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Current trends in urethral stricture management

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Asian Journal of Urology 2014年第1期1卷 46-54页

作者： christopher J.Hillary Nadir I.Osman christopher r.chapple Department of Urology Royal Hallamshire HospitalSheffieldUK

The recent International Consultation on Urological Disease(ICUD)panel 2010 confirmed that a urethral stricture is defined as a narrowing of the urethra consequent upon ischaemic spongiofibrosis,as distinct from sphincter stenoses and a urethral disruption *** possible,an anastomotic urethroplasty should be performed because of the higher success rate as compared to augmentation *** is some debate currently regarding the critical stricture length at which an anastomotic procedure can be used,but clearly the extent of the spongiofibrosis and individual anatomical factors(the length of the penis and urethra)are important,the limitation for this being extension of dissection beyond the peno-scrotal junction and the subsequent production of *** recently,there has been interest in whether to excise and anastomose or to carry out a stricturotomy and reanastomosis using a Heineke-Miculicz *** urethroplasty has evolved towards the more extensive use of oral mucosa grafts as compared to penile skin flaps,as both flaps and grafts have similar efficacy and certainly the use of either dorsal or ventral positioning seems to provide comparable *** is important that the reconstructive surgeon is well versed in the full range of available repair techniques,as no single method is suitable for all cases and will enable the management of any unexpected anatomical findings discovered intra-operatively.

关键词： Urethral stricture Stricture Lichen sclerosus Pelvic fracture Urethral injury Bladder outflow obstruction Urethroplasty Buccal mucosa graft

Non-invasive transcutaneous electrical stimulation in the treatment of overactive bladder

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Asian Journal of Urology 2015年第2期2卷 92-101页

作者： Martin Slovak christopher r.chapple Anthony T.Barker Department of Medical Physics&Clinical Engineering Sheffield Teaching Hospitals NHS Foundation TrustSheffieldUK Department of Urology Sheffield Teaching Hospitals NHS Foundation TrustSheffieldUK

We reviewed the literature on transcutaneous electrical nerve stimulation(TENS)used as a therapy for overactive bladder(OAB)symptoms,with a particular focus on:stimulation site,stimuli parameters,neural structures thought to be targeted,and the clinical and urodynamic outcomes *** majority of studies used sacral or tibial nerve *** literature suggests that,whilst TENS therapy may have neuromodulation effects,patient are unlikely to benefit to a significant extent from a single application of TENS and indeed clear benefits from acute studies have not been *** long-term studies there were differences in the descriptions of stimulation intensity,strategy of the therapy,and positioning of the electrodes,as well as in the various symptoms and pathology of the ***,most studies were uncontrolled and hence did not evaluate the placebo *** is known about the underlying mechanism by which these therapies work and therefore exactly which structures need to be stimulated,and with what *** is promising evidence for the efficacy of a transcutaneous stimulation approach,but adequate standardisation of stimulation criteria and outcome measures will be necessary to define the best way to administer this therapy and document its efficacy.

关键词： Overactive bladder Posterior tibial nerve stimulation Sites of stimulation Sacral stimulation Sham stimulation methodology Surface electrodes Transcutaneous electrical nerve stimulation

Underactive bladder:Pathophysiology and clinical significance

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Asian Journal of Urology 2018年第1期5卷 17-21页

作者： reem Aldamanhori Nadir I.Osman christopher r.chapple Department of Urology University of DammamSaudi Arabia Department of Urology Royal Hallamshire HospitalSheffieldUK

Underactive bladder(UAB)is a voiding disorder which generates disabling lower urinary tract symptoms(LUTS)due to the inability to produce an effective voiding contraction sufficient to empty the *** underlying abnormality,that is usually appreciated when performing urodynamic studies,has been defined by the International Continence Society(ICS)as detrusor underactivity(DUA).DUA is a common yet under-researched bladder *** prevalence of DUA in different patient groups suggests that multiple aetiologies are *** there is no effective therapeutic approach to treat this *** improved understanding of the underlying mechanisms is needed to facilitate the development of new advances in *** purpose of this review is to discuss the epidemiology,pathophysiology,common causes and risk factors potentially leading to DUA;to aid in the appropriate diagnosis of DUA to potentially improve treatment outcomes.

关键词： Detrusor underactivity Lower urinary tract symptoms Underactive bladder Bladder outlet obstruction

The aging bladder insights from animal models

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Asian Journal of Urology 2018年第3期5卷 135-140页

作者： Lori A.Birder Aura F.Kullmann christopher r.chapple University of Pittsburgh School of Medicine Department of PharmacologyPittsburghPAUSA University of Pittsburgh School of Medicine Department of MedicinePittsburghPAUSA Department of Urology Sheffield Teaching Hospitals NHS Foundation TrustSheffieldUK

Alterations in bladder function with aging are very common and are very likely to represent an increasing healthcare problem in the years to come with the general aging of the *** this review the authors describe the prevalence of lower urinary tract symptoms(LUTS)and comment upon potential mechanisms which may be responsible for the increasing prevalence of lower LUTS with increasing age,based on laboratory *** is clear that there is a complex interplay between the various components of the neural innervation structure of the bladder in leading to changes with age,which are likely to underpin the LUTS which are seen in the aging bladder.

关键词： Lower urinary tract symptoms Aging Etiology of lower urinary tract symptoms Bladder function

Moving beyond BPH-A contemporary update on male LUTS

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Asian Journal of Urology 2019年第2期6卷 208-209页

作者： christopher r.chapple Department of Urology The Royal Hallamshire HospitalSheffieldUK

This insightful state-of-the-art article reviews lower urinary tract symptoms(LUTS)and their interface with“socalled”benign prostatic hyperplasia(BPH),in particular,emphasising that LUTS are not just related to the *** the importance of looking beyond the symptoms,beyond the prostate at not just the potential for a treatment,but rather at the underlying functional basis for the *** is essential to take into account not only the patients’LUTS,but their general medical history,drug history and comorbidities and to carefully evaluate patients with a voiding diary,particularly where nocturia is a significant symptom.

关键词： BPH beyond urinary

Functional and reconstructive urology (part one)

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Asian Journal of Urology 2018年第3期5卷 55-56页

作者： christopher r chapple Qiang Fu Chuanliang Xu Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK. Department of Urology Shanghai Jiao Tong University Affiliated 6th People's Hospital Shanghai PR China. Department of Urology Changhai Hospital Second Military Medical University Shanghai PR China.

Dear Colleagues,It is a great honour that the Asian Journal of Urology has agreed to host two special issues on the subject of functional and reconstructive urology and to introduce the first of these *** an era when technology has come to the fore in urological practice with new developments(not only in terms of the equipment used to facilitate minimally invasive surgery but also developments such as the robot which have revolutionised access to laparoscopic surgery),it is very important to realise that functional and reconstructive urology still remains an important cornerstone of urological practice.

关键词： surgery corners constructive

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膀胱过度活动症：发病机制及治疗现状

中华泌尿外科杂志 2012年第9期33卷 699-704页

作者： Nadir I. Osman Altaf Mangera christopher r. chapple 廖利民美国谢菲尔德教学医院泌尿外科Glossop road shef-fieldS102JFUnited Kingdom 不详

内容摘要OAB为一类发病率较高的慢性疾病，严重影响患者的生活质量，给个人及社会带来了巨大的经济负担。OAB为基于症候群进行诊断的综合征，定义为“尿急，伴或不伴急迫性尿失禁，常伴有尿频和夜尿症状”。OAB无明确的病因，不包括由... 详细信息

内容摘要OAB为一类发病率较高的慢性疾病，严重影响患者的生活质量，给个人及社会带来了巨大的经济负担。OAB为基于症候群进行诊断的综合征，定义为“尿急，伴或不伴急迫性尿失禁，常伴有尿频和夜尿症状”。OAB无明确的病因，不包括由急性尿路感染或其他形式的膀胱尿道局部病变所致的症状。OAB的核心症状为尿急，尿急是指一种突发、强烈的排尿欲望，且很难被主观抑制而延迟排尿。

关键词：膀胱过度活动症发病机制治疗急迫性尿失禁急性尿路感染慢性疾病生活质量经济负担

Corrigendum to “Overcoming scarring in the urethra: Challenges for tissue engineering”

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Asian Journal of Urology 2019年第2期6卷 215-215页

作者： Abdulmuttalip Simsek reem Aldamanhori christopher r.chapple Sheila MacNeil Department of Urology Royal Hallamshire HospitalSheffieldUK Department of Materials Science&Engineering Kroto Research InstituteUniversity of SheffieldSheffieldUK

The author regrets the misprint in the sentence cited from reference 9 under section“Urethral stricture and histopathology”:“In contrast,the type III collagen in urethral stricture tissue was increased to 84%with a corresponding decrease in type I collagen(to 16%).”The correct sentence is“In contrast,the type I collagen in urethral stricture tissue was increased to 84%with a corresponding decrease in type III collagen(to 16%).”The author would like to apologise for any inconvenience caused.

关键词： stricture Cor sentence

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural regeneration research 2025年第9期20卷 2596-2597页

作者： christopher J.O’Connell Matthew J.robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic