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Adventures and lessons of an American biochemist in China

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Protein & Cell 2011年第8期2卷 601-603页

作者： christopher J.Vavricka CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

It’s very interesting how events often lead up to each other seemingly by chance,but appear almost perfectly planned out when looking *** the past two years,I have worked as an International Young Scientist Research Fellow at the Institute of Microbiology,Chinese Academy of Sciences in Beijing,*** people ask me,especially Chinese graduate students,why an American would choose to come to China as a postdoctoral researcher.

关键词： looking doctor perfectly

A Time to Remember:Neural Insights into Rapid Updating of Timed Behaviors

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Neuroscience Bulletin 2023年第4期39卷 699-702页

作者： christopher Howard Patrick Simen Neuroscience Department Oberlin CollegeOberlinOH44074USA

Processing temporal information is a critical brain function necessary for decision-making and *** timing,or processing of time intervals on the scale of seconds to minutes,is essential for associative learning,sensorimotor processing,and optimal foraging[1]and many neuropsychiatric illnesses including Parkinson's Disease,Huntington's Disease,and schizophrenia involve impaired interval timing.

关键词： Huntington impaired dating

Exotic and excited-state meson spectroscopy and radiative transitions from lattice QCD

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Chinese Physics C 2010年第9期34卷 1512-1515页

作者： christopher E.Thomas Jefferson Laboratory

We discuss recent progress in extracting the excited meson spectrum and radiative transition form factors from lattice *** mention results in the charmonium sector,including the first lattice QCD calculation of radiative transition rates involving excited charmonium states,highlighting results for high spin and exotic *** present recent results on a highly excited isovector meson spectrum from dynamical anisotropic *** carefully constructed operators we show how the continuum spin of extracted states can be reliably identified and confidently extract excited states,states with exotic quantum numbers and states of high *** spectrum includes the first spin-four state extracted from lattice *** conclude with some comments on future prospects.

关键词： lattice QCD exotics mesons spectroscopy

Pediatric inflammatory bowel disease

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World Journal of Gastroenterology 2006年第20期12卷 3204-3212页

作者： Karen A Diefenbach christopher K Breuer Department of Surgery Yale University School of Medicine Division of Pediatric Surgery330 Cedar StreetRm. 132 FMBNorth HavenCT 06520United States

Inflammatory bowel disease is an important cause of gastrointestinal pathology in children and adolescents. The incidence of pediatric inflammatory bowel disease is increasing; therefore, it is important for the clinician to be aware of the presentation of this disease in the pediatric population. Laboratory tests, radiology studies, and endoscopic procedures are helpful in diagnosing inflammatory bowel disease and differentiating between Crohn＇s disease and ulcerative colitis. Once diagnosed, the goal of medical management is to induce remission of disease while minimizing the side effects of the medication. Specific attention needs to be paid to achieving normal growth in this susceptible population. Surgical management is usually indicated for failure of medical management, complication, or malignancy. Algorithms for diagnostic evaluation and treatment of pediatric inflammatory bowel disease are presented. The specific psychosocial issues facing these patients are also discussed in this review as are the future goals of research in the complex problem of pediatric inflammatory bowel disease.

关键词： Pediatric Inflammatory bowel Ulcerative colitis Crohn's disease

Recapturing meaning: Toward a new material-based design theory for architecture

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Frontiers of Architectural Research 2022年第4期11卷 609-617页

作者： christopher Bardt Faculty of Architecture Rhode Island School of DesignRhode IslandUSA

Architects and students of architecture today are less physically engaged with modeling and drawing representations of proposed things and increasingly rely on digital means and methods that are transforming their embodied interactions with actual materials. The result is that meaning, which makes architecture so central to our cultures, is being diminished. It is being replaced by a misplaced belief that "better" buildings and architecture result from increased use of digital tools. To recapture meaning will require a new design theory for architecture that builds on material engagement theory and the critical role of resistance and sensuous reasoning in the design process, which material has historically provided.

关键词： Architecture Design Material engagement Material-based design Meaning Digital tools

Amplitude Variation with Offset Responses Modeling Study of Walkaway Vertical Seismic Profile Data at CO_2 Geological Storage Site,Ketzin,Germany

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Acta Geologica Sinica(English Edition) 2011年第5期85卷 1118-1126页

作者： Sayed Hesammoddin KAZEMEINI christopher JUHLIN Department of Earth Sciences Uppsala University

An important component of any CO_2 sequestration project is seismic monitoring for tracking changes in subsurface physical properties,such as velocity and *** reservoirs have different amplitude variation with offset(AVO) responses,which can define underground conditions. In the present paper we investigate walkaway vertical seismic profile(VSP) AVO response to CO_2 injection at the Ketzin site,the first European onshore CO_2 sequestration pilot study dealing with research on geological storage of CO_***,we performed rock physics analysis to evaluate the effect of injected CO_2 on seismic velocity using the Biot-Gassmann *** the basis of this model,the seismic response for different CO_2 injection saturation was studied using ray tracing *** then created synthetic walkaway VSP data,which we then *** contrast,synthetic seismic traces were created from borehole ***,we found that the amplitude of CO_2 injected sand layer with different gas saturations were increased with the offset when compared with the original brine target *** is the typical classⅢAVO anomaly for gas sand *** AVO responses matched the synthetic seismic traces very ***,walkaway VSP AVO response can monitor CO_2 distribution in the Ketzin area.

关键词： CO_2 injection rock physics amplitude variation with offset walkaway vertical seismic profile seismic modeling

Jet flows from bubbles during subcooled pool boiling on micro wires

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Science China(Technological Sciences) 2005年第4期48卷 385-402页

作者： D. M. christopher Laboratory of Phase Change and Interfacial Transport Phenomena Department of Thermal Engineering Tsinghua University Beijing 100084 China

An experimental investigation was conducted on subcooled nucleate boiling on ultra-small wires having diameters of 25―100 μm. High-speed photography and laser PIV (Particle Image Velocimetry) technology were used to visually observe the bubble dynamics. For highly subcooled boiling at moderate heat fluxes, the bubbles generally remained attached to the micro heating wires and bubble-top jet flows were clearly observed. Smaller bubbles usually had stronger bubble-top jet flows, while larger bubbles seemed to produce multi-jet flows. The structures of the bubble-top jet flows, as well as multi-jet flows, were proposed from the experimental observation. A model was developed to describe jet flow phenomena from bubbles on micro wires. Numerical simulations for bubbles having diameter of 0.03 and 0.06 mm showed that both the bubble-top and multi-jet flows were induced by a strong Marangoni effect due to high temperature gradients near the wire. The predicted velocity magnitudes and flow structures agreed very well with experimental measurements. The bubble size relative to the wire is an important factor affecting the jet flow structure. For a 0.03 mm bubble on a 0.1 mm wire, only a bubble-top jet flow forms, while a complex multi-jet flow pattern forms around the bubble with a weak bubble-top jet and two side jet flows for a 0.06 mm bubble.

关键词： subcooled boiling, bubble, multi-jet, jet flow, PIV, Marangoni, CFD.

Clinical variability and molecular heterogeneity inprostate cancer

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Asian Journal of Andrology 2016年第4期18卷 543-548页

作者： Jonathan Shoag christopher E Barbieri Department of Urology NewYork-Presbyterian Hospital Weill Cornell Medical College New York USA Sandra and Edward Meyer Cancer Center Weill Cornell Medica College New York USA.

Prostate cancer is a clinically heterogeneous disease, with some men having indolent disease that can safely be observed, while others have aggressive, lethal disease. Over the past decade, researchers have begun to unravel some of the genomic heterogeneity that contributes to these varying clinical phenotypes. Distinct molecular sub-classes of prostate cancer have been identified, and the uniqueness of these sub-classes has been leveraged to predict clinical outcomes, design novel biomarkers for prostate cancer diagnosis, and develop novel therapeutics. Recent work has also elucidated the temporal and spatial heterogeneity of prostate cancer, helping us understand disease pathogenesis, response to therapy, and progression. New genomic techniques have provided us with a window into the remarkable clinical and genomic heterogeneity of prostate cancer, and this new perspective will increasingly impact patient care.

关键词： cell biology ERG genomics molecular heterogeneity prostate cancer sequencing serine peptidase inhibitor, Kazaltype 1 SPOP tumor profiling

Development of a web-platform for mining applications

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International Journal of Mining Science and Technology 2018年第1期28卷 95-99页

作者： christopher Newman Zach Agioutantis Nathaniel Schaefer Department of Mining Engineering University of Kentucky

‘‘Web ground control"(web GC) provides users with instantaneous access to mine design applications anywhere, at any time, through a web *** a web-based multiple-tier architecture, users are able to easily access ground control designs, perform on-demand calculations in the field, as well as facilitate project collaborations across multiple users, devices, and operating ***, the web GC platform contains five ground control related design applications previously developed and distributed by the US National Institute of Occupational Safety and Health(NIOSH), that is, analysis of roof bolt stability(ARBS), analysis of longwall pillar stability(ALPS), analysis of retreat mining stability(ARMPS), analysis of retreat mining stability–highwall mining(ARMPS-HWM), and analysis of horizontal stress in mining(AHSM).With respect to design decisions made by the web GC development team, the web GC platform will be able to further integrate future mine design applications providing the mining industry with one of a kind umbrella suite of ground control related software available at ones *** following paper provides a detailed overview on the current state of the web GC platform with discussions ranging from back-end database development and design to the front-end user-platform *** on current progress in platform development as well as beta testing results, the web GC platform is scheduled for release in the fall of 2018.

关键词： Ground control Stability Web application Cloud computing