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中华核医学与分子影像杂志 2021年第9期41卷 566-573页

作者： christopher j.palestro 郁步惠(译) 苏洪星(译) 孙娜赵晋华(审校) Department of Radiology Hofstra Northwell School of MedicineHempsteadNew York 上海交通大学附属第一人民医院核医学科 200080

目前已有多种影像学检查可用于肌肉骨骼感染的诊断。X光片作为常规检查,即便有时不能提供诊断性信息,但可提供感兴趣区的解剖概况,利于后续影像学方法的选择和诊断。MRI的灵敏度很高,可提供详细的解剖细节。骨显像可不受基础病变的影响... 详细信息

目前已有多种影像学检查可用于肌肉骨骼感染的诊断。X光片作为常规检查,即便有时不能提供诊断性信息,但可提供感兴趣区的解剖概况,利于后续影像学方法的选择和诊断。MRI的灵敏度很高,可提供详细的解剖细节。骨显像可不受基础病变的影响,准确诊断骨髓炎。67Ga主要用于脊柱骨髓炎的诊断。体外标记白细胞显像作为一种放射性核素检查方法,可用于糖尿病足骨髓炎和人工关节感染等复杂性骨髓炎的诊断,但不能用于诊断脊柱骨髓炎。抗粒细胞抗体和抗体片段具有一定的局限性,且不能广泛供应。^(111)In-生物素可用于脊柱骨髓炎的诊断。放射性标记抗菌肽泛素合成片段是一种有前景的特异性感染显像剂。^(18)F-脱氧葡萄糖(FDG)可用于脊柱骨髓炎的诊断,但其在糖尿病足骨髓炎和人工关节感染诊断方面的价值尚不明确。初步研究表明,^(68)Ga或可用于肌肉骨骼感染的诊断。^(124)I-fialuridine最初被认为可用作特异性感染显像剂,但随后的研究结果令人失望。PET/CT和SPECT/CT显像融合了解剖成像和功能显像,彻底改变了诊断影像学。这2种融合显像系统可提高诊断的准确性,并影响患者治疗方案的选择,从而重新定义了诊断学组在疑似或确诊感染和炎性反应患者中的价值。

关键词： FDG Ga 标记白细胞骨髓炎 PET/CT SPECT/CT

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Nuclear medicine and the failed joint replacement: Past, present, and future

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World journal of Radiology 2014年第7期6卷 446-458页

作者： christopher j.palestro Division of Nuclear Medicine Molecular Imaging Long Island Jewish Medical Center

Soon after the introduction of the modern prosthetic joint,it was recognized that radionuclide imaging provides useful information about these *** bone scan was used extensively to identify causes of prosthetic joint *** became apparent,however,that although sensitive,regardless of how the images were analyzed or how it was performed,the test was not specific and could not distinguish among the causes of prosthetic *** in anatomic imaging,notably cross sectional modalities,have facilitated the diagnosis of many,if not most,causes of prosthetic failure,with the important exception of *** has led to a shift in the diagnostic paradigm,in which nuclear medicine investigations increasingly have focused on diagnosing *** recognition that bone scintigraphy could not reliably diagnose infection led to the development of combined studies,first bone/gallium and subsequently leukocyte/bone and leukocyte/marrow *** leukocyte imaging,combined with bone marrow imaging is the most accurate(about90%)imaging test for diagnosing joint arthroplasty *** value not withstanding,there are significant disadvantages to this ***-vivo techniques for labeling leukocytes,using antigranulocyte antibodieshave been explored,but have their own limitations and the results have been ***(FDG)-positron emission tomography(FDG-PET)has been extensively investigated for more than a decade but its role in diagnosing the infected prosthesis has yet to be *** peptides bind to bacterial cell membranes and are infection *** suggest that these agents may be useful for diagnosing prosthetic joint infection,but large scale studies have yet to be *** for many years nuclear medicine has focused on diagnosing prosthetic joint infection,the advent of hybrid imaging with singlephoton emission computed tomography(SPECT)/electronic computer X-ray tomography technique(CT)a

关键词： Bone scintigraphy Positron emission tomography 18F-fluorodeoxyglucose F-18 Fluoride-positron emission tomography Gallium Infection Labeled leukocytes Prosthetic joint

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Appearance of aseptic vascular grafts after endovascular aortic repair on[(18)F]fluorodeoxyglucose positron emission tomography/computed tomography

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世界放射学杂志:英文版(电子版) 2023年第8期15卷 241-249页

作者： Paige Bennett Maria Bernadette Tomas christopher F Koch Kenneth j Nichols christopher j.palestro Department of Radiology LIJMC Northwell HealthNew Hyde ParkNY 11040United States Department of Radiology Zucker School of Medicine at Hofstra/NorthwellHempsteadNY 11549United States Division of Nuclear Medicine and Molecular Imaging Department of RadiologyNorthwell HealthNew Hyde ParkNY 11040United States

BACKGROUND Diagnosis of prosthetic vascular graft infection with[(18)F]fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG PET/CT)allows for early detection of functional changes associated with infection,based on increased glucose utilization by activated macrophages and *** vascular grafts,like all foreign bodies,can stimulate an inflammatory response,which can present as increased activity on 18F-FDG PET/***,distinguishing aseptic inflammation from graft infection,though important,can be *** the case of endovascular aneurysm repair(EVAR),a minimally invasive procedure involving the transfemoral insertion of an endoprosthetic stent graft,the normal postoperative appearance of these grafts on 18F-FDG PET/CT can vary over time,potentially confounding study *** To investigate the visual,semiquantitative,and temporal characteristics of aseptic vascular grafts in patients status post *** In this observational retrospective cohort study,patients with history of EVAR who underwent 18F-FDG PET/CT for indications other than infection were identified *** patients were asymptomatic for graft infection-no abdominal pain,fever of unknown origin,sepsis,or leukocytosis-at the time of imaging and for≥2 mo after each PET/*** studies such as CT for each patient were also reviewed,and any patients with suspected or confirmed vascular graft infection were *** hundred two scans performed on 43 patients(34 males;9 females;age=77±8 years at the time of the final PET/CT)were retrospectively *** 43 patients had an abdominal aortic(AA)vascular graft,40 patients had a right iliac(RI)limb graft,and 41 patients had a left iliac(LI)limb *** patients had 1 PET/CT and 21 patients had from 2 to 9 PET/*** were imaged between 2 mo to 168 mo(about 14 years)post *** grafts were imaged within 6 mo of placement,including three that were imaged wit

关键词： Aseptic vascular grafts Endovascular aortic repair [(18)F]fluorodeoxyglucose positron emission tomography/computed tomography

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