternative to optogenetics for controlling the neuronal circuitry with high spatial ***,bi-directional interfaces capable of simultaneously delivering infrared light and recording electrical signals from the brain with minimal inflammation have not yet been ***,we have developed a soft fibre-based device using high-performance polymers which are>100-fold softer than conventional silica glass used in standard optical *** developed implant is capable of stimulating the brain activity in localized cortical domains by delivering laser pulses in the 2μm spectral region while recording electrophysiological *** and local field potentials were recorded in vivo from the motor cortex and hippocampus in acute and chronic settings,*** analysis of the brain tissue indicated insignificant inflammatory response to the infrared pulses while the signal-to-noise ratio of recordings still remained *** neural interface constitutes a step forward in expanding infrared neurostimulation as a versatile approach for fundamental research and clinically translatable therapies.

关键词： neural stimulation recording

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Thermo-mechanical dynamics of nanoimprinting anti-reflective structures onto small-core mid-IR chalcogenide fibers [Invited]

引用

Chinese Optics Letters 2021年第3期19卷 46-52页

作者： Christian R.Petersen Mikkel B.Lotz christos markos Getinet Woyessa David Furniss Angela B.Seddon Rafael J.Taboryski O.Bang DTU Fotonik Technical University of DenmarkDK-2800 Kgs.LyngbyDenmark DTU Nanolab Technical University of DenmarkDK-2800 Kgs.LyngbyDenmark NORBLIS DK-2830 VirumDenmark Mid-Infrared Photonics Group University of NottinghamNottingham NG72RDUK NKT Photonics DK-3460 Bi「ke「0dDenmark

Thermal nanoimprinting is a fast and versatile method for transferring the anti-reflective properties of subwavelength nanostructures onto the surface of highly reflective substrates, such as chalcogenide glass optical fiber end faces. In this paper, the technique is explored experimentally on a range of different types of commercial and custom-drawn optical fibers to evaluate the influence of geometric design, core/cladding material, and thermo-mechanical properties. Up to32.4% increased transmission and 88.3% total transmission are demonstrated in the 2–4.3 μm band using a mid-infrared(IR) supercontinuum laser.

关键词： nanoimprint lithography anti-reflection hot imprint chalcogenide glass optical fiber mid-infrared supercontinuum

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Intestinal barrier dysfunction as a key driver of severe COVID-19

引用

World Journal of Virology 2023年第2期12卷 68-90页

作者： Efthymios P Tsounis christos Triantos christos Konstantakis markos Marangos Stelios F Assimakopoulos Division of Gastroenterology Department of Internal MedicineMedical SchoolUniversity Hospital of PatrasPatras 26504Greece Division of Infectious Diseases Department of Internal MedicineMedical SchoolUniversity of PatrasUniversity Hospital of PatrasPatras 26504Greece

The intestinal lumen harbors a diverse consortium of microorganisms that participate in reciprocal crosstalk with intestinal immune cells and with epithelial and endothelial cells,forming a multi-layered barrier that enables the efficient absorption of nutrients without an excessive influx of *** being a lung-centered disease,severe coronavirus disease 2019(COVID-19)affects multiple systems,including the gastrointestinal tract and the pertinent gut barrier *** acute respiratory syndrome coronavirus 2(SARS-CoV-2)can inflict either direct cytopathic injury to intestinal epithelial and endothelial cells or indirect immune-mediated ***,SARS-CoV-2 undermines the structural integrity of the barrier by modifying the expression of tight junction *** addition,SARS-CoV-2 induces profound alterations to the intestinal microflora at phylogenetic and metabolomic levels(dysbiosis)that are accompanied by disruption of local immune *** ensuing dysregu-lation of the gut-lung axis impairs the ability of the respiratory immune system to elicit robust and timely responses to restrict viral *** intestinal vasculature is vulnerable to SARS-CoV-2-induced endothelial injury,which simultaneously triggers the activation of the innate immune and coagulation systems,a condition referred to as“immunothrombosis”that drives severe thrombotic ***,increased intestinal permeability allows an aberrant dissemination of bacteria,fungi,and endotoxin into the systemic circulation and contributes,to a certain degree,to the over-exuberant immune responses and hyper-inflammation that dictate the severe form of *** this review,we aim to elucidate SARS-CoV-2-mediated effects on gut barrier homeostasis and their implications on the progression of the disease.

关键词： COVID-19 SARS-CoV-2 Intestinal barrier Dysbiosis Immunothrombosis Gut-lung axis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：