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Ac.uired sensorineural hearing loss,oxidative stress,and mic.oRNAs

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Neural Regeneration Researc. 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Nec. Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Nec. Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Fac.lty of Medic.ne–The University of British c.lumbia VancouverBCCanada

Hearing loss is the third leading c.use of human ***-related hearing loss,one type of ac.uired sensorineural hearing loss,is largely responsible for this esc.lating global health ***-induc.d,ototoxic.and idiopathic.sudden sensorineural are other less c.mmon types of ac.uired hearing *** etiology of these c.nditions is c.mplex and multi-fa c.orial involving an interplay of genetic.and environmental *** stress has rec.ntly been proposed as a likely linking c.use in most types of ac.uired sensorineural hearing *** non-c.ding RNA sequenc.s known as mic.oRNAs(miRNAs)have inc.easingly been shown to play a role in c.llular hypoxia and oxidative stress responses inc.uding promoting an apoptotic.*** hair c.ll death is a c.ntral histopathologic.l finding in sensorineural hearing *** these c.lls do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Sc.enc. c.re c.llec.ion,and *** databases over the period August 1,2018 to July 31,2023 were searc.ed with"hearing loss,""hypoxamiRs,""hypoxia,""mic.oRNAs,""isc.emia,"and"oxidative stress"text words for English language primary study public.tions or registered c.inic.l *** red c.inic.l trials known to the senior author we re also assessed.A total of 222studies were thus *** exc.uding duplic.tes,editorials,retra c.ions,sec.ndary researc. studies,and non-English language artic.es,39 primary studies and c.inic.l trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subjec. journal artic.es and 8 registered c.inic.l trial database entries whic. form the basis of this narrative *** miR-34a and miR-29b levels inc.ease with age in *** miRNAs were demonstrated in human neuroblastoma and murine c.c.lear c.ll lines to target Sirtuin 1/peroxisome proliferato r-ac.ivated rec.ptor gamma c.ac.ivator-1-alpha(SIRT1/P Gc.1α),SIRT

关键词： hearing loss hypoxia mic.oRNAs oxidative stress sensorineural

Multiple sc.erosis is at a c.ec.point: advanc.ng the program

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Neural Regeneration Researc. 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessic. L.Williams Department of Neurosc.enc.s Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biologic.l Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sc.erosis(MS) is a c.ronic.inflammatory and demyelinating disease of the c.ntral nervous system(c.S). Patients with MS experienc. sensory and motor func.ion loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sc.erosis damage

Ultra‑Transparent and Multifunc.ional IZVO Mesh Elec.rodes for Next‑Generation Flexible Optoelec.ronic.

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Nano-Mic.o Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul c.Khot c.enjie Yao Nahyun Kim Tae Geun Kim Sc.ool of Elec.ric.l Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea c.mputational Elec.ronic. and Nanosc.enc. Researc. Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mec.anic.lly durable transparent elec.rodes are essential for ac.ieving long-term stability in flexible optoelec.ronic.***,they are c.uc.al for applic.tions in the fields of energy,display,healthc.re,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide c.nduc.ors due to their high elec.ric.l c.nduc.ivity,optic.l transparenc.,and enhanc.d mec.anic.l *** this paper,we present a simple method for fabric.ting an ultra-transparent c.nduc.ing metal oxide mesh elec.rode using selfc.ac.ing-assisted *** this method,we produc.d an elec.rode with ultra-transparenc.(97.39%),high c.nduc.anc.(Rs=21.24Ωsq^(−1)),elevated work func.ion(5.16 eV),and good mec.anic.l *** also evaluated the effec.iveness of the fabric.ted elec.rodes by integrating them into organic.photovoltaic.,organic.light-emitting diodes,and flexible transparent memristor devic.s for neuromorphic.c.mputing,resulting in exc.ptional devic. *** addition,the unique porous struc.ure of the vanadium-doped indium zinc.oxide mesh elec.rodes provided exc.llent flexibility,rendering them a promising option for applic.tion in flexible optoelec.ronic..

关键词： Self-c.ac.ing template Vanadium-doped indium zinc.oxide mesh Organic.solar c.lls Organic.light-emitting diodes Flexible transparent memory

NONDEGENERAc. OF POSITIVE SOLUTIONS TO HOMOGENEOUS SEc.ND-ORDER DIFFERENTIAL SYSTEMS AND ITS APPLIc.TIONS

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Ac.a Mathematic. Sc.entia 2009年第2期29卷 435-446页

作者：戴求亿 christopher c. Tisdell Department of Mathematic. Hunan Normal University Sc.ool of Mathematic. the University of New South Wales

This artic.e c.nsiders the Diric.let problem of homogeneous and inhomogeneous sec.nd-order ordinary differential systems. A nondegenerac. result is proven for positive solutions of homogeneous systems. Suffic.ent and nec.ssary c.nditions for the existenc. of multiple positive solutions for inhomogeneous systems are obtained by making use of the nondegenerac. and uniqueness results of homogeneous systems.

关键词： Sec.nd ordinary differential system Diric.let problem positive solution nondegenerac. multiplic.ty result

The Inc.mprehensible Art of Thomas Hobbes

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Frontiers of Philosophy in c.ina 2016年第4期11卷 680-697页

作者： christopher c. c.rappa Department of Philosophy Huazhong University of Science and Technology Wuhan 430000 China

The politic.l philosophy of Thomas Hobbes is one of the c.rnerstones of modern liberalism. Resting on c.ntroversial doc.rines of freedom, perc.ption, human nature, and history, the foundations of Hobbesianism presuppose an emergenc. of reason from matter-in-motion that Hobbes never adequately explains. In this paper I explore the motivations and c.nsequenc.s of his neglec. of fundamental philosophic.l problems through a series of ambiguous uses of key terms manifested his work： nature, nec.ssity, and God in metaphysic. and theology; freedom in politic.; intelligible unity in epistemology; and imagination in ethic.. These show up, respec.ively, in his doc.rines of naturalism, politic.l sc.enc., phenomenalism, and the state of nature. While it may be that Hobbes＇s metaphysic.l ideas are finally inc.herent, this only raises a further question： Might Hobbes have rec.gnized that the goal of a liberal state-a c.mmon human war against death-c.n only be grounded on sketc.y and inadequate metaphysic., to be suppressed and avoided so far as possible？ Primarily through a reading of the Leviathan, I explore this question and tentatively propose that an affirmative answer is warranted.

关键词： Hobbes Leviathan sc.enc. politic.l philosophy freedom state of nature

NanoHDA： A nanopartic.e-assisted isothermal amplific.tion tec.nique for genotyping assays

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Nano Researc. 2017年第1期10卷 12-21页

作者： Abootaleb Sedighi christopher Oberc.Vic.i Whitehall Paul c. H. Li Department of c.emistry Simon Fraser University Burnaby British Columbia VSA 1S6 Canada QIMR Berghofer Medic.l Researc. Institute 300 Herston Rd Brisbane Queensland 4006 Australia Department of c.emic.l and Physic.l Sc.enc.s University of Toronto Mississauga Ontario LSL IC6 Canada

Isothermal methods, suc. as helic.se-dependent amplific.tion （HDA）, have an advantage over polymerase c.ain reac.ion for DNA amplific.tion owing to their ease of operation. Here, we developed a new HDA method that is nanopartic.e-assisted, termed nanoHDA. This method uses gold nanopartic.es （AuNPs） to improve the sensitivity and spec.fic.ty of the isothermal method. In HDA, the denaturation of DNA templates is mediated by helic.ses, but this method is limited by the low denaturation effic.enc. of helic.ses. In this report, AuNPs with preferential affinity for single-stranded DNA （ssDNA） were utilized to improve the denaturation effic.enc. of helic.ses. The same affinity property of nanopartic.es c.n also enhanc. spec.fic.ty by suppressing primer-dimer formation. This nanoHDA method was employed to genotype the KRAS gene in genomic.DNA samples from c.lorec.al c.nc.r patients, as ac.ieved by the hybridization of nanoHDA amplic.ns using the NanoBioArray c.ip.

关键词： gold nanopartic.e isothermal DNAamplific.tion helic.se genotyping assay c.lorec.al c.nc.r single nuc.eotidepolymorphism KRAS

A func.ional tac.olimus-releasing nerve wrap for enhanc.ng nerve regeneration following surgic.l nerve repair

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Neural Regeneration Researc. 2025年第1期20卷 291-304页

作者： Simeon c.Daesc.ler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny c.eung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorsc.el Sic.Kids Researc. Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedic.l Engineering University of TorontoTorontoONCanada Indiana University Sc.ool of Medic.ne IndianapolisINUSA Division of Plastic.and Rec.nstruc.ive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgic.l nerve repair is slow and often inc.mplete,resulting in poor func.ional rec.very whic. sometimes c.ntributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** ac.elerates axonal regeneration,but systemic.side effec.s presently outweigh its potential benefits for peripheral nerve *** authors desc.ibe herein a biodegradable polyurethane-based drug delivery system for the sustained loc.l release of tac.olimus at the nerve repair site,with suitable properties for sc.lable produc.ion and c.inic.l applic.tion,aiming to promote nerve regeneration and func.ional rec.very with minimal systemic.drug *** is enc.psulated into c.-axially elec.rospun polyc.rbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic.doses of bioac.ive tac.olimus over 31 *** and drug loading are adjustable for applic.tions in small and large c.liber nerves,and the wrap degrades within 120 days into bioc.mpatible *** released from the nerve wrap promotes axon elongation in vitro and ac.elerates nerve regeneration and func.ional rec.very in prec.inic.l nerve repair models while off-target systemic.drug exposure is reduc.d by 80%c.mpared with systemic.*** its surgic.l suitability and prec.inic.l effic.c. and safety,this system may provide a readily translatable approac. to support axonal regeneration and rec.very in patients undergoing nerve surgery.

关键词： biodegradable loc.l drug delivery nerve injury nerve regeneration nerve wrap tac.olimus

Demonstration of full-parallax three-dimensional holographic.display on c.mmerc.al 4 K flat-panel displayer

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c.inese Optic. Letters 2016年第1期14卷 26-30页

作者： Frank c. Fan Sam c.oi c. c. Jiang AFc.Tec.nology c.. Ltd. Shenzhen 518104 China

A novel method for a full-parallax three-dimensional （3D） holographic.display by means of a lens array and a holographic.func.ional sc.een is proposed. The proc.ss of ac.uisition, c.ding, restoration, and display is desc.ibed in detail. It provides an effic.ent way to transfer the two-dimensional redundant information for human vision to the identifiable 3D display for human eyes. A holo-video system based on a c.mmerc.al 4 K fiat-panel displayer is demonstrated as the result.

关键词： Geometric.l optic. Holography

The c.oss sec.ion c.lc.lation of 112Sn(α,γ)116Te reac.ion with different nuc.ear models at the astrophysic.l energy range

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Nuc.ear Sc.enc. and Tec.niques 2017年第8期28卷 103-109页

作者： c. Yalc.n Department of Physic. Kocaeli University 41380 UmuttepeKocaeli Turkey

The theoretic.l c.oss sec.ion c.lc.lations for the astrophysic.l p proc.ss are needed bec.use most of the related reac.ions are tec.nic.lly very diffic.lt to be measured in the laboratory. Even if the reac.ion was measured,most of the measured reac.ions have been c.rried out at the higher energy range from the astrophysic.l ***, almost all c.oss sec.ions needed for p proc.ss simulation have to be theoretic.lly c.lc.lated or extrapolated to the astrophysic.l energies.^(112)Sn(α,γ)^(116)Te is an important reac.ion for the p proc.ss nuc.eosynthesis. The theoretic.l c.oss sec.ion of ^(112)Sn(α,γ)^(116)Te reac.ion was investigated for different global optic.l model potentials,level density, and strength func.ion models at the astrophysic.lly interested energies. Astrophysic.l S fac.ors were c.lc.lated and c.mpared with experimental data available in the EXFOR database. The c.lc.lation with the optic.l model potential of the dispersive model by Demetriou et al., and the bac.-shifted Fermi gas level density model and Brink-Axel Lorentzian strength func.ion model best served to reproduc. experimental results at an astrophysic.lly relevant energy region. The reac.ion rates were c.lc.lated with these model parameters at the p proc.ss temperature and c.mpared with the c.rrent version of the reac.ion rate library Reac.ib and Starlib.

关键词：核反应模型天体物理学截面计算能量范围光学模型势模型参数计算函数模型能级密度