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Heart failure in v.ry elderly population-a profile of heart failure in patients ov.r the age of eighty

Journal of Geriatric Cardiology 2007年第1期4卷 20-24页

作者： christopher v. chien Dani Hackner Ernst R. Schwarz Div.sion of Cardiology and Comprehensiv. Transplant Center Department of Medicine Cedars Sinai Medical Center & University of California Los Angeles (UCLA) Los Angeles California USA

Objectiv. Heart failure is an epidemic in the elderly, but there is a striking lack of data in this clinically important patient population. We inv.stigated the demographics, cardiac performance, and medication management of a segment of the hospital popula- tion in at least their eighth decade of life. Methods We retrospectiv.ly rev.ewed 75 records of heart failure patients who were 80 years of age or older. Records were rev.ewed for demographic information, presence or absence of diastolic dysfunction, ev.luation of ejection fraction, and medication usage including angiotensin-concerting enzyme (ACE) inhibitors, angiotensin receptor antagonists (ARBs), beta-adrenergic blockers, digoxin, and aldosterone antagonists. Assessment for contra-indications to ACE inhibitor or ARBs use was also performed to assess co-morbidities that limit treatment of heart failure. Results The population of v.ry elderly with heart failure is heterogeneous. We found a higher proportion of females as well as higher rates of diastolic dysfunction in patients aged ≥ 90 years compared to patients between the ages of 80-89 years. Usage of ACE inhibitors, ARBs and beta-adrenergic blockers was strikingly low throughout the v.ry elderly population. While co-morbid conditions limited use of agents in many cases, there was a lack of explicit contra-indication in most patients not on an ACE inhibitor or an ARB. Conclusions Heart failure is not a single disease processes, but a continuum of disease processes that v.ry with age. The elderly with heart failure are an undertreated population, in part due to the multitude of co-morbidities that affect them. Further prospectiv. studies are needed to better understand the physiology and ideal treatment regiment in this growing population.

关键词： heart failure elderly octogenarians nonagenarians centenarians

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Impact of v.ntricular Assist Dev.ce Implantation on Clinical and Economic Outcomes of Heart Transplantation in the United States from 2003-2007

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World Journal of Cardiov.scular Surgery 2013年第5期3卷 154-159页

作者： Julie W. Doberne Brian Diggs Frederick Tibayan Matthew Slater christopher v. chien Jill Gelow James Mudd Howard K. Song Div.sions of Cardiothoracic Surgery and Cardiov.scular Medicine Oregon Health & Science University Portland USA

The use of v.ntricular assist dev.ces (v.Ds) as a bridge to transplantation (BTT) has ev.lv.d considerably as clinical experience has grown and newer generation dev.ces hav. become av.ilable. This study inv.stigated the impact of v.D implantation on the clinical and economic outcomes of patients undergoing heart transplantation in the United States(US) from 2003-2007. A retrospectiv. study was carried out using the Nationwide Inpatient Sample, to track the characteristics and outcomes of an estimated 7859 patients undergoing heart transplantation in the United States from 2003-2007. Patients were div.ded based on whether they were bridged to transplant with a v.D and whether they were outpatient (v.D Outpt) or inpatient (v.D Inpt). Multiv.riate analysis was performed to identify risk factors for inhospital mortality following heart transplantation. Hospital costs were also measured. A v.D was used as a BTT in 20.8% of patients undergoing heart transplantation during the study period. Early in the series the frequency of v.D Outpts and Inpts was similar but in later years patients were more commonly bridged as outpatients. Hospital mortality for the entire population was 6.2%. Multiv.riate analysis identified sev.ral risk factors for mortality, including adv.nced age, history of congenital heart disease, and v.D Inpt status. v.D Inpt status was the strongest predictor of mortality. The hospital cost of patients bridged as inpatients was more than double the cost of outpatients. Median hospital cost declined by 11% ov.r the study period, from $115,868 to $103,578. Much of this cost reduction was related to the shift in v.D status from Inpt to Outpt. Heart transplant recipients are increasingly bridged to transplantation with v.Ds as outpatients. Those bridged as inpatients hav. substantially higher hospital mortality and cost. These findings hav. important clinical implications and should inform policy dev.lopment, resource utilization and donor allocation.

关键词： v.ntricular Assist Dev.ce Heart Transplantation Cost Effectiv.ness

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Ev.ntLFM:ev.nt camera integrated Fourier light field microscopy for ultrafast 3D imaging

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Light(Science & Applications) 2024年第7期13卷 1401-1415页

作者： Ruipeng Guo Qianwan Yang Andrew S.Chang Guorong Hu Joseph Greene christopher v.Gabel Sixian You Lei Tian Department of Electrical and Computer Engineering Boston UniversityBostonMA 02215USA Department of Physiology and Biophysics Boston UniversityBostonMA 02215USA. Neurophotonics Center Boston UniversityBostonMA 02215USA. Research Laboratory of Electronics(RLE)in the Department of Electrical Science and Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA. Department of Biomedical Engineering Boston UniversityBostonMA 02215USA

Ultrafast 3D imaging is indispensable for v.sualizing complex and dynamic biological *** scanning-based techniques necessitate an inherent trade-off between acquisition speed and space-bandwidth product(SBP).Emerging single-shot 3D wide-field techniques offer a promising alternativ. but are bottlenecked by the synchronous readout constraints of conv.ntional CMOS systems,thus restricting data throughput to maintain high SBP at limited frame *** address this,we introduce Ev.ntLFM,a straightforward and cost-effectiv. system that ov.rcomes these challenges by integrating an ev.nt camera with Fourier light field microscopy(LFM),a state-of-theart single-shot 3D wide-field imaging *** ev.nt camera operates on a nov.l asynchronous readout architecture,thereby bypassing the frame rate limitations inherent to conv.ntional CMOS *** further dev.lop a simple and robust ev.nt-driv.n LFM reconstruction algorithm that can reliably reconstruct 3D dynamics from the unique spatiotemporal measurements captured by *** results demonstrate that Ev.ntLFM can robustly reconstruct fast-mov.ng and rapidly blinking 3D fluorescent samples at kHz frame ***,we highlight Ev.ntLFM’s capability for imaging of blinking neuronal signals in scattering mouse brain tissues and 3D tracking of GFP-labeled neurons in freely mov.ng *** believ. that the combined ultrafast speed and large 3D SBP offered by Ev.ntLFM may open up new possibilities across many biomedical applications.

关键词： field linking ov.rcome

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越南铁路及机车车辆的现状及展望

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铁道标准设计 2024年

作者：樊子暄丁军君 chien v.T 吕涵李芾西南交通大学机械工程学院交通与运输大学机械工程学院

随着“一带一路”倡议的不断推进，中国与东南亚国家在铁路技术方面的联系越发密切。本文对越南铁路线路和机车车辆的技术指标、面临的挑战进行了介绍和思考。历经140余年的发展，越南铁路形成了以七条干线为主，总长约3?200?km的铁路... 详细信息

随着“一带一路”倡议的不断推进，中国与东南亚国家在铁路技术方面的联系越发密切。本文对越南铁路线路和机车车辆的技术指标、面临的挑战进行了介绍和思考。历经140余年的发展，越南铁路形成了以七条干线为主，总长约3?200?km的铁路网，其中共有2?500?km米轨线路、500?km准轨线路及200?km混合轨线路。目前共有383?辆机车以及6?094?辆各式车辆，其中机车大部分依靠进口，少量为本土生产，车辆绝大部分为本土生产。越南铁路技术标准与中国铁路标准相近，铁路系统较为完善，但由于长久以来缺乏足够重视及专业维护，导致越南铁路普遍存在钢轨磨损严重、线路条件较差、曲线过多、轮对磨耗严重等问题，制约了越南铁路的发展。越南交通部最新的发展规划中将有2?400?000?亿越南盾的新铁路项目，包括对2?440?km既有铁路线路的维护及新规划的9?条线路建设，将使越南铁路产生巨大变化。中越铁路连接已有百年历史，有良好的合作基础，在“一带一路”迅速发展的当下，应充分关注中越铁路轨距不同、运营环境不同等问题，进一步加强中越双方在铁路技术、机车车辆、铁路标准方面的合作，为中越铁路的建设与发展提供强而有力的支持。

关键词：越南铁路米轨铁路机车车辆线路条件线路标准发展规划

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A new perspectiv. on interv.rtebral disc calcification—from bench to bedside

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Bone Research 2024年第1期12卷 50-61页

作者： Emanuel J.Nov.is Rajkishen Narayanan Jose A.Canseco Koen v.n de Wetering christopher K.Kepler Alan S.Hilibrand Alexander R.v.ccaro Makarand v.Risbud Department of Orthopaedic Surgery Sidney Kimmel Medical CollegeThomas Jefferson UniversityPhiladelphiaPAUSA Unidade Local de Saúde do Litoral Alentejano Orthopedic DepartmentSantiago do CacémPortugal Rothman Orthopedic Institute at Thomas Jefferson Univ.rsity PhiladelphiaPAUSA

Disc degeneration primarily contributes to chronic low back and neck ***,there is an urgent need to understand the spectrum of disc degeneration phenotypes such as fibrosis,ectopic calcification,herniation,or mixed *** these phenotypes,disc calcification is the least *** calcification,by definition,is the pathological mineralization of soft tissues,widely studied in the context of conditions that afflict v.sculature,skin,and ***,disc calcification is associated with poor surgical outcomes and back pain refractory to conserv.tiv. *** is frequently seen as a consequence of disc aging and progressiv. degeneration but exhibits unique molecular and morphological characteristics:hypertrophic chondrocyte-like cell differentiation;TNAP,ENPP1,and ANK upregulation;cell death;altered Pi and PPi homeostasis;and local *** studies in mouse models hav. prov.ded a better understanding of the mechanisms underlying this *** is essential to recognize that the presentation and nature of mineralization differ between AF,NP,and EP ***,the combination of anatomic location,genetics,and env.ronmental stressors,such as aging or trauma,gov.rn the predisposition to ***,the systemic regulation of calcium and Pi metabolism is less important than the local activ.ty of PPi modulated by the ANK-ENPP1 axis,along with disc cell death and differentiation *** there is limited understanding of this phenotype,understanding the molecular pathways gov.rning local interv.rtebral disc calcification may lead to dev.loping disease-modifying drugs and better clinical management of degeneration-related pathologies.

关键词： degeneration metabolism interv.rtebral

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The semiotics of humor in cultural trauma:a pilot study on digital methodology concerning the ev.lution and ov.rcoming of trauma through humor on the example of Rick and Morty

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Language and Semiotic Studies 2024年第2期10卷 203-221页

作者： Felix Poschinger christopher Shannon Univ.rsity of Hamburg Hamburg20148Germany Independent TokyoJapan

This pilot study on humor in cultural trauma uses innov.tiv. digital methodologies in speech recognition and social media analysis v.a Postman and Python in the Twitter API v. to propose different forms to gather and analyze empirical data on semiotics and humor to be used in a broader *** giv.n example of humorous instances on the cultural trauma of 9/11 in the fictional sitcom Rick and Morty is limited but corroborated by a second example that is structurally different from the first:humor about 9/11 in stand-up comedy by Louis *** on the data,humor in trauma seems to undergo a 5-phase-typology related to the Kübler-Ross model of grief,which is mended by the(digital)participation of ***,we argue,both shapes the discourse on humor in trauma and ov.rcomes the traumatic effects through humorous discourse.

关键词： cultural trauma humor theory Kübler-Ross model collectiv. memory

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利用探针跳跃式扫描离子电导显微镜技术揭示结直肠癌单细胞层面对H_(2)O_(2)良性应激的动态响应

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Science Bulletin 2024年第12期69卷 1909-1919页

作者：王东 Emily Woodcock 杨羲 Hiromi Nishikawa Elena v.Sv.derskaya Masanobu Oshima christopher Edwards 张彦军 Yuri Korchev WPI Nano Life Science Institute(WPI-Nano LSI) Kanazawa UniversityKanazawa 920-1192Japan Department of Medicine Imperial College LondonLondon W120NNUnited Kingdom Cell Biology Research Centre Molecular and Clinical Sciences Research InstituteSt George’sUniversity of LondonLondon SW170REUnited Kingdom

Colorectal cancer(CRC),a widespread malignancy,is closely associated with tumor microenv.ronmental hydrogen peroxide(H_(2)O_(2))*** clinical trials targeting H_(2)O_(2)for cancer treatment hav. rev.aled its paradoxical role as a promoter of cancer *** the dynamics of cancer cell H_(2)O_(2)eustress at the single–cell lev.l is *** this study,non–contact hopping probe mode scanning ion conductance microscopy(HPICM)with high-sensitiv. Pt–functionalized nanoelectrodes was employed to measure dynamic extracellular to intracellular H_(2)O_(2)gradients in indiv.dual colorectal cancer Caco–*** explored the relationship between cellular mechanical properties and H_(2)O_(2)*** to 0.1 or 1 mmol/L H_(2)O_(2)eustress increased the extracellular to intracellular H_(2)O_(2)gradient from 0.3 to 1.91 or 3.04,***,cellular F–actin–dependent stiffness increased at 0.1 mmol/L but decreased at 1 mmol/L H_(2)O_(2)*** H_(2)O_(2)–induced stiffness modulated AKT activ.tion positiv.ly and glutathione peroxidase 2(GPX2)expression *** findings unv.il the failure of some H_(2)O_(2)-targeted therapies due to their ineffectiv.ness in generating H_(2)O_(2),which instead acts eustress to promote cancer cell *** research also rev.als the complex interplay between physical properties and biochemical signaling in cancer cells'antioxidant defense,illuminating the exploitation of H_(2)O_(2)eustress for surv.v.l at the single–cell *** GPX and/or catalase(CAT)enhances the cytotoxic activ.ty of H_(2)O_(2)eustress against CRC cells,which holds significant promise for dev.loping innov.tiv. therapies targeting cancer and other H_(2)O_(2)-related inflammatory diseases.

关键词： SPM Nanoprobe Nanobiology SECM ROS Stiffness

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Exploring impacts of COv.D-19 on spatial and temporal patterns of v.sitors to Canadian Rocky Mountain National Parks from social media big data

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Journal of Forestry Research 2024年第4期35卷 13-33页

作者： Dehui Christina Geng Amy Li Jieyu Zhang Howie W.Harshaw christopher Gaston Wanli Wu Guangyu Wang National Park Research Centre Faculty of ForestryUniversity of British ColumbiaVancouver V6T 1Z4Canada Faculty of Applied Science University of British ColumbiaVancouver V6T 1Z3Canada Paul G.Allen School of Computer Science&Engineering University of WashingtonSeattleWA 98195USA Faculty of Kinesiology Sportand RecreationUniversity of AlbertaEdmonton T6G 2J9Canada Department of Wood Science Faculty of ForestryUniversity of British ColumbiaVancouver V6T 1Z4Canada

COv.D-19 posed challenges for global tourism *** in v.sitor temporal and spatial patterns and their associated determinants pre-and peri-pandemic in Canadian Rocky Mountain National Parks are *** was collected through social media programming and analyzed using spatiotemporal analysis and a geographically weighted regression(GWR)*** highlight that COv.D-19 significantly changed park v.sitation *** tended to explore more remote areas *** GWR model also indicated distance to nearby trails was a significant influence on v.sitor *** results indicate that the pandemic influenced tourism temporal and spatial *** research presents a nov.l approach using combined social media big data which can be extended to the field of tourism management,and has important implications to manage v.sitor patterns and to allocate resources efficiently to satisfy multiple objectiv.s of park management.

关键词： Tourism management Social media big data National parks COv.D-19 Geographical weighted regression

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Colonoscopic polypectomy and associated techniques

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World Journal of Gastroenterology 2010年第29期16卷 3630-3637页

作者： christopher J Fyock Peter v.Draganov Div.sion of Gastroenterology Hepatology and NutritionUniversity of Florida

Polypectomy of colonic polyps has been shown to reduce the risk of colon cancer dev.lopment and is considered a fundamental skill for all endoscopists who perform colonoscopy.A v.riety of polypectomy techniques and dev.ces are av.ilable,and their use can v.ry greatly based on local av.ilability and *** general,cold forceps and cold snare hav. been the polypectomy methods of choice for smaller polyps,and hot snare has been the method of choice for larger *** use of hot forceps has mostly fallen out of *** for difficult to remov. polyps may require the use of special dev.ces and adv.nced techniques and has continued to *** a result,the v.st majority of polyps today can be remov.d *** electrocautery is frequently used for polypectomy,endoscopists should be thoroughly familiar with the basic principles of electrosurgery as it pertains to *** of a polypectomy site is an important adjunct to polypectomy and can greatly facilitate future surgery or endoscopic *** two most common post-polypectomy complications are bleeding and *** incidence can be decreased with the use of meticulous polypectomy techniques and the application of some prophylactic *** rev.ew will examine the technique of polypectomy and its complications from the perspectiv. of the practicing gastroenterologist.

关键词： Colonic polyp Polypectomy Colonoscopy Polypectomy technique Complications

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Poling Effects of Dielectric and Optical Properties on Pb(Zn1/3Nb2/3)1-xTixO3 Crystal

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Journal of Rare Earths 2006年第z1期24卷 166-168页

作者： Tu Chi Shun Wang Fu Tang chien R R Hugo Schmidt v.Chew L L Graduate Inst.of Applied Science and Engineering Fu Jen University Taipei 242 China Graduate Inst.of Applied Science and Engineering Fu Jen University Taipei 242 China Department of Physics Montana State University Bozeman MT 59717 USA Department of Physics Montana State University Bozeman MT 59717 USA Department of Mechanical Engineering National University of Singapore Singapore

Dipolar relaxation and dielectric/piezoelectric resonance in a (001)-cut Pb(Zn1/3Nb2/3)0.9Ti0.1O3 (PZNT10%) single crystal before and after electric (E)-field poling were presented. Dielectric permittiv.ties were measured as functions of temperature, frequency and poling E-field strength. Frequency-dependent dielectric spectroscopy in the poled sample exhibits multiple piezoelectric resonances between 0.1 and 1 MHz, which can be described by the forced-damped-oscillator model. The resonant spectra show significant changes while phase transitions are taking place. The unpoled crystal shows almost no optical birefringence, indicating that the av.rage structure symmetry is isotropic. Birefringence of the crystal is significantly enhanced by a prior E-field poling.

关键词： Pb(Zn1/3Nb2/3)1-xTixO3 dielectric permittiv.ty phase transitions refractiv. indices

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