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空中英语教室（高级版．彭蒙惠英语） 2024年第2期 28-29,46,47页

作者： christopher Borrelli 不详

我初次与凯姆·布兰森见面时,他正进行到字母E开头的国家:爱沙尼亚、厄立特里亚和埃及。我们的午餐是埃塞俄比亚料理,他打算第二天吃厄瓜多尔料理。布兰森已经试过智利、古巴、喀麦隆和克罗地亚料理,接下来还规划了芬兰、斐济、密克罗... 详细信息

我初次与凯姆·布兰森见面时,他正进行到字母E开头的国家:爱沙尼亚、厄立特里亚和埃及。我们的午餐是埃塞俄比亚料理,他打算第二天吃厄瓜多尔料理。布兰森已经试过智利、古巴、喀麦隆和克罗地亚料理,接下来还规划了芬兰、斐济、密克罗尼西亚联邦与法国。

关键词：厄立特里亚埃塞俄比亚料理爱沙尼亚厄瓜多尔美食喀麦隆克罗地亚

Early anticoagulation in patients with stroke and atrial fibrillation is associated with fewer ischaemic lesions at 1 month: the ATTUNE study

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stroke & Vascular Neurology 2024年第1期9卷 30-37,I0034页

作者： Angelos sharobeam Longting Lin Christina Lam Carlos Garcia-Esperon Yash Gawarikar Ronak Patel Matthew Lee-Archer Andrew Wong Michael Roizman Amanda Gilligan Andrew Lee Kee Meng Tan susan Day christopher Levi stephen M Davis Mark Parsons Bernard Yan Melbourne Brain Centre at Royal Melbourne Hospital ParkvilleVictoriaAustralia University of New south Wales south Western sydney Clinical school LiverpoolNew South WalesAustralia Department of Neurology John Hunter HospitalNewcastleNew South WalesAustralia Department of Neurology Calvary Public HospitalCanberraAustralian Capital TerritoryAustralia Department of Neurology Northern Hospital EppingEppingVictoriaAustralia Department of Neurology Royal Brisbane and Women's HospitalHerstonQueenslandAustralia The University of Queensland school of Medicine HerstonQueenslandAustralia Neurosciences Clinical Institute Epworth HealthcareRichmondVirginiaAustralia Department of Neurology Austin HealthUniversity of MelbourneHeidelbergVictoriaAustralia Flinders University College of Medicine and Public Health AdelaideSouth AustraliaAustralia Department of Neurology Gold Coast University HospitalSouthportQueenslandAustralia The University of sydney Northern Clinical school St LeonardsNew South WalesAustralia Department of Neurology and Neurophysiology Liverpool HospitalLiverpoolNew South WalesAustralia

Background The optimal time to commence anticoagulation in patients with atrial fibrillation(AF)after ischaemic stroke or transient ischaemic attack(TIA)is unclear,with guidelines differing in recommendations.A limitation of previous studies is the focus on clinically overt stroke,rather than radiologically obvious diffusion-weighted imaging ischaemic *** aimed to quantify silent ischaemic lesions and haemorrhages on MRI at 1month in patients commenced on early(s)vs late(≥4days)*** hypothesised that there would be fewer ischaemic lesions and more haemorrhages in the early anticoagulant group at 1-month *** A prospective multicentre,observational cohort study was performed at 11 Australian stroke *** and MRI data were collected at baseline and follow-up,with blinded imaging assessment performed by two *** of commencement of anticoagulation was at the discretion of the treating stroke *** We recruited 276 patients of whom 208 met the eligibility *** average age was 74.2 years(sD±10.63),and 79(38%)patients were *** National Institute of Health stroke scale score was 5(IQR 1–12).Median baseline ischaemic lesion volume was 5mL(IQR 2–17).There were a greater number of new ischaemic lesions on follow-up MRI in patients commenced on anticoagulation≥4days after index event(17%vs 8%,p=0.04),but no difference in haemorrhage rates(22%vs 32%,p=0.10).Baseline ischaemic lesion volume of≤5mL was less likely to have a new haemorrhage at 1month(p=0.02).There was no difference in haemorrhage rates in patients with an initial ischaemic lesion volume of>5mL,regardless of anticoagulation *** Commencing anticoagulations after stroke or TIA is associated with fewer ischaemic lesions at 1month in AF *** is no increased rate of haemorrhage with early *** results suggest that early anticoagulation after mild-to-moderate acute ischaemic stroke associated w

关键词： patients lesions ischaemic

Refinement of the Proposed Gamma-Ray Burst Time Delay Model

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International Journal of Astronomy and Astrophysics 2024年第2期14卷 120-147页

作者： Godson Fortune Abbey Joseph simfukwe Prospery christopher simpemba saul Paul Phiri Alok srivastava Golden Gadzirayi Nyambuya Department of Physic School of Mathematics and Natural Sciences The Copperbelt University Kitwe Republic of Zambia Fundamental Theoretical and Research Group Department of Applied Physics Faculty of Applied Sciences National University of Science & Technology Bulawayo Republic of Zimbabwe

This paper is the second instalment in our study of the observed time delay in the arrival times of radio photons emanating from Gamma Ray Bursts (GRBs). The mundane assumption in contemporary physics as to the cause of these pondersome time delays is that they are a result of the photon being endowed with a non-zero mass. While we do not rule out the possibility of a non-zero mass for the photon, our working assumption is that the major cause of these time delays may very well be that these photons are travelling in a rarefied cosmic plasma in which the medium’s electrons interact with the electric component of the Photon, thus generating tiny currents that lead to dispersion, hence, a frequency-dependent speed of Light (FDsL). In the present instalment, we “improve” on the model presented in the first instalment by dropping the assumption that the resultant pairs of these radio photons leave the shock front simultaneously. The new assumption of a non-simultaneous— albeit systematic—emission of these photon pairs allows us to obtain a much more convincing and stronger correlation in the time delay. This new correlation allows us to build a unified model for the four GRBs in our sample using a relative distance correction mechanism. The new unified model allows us to obtain as our most significant result a value for the frequency equivalence of the interstellar medium (IsM)’s conductance ν* ~ 1.500 ± 0.009 Hzand also an independent distance measure to the GRBs where we obtain for our four GRB samples an average distance of: ~69.40 ± 0.10, 40.00 ± 0.00, 58.40 ± 0.40, and 86.00 ± 1.00 Mpc, for GRB 030329, 980425, 000418 and 021004 respectively.

关键词： Gamma-Ray Bursts (GRB) Photon Mass Plasma Time Delay Fireball Model

Poroelastic solution of a wellbore in a swelling rock with non-hydrostatic stress field

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第2期14卷 303-314页

作者： Mohsen s.Masoudian Zhongwei Chen christopher Leonardi Beck Engineering Pty.Ltd. ChatswoodNew South Wales2067Australia school of Mechanical and Mining Engineering The University of QueenslandSt.LuciaQueensland4072Australia

The stress distribution around a circular borehole has been studied extensively. The existing analytical poroelastic solutions, however, often neglect the complex interactions between the solid and fluid that can significantly affect the stress solution. This is important in unconventional gas reservoirs such as coalbeds and shale formations. In order to address this limitation, this paper presents the development of a poroelastic solution that takes into account the effect of gas sorption-induced strain. The solution considers drainage of the reservoir fluid through a vertical wellbore in an isotropic, homogenous,poroelastic rock with non-hydrostatic in situ stress field. The sorption-induced shrinkage of coal is modelled using a Langmuir-type curve which relates the volumetric change to the gas pressure. The redistributed stress field around the wellbore after depletion is found by applying Biot’s definition of effective stress and Airey’s stress functions, which leads to a solution of the inhomogeneous Biharmonic equation. Two sets of boundary conditions were considered in order to simulate the unsupported cavity(open-hole) and supported cavity(lined-hole) cases. The implementation was verified against a numerical solution for both open-hole and lined-hole cases. A comparative study was then conducted to show the significance of the sorption-induced shrinkage in the stress distribution. Finally, a parametric study analysed the sensitivity of the solution to different poroelastic parameters. The results demonstrate that the developed solution is a useful tool that can be employed alongside complex flow models in order to conduct efficient, field-scale coupled hydro-mechanical simulations, especially when the stressdependent permeability of the reservoir is of concern.

关键词： Poroelasticity Coupled geomechanics Analytical solution Wellbore Cavity expansion Coalbed methane(CBM)

Multi-Elemental Analysis and 2D Image Mapping within Roots, Leaves and seeds from O. glaberrima Rice Plants Using Micro-PIXE Technique

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World Journal of Nuclear science and Technology 2024年第2期14卷 97-106页

作者： Alassane Traore Anna Ndiaye christopher Bongani Mtshali Manneh Baboucarr Jean Paul Latyr Faye Daouda Mbodj Kandiaba Traore Tapha Gueye Ababacar sadikhe Ndao Département de Physique Faculté des Sciences et Techniques Université Cheikh Anta Diop Dakar Senegal Département de Chimie Faculté des Sciences et Techniques Université Cheikh Anta Diop Dakar Senegal Tandetron Laboratory IBA Group iThemba LABS Cape Town South Africa Africa Rice Center St. Louis Senegal

Understanding metal accumulation at organ level in roots, leaves and seeds in O. glaberrima (OG) is crucial for improving physiological and metabolic aspects in growing Asian and African rice in salted areas. The micro-analytical imaging techniques are required to reveal its accumulation and distribution within plant tissues. PIXE studies have been performed to determine different elements in rice plants. The existing microbeam analytical technique at the iThemba LABs will be applied for the 2D image mapping of fresh rice tissues to perform a concentration of low atomic mass elements (such as Al, si, P, s, Cl, Ca, Ti, Mn, Fe, Cu, Br, Zn and K) with detection limits of typically 1-10 μg/g. Comparison of the distribution of the elements between leaves, root and seed samples using uptake and distribution of elements in particular environmental conditions with potential amount of salt in water have been performed. We are also expecting to indicate metal exclusion as salt tolerance strategies from leaves, root, and seed compartments using matrix correlation between samples and between elements on rice species.

关键词： PIXE 2D Mapping Rice Concentration Elemental Analysis

Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

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Precision Clinical Medicine 2024年第1期7卷 1-13页

作者： J.sebastian Garcia-Medina Karolina sienkiewicz s.Anand Narayanan Eliah G.Overbey Kirill Grigorev Krista A.Ryon Marissa Burke Jacqueline Proszynski Braden Tierney Caleb M.schmidt Nuria Mencia-Trinchant Remi Klotz Veronica Ortiz Jonathan Foox christopher Chin Deena Najjar Irina Matei Irenaeus Chan Carlos Cruchaga Ashley Kleinman JangKeun Kim Alexander Lucaci Conor Loy Omary Mzava Iwijn De Vlaminck Anvita singaraju Lynn E.Taylor Julian C.schmidt Michael A.schmidt Kelly Blease Juan Moreno Andrew Boddicker Junhua Zhao Bryan Lajoie Andrew Altomare semyon Kruglyak shawn Levy Min Yu Duane C.Hassane susan M.Bailey Kelly Bolton Jaime Mateus christopher E.Mason Department of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of stem Cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA space Exploration Technologies Corporation HawthomeCA 90250USA sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Human Performance Group BoulderCO 80302USA Children's Cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Department of systems Engineering Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Department of Environmental and Radiological Health sciences Colorado State UniversityFort CollinsCO 80523USA Cell and Molecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University st Louis Oncology Division St.LouisMO 63100USA Meinig school of Biomedical Engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative PCR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(CHIP)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of CHIP in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low Earth orbit(LEO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

Quantifying Kinematic Tremor in an NGLY1-Deficient Individual: A Case study

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Case Reports in Clinical Medicine 2024年第1期13卷 25-36页

作者： Brock Futrell christopher Alexander Malaya Dacia Martinez Diaz Christian Alfaro Hannah Elizabeth Gustafson subhalakshmi Chandrasekaran Rhea Mohan Phatak Bernhard suter Charles shannon Layne Department of Health and Human Performance University of Houston Houston USA Center for Neuromotor and Biomechanics Research University of Houston Houston USA Department of Computer science and Engineering Texas A&M University College Station USA Blue Bird Circle Rett Center Texas Children’s Hospital Houston USA Baylor College of Medicine Houston USA Center for NeuroEngineering and Cognitive science University of Houston Houston USA

NGLY1 Deficiency is an autosomal recessive congenital disorder that has been identified in less than 100 individuals. Most individuals with NGLY1 Deficiency display hyperkinetic movement disorders, including choreiform, athetoid, dystonic myoclonic, dyskinetic, and dysmetric movements. Developing a consistent and concise consensus on the classification and evaluation of tremors is essential to forward the research and treatment of tremors. It has also been reported that some individuals with NGLY1 Deficiency demonstrate tremor, but such tremor has never been formally investigated. The primary objective of this study is to determine if an individual with NGLY1 Deficiency demonstrates an identifiable tremor during a series of arm movements and, if so, describe the frequency and power characteristics of that tremor. Arm movement kinematics were obtained using a 16-camera Vicon system, and time series trajectory waveforms for three planes of a marker placed on the hand were developed. Custom MATLAB scripts were utilized to compute Fast Fourier Transformations of the data within the identified waveform segments. A mean frequency of 2.30 Hz (sD = 1.05) with a mean power of 5.02 |P1(f)| (sD = 4.63) suggests that our participant’s kinematic data did display a persistent tremor in both hands across all tasks and movement planes. Analyses of the reaching hand and the non-reaching hand suggest the participant displayed an action tremor in both postural and intention (kinetic) tremors. Future directions should include assessing additional individuals with NGLY1 Deficiency to determine if the tremor is a distinguishable disorder behavior. Additionally, evaluating other anatomical sites, such as the elbow, head, and lower limbs, would provide further insights into the characteristics of this tremor.

关键词： Tremor NGLY Fast Fourier Transformation Reaching Hyperkinetic Movement

A review of ferroelectric materials for high power devices

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Journal of Materiomics 2022年第4期8卷 739-752页

作者： sergey I.shkuratov christopher s.Lynch Loki Incorporated 1334 Royal RoadNorwoodMO65717USA Bourns College of Engineering University of California at RiversideCA92521USA

Compact autonomous ultrahigh power density energy storage and power generation devices that exploitthe spontaneous polarization of ferroelectric materials are capable of producing hundreds of kilovoltvoltages,multi-kiloampere currents,and megawatt power levels for brief interval of *** storagelife of these devices is four orders of magnitude longer than that for electrochemical batteries andelectrochemical *** is an up to date survey of ferroelectric materials used for these highpower *** types of ferroelectric ceramics possess the ability to be depolarized under adia-batic compression and can be successfully used for high power *** addition to bulk ferro-electric ceramics,multilayer ferroelectric films are very efficient materials for high power *** importance is the ability of relaxor ferroelectric single crystals to produce significantly higherelectric charge density and energy density than ceramics,making them promising materials for highpower *** provided is a brief survey of recent developments of ferroelectric materials forhigh energy density and power density dielectric *** ceramics have been developed,including antiferroelectric and relaxor antiferroelectric solid solutions,providing high energy densityand efficiency simultaneously.

关键词： Energy storage Ferroelectric Antiferroelectric Relaxor High power density

Automated Deep Learning Based Cardiovascular Disease Diagnosis Using ECG signals

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Computer systems science & Engineering 2022年第7期42卷 183-199页

作者： s.Karthik M.santhosh M.s.Kavitha A.christopher Paul Department of Computer science&Engineering SNS College of TechnologyCoimbatore641035India Department of Information Technology Karpagam Institute of TechnologyCoimbatore641105India

Automated biomedical signal processing becomes an essential process to determine the indicators of diseased *** the same time,latest develop-ments of artiﬁcial intelligence(AI)techniques have the ability to manage and ana-lyzing massive amounts of biomedical datasets results in clinical decisions and real time *** can be employed for medical imaging;however,the 1D biomedical signal recognition process is still needing to be ***(ECG)is one of the widely used 1-dimensional biomedical sig-nals,which is used to diagnose cardiovascular *** assisted diag-nostic modelsﬁnd it difﬁcult to automatically classify the 1D ECG signals owing to time-varying dynamics and diverse proﬁles of ECG *** resolve these issues,this study designs automated deep learning based 1D biomedical ECG sig-nal recognition for cardiovascular disease diagnosis(DLECG-CVD)*** DLECG-CVD model involves different stages of operations such as pre-proces-sing,feature extraction,hyperparameter tuning,and classiﬁ*** the initial stage,data pre-processing takes place to convert the ECG report to valuable data and transform it into a compatible format for further *** addition,deep belief network(DBN)model is applied to derive a set of feature ***,improved swallow swarm optimization(IssO)algorithm is used for the hyper-parameter tuning of the DBN ***,extreme gradient boosting(XGBoost)classiﬁer is employed to allocate proper class labels to the test ECG *** order to verify the improved diagnostic performance of the DLECG-CVD model,a set of simulations is carried out on the benchmark PTB-XL dataset.A detailed comparative study highlighted the betterment of the DLECG-CVD model interms of accuracy,sensitivity,speciﬁcity,kappa,Mathew correlation coefﬁcient,and Hamming loss.

关键词： Biomedical signals 1-dimensional signal electrocardiogram artiﬁcial intelligence deep learning cardiovascular disease decision making

4D imaging of void nucleation,growth,and coalescence from large and small inclusions in steel under tensile deformation

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Journal of Materials science & Technology 2022年第28期123卷 168-176页

作者： Yi Guo Timothy L.Burnett samuel A.McDonald Michael Daly Andrew H.sherry Philip J.withers shenyang National Laboratory for Materials science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Henry Royce Institute Department of MaterialsUniversity of ManchesterM139PLUK European synchrotron Radiation Facility(EsRF) 6 rue J Horowitz38000 GrenobleFrance National Nuclear Laboratory Chadwick HouseBirchwood ParkWarringtonWA36AEUK

samples of sA508 grade 3 nuclear pressure vessel ferritic steel were subjected to tensile straining whilst being simultaneously imaged in 3D in real time using high resolution,high frame rate time-lapse synchrotron computed tomography(CT).This enabled direct observation of void development from nucleation,through growth to coalescence and final failure validating many inferences made post-mortem or by theoretical models,as well as raising new *** sparse,large inclusions were found to nucleate voids at essentially zero plastic strain(consistent with zero interfacial strength);these became increasingly elongated with *** contrast,a high density of small spherical voids were found to nucleate from the sub-micron cementite particles at larger strains(>200%)only in the centre of the necked(high triaxiality)*** interfacial strength approaching 2100 MPa was inferred and soon after their nucleation,these small voids coalesce to form internal microcracks that lead to the final failure of the *** surprisingly,under these conditions of generally low triaxial constraint the large voids are simply cut across and appear to play no significant role in determining the final *** implications of these results are discussed in terms of ductile fracture behaviour and the Gurson model for ductile fracture.

关键词： Void growth Ductile fracture synchrotron X-ray tomography 4D imaging Bainitic steel