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Repeated hydrogen peroxide dosing briefly reduces cyanobacterial blooms and microcystin while increasing fecal bacteria indicators in a eutrophic pond

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journal of Environmental Sciences 2023年第2期124卷 522-543页

作者： Mark W.Lusty christopher j.Gobler School of Marine and Atmospheric Sciences Stony Brook UniversitySouthamptonNY 11968USA

This study explored the effects of H_(2)O_(2)on Cyanobacteria and non-target microbes using fluorometry,microscopy,flow cytometry,and high throughput DNA sequencing of the 16S rRNA gene during a series of mesocosm and whole-ecosystem experiments in a eutrophic pond in NY,*** addition of H_(2)O_(2)(8 mg/L)significantly reduced Cyanobacteria concentrations during a majority of experiments(66%;6 of 9)and significantly increased eukaryotic green and unicellular brown algae in 78%and 45%of experiments,*** heterotrophic bacteria declined significantly following H_(2)O_(2)addition in all experiments,bacteria indicative of potential fecal contamination(Escherichia coli,Enterococcus,fecal coliform bacteria)consistently and significantly increased in response to H_(2)O_(2),evidencing a form of‘pollution swapping’.H_(2)O_(2)more effectively reduced Cyanobacteria in enclosed mesocosms compared to whole-ecosystem *** whole-pond H_(2)O_(2)applications over a twoyear period temporarily reduced cyanobacterial levels but never reduced concentrations below bloom thresholds and populations always rebounded in two weeks or *** bacterial phyla of Cyanobacteria,Actinobacteria,and Planctomycetes were the most negatively impacted by H_(2)O_(2).Microcystis was always reduced by H_(2)O_(2),as was the toxin microcystin,but Microcystis remained dominant even after repeated H_(2)O_(2)*** H_(2)O_(2)favored the growth of eukaryotic algae over potentially harmful Cyanobacteria,the inability of H_(2)O_(2)to end cyanobacterial blooms in this eutrophic waterbody suggests it is a non-ideal mitigation approach in high biomass ecosystems and should be used judiciously due to potential negative impacts on non-target organisms and promotion of bacteria indicative of fecal contamination.

关键词： Indicator bacteria Toxic cyanobacteria Microcystin Microcystis Hydrogen peroxide Bacteria Enterococcus E.coli Pollution swapping

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Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

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Precision Clinical Medicine 2024年第1期7卷 1-13页

作者： j.Sebastian Garcia-Medina Karolina Sienkiewicz S.Anand Narayanan Eliah G.Overbey Kirill Grigorev Krista A.Ryon Marissa Burke jacqueline Proszynski Braden Tierney Caleb M.Schmidt Nuria Mencia-Trinchant Remi Klotz Veronica Ortiz jonathan Foox christopher Chin Deena Najjar Irina Matei Irenaeus Chan Carlos Cruchaga Ashley Kleinman jangKeun Kim Alexander Lucaci Conor Loy Omary Mzava Iwijn De Vlaminck Anvita Singaraju Lynn E.Taylor julian C.Schmidt Michael A.Schmidt Kelly Blease juan Moreno Andrew Boddicker junhua Zhao Bryan Lajoie Andrew Altomare Semyon Kruglyak Shawn Levy Min Yu Duane C.Hassane Susan M.Bailey Kelly Bolton jaime Mateus christopher E.Mason Department of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of Stem Cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space Exploration Technologies Corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Human Performance Group BoulderCO 80302USA Children's Cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Department of Systems Engineering Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Department of Environmental and Radiological Health Sciences Colorado State UniversityFort CollinsCO 80523USA Cell and Molecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St Louis Oncology Division St.LouisMO 63100USA Meinig School of Biomedical Engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative PCR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(CHIP)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of CHIP in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low Earth orbit(LEO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

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The complete cuide to external wall insulation / by christopher j. Pearson.

The complete cuide to external wall insulation / by Christop...

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1000年

作者： Pearson christopher j..

来源：畅想之星图书光盘版（南... 评论

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A systematic review of the attractant-decoy and repellent- plant hypotheses: do plants with heterospecific neighbours escape herbivory?

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journal of Plant Ecology 2015年第4期8卷 337-346页

作者： Ally Ruttan christopher j.Lortie Department of Biology York University4700 Keele StreetTorontoOntario M3J1P3Canada

Aims this systematic review highlights the relative support and implica-tions of the attractant-decoy and repellent-plant hypotheses,discuss-ing important linkages between these theories and the opportunity for novel integration into ecological and applied *** an extensive systematic review of the current literature on the attract-ant-decoy and repellent-plant hypotheses was done to describe the following attributes of the research to date:(i)the geographic extent(country and biome)of studies on this topic,(ii)the scope of experi-mental designs used,(iii)the level of support for these hypotheses with respect to the breadth of ecological niches tested,(iv)the level of support for these hypotheses with respect to the classes of herbi-vores examined and,lastly,(v)the ecological impact or purpose of these ***,we summarize important research gaps in the empirical literature on this topic and identify novel opportunities for critical linkages between ecological and applied *** Findingsa total of 37%of experiments testing these two associated hypotheses were done in North america,frequently in either temperate broadleaf(26%of studies)or taiga ecosystems(15%of studies).the majority of these studies involved experimental manipulations such as removing and transplanting vegetation and either tracked or excluded mammalian *** implications were primarily examined(59%of studies),but there were also implications described for agriculture and commercial forestry in 22%of *** repellent-plant hypothesis was well supported in many ecological systems,particularly for mammalian herbivores,but the attractant-decoy hypothesis has been less frequently tested,thereby representing an important research *** herbivores were under-represented in all categories except in applied contexts such as commercial forestry and *** is a clear need for studies to connect these two ecological hypotheses with the manageme

关键词： associated plant defence attractant-decoy herbivory neighbour repellent-plant systematic review

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Exploiting a chink in the armor:engineering broadly neutralizing monoclonal antibodies for SARS-like viruses

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Signal Transduction and Targeted Therapy 2021年第7期6卷 1944-1945页

作者： Mirko Cortese christopher j.Neufeldt Department of Infectious Diseases Molecular VirologyHeidelberg UniversityHeidelbergGermany

In a recent article published in Science,Rappazzo and co-authors1 engineered a human monoclonal antibody to bind and neutralize a broad range of SARS-like *** authors used a directed evolution approach with yeast surface display on antibodies isolated from a SARS-CoV-1 survivor,to engineer a broad-spectrum neutralizing antibody with improved neutralization breath,potency,and resistance to viral spike glycoprotein(S protein)mutations(Fig.1).

关键词： neutral SARS antibodies

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Chromatoprobe as a sample-sparing technique for residual solvent analysis of drug discovery candidates by gas chromatography

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药物分析学报：英文版 2017年第4期7卷 265-269页

作者： christopher j.Poronsky jingfang Qian Cutrone Bristol-Myers Squibb Research and DevelopmentWallingfordCT 06492USA

In drug discovery research, residual solvent measurement is an integral part of purity analysis for synthesis of a drug candidate before it is used for toxicity testing. This is usually carried out using gas chromatography(GC)with direct injection sample introduction. This method requires testing compounds to be soluble at high concentrations( > 50 mg/mL, usually in DMSO) to achieve acceptable sensitivity, a hurdle which is not always achievable for some samples such as cyclic peptides and oligonucleotides. To overcome the limitation associated with the direct injection approach, a new method using the Chromatoprobe thermal extraction device was developed for quantifying residual solvents of drug discovery compounds. This method not only consumes significantly less material(less than 1 mg), but also shows higher sensitivity than the direct injection *** addition, because no diluent is required with the Chromatoprobe thermal extraction, all residual solvents can be detected and measured without further method optimization. In our study, we compared data from GC residual solvent analysis using the Chromatoprobe solid sample introduction to those of the direct injection method for seven in-house samples. Our results showed a good agreement between the data from these two sample introduction methods. Thus, the Chromatoprobe sample introduction method provided a samplesparing alternative to the direct injection method for the measurement of residual solvents in drug *** method can be particularly useful for residual solvent analysis in samples that are available only in limited amounts, poorly soluble, and/or unstable in the diluents used for the direct injection method.

关键词： Chromatoprobe Thermal extraction Gas chromatography Residual solvent Drug discovery

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The floristic relationship between the upland and lowland Carboniferous wetlands of Variscan Euramerica——Evidence from some medullosalean pteridosperm fronds

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journal of Palaeogeography 2019年第2期8卷 130-141页

作者： christopher j.Cleal Borja Cascales-Mi?ana Department of Natural Sciences National Museum Wales CNRS University of Lille

Alethopteris grandinii represents remains of fronds of a medullosalean pteridosperm(probably a small tree) that rapidly migrated across the lowland wetland habitats of Variscan Euramerica in middle Asturian(late Moscovian)*** was probably caused by changing drainage patterns within the lowland coal swamps,in response to climate and landscape ***,these medullosaleans had first appeared rather earlier,in early Bolsovian(early Moscovian) times,in upland wetland *** upland habitats may have pre-adapted these plants to the changed condition in the lowland coal swamps.

关键词： Carboniferous Coal swamps Medullosales Upland Migration

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The information content of financial survey response data

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Financial Innovation 2015年第1期1卷 131-150页

作者： j christopher Westland University of Illinois

Market data for financial studies typically derives from either historical transactions or contemporaneous surveys of sentiment and *** research communities analyzing data from these opposing categories of source data see themselves as distinct,with advantages not shared by the *** research investigates these latter claims in an information theoretic context,and suggests where methods and controls can be *** current research develops a Fisher Information metric for Likert scales,and explores the effect of particular survey design decisions or results on the information content.A Fisher Information metric outperforms earlier metrics by converging reliably to values that are intuitive in the sense that they suggest that information captured from subjects is fairly *** results of the analysis suggest that varying bias and response dispersion inherent in specific surveys may require increases of sample size by several orders of magnitude to compensate for information loss and in order to derive valid conclusions at a given significance and power of tests.A prioritization of quality of design,and the factors relevant to survey design are presented in the conclusions,and illustrative examples provide insight and guidance to the assessment of information content in a survey.

关键词： Financial transactions Information theory Survey Economics Mathematical models

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Enhancing sintering resistance of atomically dispersed catalysts in reducing environments with organic monolayers

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Green Energy & Environment 2022年第6期7卷 1263-1269页

作者： jing Zhang Chithra Asokan Gregory Zakem Phillip christopher j.Will Medlin Department of Chemical and Biological Engineering University of ColoradoBoulderCOUSA Department of Chemical Engineering University of CaliforniaSanta BarbaraSanta BarbaraCAUSA

Atomically dispersed precious metal catalysts maximize atom efficiency and exhibit unique ***,they are susceptible to *** reactions occurring in reducing environments tend to result in atomically dispersed metals sintering at lower temperatures than in oxidative or inert atmospheres due to the formation of mobile metal-H or metal-CO ***,we develop a new approach to mitigate sintering of oxide supported atomically dispersed metals in a reducing atmosphere using organophosphonate self-assembled monolayers(SAMs).We demonstrate this for the case of atomically dispersed Rh on Al_(2)O_(3) and TiO_(2) using a combination of CO probe molecule FTIR,temperature programmed desorption,and alkene hydrogenation rate *** suggests that SAM functionalization of the oxide provides physical diffusion barriers for the metal and weakens the interactions between the reducing gas and metal,thereby discouraging the adsorbate-promoted diffusion of metal atoms on oxide *** results show that support functionalization by organic species can provide improved resistance to sintering of atomically dispersed metals with maintained catalytic reactivity.

关键词： Atomically dispersed catalysts Organic monolayers Rh Single atom catalysis Sintering

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Edible hybrid microbial-electronic sensors for bleeding detection and beyond

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Hepatobiliary Surgery and Nutrition 2019年第2期8卷 157-160页

作者： christopher j.Bettinger Department of Materials Science and Engineering Carnegie Mellon UniversityPittsburghPAUSA Department of Biomedical Engineering Carnegie Mellon UniversityPittsburghPAUSA

Introduction to edible electronics Edible electronic devices are orally deployable electrified medical devices that have great potential to diagnose and treat many types of *** in edible electronic devices has accelerated in recent years for several ***,the role of gut health on overall health is becoming *** composition influences metabolism,immunity,and cognitive *** gut microbiome is also a valuable biomarker for distinguishing between healthy and diseased *** and longitudinal surveillance may could detect disorders such as inflammatory bowel disease(IBD),Crohn's disease,colorectal cancer,or ***,the availability of computing platforms and genomic information are becoming more prevalent,cost-effective,and *** and low-cost electronics serve as a core technology for designing and fabricating edible electronic *** computing platforms can provide a complementary monitoring network to interrogate ingestible medical devices in ambulatory ***,there have been critically enabling advances in materials,non-conventional fabrication,and device ***,Mimee et *** many of these capabilities to create an edible electronic device to detect bleeding in clinically relevant animal *** key innovation is the use of genetically engineered bacteria that transduce biochemical markers for bleeding into optical signals that can be measured,quantified,recorded,and communicated to external devices outside the body.

关键词： metabolism immunity becoming

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